J. Sturis

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Computer model for mechanisms underlying ultradian oscillations of insulin and glucose.

E. Mosekilde, J. Sturis, K. Polonsky, 1991, The American journal of physiology.

Phase-locking regions in a forced model of slow insulin and glucose oscillations.

E. Mosekilde, J. Sturis, K. Polonsky, 1995, Chaos.

Comparison of the pharmacokinetics of three concentrations of insulin aspart during continuous subcutaneous insulin infusion (CSII) in a pig model

J. Sturis, U. Ribel, S. B. Petersen, 2013, The Journal of pharmacy and pharmacology.

Modeling the insulin-glucose feedback system: the significance of pulsatile insulin secretion.

E. Mosekilde, J. Sturis, I. Tolic, 2000, Journal of theoretical biology.

Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations.

K. Clément, M. Stoffel, P. Froguel, 1994, The Journal of clinical investigation.

Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects With Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12

A. Hattersley, P. Froguel, M. Byrne, 1996, Diabetes.

Sleepiness, Performance, and Neuroendocrine Function during Sleep Deprivation: Effects of Exposure to Bright Light or Exercise

M. Byrne, J. Sturis, E. van Cauter, 1997, Journal of biological rhythms.

Abnormalities in the ultradian oscillations of insulin secretion and glucose levels in Type 2 (non-insulin-dependent) diabetic patients

J. Sturis, J. D. Blackman, J. Sturis, 1992, Diabetologia.

Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes.

J D Veldhuis, S M Pincus, Steven M. Pincus, 2000, Diabetes.

Temporal Profiles and Clinical Significance of Pulsatile Insulin Secretion

Jeppe Sturis, J. Sturis, K. Polonsky, 1998, Hormone Research in Paediatrics.

24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.

A J Scheen, J. Sturis, K. Polonsky, 1995, The Journal of clinical investigation.

Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus.

J. Sturis, K. Polonsky, E. van Cauter, 1993, The Journal of clinical investigation.

Entrainment of pulsatile insulin secretion by oscillatory glucose infusion.

J. Sturis, K. Polonsky, E. van Cauter, 1991, The Journal of clinical investigation.

Small-molecule agonists for the glucagon-like peptide 1 receptor

Jeppe Sturis, Jarek Kostrowicki, Carsten Behrens, 2007, Proceedings of the National Academy of Sciences.

Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.

M. Byrne, J. Sturis, K. Polonsky, 1995, The Journal of clinical investigation.

Acute hyperglycemia alters the ability of the normal beta-cell to sense and respond to glucose.

M. Byrne, J. Sturis, B. Göke, 2002, American journal of physiology. Endocrinology and metabolism.

Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone.

J. Sturis, K. Polonsky, C. Burant, 1996, The American journal of physiology.

Effects of morning cortisol elevation on insulin secretion and glucose regulation in humans.

M. Byrne, J. Sturis, K. Polonsky, 1996, The American journal of physiology.

Alterations in the kinetics of C-peptide and insulin secretion in hyperthyroidism.

J. Sturis, K. Polonsky, N. O'Meara, 1993, The Journal of clinical endocrinology and metabolism.

Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: evidence of several aberrations

J. Holst, M. Walker, J. Sturis, 1999, Diabetologia.

The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose.

A. Chang, J. Halter, A. Galecki, 2003, Diabetes.

Compensation in Pancreatic β-Cell Function in Subjects With Glucokinase Mutations

E. Mosekilde, P. Froguel, J. Sturis, 1994, Diabetes.

Insulin detemir is a fully efficacious, low affinity agonist at the insulin receptor

J. Sturis, U. Ribel, E. Nishimura, 2010, Diabetes, obesity & metabolism.

Hypoglycemic Thresholds for Cognitive Dysfunction in IDDM

J. Sturis, K. Polonsky, V. Towle, 1992, Diabetes.

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

J. Sturis, M. Donath, K. Maedler, 2004, Diabetes.

Repaglinide treatment amplifies first‐phase insulin secretion and high‐frequency pulsatile insulin release in Type 2 diabetes

J. Sturis, N. Porksen, S. Pincus, 2005, Diabetic medicine : a journal of the British Diabetic Association.

Alterations in the Patterns of Insulin Secretion Before and After Diagnosis of IDDM

J. Sturis, K. Polonsky, K. Herold, 1995, Diabetes Care.

GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics.

J. Sturis, U. Ribel, K. Wassermann, 2003, British journal of pharmacology.

NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity.

J. Sturis, K. Polonsky, L. Philipson, 1996, The American journal of physiology.

Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects.

J. Sturis, M. Zdravkovic, P. Rolan, 2002, Diabetes care.

Synergistic effect of the human GLP‐1 analogue liraglutide and a dual PPARα/γ agonist on glycaemic control in Zucker diabetic fatty rats

J. Sturis, K. Wassermann, J. Rømer, 2009, Diabetes, obesity & metabolism.

Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective KATP Channel Opener

J. Sturis, K. Skak, H. Markholst, 2004 .

Pharmacokinetics and pharmacodynamics of different modes of insulin pump delivery. A randomized, controlled study comparing subcutaneous and intravenous administration of insulin aspart

J. Sturis, O. Skyggebjerg, T. Lauritzen, 2011, Diabetic Medicine.

Effects of aging on glucose regulation during wakefulness and sleep.

M. Byrne, J. Sturis, K. Polonsky, 1995, The American journal of physiology.

Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance.

J. Sturis, K. Polonsky, G. Bell, 1996, The New England journal of medicine.

Prevention of diabetes does not completely prevent insulin secretory defects in the ZDF rat.

J. Sturis, K. Polonsky, J. Tang, 1995, The American journal of physiology.

GLP-1 derivatives as novel compounds for the treatment of type 2 diabetes: Selection of NN2211 for clinical development

P. J. Larsen, J. Holst, J. Sturis, 2001 .

Insulin Secretory Profiles and C-Peptide Clearance Kinetics at 6 Months and 2 Years After Kidney-Pancreas Transplantation

J. Sturis, K. Polonsky, E. Cauter, 1992, Diabetes.

A novel high-affinity peptide antagonist to the insulin receptor.

J. Sturis, U. Ribel, B. Hansen, 2008, Biochemical and biophysical research communications.

Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.

J. Sturis, C. Fledelius, R. Alemzadeh, 2004, Metabolism: clinical and experimental.

Continuous Glucose Monitoring Sensor Glucose Levels and Insulin Pump Infusion Set Wear-Time During Treatment with Fast-Acting Insulin Aspart: A Post Hoc Analysis of Onset 5

J. Sturis, A. Gorst-rasmussen, M. Ekelund, 2021, Diabetes technology & therapeutics.

NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs.

J. Sturis, U. Ribel, C. Deacon, 2002, European journal of pharmacology.

Analytical problems in detecting rapid insulin secretory pulses in normal humans.

J. Sturis, K. Polonsky, E. van Cauter, 1993, The American journal of physiology.

Abnormal temporal patterns of glucose tolerance in obesity: relationship to sleep-related growth hormone secretion and circadian cortisol rhythmicity.

M. Byrne, J. Sturis, K. Polonsky, 1994, The Journal of clinical endocrinology and metabolism.

Glucocorticoid induced insulin resistance impairs basal but not glucose entrained high-frequency insulin pulsatility in humans

J. Sturis, R. Dall, J. Veldhuis, 2002, Diabetologia.

Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.

M. Stoffel, J. Sturis, K. Polonsky, 1995, Diabetes.

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

M. Stoffel, J. Sturis, K. Polonsky, 1995, Diabetes.

Preliminary studies on the immediate phase-shifting effects of light and exercise on the human circadian clock.

M. Byrne, J. Sturis, E. van Cauter, 1993, Journal of biological rhythms.

Elucidating the Mechanism of Absorption of Fast-Acting Insulin Aspart: The Role of Niacinamide

J. Sturis, H. H. Refsgaard, U. Ribel, 2019, Pharmaceutical Research.

Measurements of insulin responses as predictive markers of pancreatic beta-cell mass in normal and beta-cell-reduced lean and obese Göttingen minipigs in vivo.

J. Sturis, R. Carr, M. Wilken, 2006, American Journal of Physiology. Endocrinology and Metabolism.

Hopf bifurcation analysis applied to predator-prey modeling

J. Sturis, J. Sturis, P. Gross, 1992 .

Abnormal Insulin Secretion, Not Insulin Resistance, Is the Genetic or Primary Defect of MODY in the RW Pedigree

J. Halter, J. Sturis, K. Polonsky, 1994, Diabetes.

Altered Insulin Secretory Responses to Glucose in Subjects with a Mutation in the MODY1 Gene on Chromosome 20

J. Halter, M. Stoffel, M. Byrne, 1995, Diabetes.

Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance

Jeppe Sturis, J. Sturis, K. Polonsky, 1992, Diabetes.

NN414, a SUR1/Kir6.2-selective potassium channel opener, reduces blood glucose and improves glucose tolerance in the VDF Zucker rat.

J. Sturis, R. Carr, C. L. Brand, 2003, Diabetes.

Combination of the insulin sensitizer, pioglitazone, and the long‐acting GLP‐1 human analog, liraglutide, exerts potent synergistic glucose‐lowering efficacy in severely diabetic ZDF rats

J. Sturis, N. Vrang, L. B. Knudsen, 2008, Diabetes, obesity & metabolism.

Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes.

J. Sturis, J. Veldhuis, O. Schmitz, 2002, Diabetes.

Bedtime Administration of NN 2211 , a Long-Acting GLP-1 Derivative , Substantially Reduces Fasting and Postprandial Glycemia in Type 2 Diabetes

J. Sturis, J. Veldhuis, O. Schmitz, 2002 .

One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.

Jeppe Sturis, J. Sturis, B. Landau, 2004, Diabetes.

Insulin secretion and clearance during low-dose graded glucose infusion.

M. Byrne, J. Sturis, K. Polonsky, 1995, The American journal of physiology.

Concordant induction of rapid in vivo pulsatile insulin secretion by recurrent punctuated glucose infusions.

Steven M. Pincus, J. Sturis, J. Veldhuis, 2000, American journal of physiology. Endocrinology and metabolism.

Alterations in the ultradian oscillations of insulin secretion and plasma glucose in aging

J. Sturis, K. Polonsky, E. Cauter, 1996, Diabetologia.

Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat.

J. Sturis, K. Polonsky, J. Polonský, 1994, The American journal of physiology.

Ultradian oscillations of leptin secretion in humans.

J. Sturis, K. Polonsky, J. Ohannesian, 1996, Biochemical and biophysical research communications.

The conscious Göttingen minipig as a model for studying rapid pulsatile insulin secretion in vivo

J. Sturis, M. Wilken, J. Sturis, 2002, Diabetologia.

35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts.

Thomas J. Smith, B. M. Rasmussen, V. C. Phan, 1999, Diabetologia.

Novel Tricyclic-α-alkyloxyphenylpropionic Acids: Dual PPARα/γ Agonists with Hypolipidemic and Antidiabetic Activity

Ingrid Pettersson, Jeppe Sturis, J. Sturis, 2002 .

Commemorating insulin's centennial: engineering insulin pharmacology towards physiology.

J. Sturis, T. Hoeg-Jensen, H. Haahr, 2021, Trends in pharmacological sciences.

Nocturnal exercise phase delays circadian rhythms of melatonin and thyrotropin and thyrotropin secretion in normal men

M. Byrne, J. Sturis, R. Leproult, 1994 .

Factors Affecting Performance of Insulin Pen Injector Technology: A Narrative Review

J. Sturis, T. Sparre, D. B. Steensgaard, 2022, Journal of diabetes science and technology.

Defects in Insulin Secretion and Action in Women With a History of Gestational Diabetes

J. Sturis, K. Polonsky, D. Finegood, 1995, Diabetes.

Elevated plasma glucose 2 h postchallenge predicts defects in beta-cell function.

M. Byrne, J. Sturis, K. Polonsky, 1996, The American journal of physiology.

Beta-Cell Function in Polycystic Ovary Syndrome

M. Byrne, J. Sturis, K. Polonsky, 1996 .

Dual PPARα/γ activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats

J. Sturis, K. Wassermann, B. Hansen, 2003 .

Nocturnal exercise phase delays circadian rhythms of melatonin and thyrotropin secretion in normal men.

M. Byrne, J. Sturis, E. van Cauter, 1994, The American journal of physiology.

High-frequency oscillations in circulating amylin concentrations in healthy humans.

J. Sturis, A. P. Hansen, S. Pincus, 2000, American journal of physiology. Endocrinology and metabolism.

Beta-cell selective KATP-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity

Jeppe Sturis, Ralf Langen, J. Sturis, 2010, Regulatory Peptides.

GLP‐1 derivative liraglutide in rats with β‐cell deficiencies: influence of metabolic state on β‐cell mass dynamics

J. Sturis, U. Ribel, K. Wassermann, 2003 .

Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus.

R. Wing, J. Sturis, K. Polonsky, 1993, The Journal of clinical endocrinology and metabolism.

Dual PPARalpha /gamma activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats.

J. Sturis, K. Wassermann, B. Hansen, 2003, American journal of physiology. Endocrinology and metabolism.

Demonstration of rapid light-induced advances and delays of the human circadian clock using hormonal phase markers.

M. Byrne, J. Sturis, E. van Cauter, 1994, The American journal of physiology.

Measurements of insulin responses as predictive markers of pancreatic β-cell mass in normal and β-cell-reduced lean and obese Göttingen minipigs in vivo

J. Sturis, R. Carr, M. Wilken, 2006 .

Repaglinide acutely amplifies pulsatile insulin secretion by augmentation of burst mass with no effect on burst frequency.

J. Sturis, S. Pincus, J. Veldhuis, 2000, Diabetes care.

Effects of metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome.

J. Sturis, K. Polonsky, M. Cavaghan, 1997, The Journal of clinical endocrinology and metabolism.

Fast-acting insulin aspart (Fiasp®) improves glycemic outcomes when used with MiniMedTM 670G hybrid closed-loop system in simulated trials compared to NovoLog®

R. Vigersky, J. Sturis, B. Grosman, 2021, Comput. Methods Programs Biomed..

Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.

J. Sturis, K. Wassermann, J. Fleckner, 2002, Journal of medicinal chemistry.

Clinical Phenotypes, Insulin Secretion, and Insulin Sensitivity in Kindreds With Maternally Inherited Diabetes and Deafness Due to Mitochondrial tRNALeu(UUR) Gene Mutation

P. Froguel, M. Byrne, J. Sturis, 1996, Diabetes.

Oscillatory Insulin Secretion After Pancreas Transplant

M. Byrne, J. Sturis, K. Polonsky, 1993, Diabetes.

lean and obese Göttingen minipigs in vivo -cell-reduced β -cell mass in normal and β of pancreatic of insulin responses as predictive markers

J. Sturis, R. Carr, M. Wilken, 2016 .

Alternative insulin delivery systems: how demanding should the patient be?

M. Byrne, J. Sturis, K. Polonsky, 1997, Diabetologia.

Sensory nerve inactivation by resiniferatoxin improves insulin sensitivity in male obese Zucker rats.

J. Sturis, A. Hansen, J. Fleckner, 2005, American journal of physiology. Endocrinology and metabolism.

19 – Modeling Modulatory Effects on Pulsatility

E. Mosekilde, J. Sturis, E. Cauter, 1994 .

Aspects of Oscillatory Insulin Secretion

E. Mosekilde, J. Sturis, K. Polonsky, 1991 .

Chaotic structures in generic management models: Pedagogical principles and examples

David F. Andersen, Jeppe Sturis, J. Sturis, 1988 .

Local and global bifurcations in a model of the economic long wave

Morten Brøns, Jeppe Sturis, J. Sturis, 1991 .

[6] - Techniques for Assessing Ultradian Rhythms in Hormonal Secretion

J. Sturis, E. Cauter, 1995 .

Changes in Pancreatic Islet Glucokinase and Hexokinase Activities With Increasing Age, Obesity, and the Onset of Diabetes

J. Sturis, K. Polonsky, G. Bell, 1997, Diabetes.

Insulin secretion in insulin-resistant women with a history of gestational diabetes.

M. Byrne, J. Sturis, K. Polonsky, 1995, Metabolism: clinical and experimental.

Defects in Insulin Secretion and Action in Women With a History of Gestational Diabetes

J. Sturis, K. Polonsky, D. Finegood, 1995, Diabetes.

Differential effects of glucose stimulation upon rapid pulses and ultradian oscillations of insulin secretion.

J. Sturis, K. Polonsky, E. van Cauter, 1993, The Journal of clinical endocrinology and metabolism.

Local and global bifurcations at infinity in models of glycolytic oscillations

J. Sturis, M. Brøns, 1997, Journal of mathematical biology.