Roger L. Williams

发表

Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases

K. Shokat, Z. Knight, Beth Apsel, 2008, Nature chemical biology.

A segment of cold shock protein directs the folding of a combinatorial protein.

Lutz Riechmann, Eric Girard, Roger L. Williams, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

Phillip T. Hawkins, Roger L. Williams, P. Hawkins, 2000, Cell.

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi

Roger L. Williams, S. d'Auria, A. Varriale, 2013, Nature.

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Robbie Loewith, William A. Weiss, Kevan M. Shokat, 2006, Cell.

Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit

Yuval Inbar, Haim J. Wolfson, Dina Schneidman-Duhovny, 2007, Science.

Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

Nada Jabado, James Curtis, Sergey Nejentsev, 2013, Science.

Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases

Roger L. Williams, A. Berndt, W. Hon, 2011, Oncogene.

The p110δ crystal structure uncovers mechanisms for selectivity and potency of novel PI3K inhibitors

Yi Liu, Kevan M. Shokat, Fabrice Gorrec, 2009, Nature chemical biology.

Structural Principles of Lipid Second Messenger Recognition

Roger L. Williams, 2010 .

Chapter 149 - Structural Principles of Lipid Second Messenger Recognition

Roger L. Williams, 2003 .

PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control

Emilio Hirsch, John E. Burke, Roger L. Williams, 2013, PLoS biology.

Structural insights into phosphoinositide 3-kinase catalysis and signalling

Christian Ried, Roger L. Williams, L. Stephens, 1999, Nature.

Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors

Kevan M. Shokat, John E. Burke, K. Shokat, 2014, Science.

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

Jan Steyaert, John E. Burke, Yohei Ohashi, 2015, Science.

Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases

John E. Burke, Oscar Vadas, Roger L. Williams, 2011, Science Signaling.

Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron-transfer dissociation hydrogen/deuterium exchange mass spectrometry

Roger L. Williams, S. Maslen, Glenn R. Masson, 2017, The Biochemical journal.

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS)

John E. Burke, Roger L. Williams, J. Burke, 2013, Advances in biological regulation.

The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase.

Michael I. Wilson, Roger L. Williams, P. Hawkins, 2004, Advances in enzyme regulation.

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

D. Sabatini, Balaji Santhanam, Roger L. Williams, 2019, Science.

Structural and Membrane Binding Analysis of the Phox Homology Domain of Phosphoinositide 3-Kinase-C2α*

Roger L. Williams, M. Waterfield, J. Bravo, 2006, Journal of Biological Chemistry.

Activation of GCN2 by the ribosomal P-stalk

Roger L. Williams, R. Hegde, O. Perisic, 2019, Proceedings of the National Academy of Sciences.

The effects of neutral detergents on the crystallization of soluble proteins

Roger L. Williams, A. McPherson, M. Mcgrath, 1986 .

Faculty Opinions recommendation of Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis.

Roger L. Williams, 2001 .

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway.

Roger L. Williams, J. Burke, J. Falke, 2016, Biophysical journal.

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Roger L. Williams, A. Bresnick, J. Backer, 2013, Proceedings of the National Academy of Sciences.

Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

Roger L. Williams, J. Burke, O. Perisic, 2011, Structure.

Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

Roger L. Williams, J. Burke, O. Perisic, 2011, Structure.

ARAP3 Is a PI3K- and Rap-Regulated GAP for RhoA

Roger L. Williams, P. Hawkins, L. Stephens, 2004, Current Biology.

Structural Mechanisms of PTEN Regulation.

Roger L. Williams, G. Masson, 2019, Cold Spring Harbor perspectives in medicine.

Nm23/nucleoside diphosphate kinase: Toward a structural and biochemical understanding of its biological functions

Roger L. Williams, P. Steeg, A. De La Rosa, 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α

Christopher M Johnson, M. Neuberger, Roger L. Williams, 2013, FEBS letters.

Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.

S. Emr, Roger L. Williams, R. Crowther, 2008, Structure.

A class of highly selective inhibitors bind to an active state of PI3Kγ

Roger L. Williams, G. Dahl, M. Wymann, 2019, Nature Chemical Biology.

PIKKs--the solenoid nest where partners and kinases meet.

Roger L. Williams, Domagoj Baretić, 2014, Current opinion in structural biology.

Identification of a Potent Phosphoinositide 3‐Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs

Roger L. Williams, E. Hirsch, E. Ciraolo, 2017, ChemMedChem.

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

Roger L. Williams, J. Burke, O. Perisic, 2015, The Biochemical journal.

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Prajwal, Roger L. Williams, J. LoPiccolo, 2015, The Biochemical journal.

Tor forms a dimer through an N-terminal helical solenoid with a complex topology

Christopher M Johnson, Roger L. Williams, Y. Ohashi, 2016, Nature Communications.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α

B. Kuster, Roger L. Williams, G. Médard, 2022, Nature Chemical Biology.

Membrane trafficking: Arls squeeze the fat out.

Roger L. Williams, 2011, Nature chemical biology.

A pharmacological map of the PI 3K family defines a role for p 110 alpha in insulin signaling

Goldenberg, Tóth, Eli R. Zunder, 2017 .

The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria

Elsje G. Otten, Roger L. Williams, F. Randow, 2019, Molecular cell.

Finding a fitting shoe for Cinderella

Roger L. Williams, O. Perisic, Simon Miller, 2010 .

Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor.

Roger L. Williams, O. Perisic, Simon Miller, 2010, Autophagy.

Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

J. Boulanger, Christopher M Johnson, Roger L. Williams, 2020, eLife.

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi

S. Munro, Roger L. Williams, Minmin Yu, 2016, Cell reports.

The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain

M. Bycroft, Roger L. Williams, K. Hofmann, 2012, Structure.

Increased Hepatic Microsomal Enzyme Activity from Occupational Exposure to Certain Organochlorine Pesticides

Roger L. Williams, J. Robinson, D. Stewart, 1972, Nature.

Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry.

Roger L. Williams, J. Burke, G. Masson, 2016, Methods in molecular biology.

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

D. Fabbro, M. Zvelebil, Roger L. Williams, 2017, Nature Communications.

5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.

J. Mestan, D. Fabbro, M. Zvelebil, 2017, Journal of medicinal chemistry.

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA)

Glenn R Masson, John E Burke, Oscar Vadas, 2012, Proceedings of the National Academy of Sciences.

Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

Roger L. Williams, O. Perisic, L. Essen, 1996, Nature.

Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations

A. D. Clark, Jianping Ding, Roger L. Williams, 1992, Nature.

Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology

J. McElwee, S. Pittaluga, Y. Zhang, 2019, Nature Communications.

PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62.

Michael I. Wilson, Roger L. Williams, O. Perisic, 2003, Molecular cell.

Binding of the PX domain of p47phox to phosphatidylinositol 3,4‐bisphosphate and phosphatidic acid is masked by an intramolecular interaction

Jerónimo Bravo, Wonhwa Cho, Roger L. Williams, 2002, The EMBO journal.

Structures of closed and open conformations of dimeric human ATM

A. Fersht, Balaji Santhanam, Roger L. Williams, 2017, Science Advances.

Mammalian phosphoinositide-speci¢c phospholipase C

Roger L. Williams, 1999 .

Connecting with an old partner in a new way.

Roger L. Williams, J. Burke, 2013, Cancer cell.

Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex

Roger L. Williams, C. Sachse, J. Burke, 2016, Autophagy.

Structural basis for the heterodimeric interaction between the acute leukaemia‐associated transcription factors AML1 and CBFβ

Roger L. Williams, J. Bravo, T. Rabbitts, 2000, The EMBO journal.

ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes

M. Lamers, Roger L. Williams, O. Perisic, 2012, Proceedings of the National Academy of Sciences.

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

Roger L. Williams, L. Parts, Felicity Allen, 2019, eLife.

The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.

Fabrice Gorrec, Simon Miller, Kevan M Shokat, 2010, Nature chemical biology.

Structural basis for the interaction of [E160A-E189A]-trichosanthin with adenine.

Roger L. Williams, P. Shaw, Kam-Bo Wong, 2003, Toxicon : official journal of the International Society on Toxinology.

ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.

B. González, Roger L. Williams, O. Perisic, 2004, Developmental cell.

Phosphoinositide 3-kinases as drug targets in cancer.

Roger L. Williams, P. Hawkins, L. Stephens, 2005, Current opinion in pharmacology.

Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling

Roger L. Williams, J. Falke, Thomas C. Buckles, 2017, Biophysical journal.

Form and flexibility in phosphoinositide 3-kinases.

Roger L. Williams, Simon Miller, A. Berndt, 2009, Biochemical Society transactions.

Mapping the Phospholipid-binding Surface and Translocation Determinants of the C2 Domain from Cytosolic Phospholipase A2 *

Roger L. Williams, H. Paterson, O. Perisic, 1999, The Journal of Biological Chemistry.

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS

Roger L. Williams, T. Rabbitts, Tomoyuki N. Tanaka, 2007, The EMBO journal.

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

Roger L. Williams, P. Hawkins, L. Stephens, 2000, Cell.

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

Roger L. Williams, G. Murshudov, S. Freund, 2021, bioRxiv.

The structural basis for mTOR function.

Roger L. Williams, Domagoj Baretić, 2014, Seminars in cell & developmental biology.

The emerging shape of the ESCRT machinery

Roger L. Williams, S. Urbé, 2007, Nature Reviews Molecular Cell Biology.

VPS34 complexes from a structural perspective

Roger L. Williams, Y. Ohashi, S. Tremel, 2018, Journal of Lipid Research.

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

Roger L. Williams, P. Hawkins, L. Stephens, 2011, Molecular cell.

Structure of Lipid Kinase p110b/p85b Elucidates anUnusualSH2-Domain-MediatedInhibitoryMechanism

Roger L. Williams, P. Hawkins, L. Stephens, 2022 .

G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness

Roger L. Williams, R. Taussig, A. Bresnick, 2012, Science Signaling.

Protein – Coupled Receptor – Mediated Activation of p 110 b by G bg Is Required for Cellular Transformation and Invasiveness

Roger L. Williams, R. Taussig, A. Bresnick, 2012 .

Synergy in activating class I PI3Ks.

Roger L. Williams, J. Burke, 2015, Trends in biochemical sciences.

Replacements of Single Basic Amino Acids in the Pleckstrin Homology Domain of Phospholipase C-δ1 Alter the Ligand Binding, Phospholipase Activity, and Interaction with the Plasma Membrane*

Roger L. Williams, R. Williams, M. Hirata, 1998, The Journal of Biological Chemistry.

Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

S. Emr, Roger L. Williams, O. Perisic, 2007, Nature.

Phosphoproteomic identification of ULK substrates reveals VPS15‐dependent ULK/VPS34 interplay in the regulation of autophagy

Roger L. Williams, Helen R. Flynn, A. Snijders, 2021, The EMBO journal.

Structural role of Sfi1p–centrin filaments in budding yeast spindle pole body duplication

Roger L. Williams, C. Robinson, J. Kilmartin, 2006, The Journal of cell biology.

Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.

B. González, Roger L. Williams, D. Veprintsev, 2004, Molecular cell.

Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division.

Roger L. Williams, S. Bell, P. Chong, 2011, Molecular cell.

Structural Insights into Endosomal Sorting Complex Required for Transport (ESCRT-I) Recognition of Ubiquitinated Proteins*

Roger L. Williams, D. Veprintsev, H. Teo, 2004, Journal of Biological Chemistry.

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

G. Merlo, Roger L. Williams, Joseph Fogerty, 2021, Science.

A Role for the ESCRT System in Cell Division in Archaea

Roger L. Williams, S. Bell, S. Freund, 2008, Science.

Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus.

S. Munro, Roger L. Williams, D. Veprintsev, 2003, Molecular cell.

Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11

K. Shokat, Roger L. Williams, J. Burke, 2016, Protein science : a publication of the Protein Society.

Tyrosine Residues in Phospholipase Cγ2 Essential for the Enzyme Function in B-cell Signaling*

Roger L. Williams, J. Bravo, A. Paul, 2001, The Journal of Biological Chemistry.

Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR.

Roger L. Williams, Taiana Maia de Oliveira, C. Phillips, 2019, Progress in biophysics and molecular biology.

Calcium-dependent Membrane Penetration Is a Hallmark of the C2 Domain of Cytosolic Phospholipase A2 Whereas the C2A Domain of Synaptotagmin Binds Membranes Electrostatically*

Roger L. Williams, B. Davletov, O. Perisic, 1998, The Journal of Biological Chemistry.

PTEN regulates cilia through Dishevelled

Roger L. Williams, J. Wrana, L. Pelletier, 2015, Nature Communications.

C2 domain conformational changes in phospholipase C-δ1

J. Hurley, Roger L. Williams, L. Essen, 1996, Nature Structural Biology.

Faculty Opinions recommendation of Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association.

Roger L. Williams, 2002 .

A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39

Robbie Loewith, William A. Weiss, B. Gonzalez, 2006 .

Structural and Membrane Binding Analysis of the Phox Homology Domain of Bem1p

Roger L. Williams, D. Murray, W. Cho, 2007, Journal of Biological Chemistry.

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

Roger L. Williams, J. Burke, D. Maloney, 2014, The Biochemical journal.

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System

Roger L. Williams, A. Breeze, D. Svergun, 2018, Structure.

Disease Variants of FGFR 3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc 37 in Hsp 90 Chaperone System

Roger L. Williams, A. Breeze, D. Svergun, 2022 .

Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2*

M. Bycroft, Roger L. Williams, O. Perisic, 1998, The Journal of Biological Chemistry.

ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes

S. Emr, Roger L. Williams, D. Veprintsev, 2006, Cell.

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

K. Shokat, Roger L. Williams, O. Perisic, 2010, Science.

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

S. Munro, J. Briggs, Roger L. Williams, 2021, Nature communications.

The US regulatory and pharmacopeia response to the global heparin contamination crisis

Roger L. Williams, J. Woodcock, D. Keire, 2016, Nature Biotechnology.

The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism

Roger L. Williams, E. Pardon, J. Steyaert, 2020, Biophysical Journal.

Catalytic Domain of Phosphoinositide-specific Phospholipase C (PLC)

Roger L. Williams, C. Downes, O. Perisic, 1998, The Journal of Biological Chemistry.

A small molecule PI3Kα activator for cardioprotection and neuroregeneration

Ralitsa R. Madsen, Roger L. Williams, P. Hawkins, 2023, Nature.

Structural insight into the ESCRT‐I/‐II link and its role in MVB trafficking

S. Emr, Roger L. Williams, D. Veprintsev, 2007, The EMBO journal.

Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module.

Roger L. Williams, J. Burke, J. Falke, 2016, Biochemistry.

The structural basis of novel endosome anchoring activity of KIF16B kinesin

Michael I. Wilson, Roger L. Williams, D. Murray, 2007, The EMBO journal.

Corrigendum: The p110[delta] structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

K. Shokat, Roger L. Williams, S. Miller, 2010 .

Kinases Charging to the Membrane

Roger L. Williams, M. Hadders, 2010, Cell.

Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

Roger L. Williams, P. Hawkins, L. Stephens, 2020, Science Signaling.

PI3Kβ downstream of GPCRs – crucial partners in oncogenesis

Roger L. Williams, J. Backer, O. Vadas, 2012, Oncotarget.

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

Roger L. Williams, M. Rathinaswamy, U. Dalwadi, 2022, bioRxiv.

Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.

Roger L. Williams, P. Hawkins, L. Stephens, 2000, Molecular cell.

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

A. D. Clark, Jianping Ding, Roger L. Williams, 1993, Proceedings of the National Academy of Sciences of the United States of America.

The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.

Roger L. Williams, P. Hawkins, L. Stephens, 2001, Molecular cell.

Evolution and assembly of ESCRTs.

Roger L. Williams, S. Bell, A. Pobbati, 2009, Biochemical Society transactions.

The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D -galactose.

M. Bycroft, Roger L. Williams, M. Proctor, 1999, Journal of molecular biology.

Abstract 671: BKM120-mediated G2 arrest: Structural and functional segregation of off-target action and PI3K inhibition

D. Fabbro, M. Zvelebil, Roger L. Williams, 2015 .

Crystal structure of Myxococcus xanthus nucleoside diphosphate kinase and its interaction with a nucleotide substrate at 2.0 A resolution.

S. Inouye, M. Inouye, Roger L. Williams, 1994, Journal of molecular biology.

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

Roger L. Williams, J. Downward, P. Hawkins, 2018, Proceedings of the National Academy of Sciences.

A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.

Roger L. Williams, R. Williams, O. Perisic, 1997, Biochemistry.

Structural and Membrane Binding Analysis of the PX Domain of Phosphoinositide 3-Kinase-C2α *

Melchor Fernández Almagro, Roger L. Williams, M. Waterfield, 2006 .

Corrigendum: The p110[delta] structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

K. Shokat, Roger L. Williams, S. Miller, 2010 .

Allosteric activation of PI3Kα by oncogenic mutations

Roger L. Williams, J. Burke, O. Perisic, 2013, Oncotarget.

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing.

Roger L. Williams, M. Anandapadamanaban, 2017, Biochemistry.

VPS34 complexes from a structural perspective

Roger L. Williams, Y. Ohashi, S. Tremel, 2018, Journal of Lipid Research.

Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies.

S. Emr, Roger L. Williams, D. Veprintsev, 2007, Biochemical Society symposium.

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

Roger L. Williams, M. Rathinaswamy, U. Dalwadi, 2023, Cell reports.

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Roger L. Williams, A. Bresnick, J. Backer, 2013, Proceedings of the National Academy of Sciences.

Structural role of Sfi1p–centrin filaments in budding yeast spindle pole body duplication

Roger L. Williams, C. Robinson, J. Kilmartin, 2006, The Journal of cell biology.

The crystal structure of a human nucleoside diphosphate kinase, NM23-H2.

Roger L. Williams, R. Williams, O. Perisic, 1995, Journal of molecular biology.

Mammalian phosphoinositide-specific phospholipase C.

Roger L. Williams, R. Williams, 1999, Biochimica et biophysica acta.

Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane.

Roger L. Williams, R. Williams, H. Paterson, 1995, The Biochemical journal.

Regulation of a Class III PI3K Lipid Kinase (VPS34 Complex II) by the Small G Protein Rab5A: Single Molecule Analysis Reveals a Dual Regulatory Mechanism.

Roger L. Williams, E. Pardon, J. Steyaert, 2020, Biophysical journal.

Evolution and assembly of ESCRTs.

Roger L. Williams, S. Bell, A. Pobbati, 2009, Biochemical Society Transactions.