J. Luz

发表

Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution.

I. Wilson, A. Heine, J. Luz, 2004, Journal of molecular biology.

Protein production and purification

K. Gunsalus, G. Montelione, J. Bray, 2008, Nature Methods.

Observation of Covalent Intermediates in an Enzyme Mechanism at Atomic Resolution

Chi-Huey Wong, A. Heine, J. Luz, 2001, Science.

Structural and thermodynamic correlates of T cell signaling.

Ian A Wilson, I. Wilson, J. Luz, 2002, Annual review of biophysics and biomolecular structure.

Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site.

J. Luz, D. Clawson, D. Sindelar, 2015, Journal of medicinal chemistry.

Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design.

J. Luz, D. Clawson, C. Suen, 2014, Journal of medicinal chemistry.

Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).

J. Luz, M. Hickey, S. D. Kahl, 2020, Biochimica et biophysica acta. General subjects.

XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators.

Adam Godzik, Ian A Wilson, Barbara J Meyer, 2003, Genes & development.

Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.

Shobha N. Bhattachar, J. Luz, M. J. Fisher, 2016, Bioorganic & medicinal chemistry letters.

2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy.

P. Jadhav, J. Luz, J. Henck, 2016, Journal of medicinal chemistry.

Substrate Specificity and Kinetic Mechanism of the Insect Sulfotransferase, Retinol Dehydratase*

J. Luz, E. Vakiani, J. Buck, 1998, The Journal of Biological Chemistry.

The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.

J. Luz, Y. Qian, T. Gheyi, 2013, Journal of medicinal chemistry.

Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1.

Kevin T Bain, Stephen K Burley, Shane Atwell, 2010, Journal of molecular biology.

Supine Orientation of a Murine MHC Class I Molecule on the Membrane Bilayer

Ian A Wilson, I. Wilson, J. Luz, 2004, Current Biology.

Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

Vasso Apostolopoulos, Markus G. Rudolph, Mingdong Huang, 2002, The Journal of experimental medicine.

Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A.

I. Wilson, R. Sun, J. Luz, 2005, Journal of molecular biology.

A Peptide That Antagonizes TCR-Mediated Reactions with Both Syngeneic and Allogeneic Agonists: Functional and Structural Aspects1

Qing Ge, Markus G. Rudolph, Herman N. Eisen, 2004, The Journal of Immunology.

Structural Aspects Allogeneic Agonists: Functional and Reactions with Both Syngeneic and a Peptide That Antagonizes Tcr-mediated

J. Luz, M. Rudolph, Jianzhu Chen, 2022 .

Crystallization of retinol dehydratase from Spodoptera frugiperda: improvement of crystal quality by modification by ethylmercurythiosalicylate.

J. Luz, M. Newcomer, S. Pakhomova, 2000, Acta crystallographica. Section D, Biological crystallography.

The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

J. Luz, S. Young, M. Ploug, 2020, Journal of Lipid Research.

Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.

Shobha N. Bhattachar, J. Luz, M. Hickey, 2016, Journal of medicinal chemistry.

Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.

J. Luz, M. J. Fisher, Matthew R. Lee, 2015, Journal of medicinal chemistry.

Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.

J. Luz, F. Cañada, P. Murphy, 2021, Biochemistry.

Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.

Shobha N. Bhattachar, J. Luz, M. J. Fisher, 2017, Bioorganic & medicinal chemistry letters.

Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.

Shobha N. Bhattachar, J. Luz, M. Hickey, 2016, Journal of medicinal chemistry.