A. Mittermaier

发表

Observing biological dynamics at atomic resolution using NMR.

L. Kay, A. Mittermaier, 2009, Trends in biochemical sciences.

Binding mechanism of an SH3 domain studied by NMR and ITC.

A. Mittermaier, J. Demers, 2009, Journal of the American Chemical Society.

Studying excited states of proteins by NMR spectroscopy

Frederick W. Dahlquist, Lewis E. Kay, L. Kay, 2001, Nature Structural Biology.

Discovery of covalent prolyl oligopeptidase boronic ester inhibitors.

A. Mittermaier, N. Moitessier, C. Dufresne, 2019, European journal of medicinal chemistry.

Exploring the role of post‐translational modifications in regulating α‐synuclein interactions by studying the effects of phosphorylation on nanobody binding

C. Dobson, A. Mittermaier, M. Vendruscolo, 2018, Protein science : a publication of the Protein Society.

A platinum(II) phenylphenanthroimidazole with an extended side-chain exhibits slow dissociation from a c-Kit G-quadruplex motif.

A. Mittermaier, N. Moitessier, H. Sleiman, 2013, Chemistry.

Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry

A. Mittermaier, Stephane De Cesco, N. Moitessier, 2018, Nature Communications.

Analyzing protein-ligand interactions by dynamic NMR spectroscopy.

A. Mittermaier, Erick Meneses, 2013, Methods in molecular biology.

Transient equilibrium mapping: A new tool for measuring the thermodynamics of slowly assembling supramolecular systems

A. Mittermaier, H. Sleiman, Christophe Lachance‐Brais, 2021 .

Integrated Synthetic, Biophysical and Computational Investigations of Covalent Inhibitors of Prolyl Oligopeptidase and Fibroblast Activation Protein α.

A. Mittermaier, Stephane De Cesco, N. Moitessier, 2019, Journal of medicinal chemistry.

Platinum(II) Phenanthroimidazoles for Targeting Telomeric G‐Quadruplexes

A. Mittermaier, Nathanael Weill, N. Moitessier, 2012, ChemMedChem.

Enzyme Kinetics by Isothermal Titration Calorimetry: Allostery, Inhibition, and Dynamics

A. Mittermaier, N. Moitessier, Guanyu Wang, 2020, Frontiers in Molecular Biosciences.

COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

Xi-Ping Huang, B. Roth, D. Ricke, 2020, Frontiers in Pharmacology.

Efficient and Rapid Mechanochemical Assembly of Platinum(II) Squares for Guanine Quadruplex Targeting.

A. Mittermaier, H. Sleiman, T. Friščić, 2017, Journal of the American Chemical Society.

Stabilization of i-motif structures by 2 (cid:2) - (cid:2) -ﬂuorination of DNA

A. Mittermaier, C. Wilds, C. González, 2016 .

Rapid characterization of folding and binding interactions with thermolabile ligands by DSC.

A. Mittermaier, P. E. Johnson, S. Slavkovic, 2016, Chemical communications.

Conformational Dynamics of Strand Register Shifts in DNA G-quadruplexes.

H. Schwalbe, A. Mittermaier, A. Heckel, 2019, Journal of the American Chemical Society.

Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-α for different indications.

A. Mittermaier, N. Moitessier, C. Dufresne, 2022, European journal of medicinal chemistry.

Using transient equilibria (TREQ) to measure the thermodynamics of slowly assembling supramolecular systems

A. Mittermaier, H. Sleiman, Christophe Lachance‐Brais, 2021, Science advances.

NMR dynamics-derived insights into the binding properties of a peptide interacting with an SH2 domain.

L. Kay, A. Mittermaier, J. Forman-Kay, 2005, Biochemistry.

Multiple-site exchange in proteins studied with a suite of six NMR relaxation dispersion experiments: an application to the folding of a Fyn SH3 domain mutant.

P. Neudecker, L. Kay, A. Mittermaier, 2005, Journal of the American Chemical Society.

Side-chain interactions in the folding pathway of a Fyn SH3 domain mutant studied by relaxation dispersion NMR spectroscopy.

L. Kay, A. Mittermaier, D. Korzhnev, 2005, Biochemistry.

Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors

Itai Sharon, A. Mittermaier, N. Moitessier, 2021, European Journal of Medicinal Chemistry.

Covalent inhibitors design and discovery.

Nicolas Moitessier, A. Mittermaier, Stephane De Cesco, 2017, European journal of medicinal chemistry.

EDTA-Gradient Loading of Doxorubicin into Ferrocene-Containing Liposomes: Effect of Lipid Composition and Visualization of Triggered Release by Cryo-TEM.

A. Mittermaier, J. Mauzeroll, William L. Odette, 2021, Langmuir : the ACS journal of surfaces and colloids.

Tuning DNA Supramolecular Polymers by the Addition of Small, Functionalized Nucleobase Mimics.

A. Mittermaier, H. Sleiman, C. Sherrill, 2021, Journal of the American Chemical Society.

Elucidating Protein Binding Mechanisms by Variable‐c ITC

A. Mittermaier, K. Auclair, Lee A Freiburger, 2009, Chembiochem : a European journal of chemical biology.

Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme

A. Mittermaier, A. Berghuis, T. Sprules, 2011, Nature Structural &Molecular Biology.

Van't Hoff global analyses of variable temperature isothermal titration calorimetry data.

A. Mittermaier, K. Auclair, Lee A Freiburger, 2012, Thermochimica acta.

Applications of isothermal titration calorimetry in pure and applied research from 2016 to 2020

A. Mittermaier, R. Falconer, B. Schuur, 2021, Journal of molecular recognition : JMR.

Conformational plasticity surrounding the active site of NADH oxidase from Thermus thermophilus

A. Mittermaier, J. D. Di Trani, T. Miletti, 2015, Protein science : a publication of the Protein Society.

Electrostatic Interactions in the Binding Pathway of a Transient Protein Complex Studied by NMR and Isothermal Titration Calorimetry*

A. Mittermaier, Erick Meneses, 2014, The Journal of Biological Chemistry.

Calorimetry Studied by NMR and Isothermal Titration Pathway of a Transient Protein Complex Electrostatic Interactions in the Binding Molecular Biophysics :

A. Mittermaier, Erick Meneses, 2014 .

Complete Kinetic Characterization of Enzyme Inhibition in a Single Isothermal Titration Calorimetric Experiment.

A. Mittermaier, N. Moitessier, J. D. Di Trani, 2018, Analytical chemistry.

A study of protein side-chain dynamics from new 2H auto-correlation and 13C cross-correlation NMR experiments: application to the N-terminal SH3 domain from drk.

L. Kay, A. Mittermaier, D. Yang, 1998, Journal of molecular biology.

Analysis of deuterium relaxation-derived methyl axis order parameters and correlation with local structure

L. Kay, A. Mittermaier, J. Forman-Kay, 1999, Journal of biomolecular NMR.

Chi1 torsion angle dynamics in proteins from dipolar couplings.

L. Kay, A. Mittermaier, Lewis E. Kay, 2001, Journal of the American Chemical Society.

Amplified Self‐Immolative Release of Small Molecules by Spatial Isolation of Reactive Groups on DNA‐Minimal Architectures

A. Mittermaier, H. Sleiman, Christopher D Hennecker, 2020, Angewandte Chemie.

Amplified Self-Immolative Release of Small Molecules by Spatial Isolation of Reactive Groups on DNA-Minimal Architectures.

A. Mittermaier, H. Sleiman, Christopher D Hennecker, 2020, Angewandte Chemie.

Relaxation dispersion NMR spectroscopy for the study of protein allostery

A. Mittermaier, P. Farber, 2015, Biophysical Reviews.

Parallel reaction pathways accelerate folding of a guanine quadruplex

H. Schwalbe, A. Mittermaier, A. Heckel, 2021, Nucleic acids research.

Changes in side-chain and backbone dynamics identify determinants of specificity in RNA recognition by human U1A protein.

L. Kay, G. Varani, A. Mittermaier, 1999, Journal of molecular biology.

Side chain burial and hydrophobic core packing in protein folding transition states

A. Mittermaier, P. Farber, 2008, Protein science : a publication of the Protein Society.

New Tools Provide New Insights in NMR Studies of Protein Dynamics

Lewis E. Kay, L. Kay, A. Mittermaier, 2006, Science.

G-quadruplex dynamics.

A. Mittermaier, R. Harkness, 2017, Biochimica et biophysica acta. Proteins and proteomics.

Inhibition and activation of kinases by reaction products: a quick, reporter-free assay.

A. Mittermaier, J. D. Di Trani, K. Auclair, 2019, Analytical Chemistry.

Frustrated folding of guanine quadruplexes in telomeric DNA

A. Mittermaier, Christopher D Hennecker, Ana C. Murrieta, 2021, Nucleic acids research.

A simple in vivo assay for increased protein solubility

A. Mittermaier, A. Davidson, J. Forman-Kay, 1999, Protein science : a publication of the Protein Society.

Structural Polymorphism of Guanine Quadruplex-Containing Regions in Human Promoters

A. Mittermaier, N. Moitessier, Chuyang Zhang, 2022, International journal of molecular sciences.

Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization*♦

A. Mittermaier, R. Vernon, J. Forman-Kay, 2015, The Journal of Biological Chemistry.

Active site dynamics in NADH oxidase from Thermus thermophilus studied by NMR spin relaxation

A. Mittermaier, P. Farber, T. Miletti, 2011, Journal of biomolecular NMR.

Analyzing protein folding cooperativity by differential scanning calorimetry and NMR spectroscopy.

A. Mittermaier, T. Sprules, P. Farber, 2010, Journal of the American Chemical Society.

The response of internal dynamics to hydrophobic core mutations in the SH3 domain from the Fyn tyrosine kinase

L. Kay, A. Mittermaier, Lewis E Kay, 2004, Protein science : a publication of the Protein Society.

The effects of mutations on motions of side-chains in protein L studied by 2H NMR dynamics and scalar couplings.

David Baker, D. Baker, L. Kay, 2003, Journal of molecular biology.

The Effects of Mutations on Motions of Side-chains in Protein L Studied by 2 H NMR Dynamics and

L. Kay, A. Mittermaier, D. Baker, 2003 .

Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein.

Francisco N. Newby, C. Dobson, A. Mittermaier, 2016, Biochemistry.

COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

Xi-Ping Huang, B. Roth, D. Ricke, 2021, Frontiers in Pharmacology.

i-Motif folding intermediates with zero-nucleotide loops are trapped by 2′-fluoroarabinocytidine via F···H and O···H hydrogen bonds

A. Mittermaier, M. Damha, M. Orozco, 2023, Communications Chemistry.

An enzyme cofactor with a split personality

A. Mittermaier, 2015, Nature Structural &Molecular Biology.

Slow internal dynamics in proteins: application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme.

L. Kay, F. Dahlquist, A. Mittermaier, 2002, Journal of the American Chemical Society.

G-register exchange dynamics in guanine quadruplexes

A. Mittermaier, R. Harkness, 2016, Nucleic acids research.

Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry

A. Mittermaier, Stephane De Cesco, N. Moitessier, 2018, Nature Communications.

Measuring Rapid Time-Scale Reaction Kinetics Using Isothermal Titration Calorimetry.

A. Mittermaier, N. Moitessier, J. D. Di Trani, 2017, Analytical chemistry.

Global ITC fitting methods in studies of protein allostery.

A. Mittermaier, K. Auclair, Lee A Freiburger, 2015, Methods.

Binding interactions in a kinase active site modulate background ATP hydrolysis.

A. Mittermaier, Yun Wang, Grace Hanrahan, 2021, Biochimica et biophysica acta. Proteins and proteomics.

Importance of the β5-β6 Loop for the Structure, Catalytic Efficiency, and Stability of the Carbapenem-Hydrolyzing Class D β-lactamase Subfamily OXA-143.

A. Mittermaier, N. Doucet, R. J. Oliveira, 2019, Biochemistry.

Side chain electrostatic interactions and pH‐dependent expansion of the intrinsically disordered, highly acidic carboxyl‐terminus of γ‐tubulin

A. Mittermaier, J. Vogel, B. Payliss, 2019, Protein science : a publication of the Protein Society.

Concerted millisecond timescale dynamics in the intrinsically disordered carboxyl terminus of γ‐tubulin induced by mutation of a conserved tyrosine residue

A. Mittermaier, C. Oliver, J. Vogel, 2018, Protein science : a publication of the Protein Society.

Mapping the energy landscapes of supramolecular assembly by thermal hysteresis

A. Mittermaier, H. Sleiman, N. Avakyan, 2018, Nature Communications.

Protein stabilization by specific binding of guanidinium to a functional arginine‐binding surface on an SH3 domain

A. Zarrine-Afsar, L. Kay, A. Mittermaier, 2006, Protein science : a publication of the Protein Society.

Collecting variable-concentration isothermal titration calorimetry datasets in order to determine binding mechanisms.

A. Mittermaier, K. Auclair, Lee A Freiburger, 2011, Journal of visualized experiments : JoVE.

3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors.

Nicolas Moitessier, A. Mittermaier, Stephane De Cesco, 2016, Journal of medicinal chemistry.

Virtual screening and computational optimization for the discovery of covalent prolyl oligopeptidase inhibitors with activity in human cells.

Nicolas Moitessier, Louis-David Cantin, Lucienne Juillerat-Jeanneret, 2012, Journal of medicinal chemistry.

Protein alignment using cellulose nanocrystals: practical considerations and range of application

A. Mittermaier, D. Gray, A. Denisov, 2010, Journal of biomolecular NMR.

Concerted dynamics link allosteric sites in the PBX homeodomain.

A. Mittermaier, P. Farber, Anthony Mittermaier, 2011, Journal of molecular biology.

Relaxation dispersion NMR spectroscopy for the study of protein allostery

A. Mittermaier, P. Farber, 2015, Biophysical Reviews.

An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR

L. Kay, A. Goldberg, A. Mittermaier, 2019, Proceedings of the National Academy of Sciences.

L. Kay, A. Mittermaier, D. Korzhnev, 2005, Journal of biomolecular NMR.

Stabilization of i-motif structures by 2′-β-fluorination of DNA

A. Mittermaier, C. Wilds, M. Damha, 2016, Nucleic acids research.

Local folding and misfolding in the PBX homeodomain from a three-state analysis of CPMG relaxation dispersion NMR data.

A. Mittermaier, P. Farber, J. Slager, 2012, The journal of physical chemistry. B.

Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme.

A. Mittermaier, A. Berghuis, K. Auclair, 2014, Nature chemical biology.

Correlation between 2H NMR side-chain order parameters and sequence conservation in globular proteins.

L. Kay, A. Mittermaier, A. Davidson, 2003, Journal of the American Chemical Society.

Effect of deuteration on some structural parameters of methyl groups in proteins as evaluated by residual dipolar couplings

L. Kay, A. Mittermaier, 2002, Journal of biomolecular NMR.

Characterizing Bi-substrate Enzyme Kinetics at High Resolution by 2D-ITC.

A. Mittermaier, Yun Wang, 2021, Analytical chemistry.

COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

Xi-Ping Huang, B. Roth, D. Ricke, 2020 .

Computational and biophysical methods for the discovery and optimization of covalent drugs.

A. Mittermaier, N. Moitessier, Guanyu Wang, 2023, Chemical communications.

Binding mechanism of an SH3 domain studied by NMR and ITC.

A. Mittermaier, J. Demers, 2009, Journal of the American Chemical Society.

A. Mittermaier, Stephane De Cesco, N. Moitessier, 2016, Journal of medicinal chemistry.

Measuring Rapid Time-Scale Reaction Kinetics Using Isothermal Titration Calorimetry.

A. Mittermaier, N. Moitessier, Justin M. Di Trani, 2017, Analytical chemistry.

Analysis of deuterium relaxation-derived methyl axis order parameters and correlation with local structure

L. Kay, A. Mittermaier, J. Forman-Kay, 1999, Journal of biomolecular NMR.

Measurement of (13)C(alpha)-(13)C(beta) dipolar couplings in (15)N,(13)C,(2)H-labeled proteins: application to domain orientation in maltose binding protein.

L. Kay, A. Mittermaier, Daiwen Yang, 2001, Journal of the American Chemical Society.

Collecting variable-concentration isothermal titration calorimetry datasets in order to determine binding mechanisms.

A. Mittermaier, K. Auclair, Lee A Freiburger, 2011, Journal of visualized experiments : JoVE.

Complete Kinetic Characterization of Enzyme Inhibition in a Single Isothermal Titration Calorimetric Experiment.

A. Mittermaier, N. Moitessier, Justin M. Di Trani, 2018, Analytical chemistry.