M. Wurfel

发表

Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies.

M. Rieder, D. Nickerson, Xihong Lin, 2012, American journal of human genetics.

A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease.

Michael Wasnick, Joshua M Akey, Dennis C. Ko, 2009, American journal of human genetics.

Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death

Dennis C. Ko, Samuel I. Miller, R. Pfuetzner, 2012, Proceedings of the National Academy of Sciences.

High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report

Ivana V. Yang, M. Tobin, John Quackenbush, 2019, Annals of the American Thoracic Society.

Gene-expression variation within and among human populations.

John D. Storey, J. Akey, M. Wurfel, 2007, American journal of human genetics.

Covid-19 in Critically Ill Patients in the Seattle Region — Case Series

T. West, M. Wurfel, S. Pipavath, 2020, The New England journal of medicine.

Genome‐Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor

M. Gonzalez-Garay, R. Kittles, D. Christiani, 2018, American journal of respiratory and critical care medicine.

Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS

M. Wurfel, J. Kane, S. Wright, 1994, The Journal of experimental medicine.

Identification and Characterization of a Loss-of-Function Human MPYS Variant

Ivana V. Yang, M. Wurfel, D. Schwartz, 2010, Genes and Immunity.

Microarray-based analysis of ventilator-induced lung injury.

M. Wurfel, 2007, Proceedings of the American Thoracic Society.

Targeted Deletion of the Lipopolysaccharide (LPS)-binding Protein Gene Leads to Profound Suppression of LPS Responses Ex Vivo, whereas In Vivo Responses Remain Intact

M. Wurfel, R. Thieringer, B. Monks, 1997, The Journal of experimental medicine.

Differential regulation of membrane CD14 expression and endotoxin-tolerance in alveolar macrophages.

M. Wurfel, Shu-Min Lin, T. Martin, 2004, American journal of respiratory cell and molecular biology.

Identifying Patients with Pneumonia from Free-Text Intensive Care Unit Reports

Fei Xia, Lucy Vanderwende, Meliha Yetisgen-Yildiz, 2011 .

Endotracheal aspirates contain a limited number of lower respiratory tract immune cells

M. Wurfel, M. Orlov, C. Mikacenic, 2021, Critical Care.

Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein

M. Wurfel, S. Wright, E. Hailman, 1995, The Journal of experimental medicine.

Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14

M. Wurfel, D. Johnson, M. Kelley, 1994, The Journal of experimental medicine.

A TRIFfic Perspective on Acute Lung Injury

M. Wurfel, T. Martin, 2008, Cell.

Lipopolysaccharide (LPS) binding protein catalyzes binding of LPS to lipoproteins.

M. Wurfel, S. Wright, 1995, Progress in clinical and biological research.

Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells.

M. Wurfel, D. Maloney, C. Turtle, 2017, Cancer discovery.

Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor-modified T-cell therapy.

Daniel Li, Xueyan Chen, M. Wurfel, 2017, Blood.

The ABO Histo-Blood Group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.

M. Reilly, D. Christiani, M. Wurfel, 2020, The Journal of clinical investigation.

Systemic Angiopoietin-1/2 Dysregulation in Pediatric Sepsis and Septic Shock

M. Wurfel, W. Liles, M. Silverman, 2019, International journal of medical sciences.

Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk.

Xihong Lin, F. Chen, D. Christiani, 2015, Chest.

Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes

A. Garg, A. Go, P. Kimmel, 2020, JAMA network open.

Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events after Hospitalization: Findings from ASSESS-AKI and ARID studies

J. Kaufman, A. Garg, A. Go, 2021, medRxiv.

Alveolar CCN1 is Associated with Mechanical Stretch and Acute Respiratory Distress Syndrome Severity.

M. Wurfel, S. Gharib, S. Grazioli, 2020, American journal of physiology. Lung cellular and molecular physiology.

The Duffy Antigen Modifies Systemic and Local Tissue Chemokine Responses following Lipopolysaccharide Stimulation1

Janet S. Lee, S. Sutlief, M. Wurfel, 2006, The Journal of Immunology.

Genomics and proteomics of lung disease: conference summary.

John Quackenbush, Naftali Kaminski, Scott T Weiss, 2007, American journal of physiology. Lung cellular and molecular physiology.

Soluble CD 14 Acts as a Shuttle in the Neutralization of Lipopolysaccharide ( LPS ) by LPS-binding Protein and Reconstituted High Density Lipoprotein

M. Wurfel, S. Wright, E. Hailman, 2003 .

Covid-19 in Critically Ill Patients in the Seattle Region — Case Series

T. West, M. Wurfel, S. Pipavath, 2020, The New England Journal of Medicine.

TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia.

Janet S. Lee, M. Wurfel, Shu-Min Lin, 2005, American journal of physiology. Lung cellular and molecular physiology.

Lipopolysaccharide ( LPS )-binding Protein Accelerates the Binding o f LPS to CD 14 By

M. Wurfel, H. Lichenstein, David A. Johnson, 2003 .

Inflammatory basis of exercise-induced bronchoconstriction.

W. Henderson, M. Wurfel, T. Hallstrand, 2005, American journal of respiratory and critical care medicine.

This information is current as Innate Immunity Unbiased Approach to Identify Modulators of Lipopolysaccharide in Normal Subjects : An Identification of High and Low Responders to Bumgarner

Roger E Bumgarner, M. Wurfel, J. Strout, 2005 .

Alveolar MMP28 is associated with clinical outcomes and measures of lung injury in acute respiratory distress syndrome

M. Wurfel, C. Mikacenic, A. Manicone, 2020, Critical Care.

Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome : Plasma sRAGE as a Causal Intermediate in ARDS Risk

D. Christiani, M. Wurfel, M. Matthay, 2019 .

Presence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus-2 on Admission Is Associated With Decreased Mortality in COVID-19 Critical Illness

M. Wurfel, W. Liles, P. Bhatraju, 2022, Critical care explorations.

Essential role of MMP-12 in Fas-induced lung fibrosis.

Janet S. Lee, M. Wurfel, S. Shapiro, 2007, American journal of respiratory cell and molecular biology.

Trajectory of Kidney Function: The Canary in Sepsis

M. Wurfel, J. Himmelfarb, P. Bhatraju, 2020, American journal of respiratory and critical care medicine.

Alveolar levels of immuno-inflammatory mediators in diffuse alveolar hemorrhage after allogeneic transplant

M. Wurfel, M. Boeckh, T. Watkins, 2018, Bone Marrow Transplantation.

References Subscriptions Permissions Email Alerts Duffy Antigen Facilitates Movement of Chemokine Across the Endothelium In Vitro and Promotes Neutrophil Transmigration In

Janet S. Lee, M. Wurfel, J. Rhim, 2013 .

Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family.

M. Wurfel, J. Mayer, D. Johnson, 1994, The Journal of biological chemistry.

Cutting Edge: Genetic Variation in TLR1 Is Associated with Pam3CSK4-Induced Effector T Cell Resistance to Regulatory T Cell Suppression

M. Wurfel, J. Buckner, C. Mikacenic, 2014, The Journal of Immunology.

Effector T Cell Resistance to Regulatory T-Induced 4 CSK 3 Associated with Pam Is TLR 1 Cutting Edge : Genetic Variation in Buckner and

M. Wurfel, C. Mikacenic, F. Radella, 2014 .

Th17 cells are associated with protection from ventilator associated pneumonia

M. Wurfel, M. Orlov, C. Mikacenic, 2017, PloS one.

Endotracheal aspirates contain a limited number of lower respiratory tract immune cells

M. Wurfel, M. Orlov, C. Mikacenic, 2020, Critical Care.

Lipopolysaccharide-binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers: preferential interaction with particular classes of lipid.

M. Wurfel, S. Wright, 1997, Journal of immunology.

MCP-1 gene activation marks acute kidney injury.

M. Wurfel, E. Siew, T. Ikizler, 2011, Journal of the American Society of Nephrology : JASN.

Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome.

K. Tomer, M. Wurfel, W. Janssen, 2019, The Journal of allergy and clinical immunology.

Identification of High and Low Responders to Lipopolysaccharide in Normal Subjects: An Unbiased Approach to Identify Modulators of Innate Immunity 1

Roger E Bumgarner, M. Wurfel, T. Martin, 2005, The Journal of Immunology.

Prone positioning for non-intubated hypoxaemic patients with COVID-19: cheap, easy and makes sense, but does it work?

M. Wurfel, E. Morrell, 2021, European Respiratory Journal.

Genetic variation in the FAS gene and associations with acute lung injury.

C. Goss, M. Wurfel, A. Nathens, 2011, American journal of respiratory and critical care medicine.

Genetic Variation in theFASGene and Associations with Outcomes in Acute Lung Injury.

C. Goss, M. Wurfel, Tarah D. Holden, 2009, ATS 2009.

Lipopolysaccharide Stimulation Local Tissue Chemokine Responses following The Duffy Antigen Modifies Systemic and

Janet S. Lee, M. Wurfel, M. Rosengart, 2006 .

Angiopoietins as Prognostic Markers for Future Kidney Disease and Heart Failure Events after Acute Kidney Injury

A. Garg, A. Go, P. Kimmel, 2022, Journal of the American Society of Nephrology : JASN.

Plasma Soluble CD14 Subtype Levels Are Associated With Clinical Outcomes in Critically Ill Subjects With Coronavirus Disease 2019

T. West, M. Wurfel, P. Bhatraju, 2021, Critical care explorations.

Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin

G. O’Keefe, D. Christiani, M. Wurfel, 2012, Journal of Medical Genetics.

A Two‐Biomarker Model Predicts Mortality in the Critically Ill with Sepsis

C. Robinson-Cohen, D. Christiani, M. Wurfel, 2017, American journal of respiratory and critical care medicine.

Identification of persistent and resolving subphenotypes of acute hypoxemic respiratory failure in two independent cohorts

M. Wurfel, W. Liles, L. Ware, 2021, Critical Care.

Transglutaminase 2, a Novel Regulator of Eicosanoid Production in Asthma Revealed by Genome-Wide Expression Profiling of Distinct Asthma Phenotypes

W. Henderson, M. Gelb, M. Wurfel, 2010, PloS one.

Survey of Innate Immune Responses to Burkholderia pseudomallei in Human Blood Identifies a Central Role for Lipopolysaccharide

T. West, M. Emond, M. Wurfel, 2013, PloS one.

Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei

T. West, M. Wurfel, Nicolle D Myers, 2019, PLoS neglected tropical diseases.

A Variational Bayes Discrete Mixture Test for Rare Variant Association

Benjamin A. Logsdon, Deborah A Nickerson, Christopher J O'Donnell, 2014, Genetic epidemiology.

APOε4 is associated with enhanced in vivo innate immune responses in human subjects.

P. Blackshear, K. Barnes, M. Wurfel, 2014, The Journal of allergy and clinical immunology.

Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes

D. Christiani, M. Wurfel, S. Gharib, 2020, BMC Nephrology.

Genetics of Pulmonary Fibrosis

G. Raghu, M. Wurfel, 2002, Seminars in respiratory and critical care medicine.

TLRs in COVID-19: How they drive immunopathology and the rationale for modulation

M. Wurfel, E. Morrell, F. Mabrey, 2021, Innate immunity.

Peripheral and Alveolar Cell Transcriptional Programs Are Distinct in Acute Respiratory Distress Syndrome

M. Wurfel, S. Gharib, C. Mikacenic, 2017, American journal of respiratory and critical care medicine.

Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy

C. Robinson-Cohen, D. Christiani, M. Wurfel, 2019, American journal of respiratory and critical care medicine.

Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis

Xihong Lin, D. Christiani, M. Wurfel, 2018, Intensive Care Medicine.

Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients

C. Robinson-Cohen, M. Wurfel, R. Katz, 2016, Critical Care.

Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness

M. Wurfel, K. Kain, R. Katz, 2015, PloS one.

ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.

H. Hakonarson, Mingyao Li, R. Gallop, 2011, American journal of respiratory and critical care medicine.

Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS.

D. Christiani, M. Wurfel, M. Matthay, 2019, American journal of respiratory and critical care medicine.

Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity

M. J. Broadhurst, M. Wurfel, T. Uyeki, 2022, Critical care explorations.

Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study

B. Kestenbaum, T. West, M. Wurfel, 2021, Critical Care.

Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness

Scott R. Presnell, Sarah E. Holton, T. West, 2022, American journal of physiology. Lung cellular and molecular physiology.

Hyaluronic acid is associated with organ dysfunction in acute respiratory distress syndrome

M. Wurfel, P. Bhatraju, C. Mikacenic, 2017, Critical Care.

Interleukin-17A Is Associated With Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome

M. Wurfel, S. Gharib, C. Mikacenic, 2016, Critical care medicine.

Genome-Wide Association Study Of Acute Lung Injury Risk Loci In The Ispaar Consortium

H. Hakonarson, Xihong Lin, G. O’Keefe, 2011, ATS 2011.

Inflammation and Immune-Related Candidate Gene Associations with Acute Lung Injury Susceptibility and Severity: A Validation Study

D. Christiani, M. Wurfel, Tarah D. Holden, 2012, PloS one.

Genome Wide Association Identifies PPFIA1 as a Candidate Gene for Acute Lung Injury Risk Following Major Trauma

H. Hakonarson, Cecilia Kim, Mingyao Li, 2012, PloS one.

TNFAIP2 Inhibits Early TNFa-Induced NF-κB Signaling and Decreases Survival in Septic Shock Patients

M. Wurfel, C. Fjell, K. Walley, 2015, Journal of Innate Immunity.

A Nonsynonymous Polymorphism of IRAK4 Associated with Increased Prevalence of Gram-Positive Infection and Decreased Response to Toll-Like Receptor Ligands

M. Wurfel, K. Walley, J. Russell, 2011, Journal of Innate Immunity.

Identifying ARDS using the Hierarchical Attention Network with Sentence Objectives Framework pdf

Meliha Yetisgen-Yildiz, Kevin Lybarger, Mark M. Wurfel, 2021, AMIA.

COPD disease severity and innate immune response to pathogen-associated molecular patterns

M. Wurfel, S. Gharib, V. Fan, 2016, International journal of chronic obstructive pulmonary disease.

Body mass index and chronic kidney disease outcomes after acute kidney injury: a prospective matched cohort study

J. Kaufman, A. Garg, A. Go, 2021, BMC Nephrology.

Archaic Hominin Admixture Facilitated Adaptation to Out-of-Africa Environments

J. Akey, M. Wurfel, Benjamin Vernot, 2016, Current Biology.

Impaired TLR5 Functionality Is Associated with Survival in Melioidosis

T. West, M. Emond, M. Wurfel, 2013, The Journal of Immunology.

Rare loss of function variants in candidate genes and risk of colorectal cancer

Taylor J. Maxwell, Jennifer G. Robinson, Andrew J. Sanford, 2018, Human Genetics.

Toll-Like Receptor 1 Polymorphisms and Associated Outcomes in Sepsis After Traumatic Injury: A Candidate Gene Association Study

G. O’Keefe, M. Wurfel, Tarah D. Holden, 2014, Annals of surgery.

Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death

David C. Christiani, Jason D. Christie, Michael A. Matthay, 2016, Critical Care.

Cholesterol-25-hydroxylase promotes efferocytosis and resolution of lung inflammation.

M. Wurfel, W. Janssen, E. Abraham, 2020, JCI insight.

Screening for Proteinuria: A Tool for Predicting Rapid Declines in Kidney Function?

A. Garg, R. Bellomo, D. Gerhold, 2011 .

A common TLR1 polymorphism is associated with higher parasitaemia in a Southeast Asian population with Plasmodium falciparum malaria

M. Wurfel, K. Kain, W. Liles, 2016, Malaria Journal.

Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis.

M. Rieder, D. Nickerson, G. Martin, 2008, American journal of respiratory and critical care medicine.

Relationships Between Age, Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), and Mortality Among Critically Ill Adults: A Cohort Study

M. Wurfel, W. Liles, P. Bhatraju, 2021, Shock.

A Case for Targeting Th17 Cells and IL-17A in SARS-CoV-2 Infections

M. Wurfel, M. Orlov, C. Mikacenic, 2020, The Journal of Immunology.

Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis.

M. Wurfel, B. Nordestgaard, C. M. Madsen, 2020, Circulation.

Polymorphisms of the IL1-Receptor Antagonist Gene (IL1RN) Are Associated With Multiple Markers of Systemic Inflammation

C. Desmarais, C. Carlson, M. Rieder, 2008, Arteriosclerosis, thrombosis, and vascular biology.

A Retrospective Cohort Study That Examined the Impact of Cannabis Consumption on Long-Term Kidney Outcomes.

J. Kaufman, A. Garg, M. Wurfel, 2023, Cannabis and cannabinoid research.

Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity

Roger E Bumgarner, M. Wurfel, T. Martin, 2006, The Journal of Immunology.

A prospective cohort study of acute kidney injury and kidney outcomes, cardiovascular events, and death

A. Garg, A. Go, P. Kimmel, 2020, Kidney International.

A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury*

P. Parsons, D. Heyland, M. Wurfel, 2011, Critical care medicine.

Melanocortin-1 Receptor Polymorphisms and the Risk of Complicated Sepsis After Trauma: A Candidate Gene Association Study

G. O’Keefe, M. Wurfel, N. Gibran, 2017, Shock.

Interleukin-6 improves infection identification when added to physician judgment during evaluation of potentially septic patients.

M. Wurfel, N. Shapiro, W. Liles, 2020, The American journal of emergency medicine.

Physician Judgment and Circulating Biomarkers Predict 28-Day Mortality in Emergency Department Patients.

M. Wurfel, N. Shapiro, W. Liles, 2019, Critical care medicine.

Bronchoalveolar fluid and plasma inflammatory biomarkers in contemporary ARDS patients

P. Parsons, M. Wurfel, T. Hallstrand, 2019, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Cytometry TOF identifies alveolar macrophage subtypes in acute respiratory distress syndrome.

T. West, M. Wurfel, S. Gharib, 2018, JCI insight.

Molecular and clinical signatures in Acute Kidney Injury define distinct subphenotypes that associate with death, kidney, and cardiovascular events

A. Garg, A. Go, P. Kimmel, 2021, medRxiv.

Pneumonia identification using statistical feature selection

Cosmin Adrian Bejan, Lucy Vanderwende, Fei Xia, 2012, J. Am. Medical Informatics Assoc..

Host derived biomarkers of inflammation, apoptosis, and endothelial activation are associated with clinical outcomes in patients with bacteremia and sepsis regardless of microbial etiology

M. Wurfel, R. Katz, J. Himmelfarb, 2016, Virulence.

Alveolar Macrophage Transcriptional Programs are Associated with Outcomes in Acute Respiratory Distress Syndrome.

M. Wurfel, S. Gharib, P. Bhatraju, 2019, American journal of respiratory and critical care medicine.

Integrated Analysis of Blood and Urine Biomarkers to Identify Acute Kidney Injury Subphenotypes and Associations With Long-term Outcomes.

J. Kaufman, A. Garg, A. Go, 2023, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Variation in the TLR10/TLR1/TLR6 Locus is the Major Genetic Determinant of Inter-Individual Difference in TLR1/2-Mediated Responses

A. Reiner, D. Nickerson, M. Wurfel, 2012, Genes and Immunity.

CXCL10 and Soluble Programmed Death-Ligand 1 during Respiratory Viral Infections Are Associated with Chronic Lung Allograft Dysfunction in Lung Transplant Recipients.

M. Wurfel, A. Limaye, P. Bhatraju, 2022, American Journal of Respiratory Cell and Molecular Biology.

A prospective cohort study of acute kidney injury and kidney outcomes, cardiovascular events, and death

J. Kaufman, A. Garg, A. Go, 2020, Kidney International.

A prospective cohort study of acute cardiovascular events, and death

A. Garg, A. Go, P. Kimmel, 2022 .

Post-Acute Kidney Injury Proteinuria and Subsequent Kidney Disease Progression: The Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study.

A. Go, P. Kimmel, M. Wurfel, 2020, JAMA internal medicine.

Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness

C. Robinson-Cohen, D. Christiani, M. Wurfel, 2021, Critical care medicine.

Elevated Plasma von Willebrand Factor Levels Are Associated With Subsequent Ischemic Stroke in Persons With Treated HIV Infection

Jeffrey N. Martin, M. Wurfel, C. Marra, 2021, Open forum infectious diseases.

Genetic pleiotropy between asthma and obesity in a community-based sample of twins.

M. Wurfel, M. Fischer, D. Buchwald, 2005, The Journal of allergy and clinical immunology.

Mediators of monocyte chemotaxis and matrix remodeling are associated with the development of fibrosis in patients with COVID-19

Sarah E. Holton, S. Ziegler, M. Wurfel, 2023, medRxiv.

25-Hydroxycholesterol exacerbates vascular leak during acute lung injury

M. Wurfel, P. Rai, J. Madenspacher, 2023, JCI insight.

IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist.

Mingyao Li, R. Gallop, G. O’Keefe, 2013, American journal of respiratory and critical care medicine.

Assessment of kidney proximal tubular secretion in critical illness

B. Kestenbaum, M. Wurfel, E. Siew, 2021, JCI insight.

Associations between single nucleotide polymorphisms in the FAS pathway and acute kidney injury

M. Wurfel, A. Burt, J. Himmelfarb, 2015, Critical Care.

Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trial

L. Esserman, R. Wahab, R. Wunderink, 2023, eClinicalMedicine.

Strong toll-like receptor responses in cystic fibrosis patients are associated with higher lung function.

C. Goss, M. Wurfel, Tarah D. Holden, 2019, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Genetic Variation in MAP3K1 Associates with Ventilator‐Free Days in Acute Respiratory Distress Syndrome

M. Wurfel, Shane D. O'Mahony, F. Radella, 2018, American journal of respiratory cell and molecular biology.

IL1RN single-nucleotide polymorphisms in septic shock: can genetics clear the fog of the cytokine storm?

M. Wurfel, C. Mikacenic, 2014, American journal of respiratory and critical care medicine.

Genetic variants associated with susceptibility to Helicobacter pylori.

M. Wurfel, T. Hawn, 2013, JAMA.

Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome.

Roger Bumgarner, Roger E Bumgarner, M. Wurfel, 2008, American journal of respiratory and critical care medicine.

Usual Interstitial Pneumonia

G. Raghu, W. Travis, M. Wurfel, 2001, Seminars in respiratory and critical care medicine.

Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

Benjamin S. Freedman, H. Ruohola-Baker, M. Wurfel, 2021, JCI insight.

Alveolar Biomarker Profiles in Subphenotypes of the Acute Respiratory Distress Syndrome

M. Wurfel, M. Fessler, P. Bhatraju, 2022, Critical care medicine.

A Prediction Model for Severe AKI in Critically Ill Adults That Incorporates Clinical and Biomarker Data.

B. Kestenbaum, D. Christiani, M. Wurfel, 2019, Clinical journal of the American Society of Nephrology : CJASN.

Cytokine release syndrome (CRS) and neurotoxicity (NT) after CD19-specific chimeric antigen receptor- (CAR-) modified T cells.

M. Wurfel, D. Maloney, C. Turtle, 2017 .

Comparison of Clinical Features and Outcomes in Critically Ill Patients Hospitalized with COVID-19 versus Influenza

T. West, M. Wurfel, W. Liles, 2020, Annals of the American Thoracic Society.

Targeting innate immunity by blocking CD14: Novel approach to control inflammation and organ dysfunction in COVID-19 illness

M. Wurfel, R. Ulevitch, T. Martin, 2020, EBioMedicine.

Association of Trauma Molecular Endotypes With Differential Response to Transfusion Resuscitation Strategies.

G. O’Keefe, M. Wurfel, E. Bulger, 2023, JAMA surgery.

Circulating levels of soluble Fas (sCD95) are associated with risk for development of a nonresolving acute kidney injury subphenotype

C. Robinson-Cohen, M. Wurfel, S. Heckbert, 2017, Critical Care.

On-time clinical phenotype prediction based on narrative reports

Cosmin Adrian Bejan, Lucy Vanderwende, Mark M. Wurfel, 2013, AMIA.

Assessing Pneumonia Identification from Time-Ordered Narrative Reports

Cosmin Adrian Bejan, Lucy Vanderwende, Mark M. Wurfel, 2012, AMIA.

Tocilizumab in hospitalized patients with COVID-19: Clinical outcomes, inflammatory marker kinetics, safety, and a review of the literature

M. Wurfel, W. Leisenring, C. Turtle, 2020, medRxiv.

Phase 2, randomized, double-blind, placebo-controlled multi-center trial of the clinical and biological effects of anti-CD14 treatment in hospitalized patients with COVID-19 pneumonia

W. Self, M. Wurfel, H. Nian, 2023, EBioMedicine.

Mitochondrial N-formyl methionine peptides contribute to exaggerated neutrophil activation in patients with COVID-19

M. Wurfel, W. Liles, I. Stanaway, 2023, Virulence.

The Autoimmune Risk R262W Variant of the Adaptor SH2B3 Improves Survival in Sepsis.

M. Wurfel, D. Liggitt, D. Rawlings, 2021, Journal of Immunology.

Joint Modeling of Clinical and Biomarker Data in Acute Kidney Injury Defines Unique Subphenotypes with Differing Outcomes

J. Kaufman, A. Garg, A. Go, 2023, Clinical journal of the American Society of Nephrology : CJASN.

Plasma Interleukin-6 (IL-6), Angiopoietin-2, and C-Reactive Protein Levels Predict Subsequent Type 1 Myocardial Infarction in Persons With Treated HIV Infection

M. Budoff, Jeffrey N. Martin, M. Wurfel, 2023, Journal of acquired immune deficiency syndromes.

Automated classification of radiology reports for acute lung injury: Comparison of keyword and machine learning based natural language processing approaches

Imre Solti1, Colin R. Cooke, Fei Xia, 2009, 2009 IEEE International Conference on Bioinformatics and Biomedicine Workshop.

Perceived Hospital Stress, Severe Acute Respiratory Syndrome Coronavirus 2 Activity, and Care Process Temporal Variance During the COVID-19 Pandemic*

M. J. Broadhurst, M. Wurfel, T. Uyeki, 2023, Critical care medicine.

Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome.

D. Christiani, M. Wurfel, L. Su, 2014, American journal of respiratory cell and molecular biology.

Automated tools for phenotype extraction from medical records.

Cosmin A Bejan, Lucy Vanderwende, Fei Xia, 2013, AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science.

Tocilizumab in hospitalized patients with COVID‐19: Clinical outcomes, inflammatory marker kinetics, and safety

M. Wurfel, W. Leisenring, C. Turtle, 2020, Journal of medical virology.

Genome-wide Association Study for AKI

J. Kaufman, A. Garg, A. Go, 2023, Kidney360.

APOε4 is associated with enhanced in vivo innate immune responses in human subjects.

P. Blackshear, K. Barnes, M. Wurfel, 2014, The Journal of allergy and clinical immunology.

Latent Class Analysis in a Trauma Cohort with Hemorrhagic Shock Identifies Two Distinct Sub-Phenotypes with a Differential Treatment Response to Blood Transfusion Ratios

M. Wurfel, E. Fox, J. Holcomb, 2022, D15. GOOD, BETTER, BEST CARE: WHAT CAN WE?.

Granzyme B, a New Player in Activation-Induced Cell Death, Is Down-Regulated by Vasoactive Intestinal Peptide in Th2 but Not Th1 Effectors1

Roger E Bumgarner, M. Wurfel, S. Mayor, 2005, The Journal of Immunology.

A common TLR1 polymorphism is associated with higher parasitaemia in a Southeast Asian population with Plasmodium falciparum malaria

M. Wurfel, K. Kain, W. Liles, 2016, Malaria Journal.

Ventilator-associated pneumonia: Bacteremia and death after traumatic injury

G. O’Keefe, M. Wurfel, H. Evans, 2012, The journal of trauma and acute care surgery.

Progressive Pulmonary Fibrosis After Non-Critical COVID-19: A Case Report

T. West, M. Wurfel, S. Pipavath, 2021, The American journal of case reports.

Polymorphisms of the IL1-Receptor Antagonist Gene (IL1RN) Are Associated With Multiple Markers of Systemic Inflammation

C. Desmarais, M. Rieder, M. Wurfel, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14

M. Wurfel, H. Lichenstein, David A. Johnson, 1994, The Journal of experimental medicine.

Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies.

M. Wurfel, E. Siew, Chi-yuan Hsu, 2022, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Granzyme B, a New Player in Activation-Induced Cell Death, Is Down-Regulated by Vasoactive Intestinal Peptide in Th2 but Not Th1 Effectors1

D. Kioussis, M. Wurfel, M. Tolaini, 2005, The Journal of Immunology.

Differential absolute plasma IL-6 concentrations between two immunoassay platforms in intensive care unit patients with COVID-19

M. Wurfel, W. Liles, P. Bhatraju, 2023, Biomarkers in Medicine.

Identification of Patients with Acute Lung Injury from Free-Text Chest X-Ray Reports

Cosmin Adrian Bejan, Mark M. Wurfel, Meliha Yetisgen-Yildiz, 2013, BioNLP@ACL.

Genetic insights into sepsis: what have we learned and how will it help?

M. Wurfel, 2008, Current pharmaceutical design.

Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Latrogenic Anemia.

W. Self, M. Wurfel, N. Shapiro, 2020, American journal of respiratory and critical care medicine.

This information is current as Immunodeficiency Patients Differentiation of Common Variable Defined Blocks in Terminal Plasma Cell

Roger E Bumgarner, M. Wurfel, T. Martin, 2005 .

Development and validation of a biomarker-based model to predict persistent hypoxemic respiratory failure among mechanically ventilated adults

M. Wurfel, N. Sathe, A. E. Fohner, 2022 .

The transcriptional and phenotypic characteristics that define alveolar macrophage subsets in acute hypoxemic respiratory failure

Sarah E. Holton, M. Wurfel, V. Gersuk, 2023, Nature communications.

Mediators of monocyte chemotaxis and matrix remodeling are associated with mortality and pulmonary fibroproliferation in patients with severe COVID-19

M. Wurfel, S. Pipavath, C. Mikacenic, 2024, PloS one.