P. Shinn

发表

The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics

Ruili Huang, Noel Southall, Yuhong Wang, 2011, Science Translational Medicine.

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

David M. Reif, Daniel M. Rotroff, R. Judson, 2014, Scientific Reports.

Empirical Analysis of Transcriptional Activity in the Arabidopsis Genome

Joseph M. Dale, Nancy F. Hansen, Ronald W. Davis, 2003, Science.

Genome-Wide Analysis of Chromosomal Features Repressing Human Immunodeficiency Virus Transcription

Mary K. Lewinski, F. Bushman, C. Berry, 2005, Journal of Virology.

A role for LEDGF/p75 in targeting HIV DNA integration

Paul Shinn, Jeremy Leipzig, Christian Hoffmann, 2005, Nature Medicine.

Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana

M. Schmid, C. Berry, J. Ecker, 2003, Science.

Genome-wide High-Resolution Mapping and Functional Analysis of DNA Methylation in Arabidopsis

M. Pellegrini, Shawn Cokus, J. Ecker, 2006, Cell.

Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences

F. Bushman, C. Berry, J. Ecker, 2004, PLoS biology.

Fluorescence spectroscopic profiling of compound libraries.

Ruili Huang, Noel Southall, P. Shinn, 2008, Journal of medicinal chemistry.

Common Sequence Polymorphisms Shaping Genetic Diversity in Arabidopsis thaliana

Richard M. Clark, Tina T. Hu, B. Schölkopf, 2007, Science.

Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana

Paul Shinn, Andre Marziali, William C. Nierman, 2000, Nature.

A multiplex calcium assay for identification of GPCR agonists and antagonists.

Noel Southall, P. Shinn, C. Austin, 2010, Assay and drug development technologies.

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

Ruili Huang, Misha Itkin, Paul Shinn, 2016, Nature Medicine.

Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors.

Paul Shinn, Shihua He, Wei Zheng, 2018, Journal of medicinal chemistry.

The NCATS Pharmaceutical Collection: a 10-year update.

Ruili Huang, Paul Shinn, Anton Simeonov, 2019, Drug discovery today.

Retroviral DNA Integration: Viral and Cellular Determinants of Target-Site Selection

Paul Shinn, Sridhar Hannenhalli, Francis Collins, 2006, PLoS pathogens.

Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma.

Paul Shinn, Rajarshi Guha, Marc Ferrer, 2012, Cancer cell.

A Homogenous Luminescence Assay Reveals Novel Inhibitors for Giardia Lamblia Carbamate Kinase

Catherine Z. Chen, Noel Southall, P. Shinn, 2012, Current chemical genomics.

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

Sam Michael, Paul Shinn, Anton Simeonov, 2020, bioRxiv.

Synergistic drug combination effectively blocks Ebola virus infection

P. Shinn, Wei Zheng, X. Qiu, 2017, Antiviral research.

Sharing and community curation of mass spectrometry data with GNPS

Erin E. Carlson, Roger G. Linington, Katherine R. Duncan, 2016 .

Quantitative High-Throughput Screening Using a Live-Cell cAMP Assay Identifies Small-Molecule Agonists of the TSH Receptor

Noel Southall, Adam Yasgar, P. Shinn, 2008, Journal of biomolecular screening.

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Jared T. Shaw, Derek S. Tan, D. E. Olson, 2018, ACS central science.

Synergistic and Antagonistic Drug Combinations against SARS-CoV-2

Tesia M. Bobrowski, Catherine Z. Chen, A. Zakharov, 2020, Molecular Therapy.

Retro Drug Design: From Target Properties to Molecular Structures

Ruili Huang, P. Shinn, Hongmao Sun, 2022, J. Chem. Inf. Model..

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles

Catherine Z. Chen, P. Shinn, Wei Zheng, 2020, bioRxiv.

Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles

Catherine Z. Chen, P. Shinn, Wei Zheng, 2020, ACS pharmacology & translational science.

Non-covalent TMPRSS2 inhibitors identified from virtual screening.

A. Zakharov, P. Shinn, M. Hall, 2020, bioRxiv : the preprint server for biology.

Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors

Paul Shinn, Rajarshi Guha, Marc Ferrer, 2014, Proceedings of the National Academy of Sciences.

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells

Sam Michael, Christopher P Austin, Paul Shinn, 2014, Proceedings of the National Academy of Sciences.

Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance

Noel Southall, P. Shinn, Wei Zheng, 2018, Oncogene.

Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19

Catherine Z. Chen, P. Shinn, M. Hall, 2022, ACS infectious diseases.

Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening

P. Shinn, K. Williamson, Wei Zheng, 2017, Malaria Journal.

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models*

Jennifer T. Fox, Mindy I. Davis, L. DeLucas, 2016, The Journal of Biological Chemistry.

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening

Catherine Z. Chen, P. Shinn, Xin Hu, 2020, bioRxiv.

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

Catherine Z. Chen, Ruili Huang, P. Shinn, 2021, Frontiers in Pharmacology.

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

Catherine Z. Chen, Ruili Huang, P. Shinn, 2020, bioRxiv.

CORRECTION TO IDENTIFICATION OF CLINICALLY UTILIZED DRUGS THAT ACTIVATE PREGNANE X RECEPTORS

Ruili Huang, P. Shinn, C. Austin, 2011 .

High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2

Olivia W. Lee, P. Shinn, A. Jadhav, 2018, The Journal of Biological Chemistry.

Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.

David M. Reif, R. Judson, D. Dix, 2010, Environmental science & technology.

Quantitative bioactivity signatures of dietary supplements and natural products

Deborah K. Ngan, A. Zakharov, Ruili Huang, 2022, bioRxiv.

Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens

Noel Southall, P. Shinn, Wei Zheng, 2013, PloS one.

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations

Sam Michael, Paul Shinn, James Inglese, 2015, Scientific Reports.

Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria

Noel Southall, P. Shinn, Wei Zheng, 2016, Emerging microbes & infections.

Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19

Catherine Z. Chen, A. Zakharov, P. Shinn, 2021, ACS pharmacology & translational science.

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

Kristian Fog Nielsen, Paul Shinn, Dac-Trung Nguyen, 2016, Nature Biotechnology.

HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots

Paul Shinn, Joseph R. Ecker, F. Bushman, 2002, Cell.

A Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19

Catherine Z. Chen, P. Shinn, M. Hall, 2022, bioRxiv.

Discovery of TMPRSS2 inhibitors from virtual screening

Catherine Z. Chen, A. Zakharov, P. Shinn, 2020, bioRxiv.

The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

Catherine Z. Chen, P. Shinn, M. Hall, 2020, ACS infectious diseases.

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

Catherine Z. Chen, P. Shinn, M. Hall, 2020, bioRxiv.

Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia

Paul Shinn, Rajarshi Guha, Marc Ferrer, 2015, Retrovirology.

Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus

Joshua C. Johnson, P. Shinn, R. Guha, 2016, PloS one.

Mutation Profiles in Glioblastoma 3D Oncospheres Modulate Drug Efficacy

Zev A. Binder, M. Ferrer, G. Riggins, 2018, SLAS technology.

Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening

Damien Y. Duveau, Shawn M. Gillespie, M. Ferrer, 2019, Science Translational Medicine.

Small Molecule Inhibitors of the Human Histone Lysine Methyltransferase NSD2 / WHSC1 / MMSET Identified from a Quantitative High-Throughput Screen with Nucleosome Substrate

Olivia W. Lee, P. Shinn, A. Jadhav, 2017, bioRxiv.

Identification of Clinically Used Drugs That Activate Pregnane X Receptors

Ruili Huang, P. Shinn, C. Austin, 2011, Drug Metabolism and Disposition.

Large-scale pharmacological profiling of 3D tumor models of cancer cells

Sam Michael, Paul Shinn, Steve Titus, 2016, Cell Death & Disease.

High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines

Catherine Z. Chen, Noel Southall, P. Shinn, 2013, Human molecular genetics.

Integration Targeting by Avian Sarcoma-Leukosis Virus and Human Immunodeficiency Virus in the Chicken Genome

Paul Shinn, Jeremy Leipzig, Frederic D Bushman, 2005, Journal of Virology.

Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small Molecules.

Ruili Huang, P. Shinn, A. Simeonov, 2021, Methods in molecular biology.

A 1536-Well Quantitative High-Throughput Screen to Identify Compounds Targeting Cancer Stem Cells

Lesley A. Mathews, M. Ferrer, P. Shinn, 2012, Journal of biomolecular screening.

Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell–Like Phenotype

M. Ferrer, P. Shinn, R. Guha, 2019, Molecular Cancer Therapeutics.

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

Paul Shinn, Wei Zheng, Jennifer Kouznetsova, 2014, Emerging Microbes & Infections.

Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures.

Paul Shinn, Rajarshi Guha, Elena Postnikova, 2018, The Journal of infectious diseases.

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

Antony J. Williams, Ryan R. Lougee, R. Judson, 2020, Chemical research in toxicology.

Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion

N. Crawford, P. Shinn, James Inglese, 2015, Disease Models & Mechanisms.

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays

Ruili Huang, Paul Shinn, Anton Simeonov, 2015, PloS one.

Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action.

Ruili Huang, Christopher P Austin, Paul Shinn, 2010, Biochemical pharmacology.

The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality.

Ruili Huang, P. Shinn, C. Austin, 2013, Drug discovery today.

Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors

Ruili Huang, Paul Shinn, Menghang Xia, 2011, Environmental health perspectives.

Compound Management for Quantitative High-Throughput Screening

Sam Michael, Christopher P Austin, Paul Shinn, 2008, JALA.

Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia

Damien Y. Duveau, M. Ferrer, T. Waldmann, 2015, Retrovirology.

Multiplexing High‐Content Flow (HCF) and Quantitative High‐Throughput Screening (qHTS) to Identify Compounds Capable of Decreasing Cell Viability, Activating Caspase 3/7, Expressing Annexin V, and Changing Mitochondrial Membrane Integrity

Sam Michael, Paul Shinn, Marc Ferrer, 2013, Current protocols in chemical biology.

Correction: Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens

Paul Shinn, Noel Southall, Wei Sun, 2013, PLoS ONE.

An OpenData portal to share COVID-19 drug repurposing data in real time

Sam Michael, Paul Shinn, Ke Wang, 2020, bioRxiv.

Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability.

Vishal B. Siramshetty, P. Shinn, Dac-Trung Nguyen, 2022, Bioorganic & medicinal chemistry.

Monitoring Compound Integrity With Cytochrome P450 Assays and qHTS

Christopher P Austin, Paul Shinn, Noel Southall, 2009, Journal of biomolecular screening.

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).

T. Misteli, P. Shinn, C. Austin, 2009, Bioorganic & medicinal chemistry letters.

Targeting ACE2–RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay

P. Shinn, M. Hall, M. Shen, 2020, ACS pharmacology & translational science.

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening

Catherine Z. Chen, P. Shinn, Xin Hu, 2020, ACS pharmacology & translational science.

Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay

P. Shinn, M. Hall, M. Shen, 2020, bioRxiv.

Retro Drug Design: From Target Properties to Molecular Structures

Ruili Huang, P. Shinn, Hongmao Sun, 2021, bioRxiv.

HIV integration site selection: targeting in macrophages and the effects of different routes of viral entry.

Paul Shinn, Jeremy Leipzig, Frederic D Bushman, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Integration site selection by HIV-based vectors in dividing and growth-arrested IMR-90 lung fibroblasts.

Paul Shinn, Jeremy Leipzig, Frederic D Bushman, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening

P. Shinn, K. Williamson, Wei Zheng, 2017, Malaria Journal.

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection

Emily M. Lee, Catherine Z. Chen, G. Ming, 2021, Bioorganic & Medicinal Chemistry Letters.

Discovery of Small Molecule Entry Inhibitors Targeting the Fusion Peptide of SARS-CoV-2 Spike Protein

Catherine Z. Chen, P. Shinn, M. Hall, 2021, ACS medicinal chemistry letters.

Quantitative High-Throughput Screening Using a Live-Cell cAMP Assay Identifies Small-Molecule Agonists of the TSH Receptor

Noel Southall, Adam Yasgar, P. Shinn, 2008, Journal of biomolecular screening.

Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana

Eugen C. Buehler, B. Haas, S. Salzberg, 1999, Nature.

mQC: A Heuristic Quality-Control Metric for High-Throughput Drug Combination Screening

Sam Michael, Paul Shinn, Lu Chen, 2016, Scientific Reports.

High-Throughput Screening for Drug Combinations.

Sam Michael, Paul Shinn, Lu Chen, 2019, Methods in molecular biology.

Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma.

R. M. Simpson, P. Shinn, W. Dubois, 2023, Cancer letters.

Preclinical Evaluation of the FGFR-Family Inhibitor Futibatinib for Pediatric Rhabdomyosarcoma.

Jun S. Wei, E. Calleja, P. Shinn, 2023, Cancers.

The Toxmatrix: Chemo-Genomic Profiling Identifies Interactions That Reveal Mechanisms of Toxicity.

Ruili Huang, Paul Shinn, Anton Simeonov, 2017, Chemical research in toxicology.

Agonists of the TSH Receptor Quantitative High-Throughput Screening Using a Live-Cell cAMP Assay Identifies Small-Molecule

Noel Southall, Adam Yasgar, P. Shinn, 2008 .

Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.

Deborah K. Ngan, A. Zakharov, Ruili Huang, 2023, ACS pharmacology & translational science.

Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.

David M. Reif, Daniel M. Rotroff, R. Judson, 2010, Environmental science & technology.