Dac-Trung Nguyen

发表

The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics

Ruili Huang, Noel Southall, Yuhong Wang, 2011, Science Translational Medicine.

The Sequence of the Human Genome

Timothy B. Stockwell, William H. Majoros, Helen M. Moore, 2001, Science.

DrugCentral 2021 supports drug discovery and repositioning

Tudor I. Oprea, Jeremy J. Yang, T. Oprea, 2020, Nucleic Acids Res..

A specific mechanism for nonspecific activation in reporter-gene assays.

James Inglese, Dac-Trung Nguyen, Natasha Thorne, 2008, ACS chemical biology.

Phenotypically Similar Rare Disease Identification from an Integrative Knowledge Graph for Data Harmonization: Preliminary Study

Dac-Trung Nguyen, A. Pariser, E. Sid, 2020, JMIR medical informatics.

Sharing and community curation of mass spectrometry data with GNPS

Erin E. Carlson, Roger G. Linington, Katherine R. Duncan, 2016 .

A quantitative high throughput assay for identifying gametocytocidal compounds.

Dac-Trung Nguyen, K. Williamson, Wei Zheng, 2013, Molecular and biochemical parasitology.

An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software

A. Zakharov, Dac-Trung Nguyen, A. Simeonov, 2016, Drug Metabolism and Disposition.

Unexplored therapeutic opportunities in the human genome

Anton Simeonov, Christian von Mering, Tudor I. Oprea, 2018, Nature Reviews Drug Discovery.

A high-throughput screening assay for assessing the viability of Cryptococcus neoformans under nutrient starvation conditions

Dac-Trung Nguyen, Wei Zheng, P. Williamson, 2013, Analytical and Bioanalytical Chemistry.

Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk).

T. Misteli, Dac-Trung Nguyen, D. Auld, 2011, Bioorganic & medicinal chemistry letters.

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

Kristian Fog Nielsen, Paul Shinn, Dac-Trung Nguyen, 2016, Nature Biotechnology.

Advancing precision medicine with personalized drug screening.

Catherine Z. Chen, Noel Southall, Dac-Trung Nguyen, 2019, Drug discovery today.

Pharos: Collating protein information to shed light on the druggable genome

Rajarshi Guha, Tudor I. Oprea, Larry A. Sklar, 2016, Nucleic Acids Res..

TCRD and Pharos 2021: mining the human proteome for disease biology

Anton Simeonov, Tudor I. Oprea, Noel Southall, 2020, Nucleic Acids Res..

Drug target ontology to classify and integrate drug discovery data

Tudor I. Oprea, Stephen L. Mathias, Jeremy J. Yang, 2017, bioRxiv.

The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics

Ruili Huang, Anton Simeonov, Rajarshi Guha, 2019, Front. Pharmacol..

DrugCentral 2018: an update

Tudor I. Oprea, Vasileios Stathias, Dac-Trung Nguyen, 2018, Nucleic Acids Res..

CATMoS: Collaborative Acute Toxicity Modeling Suite

Kimberley M. Zorn, Daniel P. Russo, Timothy E. H. Allen, 2021, Environmental health perspectives.

A high-throughput screening assay for determining cellular levels of total tau protein.

S. Prusiner, J. Gever, Dac-Trung Nguyen, 2013, Current Alzheimer research.

Unexplored therapeutic opportunities in the human genome

Anton Simeonov, Christian von Mering, Tudor I. Oprea, 2018, Nature Reviews Drug Discovery.

Tox21Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Chemicals and Drugs

Ruili Huang, Anton Simeonov, Menghang Xia, 2016, Front. Environ. Sci..

Pharos 2023: an integrated resource for the understudied human proteome

Tudor I. Oprea, Karlie R. Sharma, Keith J. Kelleher, 2022, Nucleic Acids Res..

An integrative knowledge graph for rare diseases, derived from the Genetic and Rare Diseases Information Center (GARD)

Noel Southall, Dac-Trung Nguyen, Eric Sid, 2020, J. Biomed. Semant..

Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening.

Christopher P Austin, Anton Simeonov, James Inglese, 2009, Assay and drug development technologies.

How to Illuminate the Druggable Genome Using Pharos

Tudor I. Oprea, Noel Southall, Dac-Trung Nguyen, 2020, Current protocols in bioinformatics.

A Grid Algorithm for High Throughput Fitting of Dose-Response Curve Data

Ruili Huang, Yuhong Wang, Ajit Jadhav, 2010, Current chemical genomics.

Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features.

Ruili Huang, Christopher P Austin, Raymond R Tice, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

Ruili Huang, Scott Boyer, Xin Hu, 2020, Environmental health perspectives.

Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550).

Dac-Trung Nguyen, F. Deflorian, J. O’Shea, 2008, Journal of medicinal chemistry.

Predicting liver cytosol stability of small molecules

Dac-Trung Nguyen, Noel T. Southall, Alexey V. Zakharov, 2020, Journal of Cheminformatics.

Critical Assessment of Artificial Intelligence Methods for Prediction of hERG Channel Inhibition in the "Big Data" Era

Vishal B. Siramshetty, A. Zakharov, Noel Southall, 2020, J. Chem. Inf. Model..

Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability.

Vishal B. Siramshetty, P. Shinn, Dac-Trung Nguyen, 2022, Bioorganic & medicinal chemistry.

Leveraging the UMLS As a Data Standard for Rare Disease Data Normalization and Harmonization

Dac-Trung Nguyen, Eric Sid, Qian Zhu, 2020, Methods of Information in Medicine.

Phenotypically Similar Rare Disease Identification from an Integrative Knowledge Graph for Data Harmonization: Preliminary Study (Preprint)

Dac-Trung Nguyen, A. Pariser, E. Sid, 2020 .

Scaffold-Based Analytics: Enabling Hit-to-Lead Decisions by Visualizing Chemical Series Linked across Large Datasets

Rajarshi Guha, Ajit Jadhav, Dac-Trung Nguyen, 2019, J. Chem. Inf. Model..

Novel Consensus Architecture To Improve Performance of Large-Scale Multitask Deep Learning QSAR Models

Noel Southall, Dac-Trung Nguyen, Alexey V Zakharov, 2019, J. Chem. Inf. Model..

BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types

Rajarshi Guha, Dac-Trung Nguyen, Stuart L. Schreiber, 2014, Nucleic Acids Res..

Erratum: CATMoS: Collaborative Acute Toxicity Modeling Suite

Stephen P. Boyd, Kimberley M. Zorn, Daniel P. Russo, 2021, Environmental health perspectives.

Global Substance Registration System: consistent scientific descriptions for substances related to health

Noel Southall, Dac-Trung Nguyen, Tyler Peryea, 2020, Nucleic Acids Res..