H. Stark

发表

Single-particle electron cryo-microscopy: towards atomic resolution

M. Heel, M. van Heel, B. Gowen, 2000, Quarterly Reviews of Biophysics.

Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex

M. Heel, H. Stark, M. Rodnina, 2002, Nature Structural Biology.

Advantages of CCD detectors for de novo three-dimensional structure determination in single-particle electron microscopy.

H. Stark, B. Sander, M. Golas, 2005, Journal of structural biology.

Self-assembly of a nanoscale DNA box with a controllable lid

J. Kjems, H. Stark, R. Subramani, 2009, Nature.

Structure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM

Marina V. Rodnina, Ralf Ficner, Lars V. Bock, 2015, Nature.

Automatic CTF correction for single particles based upon multivariate statistical analysis of individual power spectra.

H. Stark, B. Sander, M. Golas, 2003, Journal of structural biology.

Molecular Architecture of the Multiprotein Splicing Factor SF3b

Bjoern Sander, Monika M Golas, Holger Stark, 2003, Science.

GraFix: sample preparation for single-particle electron cryomicroscopy

Henning Urlaub, Bjoern Sander, Franz Herzog, 2008, Nature Methods.

Snapshots of the RNA editing machine in trypanosomes captured at different assembly stages in vivo

H. Stark, M. Golas, H. U. Göringer, 2009, The EMBO journal.

Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy

Marina V. Rodnina, Wolfgang Wintermeyer, Holger Stark, 2010, Nature.

Characterization of tailor-made copolymers of oligo(ethylene glycol) methyl ether methacrylate and N,N-dimethylaminoethyl methacrylate as nonviral gene transfer agents: influence of macromolecular structure on gene vector particle properties and transfection efficiency.

H. Stark, M. Golas, B. Sander, 2010, Biomacromolecules.

Self-assembly of ternary insulin-polyethylenimine (PEI)-DNA nanoparticles for enhanced gene delivery and expression in alveolar epithelial cells.

H. Stark, M. Golas, B. Sander, 2009, Biomacromolecules.

Systematic Analysis of Human Protein Complexes Identifies Chromosome Segregation Proteins

R. Durbin, A. Hyman, C. Conrad, 2010, Science.

Energy barriers and driving forces in tRNA translocation through the ribosome

H. Grubmüller, H. Stark, M. Rodnina, 2013, Nature Structural &Molecular Biology.

APC15 mediates CDC20 autoubiquitylation by APC/CMCC and disassembly of the mitotic checkpoint complex

Karl Mechtler, Maria Novatchkova, Anthony A Hyman, 2012, Nature Structural & Molecular Biology.

ANGULAR RECONSTITUTION IN THREE-DIMENSIONAL ELECTRON MICROSCOPY: HISTORICAL AND THEORETICAL ASPECTS

Holger Stark, George Harauz, F. Zemlin, 1997 .

Structural insight into filament formation by mammalian septins.

H. Stark, A. Wittinghofer, M. Weyand, 2007, Nature.

Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium.

H. Stark, M. Golas, B. Sander, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

The Sm domain is an ancient RNA-binding motif with oligo(U) specificity

H. Stark, R. Lührmann, T. Achsel, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Cryo-electron microscopy of spliceosomal components.

H. Stark, R. Lührmann, 2006, Annual review of biophysics and biomolecular structure.

Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy.

Bjoern Sander, Monika M Golas, Holger Stark, 2006, Molecular cell.

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

Utz Fischer, Marc Jarvis, Ashwin Chari, 2015, Nature Methods.

The Three-dimensional Structure of an Ionotropic Glutamate Receptor Reveals a Dimer-of-dimers Assembly.

H. Stark, K. Keinänen, D. Madden, 2004, Journal of molecular biology.

Parallel, distributed and GPU computing technologies in single-particle electron microscopy

Burkhard C. Heisen, Holger Stark, H. Stark, 2009, Acta crystallographica. Section D, Biological crystallography.

ANGULAR RECONSTITUTION IN THREE-DIMENSIONAL ELECTRON MICROSCOPY: PRACTICAL AND TECHNICAL ASPECTS

Holger Stark, F. Zemlin, M. Heel, 1997 .

Ribosome dynamics during decoding

H. Stark, M. Rodnina, N. Fischer, 2017, Philosophical Transactions of the Royal Society B: Biological Sciences.

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex

H. Stark, H. Urlaub, B. Kastner, 2018, Cell.

Molecular architecture of the human 17S U2 snRNP

H. Stark, H. Urlaub, C. Will, 2020, Nature.

The pathway to GTPase activation of elongation factor SelB on the ribosome

H. Grubmüller, H. Stark, M. Rodnina, 2016, Nature.

Contacts between the tRNAs and the ribosome and conservation of involved protein residues

H. Grubmüller, H. Stark, M. Rodnina, 2013 .

Structural mapping of spliceosomes by electron microscopy.

H. Stark, R. Lührmann, 2009, Current opinion in structural biology.

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex

H. Stark, H. Urlaub, B. Kastner, 2018, Cell.

Structural characterization of human tryptophan hydroxylase 2 reveals L-Phe as the superior regulatory domain ligand relevant for serotonin biosynthesis

H. Stark, B. Kragelund, P. Harris, 2022, bioRxiv.

Molecular Basis of Transcription-Coupled Pre-mRNA Capping.

P. Cramer, A. Heck, H. Stark, 2015, Molecular cell.

Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.

H. Stark, D. Haselbach, K. Tittmann, 2019, Structure.

Stacked bilayer helices: a new structural organization of amphiphilic molecules.

M. van Heel, H. Stark, C. Boettcher, 1996, Ultramicroscopy.

MolecularBasisofTranscription-CoupledPre-mRNA Capping

P. Cramer, H. Stark, F. Herzog, 2015 .

Molecular Basis of Transcr iption-CoupledPre-mRNA Capping Graphical Abstract Highlights

P. Cramer, A. Heck, H. Stark, 2015 .

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes

J. Peters, H. Stark, B. Schulman, 2016, Proceedings of the National Academy of Sciences.

Quaternary structure of the European spiny lobster (Palinurus elephas) 1x6-mer hemocyanin from cryoEM and amino acid sequence data.

Elena V Orlova, Holger Stark, E. Orlova, 2003, Journal of molecular biology.

Structure of a molluscan hemocyanin didecamer (HtH1 from Haliotis tuberculata) at 12 A resolution by cryoelectron microscopy.

H. Stark, P. Dube, J. Harris, 2000, Journal of molecular biology.

The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome.

Henning Urlaub, Holger Stark, H. Stark, 2009, Molecular cell.

Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation

Marina V. Rodnina, Alexander G. Tonevitsky, Mihaela Diaconu, 2005, Cell.

Mechanism of APC/CCDC20 activation by mitotic phosphorylation

Karl Mechtler, Jan-Michael Peters, Holger Stark, 2016, Proceedings of the National Academy of Sciences.

Structure of the Anaphase-Promoting Complex/Cyclosome Interacting with a Mitotic Checkpoint Complex

Karl Mechtler, Ivana Primorac, Franz Herzog, 2009, Science.

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.

J. Peters, H. Stark, P. Dube, 2016, Molecular cell.

Automated correlation of single particle tilt pairs for Random Conical Tilt and Orthogonal Tilt Reconstructions.

Holger Stark, Florian Hauer, Christoph Gerle, 2013, Journal of structural biology.

An Assembly Chaperone Collaborates with the SMN Complex to Generate Spliceosomal SnRNPs

H. Stark, M. Golas, B. Sander, 2008, Cell.

Visualization of elongation factor Tu on the Escherichia coli ribosome

R. Brimacombe, M. Heel, H. Stark, 1997, Nature.

3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core.

H. Stark, M. Golas, B. Kastner, 2010, Molecular cell.

Corrim-based alignment for improved speed in single-particle image processing.

H. Stark, B. Sander, M. Golas, 2003, Journal of structural biology.

GTPase Mechanisms and Functions of Translation Factors on the Ribosome

H. Stark, M. Rodnina, W. Wintermeyer, 2000, Biological chemistry.

Structure of the hepatitis C virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES.

Holger Stark, Joe D Lewis, Daniel Boehringer, 2005, Structure.

Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy.

Bjoern Sander, Monika M Golas, Holger Stark, 2005, Molecular cell.

Arrangement of RNA and proteins in the spliceosomal U1 small nuclear ribonucleoprotein particle

Holger Stark, H. Stark, P. Dube, 2001, Nature.

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

H. Stark, H. Urlaub, C. Will, 2017, Nature.

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

H. Stark, M. Golas, B. Kastner, 2008, Nature Structural &Molecular Biology.

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation

Henning Urlaub, Olexandr Dybkov, Holger Stark, 2017, Cell.

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

H. Stark, H. Urlaub, R. Lührmann, 2009, Nature Structural &Molecular Biology.

Structural insights into how Prp5 proofreads the pre-mRNA branch site

H. Stark, H. Urlaub, C. Will, 2021, Nature.

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis.

Henning Urlaub, Bjoern Sander, Monika M Golas, 2010, RNA.

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.

J. Peters, H. Stark, B. Schulman, 2019, Trends in cell biology.

Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy.

H. Stark, A. Chari, 2016, Microscopy.

Atomic-resolution protein structure determination by cryo-EM

Ashwin Chari, Holger Stark, H. Stark, 2020, Nature.

Electron radiation damage to protein crystals of bacteriorhodopsin at different temperatures

Holger Stark, H. Stark, F. Zemlin, 1996 .

Cryo-EM in drug discovery: achievements, limitations and prospects

Claudio Ciferri, Jean-Paul Renaud, Ashwin Chari, 2018, Nature Reviews Drug Discovery.

Structure and function of the intermembrane space domain of mammalian FoF1 ATP synthase

H. Stark, C. Robinson, K. Shinzawa-Itoh, 2017, bioRxiv.

Structure of the Lassa Virus Nucleoprotein Revealed by X-ray Crystallography, Small-angle X-ray Scattering, and Electron Microscopy*

M. Perbandt, C. Betzel, H. Stark, 2011, The Journal of Biological Chemistry.

Composition and three‐dimensional EM structure of double affinity‐purified, human prespliceosomal A complexes

Henning Urlaub, Bjoern Sander, Monika M Golas, 2007, The EMBO journal.

Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation

H. Stark, H. Urlaub, C. Will, 2020, Science.

Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome.

H. Stark, H. Urlaub, C. Will, 2020, Molecular cell.

Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes.

H. Stark, C. Will, B. Kastner, 2019, Cold Spring Harbor perspectives in biology.

Molecular architecture of the human U4/U6.U5 tri-snRNP

H. Stark, H. Urlaub, B. Kastner, 2016, Science.

Merging Molecular Electron Microscopy and Mass Spectrometry by Carbon Film-assisted Endoproteinase Digestion*

H. Stark, M. Golas, H. Urlaub, 2010, Molecular & Cellular Proteomics.

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome

Henning Urlaub, Reinhard Rauhut, Ashwin Chari, 2016, Science.

An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy.

Bjoern Sander, Monika M Golas, Holger Stark, 2010, Structure.

Exon, intron and splice site locations in the spliceosomal B complex

H. Stark, B. Kastner, R. Lührmann, 2009, The EMBO journal.

Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions

Henning Urlaub, Holger Stark, Daniel Boehringer, 2006, Molecular and Cellular Biology.

Three-dimensional structure of a pre-catalytic human spliceosomal complex B

Bjoern Sander, Holger Stark, Daniel Boehringer, 2004, Nature Structural &Molecular Biology.

Correction: Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation

Mark Bates, D. Görlich, H. Stark, 2016, eLife.

Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation

Mark Bates, D. Görlich, H. Stark, 2015, eLife.

protein complex isolation Nanobodies : site-specific labeling for super-resolution imaging , rapid epitope-mapping and native Böhning

Mark Bates, D. Görlich, H. Stark, 2015 .

Large-Scale Movement of Elongation Factor G and Extensive Conformational Change of the Ribosome during Translocation

M. Heel, H. Stark, M. Rodnina, 2000, Cell.

Elucidating the medium-resolution structure of ribosomal particles: an interplay between electron cryo-microscopy and X-ray crystallograhy.

M. Heel, M. van Heel, H. Stark, 1999, Structure.

The 70S Escherichia coli ribosome at 23 A resolution: fitting the ribosomal RNA.

M van Heel, E V Orlova, M Schatz, 1995, Structure.

Topology and structure of an engineered human cohesin complex bound to Pds5B

J. Peters, H. Stark, F. Herzog, 2016, Nature Communications.

Chromatin Affinity Purification and Quantitative Mass Spectrometry Defining the Interactome of Histone Modification Patterns

H. Stark, H. Urlaub, Alexandra Stützer, 2011, Molecular & Cellular Proteomics.

Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase

H. Stark, H. Urlaub, K. Tittmann, 2020, Cell.

The MIS12 complex is a protein interaction hub for outer kinetochore assembly

H. Stark, P. Dube, L. Massimiliano, 2010, The Journal of cell biology.

Architecture of the Human Ndc80-Hec1 Complex, a Critical Constituent of the Outer Kinetochore*

Andrea Musacchio, Edward D. Salmon, Holger Stark, 2005, Journal of Biological Chemistry.

GraFix: stabilization of fragile macromolecular complexes for single particle cryo-EM.

Holger Stark, H. Stark, 2010, Methods in enzymology.

Cryo-EM ofMitotic Checkpo int Complex-Bound APC / C RevealsReciprocalandConformationalRegulationof Ubiquitin Ligation Graphical

J. Peters, H. Stark, P. Dube, 2016 .

Functions of elongation factor G in translocation and ribosome recycling

H. Stark, M. Rodnina, W. Wintermeyer, 2011 .

Three-dimensional structure of the anaphase-promoting complex.

J. Peters, H. Stark, P. Dube, 2001, Molecular cell.

Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy.

H. Stark, P. Dube, B. Kastner, 2008, RNA.

Crystal structure of a core spliceosomal protein interface

Andrew M. MacMillan, Holger Stark, J. N. Mark Glover, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Supplemental Information Structural Basis of Assembly Chaperone-Mediated snRNP Formation

Utz Fischer, Hermann Schindelin, Kay Diederichs, 2012 .

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

B. Kuhlman, M. Kirschner, J. Peters, 2016, Cell.

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

J. Peters, H. Stark, P. Dube, 2015, Proceedings of the National Academy of Sciences.

Dual RING E 3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC / C Graphical

B. Kuhlman, M. Kirschner, J. Peters, 2022 .

APC15 mediates CDC20 auto-ubiquitylation by APC/CMCC and MCC disassembly

A. Hyman, J. Peters, H. Stark, 2012, Nature Structural &Molecular Biology.

GraDeR: Membrane Protein Complex Preparation for Single-Particle Cryo-EM.

H. Stark, Y. Fujiyoshi, K. Shinzawa-Itoh, 2015, Structure.

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

J. Peters, H. Stark, S. Sidhu, 2019, Proceedings of the National Academy of Sciences.

A Protein Engineering Approach for Uncovering Cryptic Ubiquitin-binding Sites: from a Ubiquitin-Variant Inhibitor of APC/C to K48 Chain Binding

J. Peters, H. Stark, S. Sidhu, 2019, bioRxiv.

Breaking the next Cryo-EM resolution barrier – Atomic resolution determination of proteins!

Ashwin Chari, Holger Stark, H. Stark, 2020, bioRxiv.

Three-dimensional reconstruction of Trypanosoma brucei editosomes using single-particle electron microscopy.

Bjoern Sander, Monika M Golas, Holger Stark, 2011, Methods in molecular biology.

Substrate binding on the APC/C occurs between the co-activator CDH1 and the processivity factor DOC1

J. Peters, H. Stark, F. Herzog, 2010, Nature Structural &Molecular Biology.

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

Dietmar Riedel, Bjoern Sander, Franz Herzog, 2005, Molecular cell.

Conformational rearrangements upon start codon recognition in human 48S translation initiation complex

H. Stark, M. Rodnina, H. Urlaub, 2021, bioRxiv.

Spontaneous reverse movement of mRNA-bound tRNA through the ribosome

H. Stark, M. Rodnina, W. Wintermeyer, 2007, Nature Structural &Molecular Biology.

Arrangement of tRNAs in Pre- and Posttranslocational Ribosomes Revealed by Electron Cryomicroscopy

R. Brimacombe, M. Heel, E. Orlova, 1997, Cell.

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design

Ricardo A. Mata, Fabian Henneberg, Ashwin Chari, 2016, Science.

DNA translocation activity of the multifunctional replication protein ORF904 from the archaeal plasmid pRN1

H. Stark, G. Lipps, M. Drechsler, 2009, Nucleic acids research.

Supplemental Information Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex : RING Repurposing for Ubiquitin Chain Assembly

Jie J. Zheng, J. Peters, H. Stark, 2014 .

EM Structure of human APC/CCDH1-EMI1 reveals multimodal mechanism of E3 ligase shutdown

J. Peters, H. Stark, B. Schulman, 2013, Nature Structural &Molecular Biology.

Structure of influenza haemagglutinin at neutral and at fusogenic pH by electron cryo‐microscopy

M. van Heel, H. Stark, A. Herrmann, 1999, FEBS letters.

Prospects and Limitations of High-Resolution Single-Particle Cryo-Electron Microscopy.

H. Stark, A. Chari, 2023, Annual review of biophysics.

Correlation of the expansion segments in mammalian rRNA with the fine structure of the 80 S ribosome; a cryoelectron microscopic reconstruction of the rabbit reticulocyte ribosome at 21 A resolution.

F. Zemlin, R. Brimacombe, M. van Heel, 1998, Journal of molecular biology.

Radical-SAM dependent nucleotide dehydratase (SAND), rectification of the names of an ancient iron-sulfur enzyme using NC-IUBMB recommendations

H. Stark, W. Hagen, M. Piccioli, 2022, Frontiers in Molecular Biosciences.

The 80S rat liver ribosome at 25 A resolution by electron cryomicroscopy and angular reconstitution.

M van Heel, M Schatz, J Stahl, 1998, Structure.

A new model for the three-dimensional folding of Escherichia coli 16 S ribosomal RNA. III. The topography of the functional centre.

M van Heel, R. Brimacombe, M. van Heel, 1997, Journal of molecular biology.

Structural characterization of human tryptophan hydroxylase 2 reveals that L-Phe is superior to L-Trp as the regulatory domain ligand

H. Stark, B. Kragelund, P. Harris, 2023, Structure.

Cryonegative staining of macromolecular assemblies.

H. Stark, S. De Carlo, 2010, Methods in enzymology.

Visualization of the Translational Elongation Cycle by Cryo-Electron Microscopy

M. Heel, R. Matadeen, E. Orlova, 2000 .

Three-dimensional electron cryomicroscopy of ribosomes.

Holger Stark, H. Stark, 2002, Current protein & peptide science.

Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs

H. Stark, D. Haselbach, A. Chari, 2017, Nature Communications.

Conformational Change in the Protein Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy

H. Stark, M. Golas, C. Will, 2005, Microscopy and Microanalysis.

Expression of enterovirus 71 virus-like particles in transgenic enoki (Flammulina velutipes)

H. Stark, Yu-Ju Lin, Ching-Tsan Huang, 2015, Applied Microbiology and Biotechnology.

Fatty Acid Synthase: Structure, Function, and Regulation.

H. Stark, A. Chari, B. Graf, 2022, Sub-cellular biochemistry.

The Ribosome Cooperates with the Assembly Chaperone pICln to Initiate Formation of snRNPs.

H. Stark, U. Fischer, A. Chari, 2016, Cell reports.