Qian-sheng Yu

发表

Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.

N. Greig, Qian-sheng Yu, XiaoXiang Zhu, 2002, Journal of medicinal chemistry.

Preclinical Investigation of the Topical Administration of Phenserine: Transdermal Flux, Cholinesterase Inhibition, and Cognitive Efficacy

N. Greig, D. Ingram, Qian-sheng Yu, 2007, Journal of Pharmacology and Experimental Therapeutics.

(-)-Phenserine Attenuates Soman-Induced Neuropathology

D. Jacobowitz, N. Greig, Wei Wu, 2014, PloS one.

A cellular model of inflammation for identifying TNF-α synthesis inhibitors

N. Greig, Qian-sheng Yu, H. Holloway, 2009, Journal of Neuroscience Methods.

Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions.

N. Greig, Qian-sheng Yu, A. Shafferman, 2009, The Biochemical journal.

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

M. Mattson, N. Greig, J. Cadet, 2002, Annals of neurology.

Tetrahydrofurobenzofuran cymserine, a potent butyrylcholinesterase inhibitor and experimental Alzheimer drug candidate, enzyme kinetic analysis

N. Greig, M. Kamal, Qian-sheng Yu, 2008, Journal of Neural Transmission.

Kinetic analysis of the inhibition of human butyrylcholinesterase with cymserine.

N. Greig, M. Kamal, Qian-sheng Yu, 2006, Biochimica et biophysica acta.

A Synthetic Uric Acid Analog Accelerates Cutaneous Wound Healing in Mice

M. Mattson, Sung-Chun Tang, N. Greig, 2010, PloS one.

Preparation and Characterization of Tetrabenazine Enantiomers against Vesicular Monoamine Transporter 2.

N. Greig, Qian-sheng Yu, H. Holloway, 2010, ACS medicinal chemistry letters.

Carbamate analogues of (−)‐physostigmine: In vitro inhibition of acetyl‐ and butyrylcholinesterase

S. Rapoport, Qian-sheng Yu, A. Brossi, 1988, FEBS letters.

Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity.

N. Greig, Qian-sheng Yu, XiaoXiang Zhu, 2003, Journal of medicinal chemistry.

Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.

N. Greig, J. Deschamps, Qian-sheng Yu, 2005, Journal of medicinal chemistry.

Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease.

N. Greig, V. Andrisano, M. Bartolini, 2009, Journal of chromatography. A.

Butyrylcholinesterase: a new therapeutic target in AD treatment?

N. Greig, D. Ingram, Qian-sheng Yu, 2001 .

An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease.

N. Greig, Qian-sheng Yu, A. Brossi, 2005, Current Alzheimer research.

A practical conversion of natural physostigmine into the potent butyrylcholinesterase inhibitor N1,N8-bisnorcymserine

N. Greig, Qian-sheng Yu, XiaoXiang Zhu, 2000 .

Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity.

N. Greig, Qian-sheng Yu, H. Holloway, 2011, Bioorganic & medicinal chemistry.

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

N. Greig, D. Ingram, Qian-sheng Yu, 2005 .

Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice

N. Greig, Qian-sheng Yu, Yoko Furukawa-Hibi, 2011, Behavioural Brain Research.

Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.

N. Greig, Qian-sheng Yu, H. Holloway, 2006, Journal of medicinal chemistry.

Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine.

N. Greig, M. Kamal, Qian-sheng Yu, 2006, Journal of Alzheimer's disease : JAD.

Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives.

C. Culmsee, M. Mattson, N. Greig, 2002, Journal of medicinal chemistry.

Practical synthesis of unnatural (+)-physostigmine and carbamate analogues

Qian-sheng Yu, A. Brossi, 1988 .

Thalidomide-based TNF-inhibitors for neurodegenerative diseases

Rogers, N. Greig, Qian-sheng Yu, 2004 .

Thalidomide-based TNF-alpha inhibitors for neurodegenerative diseases.

N. Greig, Qian-sheng Yu, XiaoXiang Zhu, 2004, Acta neurobiologiae experimentalis.

Syntheses of tetrahydrofurobenzofurans and dihydromethanobenzodioxepines from 5-hydroxy-3-methyl-3H-benzofuran-2-one. Rearrangement and ring expansion under reductive conditions on treatment with hydrides.

N. Greig, Qian-sheng Yu, H. Holloway, 2005, The Journal of organic chemistry.

Novel Anticholinesterases Based on the Molecular Skeletons of Furobenzofuran and Methanobenzodioxepine

N. Greig, J. Deschamps, Qian-sheng Yu, 2005 .

A New Therapeutic Target in Alzheimer's Disease Treatment: Attention to Butyrylcholinesterase

Xiaoxiang Zhu, Nigel H. Greig, Donald K. Ingram, 2001, Current medical research and opinion.

Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia

M. Mattson, N. Greig, Qian-sheng Yu, 2010, Journal of neurochemistry.

C-(11)-epi-deoxyarteether: formation and structure

J. Flippen-Anderson, Qian-sheng Yu, A. Brossi, 1988 .

Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway.

M. Mattson, N. Greig, Qian-sheng Yu, 2013, Biochemical and biophysical research communications.

Plumbagin promotes the generation of astrocytes from rat spinal cord neural progenitors via activation of the transcription factor Stat3

M. Mattson, N. Greig, Qian-sheng Yu, 2010, Journal of neurochemistry.

Physovenines: Efficient Synthesis of (−)- and (+)-Physovenine and Synthesis of Carbarnate Analogues of (−)-Physovenine. Anticholinesterase Activity and Analgesic Properties of Optically Active Physovenines†

N. Greig, S. Rapoport, Qian-sheng Yu, 1991 .

Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine.

N. Greig, Qian-sheng Yu, H. Holloway, 2010, Bioorganic & medicinal chemistry.

Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development

N. Greig, Qian-sheng Yu, A. Brossi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms

N. Greig, W. Wood, K. Becker, 2016, PloS one.

Identification of Novel Small Molecule Inhibitors of Amyloid Precursor Protein Synthesis as a Route to Lower Alzheimer's Disease Amyloid-β Peptide

N. Greig, Qian-sheng Yu, H. Holloway, 2006, Journal of Pharmacology and Experimental Therapeutics.

Optimizing Drugs for Brain Action

N. Greig, D. Ingram, Qian-sheng Yu, 2001 .

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid β‐peptide

C. Culmsee, M. Mattson, N. Greig, 2001 .

Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury

N. Greig, Qian-sheng Yu, B. Hoffer, 2016, Neurobiology of Disease.

Selective acetyl- and butyrylcholinesterase inhibitors reduce amyloid-β ex vivo activation of peripheral chemo-cytokines from Alzheimer's disease subjects: exploring the cholinergic anti-inflammatory pathway.

N. Greig, M. Kamal, Qian-sheng Yu, 2014, Current Alzheimer research.

Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease?

N. Greig, M. Kamal, Qian-sheng Yu, 2006, Journal of Alzheimer's disease : JAD.

Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices

M. Mattson, N. Greig, Qian-sheng Yu, 2009, Neurobiology of Aging.

Dissociation Between the Potent β-Amyloid Protein Pathway Inhibition and Cholinergic Actions of the Alzheimer Drug Candidates Phenserine and Cymserine

N. Greig, M. Kamal, Qian-sheng Yu, 2008 .

Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group.

N. Greig, Qian-sheng Yu, C. Bartolucci, 2012, The Biochemical journal.

The Experimental Alzheimer's Disease Drug Posiphen [(+)-Phenserine] Lowers Amyloid-β Peptide Levels in Cell Culture and Mice

N. Greig, Qian-sheng Yu, H. Holloway, 2007, Journal of Pharmacology and Experimental Therapeutics.

Soluble Neuroprotective Antioxidant Uric Acid Analogs Ameliorate Ischemic Brain Injury in Mice

M. Mattson, Sung-Chun Tang, N. Greig, 2007, NeuroMolecular Medicine.

Phenserine: A Selective, Long-Acting and Brain-Directed Acetylcholinesterase Inhibitor Affecting Cognition and β-APP Processing

N. Greig, V. Haroutunian, D. Ingram, 1997 .

Inhibition of Butyrylcholinesterase with Fluorobenzylcymserine, An Experimental Alzheimer's Drug Candidate: Validation of Enzoinformatics Results by Classical and Innovative Enzyme Kinetic Analyses.

N. Greig, M. Kamal, Qian-sheng Yu, 2017, CNS & neurological disorders drug targets.

Cognitive Impairments Accompanying Rodent Mild Traumatic Brain Injury Involve p53-Dependent Neuronal Cell Death and Are Ameliorated by the Tetrahydrobenzothiazole PFT-α

N. Greig, Qian-sheng Yu, Yazhou Li, 2013, PloS one.

Neurotrophic and Neuroprotective Actions of (−)- and (+)-Phenserine, Candidate Drugs for Alzheimer’s Disease

N. Greig, Qian-sheng Yu, Yazhou Li, 2013, PloS one.

Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14‐unit T‐maze induced by blockade of the N‐methyl‐D‐aspartate receptor

N. Greig, D. Ingram, Qian-sheng Yu, 1998, Neuroreport.

Reactions of (-)-Physositigmine and (-)-N-Methyphysostigmine in Refluxing Butanol and at High Temperature: Facile Preparation of (-)-Eseroline

Qian-sheng Yu, A. Brossi, B. Schönenberger, 1987 .

Racemic N1-norphenserine and its enantiomers: Unpredicted inhibition of human acetyl- and butyrylcholinesterase and β-amyloid precursor protein in vitro

N. Greig, Qian-sheng Yu, H. Holloway, 2003 .

4′-Hydroxyphenylcarbamates of (3aS)-Eseroline and (3aS)-N(1)-Noreseroline: Potential Metabolites of the Alzheimer′s Anticholinesterase Drug Phenserine.

N. Greig, Qian-sheng Yu, H. Holloway, 1999 .

Total Synthesis of Racemic Physostigmine, Physovenine and Its Sulfur Analogue by the Oxindole-5-O-tetrahydropyranyl Ether Route

Qian-sheng Yu, X. Pei, B. Lu, 1994 .

Synthesis of (±)-physovenine and (±)-7-bromophysovenine from intermediates of the synthesis of physostigmines

Qian-sheng Yu, A. Brossi, L. Chrisey, 1990 .

Improvements in the total synthesis of physostigmine: reductive cyclization of oxindoles to tricyclic indoleninepyrrolidines with lithium aluminium hydride in tetrahydrofuran

Qian-sheng Yu, A. Brossi, 1988 .

Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and cholinergic action.

N. Greig, M. Kamal, Qian-sheng Yu, 2013, Anti-inflammatory & anti-allergy agents in medicinal chemistry.

Total Synthesis of Racemic Physostigmine, Physovenine and Its Sulfur Analogue by the Oxindole-5-O-tetrahydropyranyl Ether Route.

Qian-sheng Yu, X. Pei, B. Lu, 1995 .

4′-Hydroxyphenylcarbamates of (3aS)-Eseroline and (3aS)-N(1)-Noreseroline: Potential Metabolites of the Alzheimer′s Anticholinesterase Drug Phenserine.

N. Greig, Qian-sheng Yu, H. Holloway, 1999 .

Syntheses of Aromatic Substituted 6′‐Thiothalidomides.

N. Greig, Qian-sheng Yu, A. Brossi, 2009 .

Syntheses of Aromatic Substituted6′-Thiothalidomides

N. Greig, Qian-sheng Yu, H. Holloway, 2008 .

Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide.

N. Greig, Qian-sheng Yu, H. Holloway, 2006, The Journal of pharmacology and experimental therapeutics.

Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase.

N. Greig, Qian-sheng Yu, S. Goldberg, 1998, Experimental and clinical psychopharmacology.

Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease.

N. Greig, Qian-sheng Yu, H. Holloway, 1999, Journal of medicinal chemistry.

Physovenines: Efficient Synthesis of (‐)‐ and (+)‐Physovenine and Synthesis of Carbamate Analogues of (‐)‐Physovenine. Anticholinesterase Activity and Analgesic Properties of Optically Active Physovenines.

N. Greig, S. Rapoport, Qian-sheng Yu, 1991 .

Comparative inhibitory effects of various physostigmine analogs against acetyl- and butyrylcholinesterases.

Qian-sheng Yu, A. Brossi, J. Atack, 1989, The Journal of pharmacology and experimental therapeutics.

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

Qian-sheng Yu, XiaoXiang Zhu, Sic L. Chan, 2001, Journal of neurochemistry.

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent.

Qian-sheng Yu, H. Holloway, Demao Chen, 2005, Proceedings of the National Academy of Sciences of the United States of America.