A. Brossi

A. Brossi, E. Albuquerque, B. Schönenberger, 1988, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Identification of Novel Small Molecule Inhibitors of Amyloid Precursor Protein Synthesis as a Route to Lower Alzheimer's Disease Amyloid-β Peptide

N. Greig, Qian-sheng Yu, H. Holloway, 2006, Journal of Pharmacology and Experimental Therapeutics.

Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters.

A. Brossi, Yi Xia, K. Lee, 2003, Bioorganic & medicinal chemistry letters.

Irazepine, a noncompetitive, irreversible inhibitor of 3H-diazepam binding to benzodiazepine receptors

S. Paul, A. Brossi, P. Skolnick, 1979, Nature.

Preliminary experimental and clinical results with a new synthetic emetine-like compound.

A. Brossi, J. Frey, M. Faust, 1960, Annals of biochemistry and experimental medicine.

Effects of mescaline and some of its analogs on cholinergic neuromuscular transmission

A. Brossi, P. Kopsombut, M. Maleque, 1993, Neuropharmacology.

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

M. Mattson, N. Greig, H. Holloway, 2009, Proceedings of the National Academy of Sciences.

Mammalian alkaloids : synthesis and O-methylation of (S)- and (R)-3'-hydroxycoclaurine and their N-methylated analogues with S-adenosyl-L-[methyl-14C]methionine in presence of mammalian catechol O-methyltransferase

A. Brossi, C. Creveling, D. Tadić, 1991 .

Mammalian Alkaloids: O‐methylation of (S)‐ and (R)‐dideoxynorlaudanosoline‐1‐carboxylic acid by catechol O‐methyltransferase and identification of a yellow pigment obtained at physiological pH

A. Brossi, M. Bembenek, M. Chrzanowska, 1988 .

Mammalian Alkaloids: O-Methylation of (S)- and (R)-Dideoxynorlaudanosoline-1-carboxylic Acid by Catechol O-Methyltransferase and Identification of a Yellow Pigment Obtained at Physiological pH.

A. Brossi, M. Bembenek, M. Chrzanowska, 1989 .

Spectroscopic, optical and crystallographic properties of (S)-(+)-cis-6'-bromo-N-formylnorreticuline

A. Brossi, K. Rice, R. Potenzone, 1982 .

Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines.

A. Brossi, P. Skolnick, J. Daly, 1980, Journal of medicinal chemistry.

THE PRESENT STATUS OF MALARIA CHEMOTHERAPY

A. Brossi, 1976 .

Synthesis and characterization of 6‐ and 7‐methoxy‐1‐benzyl‐2‐methyl‐1,2,3,4‐tetrahydro‐6‐ and 7‐isoquinolinols

A. Brossi, S. Teitel, A. I. Rachlin, 1967 .

Synthesen in der Isochinolinreihe Halogensubstituierte 1-(ω-Phenylalkyl)-1,2,3,4-tetrahydro-isochinoline als Analgetica

A. Brossi, M. Walter, B. Pellmont, 1960 .

Chiral drugs: Synopsis

A. Brossi, 1994, Medicinal research reviews.

Mammalian Alkaloids: Synthesis and O-Methylation of (S)- and (R)-3′- Hydroxycoclaurine and Their N-Methylated Analogues with S-Adenosyl-L-( methyl-14C)methionine in Presence of Mammalian Catechol O- Methyltransferase.

A. Brossi, C. Creveling, D. Tadić, 1992 .

A concise regiospecific synthesis of 8,8-dimethyl-2H, 8H-pyrano[6, 5-h]quinolin-2-oneand related compounds

A. Brossi, Yi Xia, K. Lee, 1999 .

Oxidation Products of Retinylidene Dimedone

A. Brossi, N. Acton, 1980 .

A novel synthesis of colchicide and analogues from thiocolchicine and congeners: reevaluation of colchicide as a potential antitumor agent.

A. Brossi, C. Chignell, M. Suffness, 1987, Journal of medicinal chemistry.

Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease?

N. Greig, M. Kamal, Qian-sheng Yu, 2006, Journal of Alzheimer's disease : JAD.

Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids.

A. Brossi, K. Rice, W. Klee, 1979, Journal of medicinal chemistry.

Phenserine: A Selective, Long-Acting and Brain-Directed Acetylcholinesterase Inhibitor Affecting Cognition and β-APP Processing

N. Greig, V. Haroutunian, D. Ingram, 1997 .

Synthesis of hormothamnione

A. Brossi, R. Alonso, 1988 .

Synthesis of 1,2,3,4-tetrahydro-1,1,2,3,3,4,4-heptamethyl-6,7-dimethoxyisoquinoline and related compounds as potential hypotensive agents.

A. Brossi, J. Finkelstein, E. Chiang, 1971, Journal of Medicinal Chemistry.

DEOXYMORPHINES: ROLE OF THE PHENOLIC HYDROXYL IN ANTINOCICEPTION AND OPIATE RECEPTOR INTERACTIONS

A. Brossi, K. Rice, W. Klee, 1979 .

The synthesis and biological properties of some dibenzazepines and dibenzazonines related to protostephanine.

A. Brossi, B. Pecherer, R. Sunbury, 1969, Journal of medicinal chemistry.

A practical synthesis of protostephanine.

A. Brossi, B. Pecherer, 1967, The Journal of organic chemistry.

Probes for a Regulatory Site on the Nicotinic Acetylcholine Receptor‐Channel. Synthesis of (±)‐7‐Debutylperhydrohistrionicotoxin, (±)‐2‐Depentyl‐7‐debutylperhydrohistrionicotoxin, and their Analogues

A. Brossi, E. Albuquerque, B. Witkop, 1985 .

Synthesen in der Isochinolinreihe Zur Konfiguration von (−)-1-(p-Chlorphenäthyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isochinolin

A. Brossi, F. Burkhardt, 1961 .

8-Methxlcorxpallihe and its O-Metbzlzzher: A Facile Sxhthesis of 8-Methxl Substituted-6, 7- Dimethoxy Tetrahsdroisoquxnolines

A. Brossi, S. Teitel, J. O'brien, 1972 .

Enantiomer (+)physostigmine prevents organophosphate‐induced subjunctional damage at the neuromuscular synapse by a mechanism not related to cholinesterase carbamylation

A. Brossi, E. Albuquerque, M. Kawabuchi, 1988, Synapse.

Oxidation Products of Phenolic Thiocolchicines: Ring a Quinones and Dienones

A. Brossi, K. Lee, J. Guan, 1998 .

Studies in the (+)-Morphinan Series VI. Dimers of Natural (—)- and Unnatural (+)-Sinomenine

A. Brossi, I. Iijima, J. Minamikawa, 1978 .

Alkaloids in mammalian tissues. 3. Condensations of L-tryptophan and L-5-hydroxytryptophan with formaldehyde and acetaldehyde.

A. Brossi, S. Teitel, A. Focella, 1973, Journal of Medicinal Chemistry.

Interaction of monoamine oxidase B with analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine derived from prodine-type analgesics.

A. Brossi, M. Bembenek, C. Abell, 1986, Journal of medicinal chemistry.

Conversion of Natural (S)-Bulbocapnine into Two (Ring A)-Substituted Derivatives of (R)-Apomorphine†

A. Brossi, R. Borer, Max Greecke, 1979 .

[Hydroxymorphinans. 6. Paper chromatography of morphinan derivatives and their excretion in urine].

A. Brossi, O. Schnider, O. Hafliger, 1955, Arzneimittel-Forschung.

Reactions of (-)-Physositigmine and (-)-N-Methyphysostigmine in Refluxing Butanol and at High Temperature: Facile Preparation of (-)-Eseroline

Qian-sheng Yu, A. Brossi, B. Schönenberger, 1987 .

Racemic N1-norphenserine and its enantiomers: Unpredicted inhibition of human acetyl- and butyrylcholinesterase and β-amyloid precursor protein in vitro

N. Greig, Qian-sheng Yu, H. Holloway, 2003 .

4′-Hydroxyphenylcarbamates of (3aS)-Eseroline and (3aS)-N(1)-Noreseroline: Potential Metabolites of the Alzheimer′s Anticholinesterase Drug Phenserine.

N. Greig, Qian-sheng Yu, H. Holloway, 1999 .

Synthesis of (±)-physovenine and (±)-7-bromophysovenine from intermediates of the synthesis of physostigmines

Qian-sheng Yu, A. Brossi, L. Chrisey, 1990 .

Phenserine, a Novel Anticholinesterase Related to Physostigmine: Total Synthesis and Biological Properties

A. Brossi, X. Pei, N. Greig, 1996 .

Progress towards a practical total synthesis of Calabar alkaloids: total synthesis of (−)-esermethole and (−)-physovenol methyl ether from (3S)-1,3-dimethyl-3-carboxymethyl-5-methoxyoxindole

A. Brossi, 俞黔生, 骆巍明, 1993 .

Improvements in the total synthesis of physostigmine: reductive cyclization of oxindoles to tricyclic indoleninepyrrolidines with lithium aluminium hydride in tetrahydrofuran

Qian-sheng Yu, A. Brossi, 1988 .

Total Synthesis of Racemic and Optically Active Compounds Related to Physostigmine and Ring‐C Heteroanalogues from 3‐[2′‐(dimethylamino)ethyl]2,3‐dihydro‐5‐methoxy‐1,3‐dimethyl‐1H‐indo l‐2‐ol

N. Greig, J. Flippen-Anderson, A. Brossi, 1994 .

4′-Hydroxyphenylcarbamates of (3aS)-Eseroline and (3aS)-N(1)-Noreseroline: Potential Metabolites of the Alzheimer′s Anticholinesterase Drug Phenserine.

N. Greig, Qian-sheng Yu, H. Holloway, 1999 .

Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents.

A. Brossi, K. Lee, P. Wongsinkongman, 2002, Bioorganic & medicinal chemistry.

13C‐ and 1H‐NMR. Assignments for colchicine derivatives

A. Brossi, H. Capraro, C. D. Hufford, 1980 .

Structure‐Activity Relationship of Oxygenated Morphinans. VII. 5‐Methylated and 14‐Hydroxy‐substituted Agonists and Antagonists of the 4‐Hydroxy‐ and 3, 4‐Dioxygenated 6‐Morphinanone Series

J. Flippen-Anderson, A. Brossi, H. Schmidhammer, 1982 .

R-(+)- and S-(-)-tetrahydroharmine : preparation of optically pure alkaloids and acid-catalyzed racemization

A. Brossi, L. Chrisey, 1990 .

Synthesis of (−)- and (+)-2-hydroxy-6-keto-N-methylmorphinans, their O-methyl ethers, and 2-deoxy congeners

A. Brossi, H. Schmidhammer, 1982 .

Antitumor Agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents

Alexander Tropsha, Weifan Zheng, Shuxing Zhang, 2007, J. Comput. Aided Mol. Des..

Acylamidoalkyl Acetophenones from Substituted Phenethylamines: 2-(2-Acetamidoethyl)-4,5-Dimethoxyacetophenone

A. Brossi, S. Teitel, L. Dolan, 2003 .

The rubremetinium and rubremetaminium cations

A. Brossi, A. Battersby, M. Terashima, 1966, Experientia.

The Synthesis of Some 9-,10-, and 11-Membered Ring Compounds Containing a Nitrogen Atom: 2,3,4,5,6,7-Hexahydro-1H-3-Benzazonines, 1,2,3,4,5,6,7,8-Octahydro-3-Benzazocines, and 2,3,4,5,6,7,8,9-Octahydro-1H-3-Benzazacy-cloundecanes

A. Brossi, F. Humiec, B. Pecherer, 1973 .

Alkaloids in the mammalian system.

A. Brossi, S. Teitel, 1974, Lloydia.

Synthesis and biological properties of 1-dimethylamino-3-methyl-3-(3-hydroxyphenyl)butane, a potential analgetic.

A. Brossi, B. Pecherer, L. Randall, 1968, Journal of medicinal chemistry.

REVERSIBLE AND IRREVERSIBLE CHOLINESTERASE INHIBITORS

A. Brossi, E. Albuquerque, B. Schönenberger, 1987 .

Activation and Blockade of the Nicotinic and Glutamatergic Synapses by Reversible and Irreversible Cholinesterase Inhibitors

A. Brossi, E. Albuquerque, B. Schönenberger, 1987 .

Total Synthesis of Racemic and Optically Active Compounds Related to Physostigmine and Ring-C Heteroanalogues from 3-(2′-(Dimethylamino) ethyl)-2,3-dihydro-5-methoxy-1,3-dimethyl-1H-indol-2-ol.

N. Greig, J. Flippen-Anderson, A. Brossi, 2010 .

Synthesis and anticholinesterase activity of (-)-N1-norphysostigmine, (-)-eseramine, and other N(1)-substituted analogues of (-)-physostigmine.

A. Brossi, J. Atack, S. I. Rapoport, 1988, Journal of Medicinal Chemistry.

Absolute configuration of cryptostylines I, II, and III by x-ray analysis and aromatic chirality method

A. Brossi, J. Blount, V. Toome, 1973 .

Interaction of analogs of histrionicotoxin with the acetylcholine receptor ionic channel complex and membrane excitability.

A. Brossi, E. Albuquerque, M. Maleque, 1984, Journal of Pharmacology and Experimental Therapeutics.

Alkaloids of Templetonia retusa. Chemistry, Structure and Absolute Configuration of (-)-Templetine

A. Brossi, J. Cannon, C. Raston, 1991 .

Syntheses of Aromatic Substituted 6′‐Thiothalidomides.

N. Greig, Qian-sheng Yu, A. Brossi, 2009 .

Syntheses of Aromatic Substituted6′-Thiothalidomides

N. Greig, Qian-sheng Yu, H. Holloway, 2008 .

Geneserine and geneseroline revisited: acid-base catalyzed equilibria of hexahydropyrrolo-[2,3-b]-indole N-oxides with hexahydro-1,2-oxazino-[5,6-b]-indoles.

J. Flippen-Anderson, A. Brossi, H. Yeh, 1989, Journal of natural products.

Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development

N. Greig, Qian-sheng Yu, A. Brossi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Antitumor Agents. Part 236. Synthesis of Water-Soluble Colchicine Derivatives

A. Brossi, Chin‐Chung Wu, K. Lee, 2005 .

Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.

A. Brossi, K. Lee, E. Hamel, 1998, Journal of medicinal chemistry.

Oxoaporphine Alkaloids: Conversion of Lysicamine into Liriodendronine and its 2‐O‐Methyl Ether, and Antifungal Activity

C. George, J. Flippen-Anderson, A. Brossi, 1991, Archiv der Pharmazie.

Conversion of natural phthalideisoquinolines into benzazepine alkaloids.

A. Brossi, S. Teitel, W. Klotzor, 1971, Journal of the American Chemical Society.

The oxidation of thebaine with m-chloroperbenzoic acid. Studies in the (+)-morphinan series. III.

A. Brossi, K. Rice, I. Iijima, 1977, Helvetica chimica acta.

THE OXIDATION OF THEBAINE WITH M-CHLOROPERBENZOIC ACID. STUDIES IN THE (.+-.)-MORPHINAN SERIES. III

A. Brossi, K. Rice, I. Iijima, 1978 .

SELECTIVE ETHER CLEAVAGE IN THE APORPHINE SERIES. CONVERSION OF (S)-BULBOCAPNINE INTO (S)-CORYTUBERINE AND (S)-CORYDINE METHYL ETHER

A. Brossi, R. Borer, M. Gerecke, 1977 .

Selective ther cleavage in the aporphine series. Conversion of (S)-bulbocapnine into (S)-corytuberine and (S)-corydine methyl ether.

A. Brossi, R. Borer, M. Gerecke, 1976, Helvetica chimica acta.

Syntheses in the isoquinoline series. Selective demethylation of 6,7- and 7,8-dimethoxy-2,3-dihydro-4(1H)-isoquinolones

A. Brossi, M. Uskoković, G. Grethe, 1968 .

The long-acting cholinesterase inhibitor heptyl-physostigmine attenuates the scopolamine-induced learning impairment of rats in a 14-unit T-maze

N. Greig, D. Ingram, A. Brossi, 1992, Neuroscience Letters.

Total syntheses and anticholinesterase activities of (3aS)-N(8)-norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues.

H. Holloway, A. Brossi, X. Pei, 1997, Journal of medicinal chemistry.

Chemical and biological study of aromatic oxygenated 6‐ketomorphinans

A. Brossi, A. E. Jacobson, H. Schmidhammer, 1983, Medicinal research reviews.

The Chemsitry of Drugs. III. Acid Hydrolysis of Antimalarial 5-Alkoxy-6,6-dimethyl-5,6-dihydro-s-triazines

A. Brossi, N. Acton, B. Bajwa, 1983 .

METABOLIC STUDIES OF VERSIDYNE, A NEW ANALGESIC, IN THE RABBIT AND IN MAN.

A. Brossi, D. E. Schwartz, J. Rieder, 1964, Biochemical pharmacology.

(E)-5-Hydroxypyrrolizidin-3-one: versatile synthon for the synthesis of 5-substituted 2-pyrrolidones and (Z)-3-alkylpyrrolizidines

J. Flippen-Anderson, A. Brossi, P. Buchs, 1982 .

Stereocontrolled Conversion of 3,5-Dioxopyrrolizidine Into (Z)- and (E)- 5-Acetonylpyrrolizidin-3-ones

A. Brossi, K. Takahashi, 1989 .

Improved Synthesis of the Lukes-ŜOrm Dilactam. Nucleophilic Opening to 5-Substituted 2-Pyrrolidine-2-Ones

A. Brossi, R. Alonso, W. Gessner, 1988 .

The structure and absolute configuration of (−)-templetine

A. Brossi, J. Cannon, J. Blount, 1974 .

Syntheses of various 2,5‐disubstituted oxazole derivatives related to natural products

A. Brossi, E. Wenis, 1965 .

Biochemical changes caused by the infusion into the substantia nigra of the rat of MPTP and related compounds which antagonise dihydropteridine reductase

A. J. Bradbury, A. Brossi, B. Costall, 1986, Neuropharmacology.

Further insight into the mode of action of the neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)

A. Brossi, C. Abell, R. Shen, 1985, FEBS letters.

Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase.

D. Ingram, A. Brossi, E. Spangler, 1995, Neuroreport.

Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide.

N. Greig, Qian-sheng Yu, H. Holloway, 2006, The Journal of pharmacology and experimental therapeutics.

Studies on the mechanism of MPTP oxidation by human liver monoamine oxidase B

A. Brossi, C. Abell, R. R. Fritz, 1986, FEBS letters.

7‐Oxo‐deacetamidocolchiceine and 7‐Benzylimino‐deacetamido‐colchiceine: Two novel products from the base catalysed reaction of (−)‐N‐Benzylidene‐deacetylcolchiceine

A. Brossi, J. Silverton, M. A. Iorio, 1978 .

Designing Drugs for Optimal Nervous System Activity

Nigel H. Greig, Donald K. Ingram, N. Greig, 1995 .

Physovenines: Efficient Synthesis of (‐)‐ and (+)‐Physovenine and Synthesis of Carbamate Analogues of (‐)‐Physovenine. Anticholinesterase Activity and Analgesic Properties of Optically Active Physovenines.

N. Greig, S. Rapoport, Qian-sheng Yu, 1991 .