M. Laruelle

发表

The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics.

Yiyun Huang, Zhihong Zhu, N. Guo, 2004, Nuclear medicine and biology.

Comparative Evaluation in Nonhuman Primates of Five PET Radiotracers for Imaging the Serotonin Transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM

Alan A. Wilson, Yiyun Huang, O. Mawlawi, 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment.

M. Laruelle, L. Kegeles, A. Abi-Dargham, 2003, Annals of the New York Academy of Sciences.

Glutamate, Dopamine, and Schizophrenia

M. Laruelle, L. Kegeles, A. Abi-Dargham, 2003 .

Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands

R. P. Maguire, M. Mintun, V. Sossi, 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Neurobiology of dopamine in schizophrenia.

M. Laruelle, A. Abi-Dargham, O. Guillin, 2007, International review of neurobiology.

The Second Revision of the Dopamine Theory of Schizophrenia: Implications for Treatment and Drug Development

M. Laruelle, 2013, Biological Psychiatry.

SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: kinetic and equilibrium paradigms.

J. Seibyl, D. Charney, M. Laruelle, 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET

B. Kolachana, D. Weinberger, M. Laruelle, 2008, Molecular Psychiatry.

Prefrontal Dopamine D1 Receptors and Working Memory in Schizophrenia

R. V. Van Heertum, Yiyun Huang, J. Gorman, 2002, The Journal of Neuroscience.

SPECT imaging of dopamine and serotonin transporters in nonhuman primate brain.

M Laruelle, M. Laruelle, R. Innis, 1994, NIDA research monograph.

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

J. Krystal, J. Seibyl, D. Charney, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort.

J. Krystal, J. Seibyl, D. Charney, 1998, The American journal of psychiatry.

Increased dopamine transmission in schizophrenia: relationship to illness phases

M. Laruelle, L. Kegeles, A. Abi-Dargham, 1999, Biological Psychiatry.

Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia

M. Laruelle, L. Kegeles, A. Abi-Dargham, 2000, Biological Psychiatry.

Altered prefrontal dopaminergic function in chronic recreational ketamine users.

Mark Slifstein, Marc Laruelle, Roberto Gil, 2005, The American journal of psychiatry.

Donepezil Impairs Memory in Healthy Older Subjects: Behavioural, EEG and Simultaneous EEG/fMRI Biomarkers

R. O’Connell, I. Robertson, B. Lawlor, 2011, Alzheimer's & Dementia.

Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [11C]McN 5652

Mark Slifstein, Marc Laruelle, Dah-Ren Hwang, 2003, Biological Psychiatry.

Modelling: when and why?

Marc Laruelle, M. Laruelle, 1999, European Journal of Nuclear Medicine.

Effects of statistical noise on graphic analysis of PET neuroreceptor studies.

M Slifstein, M Laruelle, M. Laruelle, 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

J. Seibyl, D. Charney, M. Laruelle, 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

D. Charney, M. Laruelle, S. Zoghbi, 1995 .

Increased synaptic dopamine function in associative regions of the striatum in schizophrenia.

S. Haber, Yiyun Huang, D. Hwang, 2010, Archives of general psychiatry.

J. Seibyl, M. Laruelle, S. Zoghbi, 2000, Neurobiology of Aging.

J. Seibyl, M. Laruelle, S. Zoghbi, 2000, Neurobiology of aging.

J. Seibyl, M. Laruelle, S. Zoghbi, 2002, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

Striatal dopamine transporter availability with [123I]β-CIT SPECT is unrelated to gender or menstrual cycle

J. Seibyl, M. Laruelle, S. Zoghbi, 2005, Psychopharmacology.

Imaging dopamine transmission in schizophrenia. A review and meta-analysis.

M. Laruelle, 1998, The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology.

Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.

R. V. Van Heertum, J. Mann, J. Gorman, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review

M. Laruelle, 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [11C]WAY 100635

Yiyun Huang, John H. Martin, D. Hwang, 2006, Psychopharmacology.

Baseline and Amphetamine-Stimulated Dopamine Activity Are Related in Drug-Naïve Schizophrenic Subjects

M. Laruelle, L. Kegeles, A. Abi-Dargham, 2009, Biological Psychiatry.

Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum

S. Haber, Yiyun Huang, E. Zarahn, 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Spect imaging of striatal dopamine release after amphetamine challenge in humans: Relationship between subjective effects and dopamine release

D. Charney, M. Laruelle, A. Abi-Dargham, 1995, Schizophrenia Research.

Cocaine Dependence and D2 Receptor Availability in the Functional Subdivisions of the Striatum: Relationship with Cocaine-Seeking Behavior

Yiyun Huang, D. Hwang, M. Laruelle, 2004, Neuropsychopharmacology.

In Vivo DA D1 Receptor Selectivity of NNC 112 and SCH 23390

Mark Slifstein, Marc Laruelle, Dah-Ren Hwang, 2007, Molecular Imaging and Biology.

Modulation of Amphetamine-Induced Dopamine Release by Group II Metabotropic Glutamate Receptor Agonist LY354740 in Non-Human Primates Studied with Positron Emission Tomography

Marc Laruelle, Dah-Ren Hwang, Rajesh Narendran, 2006, Neuropsychopharmacology.

Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates.

Mark Slifstein, Marc Laruelle, Diana Martinez, 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography: I. Accuracy and Precision of D2 Receptor Parameter Measurements in Ventral Striatum

Osama Mawlawi, Mark Slifstein, Marc Laruelle, 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Graphical, Kinetic, and Equilibrium Analyses of in vivo [123I]β-CIT Binding to Dopamine Transporters in Healthy Human Subjects

Robert B. Innis, Marc Laruelle, Dennis S. Charney, 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Evaluation of 11C-GSK189254 as a Novel Radioligand for the H3 Receptor in Humans Using PET

Alan A. Wilson, M. Laruelle, E. Rabiner, 2010, Journal of Nuclear Medicine.

Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents.

Yiyun Huang, B. Roth, Zhihong Zhu, 2005, Journal of medicinal chemistry.

Imaging Dopamine D3 Receptors in the Human Brain with Positron Emission Tomography, [11C]PHNO, and a Selective D3 Receptor Antagonist

Alan A. Wilson, S. Houle, M. Laruelle, 2010, Biological Psychiatry.

Measuring Dopamine Synaptic Transmission with Molecular Imaging and Pharmacological Challenges: The State of the Art

M. Laruelle, 2012 .

D3 receptor assessment in vivo: PET with [11C]PHNO and SB-277011

M. Laruelle, E. Rabiner, R. Gunn, 2008 .

Dopamine transporters, D2 receptors, and dopamine release in generalized social anxiety disorder

M. Liebowitz, F. Schneier, D. Hwang, 2009, Depression and anxiety.

No Evidence of Altered In Vivo Benzodiazepine Receptor Binding in Schizophrenia

John Seibyl, Osama Mawlawi, Marc Laruelle, 1999, Neuropsychopharmacology.

Spect imaging of the benzodiazepine receptor in schizophrenics and healthy subjects

J. Krystal, D. Charney, M. Laruelle, 1995, Schizophrenia Research.

Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates

Marc Laruelle, Eileen O. Smith, R. Roth, 1992, Synapse.

Protein precipitation: an expedient procedure for the routine analysis of the plasma metabolites of [123I]IBZM.

M. Laruelle, Y. Zea‐Ponce, 1999, Nuclear medicine and biology.

Synthesis of [123I]IBZM: a reliable procedure for routine clinical studies.

M. Laruelle, Y. Zea‐Ponce, 1999, Nuclear medicine and biology.

Imaging Receptor Occupancy by Endogenous Transmitters in Humans

M. Laruelle, A. Abi-Dargham, R. Innis, 1998 .

Pharmacokinetics of the three radioiodinated dopamine D2 receptor ligands [123I]IBF, [123I]epidepride and [123I]2'-ISP in nonhuman primates.

E. Sybirska, J. Seibyl, D. Charney, 1994, Nuclear medicine and biology.

An improved one-pot procedure for the preparation of [11C-carbonyl]-WAY100635.

D. Hwang, M. Laruelle, N. Simpson, 1999, Nuclear medicine and biology.

Positron emission tomography imaging of amphetamine‐induced dopamine release in the human cortex: A comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride

R. Narendran, M. Laruelle, G. Searle, 2009, Synapse.

Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: Quantitative analysis, test–retest reproducibility, and vulnerability to endogenous 5-HT tone

Mark Slifstein, Marc Laruelle, Peter S. Talbot, 2012, NeuroImage.

11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons.

Yiyun Huang, R. Narendran, D. Hwang, 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Biodistribution and radiation dosimetry of the dopamine D2 ligand 11C-raclopride determined from human whole-body PET.

Yiyun Huang, J. Ekelund, D. Hwang, 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Sustained Recreational Use of Ecstasy Is Associated with Altered Pre and Postsynaptic Markers of Serotonin Transmission in Neocortical Areas: A PET Study with [11C]DASB and [11C]MDL 100907

M. Laruelle, L. Kegeles, A. Abi-Dargham, 2012, Neuropsychopharmacology.

Binding of serotonergic ligands to brain membranes of alcohol-preferring AA and alcohol-avoiding ANA rats.

M. Laruelle, A. Abi-Dargham, E. Korpi, 1992, Alcohol.

In vivo evaluation of [11C]-3-[2-[(3-methoxyphenylamino)carbonyl]ethenyl]-4,6-dichloroindole-2-carboxylic acid ([11C]3MPICA) as a PET radiotracer for the glycine site of the NMDA ion channel.

M. Laruelle, A. Sultana, R. Waterhouse, 2002, Nuclear medicine and biology.

PET imaging of dopamine-D2 receptor internalization in schizophrenia.

M. Laruelle, L. Kegeles, A. Abi-Dargham, 2017, Molecular psychiatry.

Striatal and extrastriatal dopamine D 2 /D 3 receptors in schizophrenia evaluated with [ 18 F]fallypride PET

M. Laruelle, L. Kegeles, M. Slifstein, 2010 .

Quantitative Analysis of ( (cid:1) )- N - 11 C-Propyl-Norapomorphine In Vivo Binding in Nonhuman Primates

R. Narendran, D. Hwang, M. Laruelle, 2004 .

Vulnerability of positron emission tomography radiotracers to endogenous competition. New insights.

M. Laruelle, Y. Huang, 2001, The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology.

Plasmatic vasopressin neurophysin in depression: Basic levels and relations with HPA axis

M. Laruelle, J. Legros, A. Seghers, 1990, Biological Psychiatry.

INCREASED 5-HT 2A RECEPTOR AVAILABILITY IN THE ORBITOFRONTAL CORTEX OF PHYSICALLY AGGRESSIVE PERSONALITY DISORDERED PATIENTS

M. Laruelle, M. Slifstein, D. Rosell, 2011 .

The role of P-glycoprotein on blood brain barrier permeability of [11C]Loperamide in humans

S. Houle, J. Passchier, M. Laruelle, 2008, NeuroImage.

Serotonin 5-HT3 receptors in schizophrenia: a postmortem study of the amygdala

J. Kleinman, D. Weinberger, M. Laruelle, 1993, Brain Research.

Contribution of D3 receptors to the in vivo binding of [11C]PHNO in the primate brain

M. Laruelle, E. Rabiner, R. Gunn, 2008, NeuroImage.

Positron-labeled dopamine agonists for probing the high affinity states of dopamine subtype 2 receptors.

R. Narendran, D. Hwang, M. Laruelle, 2005, Bioconjugate chemistry.

Imaging the D3 receptor in humans in vivo using [11C](+)-PHNO positron emission tomography (PET).

M. Laruelle, E. Rabiner, 2010, The international journal of neuropsychopharmacology.

Prediction of Repeat-Dose Occupancy from Single-Dose Data: Characterisation of the Relationship between Plasma Pharmacokinetics and Brain Target Occupancy

Stefano Zamuner, Roger N Gunn, Graham E Searle, 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Increased prefrontal cortical D1 receptors in drug naïve patients with schizophrenia: a PET study with [11C]NNC112

R. Narendran, D. Hwang, M. Laruelle, 2012, Journal of psychopharmacology.

Evaluation of [3H]LY341495 for labeling group II metabotropic glutamate receptors in vivo.

Mark E. Schmidt, M. Laruelle, A. Sultana, 2003, Nuclear medicine and biology.

A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis- 4-methoxycyclohexyl)methanone.

Yiyun Huang, Zhihong Zhu, N. Guo, 2005, Journal of medicinal chemistry.

Dopamine Depletion and In Vivo Binding of PET D1 Receptor Radioligands: Implications for Imaging Studies in Schizophrenia

Marc Laruelle, Dah-Ren Hwang, Anissa Abi-Dargham, 2003, Neuropsychopharmacology.

Rapid Communication Age-related decline in central serotonin transporter availability with ( 123 I)b-CIT SPECT <

J. Seibyl, M. Laruelle, S. Zoghbi, 2000 .

Reproducibility of iodine-123-beta-CIT SPECT brain measurement of dopamine transporters.

J. Seibyl, D. Charney, M. Laruelle, 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Model-based sequential human PET study design for Optimal PK/RO assessment

M. Laruelle, R. Gunn, R. Gomeni, 2007 .

Human Kinetic Modeling of the 5HT6 PET Radioligand 11C-GSK215083 and Its Utility for Determining Occupancy at Both 5HT6 and 5HT2A Receptors by SB742457 as a Potential Therapeutic Mechanism of Action in Alzheimer Disease

Alan A. Wilson, S. Houle, M. Laruelle, 2015, The Journal of Nuclear Medicine.

In vivo vulnerability to competition by endogenous dopamine: Comparison of the D2 receptor agonist radiotracer (–)‐N‐[11C]propyl‐norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]‐raclopride

Mark Slifstein, Marc Laruelle, David Erritzoe, 2004, Synapse.

Within-Subject Comparison of [11C]-( + )-PHNO and [11C]raclopride Sensitivity to Acute Amphetamine Challenge in Healthy Humans

Marc Laruelle, Roger N Gunn, Andri C Tziortzi, 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies

Marc Laruelle, M. Laruelle, 2000, Brain Research Reviews.

Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies.

Yiyun Huang, M. Laruelle, R. Carson, 2009, Bioorganic & medicinal chemistry letters.

In vivo quantification of regional dopamine‐D3 receptor binding potential of (+)‐PHNO: Studies in non‐human primates and transgenic mice

Mark Slifstein, Christophe Plisson, Mickael Huiban, 2009, Synapse.

Comparison of [11C]PBR28 and [18F]FEPPA as CNS peripheral benzodiazepine receptor PET ligands in the pig

Alan A. Wilson, M. Laruelle, R. Gunn, 2008 .

(-)-N-[(11)C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D(2) receptors.

D. Hwang, M. Laruelle, L. Kegeles, 2000, Nuclear medicine and biology.

Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study

S. Kapur, B. Wexler, P. Maruff, 2012, Schizophrenia Research.

[11C]NNC 112 Selectivity for Dopamine D1 and Serotonin 5-HT2A Receptors: A PET Study in Healthy Human Subjects

M. Laruelle, L. Kegeles, A. Abi-Dargham, 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

In vivo evaluation of [11C]N-(2-chloro-5-thiomethylphenyl)-N'-(3-methoxy-phenyl)-N'-methylguanidine ([11C]GMOM) as a potential PET radiotracer for the PCP/NMDA receptor.

M. Laruelle, Y. Sudo, M. Slifstein, 2004, Nuclear medicine and biology.

Measurement of Striatal and Extrastriatal Dopamine D1 Receptor Binding Potential With [11C]NNC 112 in Humans: Validation and Reproducibility

Christer Halldin, Osama Mawlawi, Mark Slifstein, 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Epibatidine analogues as selective ligands for the αxβ2-containing subtypes of nicotinic acetylcholine receptors

Yiyun Huang, Zhihong Zhu, M. Laruelle, 2005 .

Evaluation of the novel 5-HT6 receptor radioligand, [11C]GSK-215083 in human

M. Laruelle, G. Searle, E. Rabiner, 2008, NeuroImage.

Pharmacokinetics and brain distribution in non human primate of R(-)[123I]DOI, A 5HT(2A/2C) serotonin agonist.

N. Guo, M. Laruelle, L. Kegeles, 2002, Nuclear medicine and biology.

SPECT Imaging of Resting Dopamine Synaptic Release in the Striatum of Untreated Schizophrenic Patients

M. Laruelle, L. Kegeles, A. Abi-Dargham, 1998, NeuroImage.

Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype.

Marc Laruelle, Joel Gelernter, John P Seibyl, 2004, The American journal of psychiatry.

Pharmacological and Regional Characterization of [3H]LY278584 Binding Sites in Human Brain

J. Kleinman, M. Laruelle, A. Abi-Dargham, 1993, Journal of neurochemistry.

PET imaging of dopamine-D2 receptor internalization in schizophrenia

M. Laruelle, L. Kegeles, A. Abi-Dargham, 2017, Molecular Psychiatry.

Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers.

M Slifstein, M Laruelle, M. Laruelle, 2001, Nuclear medicine and biology.

11C-GSK189254: A Selective Radioligand for In Vivo Central Nervous System Imaging of Histamine H3 Receptors by PET

M. Laruelle, R. Gunn, A. Gee, 2009, Journal of Nuclear Medicine.

The Dopamine D3 Receptor in the Pathophysiology and Treatment of Neuropsychiatric Disorders

M. Laruelle, A. Sidhu, P. Vernier, 2003 .

Radioligand for the H 3 Receptor in Humans Using PET

Alan A. Wilson, M. Laruelle, E. Rabiner, 2010 .

Alcohol Dependence Is Associated with Blunted Dopamine Transmission in the Ventral Striatum

Mark Slifstein, Marc Laruelle, Roberto Gil, 2005, Biological Psychiatry.

Coupling efficiency of brain β-adrenergic receptors to Gs protein in suicide, alcoholism and control subjects

J. Kleinman, M. Laruelle, J. Turkka, 1999, Psychopharmacology.

Schizophrenia: from dopaminergic to glutamatergic interventions.

M. Laruelle, 2014, Current opinion in pharmacology.

Striatal and Extrastriatal Dopamine D2/D3 Receptors in Schizophrenia Evaluated With [18F]fallypride Positron Emission Tomography

M. Laruelle, L. Kegeles, A. Abi-Dargham, 2010, Biological Psychiatry.

Mechanisms of action of second generation antipsychotic drugs in schizophrenia: insights from brain imaging studies

Marc Laruelle, Anissa Abi-Dargham, M. Laruelle, 2005, European Psychiatry.

Mechanism of action of antipsychotic drugs: from dopamine D(2) receptor antagonism to glutamate NMDA facilitation.

R. Narendran, M. Laruelle, L. Kegeles, 2005, Clinical therapeutics.

A new positron emission tomography imaging agent for the serotonin transporter: synthesis, pharmacological characterization, and kinetic analysis of [11C]2-[2-(dimethylaminomethyl)phenylthio]-5-fluoromethylphenylamine ([11C]AFM).

Marc Laruelle, Dah-Ren Hwang, Yasuhiko Sudo, 2004, Nuclear medicine and biology.

Occupancy of dopamine D2 receptors by the atypical antipsychotic drugs risperidone and olanzapine: theoretical implications

J. Gorman, O. Mawlawi, M. Laruelle, 2003, Psychopharmacology.

Schizophrenia and Bipolar Disorder as Putative Dopamine-Linked Illnesses

M. Laruelle, A. Sidhu, P. Vernier, 2003 .

Comparison of [123I]ß-CIT and [123I]IPCIT as single-photon emission tomography radiotracers for the dopamine transporter in nonhuman primates

D. Charney, M. Laruelle, S. Zoghbi, 2005, European Journal of Nuclear Medicine.

[123I]IPCIT and [123I]beta-CIT as SPECT tracers for the dopamine transporter: a comparative analysis in nonhuman primates.

M. Laruelle, S. Zoghbi, R. Innis, 2000, Nuclear medicine and biology.

Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene.

Marc Laruelle, Joel Gelernter, John P Seibyl, 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson disease.

M Laruelle, J. Seibyl, M. Laruelle, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Physiology, Pharmacology, and Pathophysiology of the D1-like Family of Dopamine Receptors in the Central Nervous System

M. Laruelle, A. Sidhu, P. Vernier, 2003 .

The Synaptic Hypothesis of Schizophrenia

Marc Laruelle, Juan Lerma, M. Laruelle, 2003, Neuron.

How does pindolol improve antidepressant action?

P. Celada, M. Laruelle, F. Artigas, 2001, Trends in pharmacological sciences.

The role of serotonin in the pathophysiology and treatment of schizophrenia.

G. Aghajanian, G. Aghajanian, J. Krystal, 1997, The Journal of neuropsychiatry and clinical neurosciences.

Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies

M. Laruelle, A. Abi-Dargham, 1999, Journal of psychopharmacology.

Chapter 27 Antipsychotic-Induced Changes in Striatal D2 Receptors in Schizophrenia: In Vivo Evidence from Dopamine Depletion Studies

M. Laruelle, L. Kegeles, A. Abi-Dargham, 2013 .

Chapter 24 Antipsychotic-Induced Changes in Striatal D2 Receptors in Schizophrenia: In Vivo Evidence from Dopamine Depletion Studies

M. Laruelle, L. Kegeles, A. Abi-Dargham, 2012 .

In Vivo Imaging of Dopamine Receptors

M. Laruelle, A. Abi-Dargham, 2010 .

Neuroreceptor imaging in psychiatry: theory and applications.

Mark Slifstein, Marc Laruelle, Peter S Talbot, 2005, International review of neurobiology.

Neuroreceptor imaging in psychiatric disorders

Marc Laruelle, M. Laruelle, W. Frankle, 2002, Annals of nuclear medicine.

Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine

R. Narendran, D. Hwang, M. Laruelle, 2009, Neuropsychopharmacology.

Cognitive and brain function in schizotypal personality disorder

Marc Laruelle, Anissa Abi-Dargham, Larry J Siever, 2002, Schizophrenia Research.

Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil.

M Laruelle, J. Krystal, J. Seibyl, 1998, The American journal of psychiatry.

Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies

Marc Laruelle, Eric Xanthopoulos, J. Gorman, 2000, Psychiatry Research: Neuroimaging.

Selective abnormalities of prefrontal serotonergic receptors in schizophrenia. A postmortem study.

J. Kleinman, D. Weinberger, M. Casanova, 1993, Archives of general psychiatry.

Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]β-CIT

J. Krystal, J. Seibyl, M. Laruelle, 2000, Biological Psychiatry.

SPECT Quantification of [123I]Iomazenil Binding to Benzodiazepine Receptors in Nonhuman Primates: II. Equilibrium Analysis of Constant Infusion Experiments and Correlation with in vitro Parameters

Robert B. Innis, Marc Laruelle, Dennis S. Charney, 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Schizophrenia is associated with increased synaptic dopamine in associative rather than limbic regions of the striatum: Implications for mechanisms of action of antipsychotic drugs

Mark Slifstein, Marc Laruelle, Roberto Gil, 2006 .

Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain

Richard E Carson, Marc Laruelle, Shu-Fei Lin, 2016, The Journal of Nuclear Medicine.

Synthesis and characterization of 4,6-dichloroindole-based radioligands for imaging the glycine site of the NMDA ion channel

N. Guo, M. Laruelle, A. Sultana, 2002 .

Striatal and extrastriatal dopamine release measured with PET and [18F] fallypride

Mark Slifstein, Marc Laruelle, Elizabeth Hackett, 2010, Synapse.

Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography.

Mark Slifstein, Marc Laruelle, Yiyun Huang, 2003, Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.

Interactions between D1 and D2 dopamine receptor family agonists and antagonists: the effects of chronic exposure on behavior and receptor binding in rats and their clinical implications

M. Laruelle, M. Mouradian, A. Braun, 2005, Journal of Neural Transmission.

Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652.

Mark Slifstein, Marc Laruelle, Dah-Ren Hwang, 2005, The American journal of psychiatry.

Imaging neurochemical endophenotypes: promises and pitfalls.

M Laruelle, M. Laruelle, D. Martínez, 2001, Pharmacogenomics.

The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans

Marc Laruelle, Diana Martinez, Joel Gelernter, 2001, Neuropsychopharmacology.

Regional and subcellular localization in human brain of [3H]paroxetine binding, a marker of serotonin uptake sites

Marc Laruelle, M. Laruelle, J. Maloteaux, 1988, Biological Psychiatry.

Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT.

M Laruelle, J. Seibyl, M. Laruelle, 1998, The American journal of psychiatry.

Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys

J. Seibyl, M. Laruelle, G. Tamagnan, 2014, The Journal of Nuclear Medicine.

Characterization of in vivo pharmacological properties and sensitivity to endogenous serotonin of [11C] P943: A positron emission tomography study in Papio anubis

Mark Slifstein, Marc Laruelle, Roger N Gunn, 2011, Synapse.

D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene

M Laruelle, M. Laruelle, R. Innis, 1998, Molecular Psychiatry.

Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor

Steen Jakobsen, Mark Slifstein, Marc Laruelle, 2012, The Journal of Nuclear Medicine.

Imaging Changes in Synaptic Acetylcholine Availability in Living Human Subjects

Richard E Carson, Marc Laruelle, John P Seibyl, 2013, The Journal of Nuclear Medicine.

Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine.

Mark Slifstein, Marc Laruelle, Herbert D Kleber, 2007, The American journal of psychiatry.

Microdialysis and SPECT measurements of amphetamine‐induced dopamine release in nonhuman primates

P B Hoffer, M Laruelle, D. Charney, 1997, Synapse.

Kinetic Modeling of 11C-SB207145 Binding to 5-HT4 Receptors in the Human Brain In Vivo

Claus Svarer, Nic Gillings, Marc Laruelle, 2009, Journal of Nuclear Medicine.

Positron emission tomography: imaging and quantification of neurotransporter availability.

Mark Slifstein, Marc Laruelle, Yiyun Huang, 2002, Methods.

Validation and Reproducibility of Measurement of 5-HT1A Receptor Parameters with [carbonyl-11C]WAY-100635 in Humans: Comparison of Arterial and Reference Tissue Input Functions

M Slifstein, M Laruelle, R. V. Van Heertum, 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Blood brain barrier permeability of [11C]loperamide in humans under normal and impaired P-glycoprotein function

Alan A. Wilson, S. Houle, J. Passchier, 2008 .

Imaging dopamine receptors in humans with [11C]-(+)-PHNO: Dissection of D3 signal and anatomy

Mark Jenkinson, John D. Beaver, Marc Laruelle, 2011, NeuroImage.

In vitro assessment of the agonist properties of the novel 5-HT1A receptor ligand, CUMI-101 (MMP), in rat brain tissue.

M. Laruelle, E. Rabiner, I. Christie, 2011, Nuclear medicine and biology.

Measuring Drug Occupancy in the Absence of a Reference Region: The Lassen Plot Re-Visited

Mark Slifstein, Marc Laruelle, Roger N Gunn, 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development

Marc Laruelle, Peter S Talbot, M. Laruelle, 2002, European Neuropsychopharmacology.

Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide

L. Siever, O. Mawlawi, M. Laruelle, 2004, Biological Psychiatry.

The role of model-based methods in the development of single scan techniques.

M Laruelle, M. Laruelle, 2000, Nuclear medicine and biology.

Serotonin Transporter Availability in Patients with Schizophrenia: A Positron Emission Tomography Imaging Study with [11C]DASB

Yiyun Huang, R. Narendran, D. Hwang, 2005, Biological Psychiatry.

Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans.

Mark Slifstein, Marc Laruelle, Dah-Ren Hwang, 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Pharmacological and Genetic Characterization of Two Selective Serotonin Transporter Ligands: 2-[2-(Dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-Amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB)

D. Murphy, M. Laruelle, R. Innis, 2004, Journal of Pharmacology and Experimental Therapeutics.

Imaging Cortical Dopamine D1 Receptors Using [11C]NNC112 and Ketanserin Blockade of the 5-HT2A Receptors

M. Laruelle, G. Searle, E. Rabiner, 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

(−)-N-[11C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D2 receptors

D. Hwang, M. Laruelle, L. Kegeles, 2000 .

Pharmacokinetics of the SPECT benzodiazepine receptor radioligand [123I]iomazenil in human and non-human primates.

E. Sybirska, S. Woods, J. Seibyl, 1992, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Impact of D2 Receptor Internalization on Binding Affinity of Neuroimaging Radiotracers

Mark Slifstein, Marc Laruelle, Man Jiang, 2010, Neuropsychopharmacology.

Combining PET Biodistribution and Equilibrium Dialysis Assays to Assess the Free Brain Concentration and BBB Transport of CNS Drugs

Marc Laruelle, Roger N Gunn, Qi Guo, 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Prefrontal Cortical Projections to the Midbrain in Primates: Evidence for a Sparse Connection

S. Haber, M. Laruelle, W. Frankle, 2006, Neuropsychopharmacology.

Effect of amphetamine on [18F]fallypride in vivo binding to D2 receptors in striatal and extrastriatal regions of the primate brain: Single bolus and bolus plus constant infusion studies

Mark Slifstein, Marc Laruelle, Dah-Ren Hwang, 2004, Synapse.

In vivo affinity of [18F]fallypride for striatal and extrastriatal dopamine D2 receptors in nonhuman primates

Mark Slifstein, Marc Laruelle, Dah-Ren Hwang, 2004, Psychopharmacology.

Dopamine Transmission in the Schizophrenic Brain

M. Laruelle, 2007 .

Low dopamine D(2) receptor binding potential in social phobia.

M. Liebowitz, F. Schneier, M. Laruelle, 2000, The American journal of psychiatry.

Differential Occupancy of Somatodendritic and Postsynaptic 5HT1A Receptors by Pindolol: A Dose-Occupancy Study with [11C]WAY 100635 and Positron Emission Tomography in Humans

Osama Mawlawi, Mark Slifstein, Marc Laruelle, 2001, Neuropsychopharmacology.

Pindolol augmentation of antidepressant treatment: recent contributions from brain imaging studies

M. Laruelle, D. Martínez, A. Broft, 2000, Biological Psychiatry.

Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain

Marc Laruelle, Barbara J. Sahakian, Eugenii A. Rabiner, 2010, NeuroImage.

PET Studies of Binding Competition Between Endogenous Dopamine and the D 1

R. Parsey, D. Hwang, M. Laruelle, 1999 .

PET Studies of Binding Competition between Endogenous Dopamine and the D1 Radiotracer [11C]NNC 756

Christer Halldin, Marc Laruelle, Ramin Parsey, 1998, NeuroImage.

Regional distribution of serotonergic pre‐ and postsynaptic markers in human brain

M Laruelle, M. Laruelle, J M Maloteaux, 1989, Acta psychiatrica Scandinavica. Supplementum.

Positron emission tomography study of pindolol occupancy of 5-HT(1A) receptors in humans: preliminary analyses.

R. V. Van Heertum, J. Mann, R. Parsey, 2000, Nuclear Medicine and Biology.

Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone

Yiyun Huang, John H. Martin, D. Hwang, 2011, Journal of psychopharmacology.

Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods.

Mark Slifstein, Marc Laruelle, Roger N Gunn, 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Effects of reduced endogenous 5‐HT on the in vivo binding of the serotonin transporter radioligand 11C‐DASB in healthy humans

Mark Slifstein, Marc Laruelle, Yiyun Huang, 2005, Synapse.

Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with [11C]McN 5652

R. V. Van Heertum, Yiyun Huang, J. Gorman, 2002, Psychopharmacology.

Comparison of Kinetic Modeling Methods for the In Vivo Quantification of 5-HT1A Receptors Using WAY 100635

Ramin V. Parsey, Osama Mawlawi, Mark Slifstein, 2001 .

Synthesis of potent and selective serotonin 5-HT1B receptor ligands.

Marc Laruelle, Bryan L Roth, Yiyun Huang, 2005, Bioorganic & medicinal chemistry letters.

Euphorigenic doses of cocaine reduce [123I]β-CIT SPECT measures of dopamine transporter availability in human cocaine addicts

M. Laruelle, L. Price, R. Innis, 1995, Psychopharmacology.

Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans

Marc Laruelle, Anissa Abi-Dargham, John P Seibyl, 1997, Neuropsychopharmacology.

Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naı̈ve healthy volunteers: results from a large cohort

Robert B. Innis, Marc Laruelle, Diana Martinez, 2003, European Neuropsychopharmacology.

SPECT imaging of dopamine and serotonin transporters with [123I]β‐CIT: Pharmacological characterization of brain uptake in nonhuman primates

Marc Laruelle, Eileen O. Smith, Gary Wisniewski, 1993, Synapse.

NMDA antagonist effects on striatal dopamine release: Positron emission tomography studies in humans

R. V. Van Heertum, Yiyun Huang, O. Mawlawi, 2002, Synapse.

Characterization in Humans of 18F-MNI-444, a PET Radiotracer for Brain Adenosine 2A Receptors

D. Jennings, J. Seibyl, M. Laruelle, 2015, The Journal of Nuclear Medicine.

In vivo quantification of brain serotonin transporters in humans using [11C]McN 5652.

M Slifstein, M Laruelle, R. V. Van Heertum, 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

D2 Receptor Occupancy of Olanzapine Pamoate Depot Using Positron Emission Tomography: An Open-label Study in Patients with Schizophrenia

S. Kapur, M. Keshavan, M. Laruelle, 2008, Neuropsychopharmacology.

Methyl 3β‐(4‐[125I]Iodophenyl)Tropane‐2β‐Carboxylate In Vitro Binding to Dopamine and Serotonin Transporters Under “Physiological” Conditions

Marc Laruelle, D. Charney, M. Laruelle, 1994 .

The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction.

E. Bullmore, C. Dodds, C. Davies, 2013, The international journal of neuropsychopharmacology.

Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1

Mark Slifstein, Marc Laruelle, Stefano Zamuner, 2011, Synapse.

Relationship Between Glycine Transporter 1 Inhibition as Measured with Positron Emission Tomography and Changes in Cognitive Performances in Nonhuman Primates

R N Gunn, R E Carson, M Laruelle, 2014, Neuropsychopharmacology.

Dopamine receptors and transporters : function, imaging, and clinical implication

M. Laruelle, A. Sidhu, P. Vernier, 2003 .

Amphetamine‐induced dopamine release: Duration of action as assessed with the D2/3 receptor agonist radiotracer (––)‐N‐[11C]propyl‐norapomorphine ([11C]NPA) in an anesthetized nonhuman primate

Mark Slifstein, Marc Laruelle, Diana Martinez, 2007, Synapse.

Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]‐(+)‐PHNO is a D3 receptor preferring agonist in vivo

R. Narendran, D. Hwang, M. Laruelle, 2006, Synapse.

Measurement of the Proportion of D2 Receptors Configured in State of High Affinity for Agonists in Vivo: A Positron Emission Tomography Study Using [11C]N-Propyl-norapomorphine and [11C]Raclopride in Baboons

Mark Slifstein, Marc Laruelle, Diana Martinez, 2005, Journal of Pharmacology and Experimental Therapeutics.

The 5-HT2A receptor and serotonin transporter in Asperger's Disorder: A PET study with [11C]MDL 100907 and [11C]DASB

A. Kolevzon, E. Hollander, M. Laruelle, 2011, Psychiatry Research: Neuroimaging.

Increased Serotonin 2A Receptor Availability in the Orbitofrontal Cortex of Physically Aggressive Personality Disordered Patients

Mark Slifstein, Marc Laruelle, W. Gordon Frankle, 2010, Biological Psychiatry.

Affinity and selectivity of [11C]‐(+)‐PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo

Richard E Carson, Mark Slifstein, Marc Laruelle, 2012, Synapse.

Imaging Dopamine D3 Receptors in the Human Brain with Positron Emission Tomography, [11C]PHNO, and a Selective D3 Receptor Antagonist

John D. Beaver, Mark Slifstein, Marc Laruelle, 2010, Biological Psychiatry.

Mathematical modelling of [11C]-(+)-PHNO human competition studies

John D. Beaver, Marc Laruelle, Roger N. Gunn, 2013, NeuroImage.

SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT.

P B Hoffer, M Laruelle, D. Charney, 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Single photon emission computed tomography imaging of monoamine reuptake sites in primate brain with [123I]CIT.

M Laruelle, E. Sybirska, D. Charney, 1991, European journal of pharmacology.

Synthesis and characterization of two pet radioligands for the metabotropic glutamate 1 (mGlu1) receptor

Yiyun Huang, N. Guo, R. Narendran, 2012, Synapse.

SPECT imaging of the benzodiazepine receptor: feasibility of in vivo potency measurements from stepwise displacement curves.

E. Sybirska, J. Seibyl, M. Laruelle, 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Dopaminergic Receptor Function Defined by Studying Genetically Altered Mice

M. Laruelle, A. Sidhu, P. Vernier, 2003 .

Functional neuroimaging and electrophysiology biomarkers for clinical trials for cognition in schizophrenia.

Marc Laruelle, John H Krystal, Judith M Ford, 2005, Schizophrenia bulletin.

Reproducibility of SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil.

P B Hoffer, M Laruelle, D. Charney, 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Dose–Occupancy Study of Striatal and Extrastriatal Dopamine D2 Receptors by Aripiprazole in Schizophrenia with PET and [18F]Fallypride

Mark Slifstein, Marc Laruelle, Roberto Gil, 2008, Neuropsychopharmacology.

507 In vivo evaluation of dopamine synaptic funcflon in untreated schizophrenic patients

J. Krystal, D. Charney, M. Laruelle, 1997, Schizophrenia Research.

Monoamine Transporter Occupancy of a Novel Triple Reuptake Inhibitor in Baboons and Humans Using Positron Emission Tomography Clinical Imaging

Mark Slifstein, Marc Laruelle, Roger N Gunn, 2022 .

A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA).

Yiyun Huang, Zhihong Zhu, N. Guo, 2004, Nuclear medicine and biology.

Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA).

Yiyun Huang, Zhihong Zhu, N. Guo, 2002, Nuclear medicine and biology.

Fluorinated analogues of ADAM as new PET radioligands for the serotonin transporter: Synthesis and pharmacological evaluation

Yiyun Huang, N. Guo, D. Hwang, 2001 .

Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression

R. Parsey, M. Laruelle, L. Kegeles, 2001, Biological Psychiatry.

Derivation of [(11)C]WAY-100635 binding parameters with reference tissue models: effect of violations of model assumptions.

M Slifstein, M Laruelle, R. Parsey, 2000, Nuclear medicine and biology.

Compartmental modeling of iodine-123-iodobenzofuran binding to dopamine D2 receptors in healthy subjects.

P B Hoffer, M Laruelle, D. Charney, 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Kinetic Derivation of Serotonin 5HT-1A Receptor Binding Potential with [11C]Carbonyl-Way 100635 and Competition Studies with Endogenous Serotonin

R. V. Parsey, N. Simpson, R. van Heertum, 1998, NeuroImage.

11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons.

Yiyun Huang, R. Narendran, D. Hwang, 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Simplified multidose preparation of iodine-123-beta-CIT: a marker for dopamine transporters.

M. Laruelle, R. Innis, R. Baldwin, 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Stability of [123I]IBZM SPECT measurement of amphetamine‐induced striatal dopamine release in humans

M Laruelle, R. V. Van Heertum, M. Laruelle, 1999, Synapse.

Psychiatry — Relevance with Respect to Drug Development, Examples

M. Laruelle, E. Rabiner, K. Ridler, 2012 .

Preclinical evaluation of [123I]R93274 as a SPECT radiotracer for imaging 5-HT2A receptors.

J. Leysen, D. Charney, M. Laruelle, 1997, European journal of pharmacology.

In vivo quantification of dopamine D2 receptor parameters in nonhuman primates with [123I]iodobenzofuran and single photon emission computerized tomography.

P B Hoffer, M Laruelle, D. Charney, 1994, European journal of pharmacology.

SPECT Quantification of [123I]Iomazenil Binding to Benzodiazepine Receptors in Nonhuman Primates: I. Kinetic Modeling of Single Bolus Experiments

Robert B. Innis, Marc Laruelle, Dennis S. Charney, 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Enantioselectivity of cocaine recognition sites: binding of (1S)- and (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane (beta-CIT) to monoamine transporters.

M. Laruelle, R. Innis, R. Baldwin, 1993, Journal of medicinal chemistry.

Characterization of the dopamine transporter in nonhuman primate brain: homogenate binding, whole body imaging, and ex vivo autoradiography using [125I] and [123I]IPCIT.

J. Seibyl, D. Charney, M. Laruelle, 1995, Nuclear medicine and biology.

Single photon emission tomography measurement of benzodiazepine receptor number and affinity in primate brain: a constant infusion paradigm with [123I]iomazenil.

P B Hoffer, Z Rattner, M Laruelle, 1993, European journal of pharmacology.

Characterising the plasma-target occupancy relationship of the neurokinin antagonist GSK1144814 with PET

Roger N Gunn, Graham E Searle, Jan Passchier, 2014, Journal of psychopharmacology.

Identification and evaluation of [11C]GSK931145 as a novel ligand for imaging the type 1 glycine transporter with positron emission tomography

R N Gunn, M Laruelle, J. Passchier, 2010, Synapse.

D1 and D2 receptor modulation in rat striatum and nucleus accumbens after subchronic and chronic haloperidol treatment

B. Lipska, B. Kolachana, J. Kleinman, 1992, Brain Research.

A pseudo-reference region method applied to measurement of GlyT1 occupancy in human brain using [11C]GSK931145 and PET

Cristian Salinas, Marc Laruelle, Ana M. Catafau, 2010, NeuroImage.

494 Spect measurement of human striatal synaptic dopamine concentration with [123I]IBZM

M. Laruelle, L. Kegeles, A. Abi-Dargham, 1997, Schizophrenia Research.

Positron emission tomography imaging of dopamine D2/3 receptors in the human cortex with [11C]FLB 457: Reproducibility studies

R. Narendran, M. Laruelle, E. Rabiner, 2011, Synapse.

Ibotenic acid or ablation lesions of the frontal cortex do not alter the density or the affinity of D1 and D2 receptors in the corpus striatum or nucleus accumbens

B. Lipska, D. Weinberger, M. Laruelle, 1991, Schizophrenia Research.

Neuroimaging Findings in Schizophrenia: From Mental to Neuronal Fragmentation

M. Laruelle, L. Kegeles, 2003 .

Positron Emission Tomography Imaging of the Serotonin Transporter and 5-HT1A Receptor in Alcohol Dependence

Mark Slifstein, Marc Laruelle, Roberto Gil, 2009, Biological Psychiatry.

PET imaging of the serotonin transporter and 5HT1A receptor in alcohol dependence

J. Krystal, D. Hwang, M. Laruelle, 2009 .

Clinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transports: Implications on treatment of depression and ADHD

Richard E. Carson, Marc Laruelle, Jean-Dominique Gallezot, 2014, NeuroImage.

Images in neuroscience. SPECT imaging of synaptic dopamine.

M. Laruelle, R. Innis, 1996, The American journal of psychiatry.

Striatal dopamine D2 receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findings

M. Liebowitz, F. Schneier, M. Laruelle, 2008, Depression and anxiety.

Evaluation of dopamine D2/3specific binding in the cerebellum for the positron emission tomography radiotracer [11C]FLB 457: Implications for measuring cortical dopamine release

Marc Laruelle, Rajesh Narendran, R. Narendran, 2011, Synapse.

Correlation between PET and microdialysis measurements of amphetamine induced DA release in striatal and extrastriatal brain regions in baboons

H. Moore, M. Laruelle, L. Kegeles, 2007 .

Pharmacological selectivity of the in vivo binding of [11C]NNC 112 and [11C]SCH 23390 in the cortex: A PET study in baboons

R. Narendran, J. Ekelund, D. Hwang, 2006, NeuroImage.

Imaging drug action in schizophrenia: research update

M. Laruelle, A. Abi-Dargham, 2003, European Psychiatry.

Unexpectedly high affinity of a novel histamine H3 receptor antagonist, GSK239512, in vivo in human brain, determined using PET

M. Laruelle, G. Searle, R. Gunn, 2014, British journal of pharmacology.

Ligand Tracer Kinetics: Theory and Application

Mark Slifstein, Marc Laruelle, W. Gordon Frankle, 2004 .

Reproducibility of Radioligand Measurements of Pharmacologically Induced Striatal Dopamine Release in Humans

M. Laruelle, L. Kegeles, A. Abi-Dargham, 2001 .

Spect imaging of the benzodiazepine receptor in humans using [123I]iomazenil

J. Krystal, J. Seibyl, D. Charney, 1993, Schizophrenia Research.

Dopaminergic Hyperactivity in Striatum in Schizophrenia: A Failure of Cortical Glutamatergic Control?

M. Laruelle, L. Kegeles, 2002 .

Synthesis and evaluation of 18F-UCB-H, a novel PET imaging tracer for the synaptic vesicle protein 2A

Yiyun Huang, M. Laruelle, R. Carson, 2014 .

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

J. Krystal, D. Charney, M. Laruelle, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.

J. Gorman, M. Laruelle, L. Kegeles, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies

J. Gorman, M. Laruelle, L. Kegeles, 2000, Psychiatry Research: Neuroimaging.

Measuring Drug Occupancy in the Absence of a Reference Region: The Lassen Plot Re-Visited

M. Laruelle, E. Rabiner, R. Gunn, 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Biodistribution and Radiation Dosimetry of the Serotonin 5-HT6 Ligand [11C]GSK215083 Determined from Human Whole-Body PET

Alan A. Wilson, S. Houle, N. Keat, 2012, Molecular Imaging and Biology.

Prediction of panic response to a respiratory stimulant by reduced orbitofrontal cerebral blood flow in panic disorder.

Osama Mawlawi, Mark Slifstein, Marc Laruelle, 2005, The American journal of psychiatry.

Within-subject comparison of striatal D2 receptor occupancy measurements using [123I]IBZM SPECT and [11C]Raclopride PET

Jordi Llop, Marc Laruelle, Ana M. Catafau, 2008, NeuroImage.

J. Seibyl, M. Laruelle, S. Zoghbi, 2002, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

Neuroimaging Research and Neurocircuitry Models of Obsessive-Compulsive Disorder: Proceedings of the Third IOCDC

S. Rauch, T. Hendler, E. Hollander, 1999, CNS Spectrums.

Monoamine Transporter Occupancy of a Novel Triple Reuptake Inhibitor in Baboons and Humans Using Positron Emission Tomography

M. Laruelle, E. Rabiner, R. Gunn, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboon and human using Positron Emission Tomography

M. Laruelle, E. Rabiner, R. Gunn, 2013 .

Characterization of [125I]SCH 23982 binding in human brain: Comparison with [3H]SCH 23390

J. Kleinman, D. Weinberger, M. Laruelle, 1991, Neuroscience Letters.

Prediction of Repeat-Dose Occupancy from Single-Dose Data: Characterisation of the Relationship between Plasma Pharmacokinetics and Brain Target Occupancy

M. Laruelle, G. Searle, E. Rabiner, 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

An evaluation of the brain distribution of [11C]GSK1034702, a muscarinic-1 (M1) positive allosteric modulator in the living human brain using positron emission tomography

J. Passchier, M. Laruelle, G. Searle, 2014, EJNMMI Research.