D. Labaree

发表

First in human evaluation of [11C]AFM, a novel PET tracer for the serotonin transporter

J. Ropchan, W. Williams, A. Neumeister, 2008, NeuroImage.

Sex Differences in the Brain's Dopamine Signature of Cigarette Smoking

Jenna M. Sullivan, H. Tagare, K. Cosgrove, 2014, The Journal of Neuroscience.

Test–Retest Reproducibility of Binding Parameters in Humans with 11C-LY2795050, an Antagonist PET Radiotracer for the κ Opioid Receptor

Richard E. Carson, Nabeel Nabulsi, Shu-Fei Lin, 2015, The Journal of Nuclear Medicine.

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Sites in Rhesus Brain

Yiyun Huang, D. Nutt, R. Carson, 2014, The Journal of Nuclear Medicine.

Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task

Yiyun Huang, R. Carson, J. Ropchan, 2020, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

7α-Iodine-125-Iodo-5α-Dihydrotestosterone: A Radiolabeled Ligand for the Androgen Receptor

D. Labaree, R. Hochberg, T. Brown, 1997 .

In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB

Yiyun Huang, R. Parsey, R. Carson, 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The serotonin transporter tracer [C-11]AFM provides high specific binding signals in humans

Yiyun Huang, R. Carson, J. Ropchan, 2008 .

A direct stereoselective synthesis of 7β-hydroxytestosterone

D. Labaree, R. Hochberg, R. Hoyte, 1997, Steroids.

Development and In Vivo Evaluation of a κ-Opioid Receptor Agonist as a PET Radiotracer with Superior Imaging Characteristics

Yiyun Huang, D. Labaree, Sujin Kim, 2019, The Journal of Nuclear Medicine.

Novel 18F-Labeled κ-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of 18F-LY2459989 in Nonhuman Primates

Yiyun Huang, J. Ropchan, D. Labaree, 2018, The Journal of Nuclear Medicine.

Regiospecific esterification of estrogens by lecithin:cholesterol acyltransferase.

D. Labaree, R. Hochberg, W. Kuohung, 1999, The Journal of clinical endocrinology and metabolism.

Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand 11C-BMT-136088 for Lung Imaging in Rhesus Monkeys

Richard E Carson, Jean-Dominique Gallezot, Shu-Fei Lin, 2017, The Journal of Nuclear Medicine.

First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430

Yiyun Huang, R. Carson, J. Ropchan, 2016, The Journal of Nuclear Medicine.

Use of Electronic Cigarettes Leads to Significant Beta2-Nicotinic Acetylcholine Receptor Occupancy: Evidence From a PET Imaging Study

K. Cosgrove, N. Nabulsi, D. Labaree, 2018, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Kinetic Analysis of the Metabotropic Glutamate Subtype 5 Tracer [18F]FPEB in Bolus and Bolus-Plus-Constant-Infusion Studies in Humans

Jenna M. Sullivan, Yiyun Huang, J. Seibyl, 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Imaging Nicotine- and Amphetamine-Induced Dopamine Release in Rhesus Monkeys with [11C]PHNO vs [11C]raclopride PET

Yiyun Huang, K. Cosgrove, R. Carson, 2014, Neuropsychopharmacology.

Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence.

Yiyun Huang, K. Cosgrove, R. Carson, 2016, Alcoholism, clinical and experimental research.

Synthesis of halogen-substituted pyridyl and pyrimidyl derivatives of [3,2-c]pyrazolo corticosteroids: strategies for the development of glucocorticoid receptor mediated imaging agents.

D. Labaree, R. Hochberg, R. Hoyte, 2002, Journal of medicinal chemistry.

Kinetic Modeling and Test–Retest Reproducibility of 11C-EKAP and 11C-FEKAP, Novel Agonist Radiotracers for PET Imaging of the κ-Opioid Receptor in Humans

Yiyun Huang, R. Carson, J. Ropchan, 2020, The Journal of Nuclear Medicine.

A novel 18F-labeled kappa opioid receptor antagonist as PET radiotracer: Synthesis and in vivo Evaluation

J. Ropchan, D. Labaree, Henry Huang, 2016 .

Parametric Imaging and Test–Retest Variability of 11C-(+)-PHNO Binding to D2/D3 Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner

Yiyun Huang, R. Carson, D. Labaree, 2014, The Journal of Nuclear Medicine.

Estrogen to antiestrogen with a single methylene group resulting in an unusual steroidal selective estrogen receptor modulator.

D. Labaree, G. Mor, R. Hochberg, 2004, The Journal of clinical endocrinology and metabolism.

Studies of the metabotropic glutamate receptor 5 radioligand [11C]ABP688 with N‐acetylcysteine challenge in rhesus monkeys

Yiyun Huang, K. Cosgrove, R. Carson, 2013, Synapse.

Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates.

Yiyun Huang, R. Carson, N. Nabulsi, 2018, ACS chemical neuroscience.

[7α-18F]fluoro-17α-methyl-5α-dihydrotestosterone: a ligand for androgen receptor-mediated imaging of prostate cancer

D. Labaree, P. Garg, R. Hochberg, 2001 .

Synthesis and Preclinical Evaluation of an 18F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [18F]SynVesT-2.

Yiyun Huang, R. Carson, J. Ropchan, 2020, ACS chemical neuroscience.

Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABAA-Benzodiazepine Binding with 11C-Flumazenil in Awake and Anesthetized Animals

Yiyun Huang, Graham V. Williams, K. Cosgrove, 2013, The Journal of Nuclear Medicine.

Estren (4-Estren-3α,17β-diol) Is a Prohormone that Regulates Both Androgenic and Estrogenic Transcriptional Effects through the Androgen Receptor

D. Labaree, Wei-zhong Chang, R. Hochberg, 2004 .

Preparation of the metabotropic glutamate receptor 5 (mGluR5) PET tracer [(18)F]FPEB for human use: An automated radiosynthesis and a novel one-pot synthesis of its radiolabeling precursor.

Yiyun Huang, D. Labaree, Keunpoong Lim, 2014, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Evaluation of 11 C-BU99008, a Positron Emission Tomography ligand for the Imidazoline 2 binding sites in Rhesus brain

Quelch, Yiyun Huang, D. Nutt, 2013 .

Imaging Pituitary Vasopressin 1B Receptor in Humans with the PET Radiotracer 11C-TASP699

Yiyun Huang, Ming-Rong Zhang, R. Carson, 2021, Journal of Nuclear Medicine.

mGluR5 PET Imaging Using 18F-FPEB in Medically Refractory Epilepsy Patients

Spencer, Yiyun Huang, H. Zaveri, 2019 .

Iodinated and fluorinated steroid 2′-aryl-[3,2-c] pyrazoles as potential glucocorticoid receptor imaging agents

D. Labaree, R. Hochberg, R. Hoyte, 1998, Steroids.

Binding to D 2 /D 3 Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner

Yiyun Huang, R. Carson, D. Labaree, 2014 .

Evaluation of 11C-LSN3172176 as a Novel PET Tracer for Imaging M1 Muscarinic Acetylcholine Receptors in Nonhuman Primates

Yiyun Huang, R. Carson, J. Ropchan, 2019, The Journal of Nuclear Medicine.

Characteristics of bleomycin-resistant phenotypes of human cell sublines and circumvention of bleomycin resistance by liblomycin.

D. Labaree, J. Lazo, R. Newman, 1989, Cancer research.

Microwave-enhanced nucleophilic fluorination in the synthesis of fluoropyridyl derivatives of [3,2-c]pyrazolo-corticosteroids, potential glucocorticoid receptor-mediated imaging agents.

D. Labaree, R. Hochberg, Michael G. C. Kahn, 2006, Bioorganic & medicinal chemistry letters.

[11C]GR103545: novel one-pot radiosynthesis with high specific activity.

Yu-Shin Ding, David Labaree, Ming-Qiang Zheng, 2011, Nuclear medicine and biology.

7alpha-Iodo and 7alpha-fluoro steroids as androgen receptor-mediated imaging agents.

L. Nazareth, D. Labaree, N. Weigel, 1999, Journal of medicinal chemistry.

Separating dopamine D2 and D3 receptor sources of [11C]-(+)-PHNO binding potential: Independent component analysis of competitive binding

Richard E. Carson, Jean-Dominique Gallezot, Nabeel Nabulsi, 2020, NeuroImage.

Synthesis and evaluation of 17α-E-20-(heteroaryl)norpregn-1,3,5(10),20 tetraene-3,17β-diols [17α-(heteroaryl)vinyl estradiols] as ligands for the estrogen receptor-α ligand binding domain (ERα-LBD).

D. Labaree, R. Hanson, R. Hochberg, 2012, Bioorganic & medicinal chemistry letters.

Formal total synthesis of deserpidine demonstrating a versatile amino-claisen rearrangement/Wenkert cyclization strategy for the preparation of functionalized yohimbane ring systems

D. Labaree, H. Ammon, P. Mariano, 1990 .

Model studies probing the amino-Claisen rearrangement approach to hydroisoquinoline synthesis. Development of methods for stereocontrolled introduction of reserpine E ring type functionality

D. Labaree, P. Mariano, E. W. Baxter, 1989 .

Organometallic complexes containing 17-ethynyl-17β-hydroxyandrost-4-en-3-one and related ethynyl steroids

Robert A. Stockland, D. Labaree, R. Hochberg, 2006 .

Targeting the estrogen receptor with metal-carbonyl derivatives of estradiol.

D. Labaree, R. Hanson, R. Hochberg, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of 11β-(4-substituted phenyl) estradiol analogs: transition from estrogen receptor agonists to antagonists.

J. A. Hendricks, D. Labaree, R. Hanson, 2012, Bioorganic & medicinal chemistry.

Antiproliferative actions of tamoxifen to human ovarian carcinomas in vitro.

D. Labaree, J. Lazo, P. Schwartz, 1984, Cancer research.

Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study

Yiyun Huang, K. Cosgrove, R. Carson, 2020, Molecular Imaging and Biology.

Pancreatic Beta Cell Mass PET Imaging and Quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in Rodent Models of Diabetes

Yiyun Huang, W. Soeller, J. Treadway, 2011, Molecular Imaging and Biology.

Convergent synthesis of a steroidal antiestrogen-mitomycin C hybrid using "click" chemistry.

D. Labaree, J. Essigmann, R. Hanson, 2012, Organic & biomolecular chemistry.

Synthesis and evaluation of 4-(substituted styryl/alkenyl)-3,5-bis(4-hydroxyphenyl)-isoxazoles as ligands for the estrogen receptor.

D. Labaree, Rachel E. Gershman, R. Hanson, 2012, Bioorganic & medicinal chemistry letters.

Reduced Brain Cannabinoid Receptor Availability in Schizophrenia

Yiyun Huang, R. Carson, A. Neumeister, 2016, Biological Psychiatry.

PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F]ASEM in humans

Richard E. Carson, Nabeel Nabulsi, Daniel Holden, 2017, European Journal of Nuclear Medicine and Molecular Imaging.

Imaging the Cannabinoid CB1 Receptor in Humans with [11C] OMAR: Assessment of Kinetic Analysis Methods, Test–Retest Reproducibility, and Gender Differences

Richard E Carson, Shu-Fei Lin, David Labaree, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities

D. Labaree, R. Hochberg, Jing-xin Zhang, 2014 .

Nonpolar and short side chain groups at C-11beta of estradiol result in antiestrogens.

D. Labaree, R. Hochberg, Jing-xin Zhang, 2005, Journal of medicinal chemistry.

Synthesis and evaluation of B-, C-, and D-ring-substituted estradiol carboxylic acid esters as locally active estrogens.

D. Labaree, R. Hochberg, H. Harris, 2003, Journal of medicinal chemistry.

Synthesis and evaluation of 17α-(dimethylphenyl)vinyl estradiols as probes of the estrogen receptor-α ligand binding domain

D. Labaree, R. Hanson, R. Hochberg, 2012, Steroids.

Further evaluation of [11C]MP‐10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis

Richard E Carson, Jean-Dominique Gallezot, Shu-Fei Lin, 2015, Synapse.

First-inHuman Assessment of the Novel PDE 2 A PET Radiotracer 18 FPF-05270430

Yiyun Huang, R. Carson, J. Ropchan, 2016 .

A modification to improve the reliability of [11 C]CN- production in the GE radiochemistry system.

Yiyun Huang, J. Ropchan, N. Nabulsi, 2017, Journal of labelled compounds & radiopharmaceuticals.

PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)‐[11C]O‐methylreboxetine and HRRT

R. Carson, J. Ropchan, W. Williams, 2010, Synapse.

Synthesis of benzoylbenzamide derivatives of 17α-E-vinyl estradiol and evaluation as ligands for the estrogen receptor-α ligand binding domain

M. Ondrechen, D. Labaree, R. Hanson, 2019, Steroids.

First-in-Human Evaluation of 18F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A

Yiyun Huang, R. Carson, N. Nabulsi, 2020, The Journal of Nuclear Medicine.

Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort

Richard E Carson, Jean-Dominique Gallezot, David Labaree, 2020, The Journal of Nuclear Medicine.

First-in-human evaluation of 18 F-SynVesT-1, a novel radioligand for PET imaging of synaptic vesicle protein 2A

Yiyun Huang, R. Carson, N. Nabulsi, 2020 .

Binge alcohol use is not associated with alterations in striatal dopamine receptor binding or dopamine release.

Yiyun Huang, J. Ropchan, N. Nabulsi, 2019, Drug and alcohol dependence.

Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain

Yiyun Huang, G. Marek, R. Carson, 2019, The Journal of Nuclear Medicine.

First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer

Yiyun Huang, A. Schwarz, R. Carson, 2020, The Journal of Nuclear Medicine.

Dopamine D₃ receptor alterations in cocaine-dependent humans imaged with [¹¹C](+)PHNO.

R. Carson, W. Williams, D. Labaree, 2014, Drug and alcohol dependence.

Dopamine D 3 Receptor Alterations in Cocaine-Dependent Humans Imaged with [ 11 C](+)PHNO

R. Carson, W. Williams, D. Labaree, 2014 .

First in Human Assessment of the Novel M1 Muscarinic Acetylcholine Receptor PET Radiotracer 11C-LSN3172176 Authors:Mika Naganawa1,Nabeel Nabulsi1,Shannan Henry1,David Matuskey1,Shu-fei Lin1,

Yiyun Huang, A. Schwarz, R. Carson, 2020 .

Kinetic Analysis of Drug–Target Interactions with PET for Characterization of Pharmacological Hysteresis

Richard E Carson, David Weinzimmer, Roger N Gunn, 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Radiolabeled Ligand for the Androgen Receptor

D. Labaree, R. Hochberg, T. Brown, 2006 .

Kinetic Modeling of 11C-LY2795050, A Novel Antagonist Radiotracer for PET Imaging of the Kappa Opioid Receptor in Humans

Richard E Carson, Nabeel Nabulsi, Shu-Fei Lin, 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[11C]O-methylreboxetine

Richard E. Carson, Marc N. Potenza, Jean-Dominique Gallezot, 2014, NeuroImage.

Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy

Richard E. Carson, Jean-Dominique Gallezot, Nabeel Nabulsi, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

Radiosynthesis and in vivo evaluation of [(11)C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A.

Richard E Carson, Steen Jakobsen, David Weinzimmer, 2011, Nuclear medicine and biology.

Tracer Kinetic Modeling of [11C]AFM, a New PET Imaging Agent for the Serotonin Transporter

Richard E Carson, Jean-Dominique Gallezot, Nabeel Nabulsi, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

ORIGINAL ARTICLE Tracer kinetic modeling of ( 11 C)AFM, a new PET imaging agent for the serotonin transporter

Yiyun Huang, R. Carson, J. Ropchan, 2013 .

Test–retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943

Richard E. Carson, Jean-Dominique Gallezot, David Labaree, 2015, European Journal of Nuclear Medicine and Molecular Imaging.

Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes

Yiyun Huang, R. Carson, J. Ropchan, 2018, Molecular Imaging and Biology.

Estradiol-16alpha-carboxylic acid esters as locally active estrogens.

D. Labaree, R. Hochberg, T. Y. Reynolds, 2001, Journal of medicinal chemistry.

Phosphodiesterase 10A PET Radioligand Development Program: From Pig to Human

S. Kapur, R. Carson, D. Weinzimmer, 2014, The Journal of Nuclear Medicine.

3-Ketosteroid Reductase Activity and Expression by Fetal Rat Osteoblasts*

D. Labaree, R. Hochberg, M. Centrella, 2007, Journal of Biological Chemistry.

Determination of the In Vivo Selectivity of a New κ-Opioid Receptor Antagonist PET Tracer 11C-LY2795050 in the Rhesus Monkey

Richard E. Carson, Nabeel Nabulsi, Evan D. Morris, 2013, The Journal of Nuclear Medicine.

Novel 18F-Labeled κ-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of 18F-LY2459989 in Nonhuman Primates

Yiyun Huang, J. Ropchan, D. Labaree, 2018, The Journal of Nuclear Medicine.

A novel 18 F-labeled kappa opioid receptor antagonist as PET radiotracer: Synthesis and in vivo evaluation of 18 F-LY2459989 in non-human primates

Yiyun Huang, J. Ropchan, D. Labaree, 2017 .

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Sites in Rhesus Brain

Yiyun Huang, D. Nutt, R. Carson, 2014, The Journal of Nuclear Medicine.

Imaging Nicotine- and Amphetamine-Induced Dopamine Release in Rhesus Monkeys with [11C]PHNO vs [11C]raclopride PET

Yiyun Huang, K. Cosgrove, R. Carson, 2014, Neuropsychopharmacology.

Polymer Immobilized Doxorubicin as A Regional Therapeutic Agent

L. B. Wingard, D. Labaree, J. Lazo, 1984 .

First-inHuman Studies of Brain PDE 2 A First in Human Assessment of the Novel PDE 2 A PET Radiotracer 18 FPF-05270430

Yiyun Huang, R. Carson, J. Ropchan, 2016 .

First-in-Human Studies of Brain PDE2A

Yiyun Huang, R. Carson, J. Ropchan, 2016 .

Determination of receptor occupancy in the presence of mass dose: [11C]GSK189254 PET imaging of histamine H3 receptor occupancy by PF-03654746

Richard E Carson, Jing Liu, Jean-Dominique Gallezot, 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

First-in-Human study of [18F]SynVesT-2, a novel SV2A radioligand with fast kinetics and high specific binding signals

Yiyun Huang, R. Carson, J. Ropchan, 2020 .

Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboons.

Yiyun Huang, R. Carson, J. Ropchan, 2016, Nuclear medicine and biology.

PET imaging evaluation of [18F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates

Richard E. Carson, Daniel Holden, David Labaree, 2016, European Journal of Nuclear Medicine and Molecular Imaging.