Jinpei Zhou

发表

Microwave-assisted solid phase synthesis, PEGylation, and biological activity studies of glucagon-like peptide-1(7-36) amide.

Yushi Chi, Huibin Zhang, Wen-long Huang, 2008, Bioorganic & medicinal chemistry.

Qualitative and quantitative studies on impurities in G004, a potential hypoglycaemic agent, using liquid chromatography, nuclear magnetic resonance and mass spectrometry.

Huibin Zhang, Wen-long Huang, Jinpei Zhou, 2011, Journal of pharmaceutical and biomedical analysis.

Identification of novel MEK1 inhibitors by pharmacophore and docking based virtual screening

Jinpei Zhou, Yifei Yang, Fangxia Zou, 2017, Medicinal Chemistry Research.

Design, synthesis and biological evaluation of anthranilamide derivatives as potential factor Xa (fXa) inhibitors.

Huibin Zhang, Jinpei Zhou, Junhao Xing, 2018, Bioorganic & medicinal chemistry.

Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors.

Jinpei Zhou, Yueqing Gu, F. Lan, 2017, Bioorganic chemistry.

Identification of anthranilamide derivatives as potential factor Xa inhibitors: drug design, synthesis and biological evaluation.

Huibin Zhang, Jinpei Zhou, Y. Zhang, 2015, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel 2,3-dihydroquinazolin- 4(1H)-one derivatives as potential fXa inhibitors.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2017, European journal of medicinal chemistry.

A near-infrared fluorescent probe based on boric acid hydrolysis for hydrogen peroxide detection and imaging in HeLa cells.

Huibin Zhang, Jinpei Zhou, Xiaojun Yang, 2019, Luminescence : the journal of biological and chemical luminescence.

Design, synthesis and biological evaluation of bicyclic carboxylic acid derivatives as IDO1 inhibitors.

Huibin Zhang, Jinpei Zhou, Xiaojun Yang, 2019, Bioorganic chemistry.

Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity.

Qingsong Liu, Huibin Zhang, Jinpei Zhou, 2017, Bioorganic chemistry.

Discovery of 3,5-dimethylisoxazole derivatives as novel, potent inhibitors for bromodomain and extraterminal domain (BET) family.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2021, Bioorganic & medicinal chemistry.

Development of 7-methylimidazo[1,5-a]pyrazin-8(7H)-one derivatives as a novel chemical series of BRD4 inhibitors

Huibin Zhang, Jinpei Zhou, Xueting Liu, 2018, Medicinal Chemistry Research.

2-Azetidinone derivatives: design, synthesis and evaluation of cholesterol absorption inhibitors.

Huibin Zhang, Wen-long Huang, Jinpei Zhou, 2009, European journal of medicinal chemistry.

Solid phase synthesis of fatty acid modified glucagon-like peptide-1 (7-36) amide under thermal and controlled microwave irradiation

Huibin Zhang, Wen-long Huang, Jinpei Zhou, 2010 .

DW14006 as a Direct AMPKα Activator Ameliorates Diabetic Peripheral Neuropathy in Mice

Weiqi Wang, Jinpei Zhou, W. Duan, 2020, Diabetes.

TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice.

Xu Shen, J. Chen, Jinpei Zhou, 2018, Biochemical and biophysical research communications.

A near-infrared fluorescent probe based on nucleophilic substitution–cyclization for selective detection of hydrogen sulfide and bioimaging

Huibin Zhang, Jinpei Zhou, Xiaojun Yang, 2017, Dyes and Pigments.

A New isochroman-4-one Derivative from the Peel of Musa sapientum L. and Its Total Synthesis

Huibin Zhang, Wen-long Huang, Jinpei Zhou, 2007 .

Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.

Huibin Zhang, Jinpei Zhou, Jian Zhang, 2019, Bioorganic & medicinal chemistry.

Identification of 3,5-Dimethylisoxazole Derivatives as BRD4 Inhibitors for the Treatment of Colorectal Cancer.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2020, ACS medicinal chemistry letters.

Identi ﬁ cation of 3,5-Dimethylisoxazole Derivatives as BRD4 Inhibitors for the Treatment of Colorectal Cancer

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2020 .

Pharmacokinetics-Driven Optimization of 7-Methylimidazo[1,5-a]pyrazin-8(7H)-one as Novel BRD4 Inhibitors.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2019, ACS medicinal chemistry letters.

Design, synthesis and biological activity of bicyclic carboxamide derivatives as TRK inhibitors.

Huibin Zhang, Jinpei Zhou, Pei Li, 2020, Bioorganic & medicinal chemistry.

Design, Synthesis, and in vitro Biological Evaluation of 3,5‐Dimethylisoxazole Derivatives as BRD4 Inhibitors

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2018, ChemMedChem.

Synthesis and biological evaluation of triazole based uracil derivatives as novel DPP-4 inhibitors.

Huibin Zhang, Jinpei Zhou, Bin Zhang, 2016, Organic & biomolecular chemistry.

Synthesis and Biological Activities of 2‐Amino‐thiazole‐5‐carboxylic Acid Phenylamide Derivatives

Huibin Zhang, Wen-long Huang, Jinpei Zhou, 2011, Archiv der Pharmazie.

Design, Synthesis, and Biological Evaluation of IRAK4-Targeting PROTACs.

Huibin Zhang, Jinpei Zhou, Jian Ding, 2020, ACS medicinal chemistry letters.

Synthesis and biological evaluation of GPR40/FFAR1 agonists containing 3,5-dimethylisoxazole.

Huibin Zhang, Jinpei Zhou, Junhao Xing, 2016, European journal of medicinal chemistry.

Licofelone–Nitric Oxide Donors as Anticancer Agents

Jinpei Zhou, R. Gust, Can-cheng Guo, 2011, Archiv der Pharmazie.

Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives.

Huibin Zhang, Wen-long Huang, Jinpei Zhou, 2011, European journal of medicinal chemistry.

Total synthesis of endothelin 1 by microwave-assisted solid phase method

Huibin Zhang, Wen-long Huang, Jinpei Zhou, 2010 .

Identification of Dipeptidyl Peptidase IV Inhibitors: Virtual Screening, Synthesis and Biological Evaluation

Yuan Zhang, Huibin Zhang, Jinpei Zhou, 2014, Chemical Biology and Drug Design.

Combined pharmacophore models as virtual screening protocol against BRD4(1) inhibitor

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2016, Medicinal Chemistry Research.

Design, synthesis and biological evaluation of pyridone-aminal derivatives as MNK1/2 inhibitors.

Huibin Zhang, Jinpei Zhou, Xinrui Yuan, 2019, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of isoxazole-containing biphenyl derivatives as small-molecule inhibitors targeting the programmed cell death-1/ programmed cell death-ligand 1 immune checkpoint

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2021, Molecular Diversity.

Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma.

Huibin Zhang, Jinpei Zhou, Jian Ding, 2020, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of dihydroquinoxalinone derivatives as BRD4 inhibitors.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2016, Bioorganic chemistry.

Palladium‐Catalyzed C‐H Bond Ortho Acylation/Annulation with Toluene Derivatives

Huibin Zhang, Jinpei Zhou, Lingyun Yang, 2016 .

Design, synthesis and biological evaluation of 2,5-dimethylfuran-3-carboxylic acid derivatives as potential IDO1 inhibitors.

Huibin Zhang, Jinpei Zhou, Xiaojun Yang, 2019, Bioorganic & medicinal chemistry.

Synthesis and anti-inflammatory activity of imidazo[1,2-a]pyrimidine derivatives

Huibin Zhang, Jinpei Zhou, Yue Dai, 2008 .

Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation.

Xu Shen, Huibin Zhang, Jinpei Zhou, 2017, European journal of medicinal chemistry.

Synthesis and biological evaluation of scopoletin derivatives.

Jinpei Zhou, Jie Yang, Xueting Cai, 2013, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of Ezetimibe Analogs as Possible Cholesterol Absorption Inhibitors

Huibin Zhang, Wen-long Huang, Jinpei Zhou, 2011, Letters in drug design & discovery.

Design, Synthesis, Antibacterial Evaluation and Docking Study of Novel 2‐Hydroxy‐3‐(nitroimidazolyl)‐propyl‐derived Quinolone

Huibin Zhang, Jinpei Zhou, Hui Wang, 2015, Chemical biology & drug design.

Design, synthesis and biological evaluation of novel spiro-pentacylamides as acetyl-CoA carboxylase inhibitors.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2018, Bioorganic & medicinal chemistry.

Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.

Huibin Zhang, Wen-long Huang, Jinpei Zhou, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and in vitro antitumor activity of novel scopoletin derivatives.

Huibin Zhang, Jinpei Zhou, Haiyang Zhu, 2012, Bioorganic & medicinal chemistry letters.

Total Synthesis of MC2,a Peptide from Momordica Charantia and Its Hypoglycemic Activity

Huibin Zhang, Wen-long Huang, Jinpei Zhou, 2011 .

Discovery of 1,3‐Diaryl‐pyridones as Potent VEGFR‐2 Inhibitors: Design, Synthesis, and Biological Evaluation

Jinpei Zhou, Jian Ding, Lin-jiang Tong, 2016, Chemical biology & drug design.

Synthesis and biological evaluation of cyanoguanidine derivatives of loratadine.

Huibin Zhang, Jinpei Zhou, Haiyang Zhu, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of imidazo[1,5-a]pyrazin-8(7H)-one derivatives as BRD9 inhibitors.

Huibin Zhang, Jinpei Zhou, Jian Zhang, 2019, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of 7-methylimidazo[1,5-a]pyrazin-8(7H)-one derivatives as BRD4 inhibitors.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2017, Bioorganic & medicinal chemistry.

Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application.

Huibin Zhang, Jinpei Zhou, Xinrui Yuan, 2020, Journal of medicinal chemistry.

Targeting the immunity protein kinases for immuno-oncology.

Huibin Zhang, Jinpei Zhou, Xinrui Yuan, 2019, European journal of medicinal chemistry.

3-Hydroxyisoindolin-1-one derivates: Synthesis by palladium-catalyzed CH activation as BRD4 inhibitors against human acute myeloid leukemia (AML) cells.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2019, Bioorganic chemistry.

DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation

Jinpei Zhou, Wei Wang, W. Duan, 2020, Brain, Behavior, and Immunity.

A convenient synthesis of ezetimibe analogs as cholesterol absorption inhibitors

Huibin Zhang, Wen-long Huang, Jinpei Zhou, 2010 .

Separation and Characterization of Process-Related Impurities and Forced Degradation Products of G004, a Novel Sulfonylurea Derivative

Huibin Zhang, Jinpei Zhou, Wenyuan Liu, 2015, Chromatographia.

Protective effects of hepatocyte-specific glycyrrhetic derivatives against carbon tetrachloride-induced liver damage in mice.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2017, Bioorganic chemistry.

Synthesis and Antitumor Activity of Derivatives of 23-hydroxybetulinic Acid

Jinpei Zhou, Luyong Zhang, W. Ye, 2007 .

Design, synthesis and biological activity of N-(3-substituted-phenyl)benzenesulfonamides as selective and reversible LSD1 inhibitors

Jinpei Zhou, Yueqing Gu, F. Lan, 2016, Medicinal Chemistry Research.

Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation

Huibin Zhang, Jinpei Zhou, Xuekui Yu, 2022, Cell discovery.

Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors.

Huibin Zhang, Jinpei Zhou, Tong Zhao, 2021, Bioorganic & medicinal chemistry letters.

Discovery of Novel 2‐(piperidin‐4‐yl)‐1H‐benzo[d]imidazole Derivatives as Potential Anti‐Inflammatory Agents

Huibin Zhang, Jinpei Zhou, Junhao Xing, 2015, Chemical biology & drug design.

SP6616 as a Kv2.1 inhibitor efficiently ameliorates peripheral neuropathy in diabetic mice

Jinpei Zhou, Xu Shen, Xialin Zhu, 2020, EBioMedicine.

Discovery of triazole-based uracil derivatives bearing amide moieties as novel dipeptidyl peptidase-IV inhibitors.

Huibin Zhang, Jinpei Zhou, Xiaoyan Deng, 2017, Bioorganic chemistry.

Design, synthesis and biological evaluation of imidazolopyridone derivatives as novel BRD4 inhibitors.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2020, Bioorganic & medicinal chemistry.

Exploiting the 7-methylimidazo[1,5-a]pyrazin-8(7H)-one scaffold for the development of novel chemical inhibitors for Bromodomain and Extraterminal Domain (BET) family.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2019, Bioorganic chemistry.

Design, Synthesis and Biological Evaluation of Imidazo[1,2‐a]pyridine Derivatives as Novel DPP‐4 Inhibitors

Huibin Zhang, Jinpei Zhou, Qing Cao, 2015, Chemical biology & drug design.

Development of small-molecule BRD4 degraders based on pyrrolopyridone derivative.

Huibin Zhang, Jinpei Zhou, Jian Zhang, 2020, Bioorganic chemistry.

Discovery of 1,3,4-oxadiazole derivatives as potential antitumor agents inhibiting the programmed cell death-1/programmed cell death-ligand 1 interaction.

Huibin Zhang, Jinpei Zhou, Zhibo Cheng, 2021, Bioorganic & medicinal chemistry.

Proteolysis-targeting chimaeras mediated the degradation of bromodomain and extra-terminal domain proteins.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2020, Future medicinal chemistry.

Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors.

Huibin Zhang, Jinpei Zhou, Xinrui Yuan, 2021, Bioorganic & medicinal chemistry.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2021, Molecular diversity.

Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors.

Huibin Zhang, Jinpei Zhou, Jian Ding, 2021, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of KRASG12C-PROTACs.

Huibin Zhang, Jinpei Zhou, Tong Zhao, 2023, Bioorganic & medicinal chemistry.

Design, Synthesis, and in vitro Biological Evaluation of 3,5‐Dimethylisoxazole Derivatives as BRD4 Inhibitors

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2018, ChemMedChem.

Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma.

Huibin Zhang, Jinpei Zhou, W. Duan, 2023, European journal of medicinal chemistry.