B. Manjula

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Site-specific PEGylation of hemoglobin at Cys-93(beta): correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain.

P. K. Smith, B. Manjula, A. Tsai, 2003, Bioconjugate chemistry.

and Innate Variation in Nitric Oxide Production by Mononuclear Cells Variation in the Pulmonary Hypertensive Responsiveness of Broilers to Lipopolysaccharide

M. Gladwin, S. G. Shimada, J. Stitt, 2015 .

PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin.

B. Manjula, M. Brenowitz, M. Prabhakaran, 2009, Biochemistry.

Purification and characterization of polyphosphate kinase from Neisseria meningitidis

B. Manjula, C. Tinsley, E. Gotschlich, 1993, Infection and immunity.

Influence of ions on cyclization of the amino terminal glutamine residues of tryptic peptides of streptococcal PepM49 protein. Resolution of cyclized peptides by HPLC and characterization by mass spectrometry.

B. Chait, B. Manjula, T. Fairwell, 2009, International journal of peptide and protein research.

Location of variable and conserved epitopes among the multiple serotypes of streptococcal M protein

B. Manjula, V. Fischetti, S. Hollingshead, 1985, The Journal of experimental medicine.

Antigenic domains of the streptococcal Pep M5 protein. Localization of epitopes crossreactive with type 6 M protein and identification of a hypervariable region of the M molecule

B. Manjula, A. Acharya, V. Fischetti, 1986, The Journal of experimental medicine.

Dihydroxypropylation of amino groups of proteins: use of glyceraldehyde as a reversible agent for reductive alkylation.

B. Manjula, A. Acharya, 1987, Biochemistry.

The complete amino acid sequence of a biologically active 197-residue fragment of M protein isolated from type 5 group A streptococci.

B. Manjula, A. Acharya, V. Fischetti, 1984, The Journal of biological chemistry.

Cross-linking of proteins by aldotriose: reaction of the carbonyl function of the keto amines generated in situ with amino groups.

B. Manjula, A. Acharya, Y. J. Cho, 1988, Biochemistry.

Application of reductive dihydroxypropylation of amino groups of proteins in primary structural studies: identification of phenylthiohydantoin derivative of epsilon-dihydroxypropyl-lysine residues by high-performance liquid chromatography.

B. Manjula, A. Acharya, L. Sussman, 1984, Journal of chromatography.

Streptococcal M protein: alpha-helical coiled-coil structure and arrangement on the cell surface.

G. Phillips, B. Manjula, V. Fischetti, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Presence of two distinct regions in the coiled-coil structure of the streptococcal Pep M5 protein: relationship to mammalian coiled-coil proteins and implications to its biological properties.

B. Trus, B. Manjula, V. Fischetti, 1985, Proceedings of the National Academy of Sciences of the United States of America.

SCREENING OF PHYTO-CHEMICALS, TLC PROFILING, TOTAL FLAVONOID AND PHENOLICS CONTENT, ANTI-OXIDANT ACTIVITY AND ANTI-MICROBIAL ACTIVITY OF FICUS BENGHALENSIS LINN AND FICUS RELIGIOSA LINN LATEX

B. Manjula, A. Rani, C. Tulasi, 2015 .

Complete amino acid sequence of streptococcal PepM49 protein, a nephritis-associated serotype. Conserved conformational design among sequentially distinct M protein serotypes.

B. Trus, B. Manjula, A. Acharya, 1988, The Journal of biological chemistry.

Studies on group A streptococcal M-proteins: purification of type 5 M-protein and comparison of its amino terminal sequence with two immunologically unrelated M-protein molecules.

B. Manjula, V. Fischetti, 1980, Journal of immunology.

Chronic Dosing With Aminoguanidine and Novel Advanced Glycosylation End Product-Formation Inhibitors Ameliorates Cross-Linking of Tail Tendon Collagen in STZ-Induced Diabetic Rats

B. Manjula, J. Egan, M. Kochakian, 1996, Diabetes.

Synthesis, Spectral Characterization, and Antimicrobial Activities of Schiff Base Complexes Derived From 4-Aminoantipyrine

B. Manjula, C. J. Dhanaraj, S. Antony, 2014 .

Molecular aspects of the phagocytosis resistance of group a streptococci

B. Manjula, 1988, European Journal of Epidemiology.

The interaction of mouse myeloma immunoglobulin S15 with negatively charged polysaccharide antigens.

B. Manjula, M. Potter, C. Glaudemans, 1982, Molecular immunology.

The influence of esterification of carboxyl groups of ribonuclease-A on its structure and immunological activity.

B. Manjula, A. Acharya, P. Vithayathil, 2009, International journal of peptide and protein research.

Non-conservative surface decoration of hemoglobin: influence of neutralization of positive charges at PEGylation sites on molecular and functional properties of PEGylated hemoglobin.

B. Manjula, Tao Hu, Dongxia Li, 2008, Biochimica et biophysica acta.

Deamidated active intermediates in the irreversible acid denaturation of ribonuclease-A.

B. Manjula, A. Acharya, P. Vithayathil, 2009, International journal of peptide and protein research.

Relation of streptococcal M protein with human and rabbit tropomyosin: the complete amino acid sequence of human cardiac alpha tropomyosin, a highly conserved contractile protein.

B. Manjula, V. Fischetti, S. Mische, 1987, Biochemical and biophysical research communications.

Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia

B. Manjula, P. Cabrales, M. Intaglietta, 2006, Critical care medicine.

Combining the influence of two low O2 affinity-inducing chemical modifications of the central cavity of hemoglobin.

B. Manjula, J. Friedman, M. Prabhakaran, 2007, Biochemistry.

substitutes in a rat hemorrhage model Vascular resistance and the efficacy of red cell

B. Manjula, K. Vandegriff, R. Winslow, 2015 .

Studies on DNA Cleavage and Antimicrobial screening of Transition Metal complexes of 4-aminoantipyrine Schiff base

B. Manjula, S. Antony, 2013 .

Helix formation in enzymically ligated peptides as a driving force for the synthetic reaction: example of alpha-globin semisynthetic reaction.

B. Manjula, A. Acharya, R. P. Roy, 1992, Biochemistry.

Effects of S-Nitrosation and Cross-Linking of Hemoglobin on Hypoxic Pulmonary Vasoconstriction in Isolated Rat Lungs

M. Gladwin, B. Manjula, A. Acharya, 2002, Circulation research.

The distance between the contact sites for DNP and menadione ligands in the combining region of myeloma proteins binding both haptens--I. Estimation of distance by fluorescent energy transfer in protein 460.

B. Manjula, F. Richards, R. Rosenstein, 1976, Immunochemistry.

Monoclonal anti-galactan IgA J 539 binds intercatenarily to its polysaccharide antigen. Observations on the binding of antibody to a macromolecular antigen.

B. Manjula, A. Bhattacharjee, C. Glaudemans, 1986, Molecular immunology.

Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers.

B. Manjula, R. Winslow, P. Cabrales, 2006, Blood.

Thiolation Mediated Pegylation Platform to Generate Functional Universal Red Blood Cells

B. Manjula, S. Acharya, P. Nacharaju, 2007, Artificial cells, blood substitutes, and immobilization biotechnology.

Surface decoration of red blood cells with maleimidophenyl‐polyethylene glycol facilitated by thiolation with iminothiolane: an approach to mask A, B, and D antigens to generate universal red blood cells

B. Manjula, S. Acharya, P. Nacharaju, 2005, Transfusion.

Streptococcal M6 protein expressed in Escherichia coli. Localization, purification, and comparison with streptococcal-derived M protein

B. Manjula, V. Fischetti, J. R. Scott, 1984, The Journal of experimental medicine.

Pair-wise interactions of polymerization inhibitory contact site mutations of hemoglobin-S

B. Manjula, R. Upadhya, K. Perumalsamy, 2006, The protein journal.

Interspecies hybrid HbS: complete neutralization of Val6(beta)-dependent polymerization of human beta-chain by pig alpha-chains.

D. P. Sun, B. Manjula, A. Malavalli, 2000, Journal of molecular biology.

Enhanced Molecular Volume of Conservatively Pegylated Hb: (SP-PEG5K)6-HbA is Non-Hypertensive

B. Manjula, A. Malavalli, K. Vandegriff, 2005, Artificial cells, blood substitutes, and immobilization biotechnology.

Tropomyosin-like seven residue periodicity in three immunologically distinct streptococal M proteins and its implications for the antiphagocytic property of the molecule

B. Manjula, V. Fischetti, 1980, The Journal of experimental medicine.

The interaction of two polysaccharides containing beta 1,6-linked galactopyranosyl residues with two monoclonal antigalactan immunoglobulin Fab' fragments.

B. Manjula, C. Glaudemans, A. Roy, 1981, Molecular immunology.

A common mechanism of hapten binding to immunoglobulins and their heterologous chain recombinants.

B. Manjula, R. Zidovetzki, I. Pecht, 1980, Biochemistry.

POLYFUNCTIONAL ANTIBODY COMBINING REGIONS

B. Manjula, R. Poljak, F. Saul, 1974 .

Bissulfosuccinimidyl Esters of Aliphatic Dicarboxylic Acids: A New Class of ‘Affinity Directed’ ββ Crosslinkers of HbA

B. Manjula, A. Acharya, Paul K. Smith, 1994 .

Perturbation of the Intermolecular Contact Regions (Molecular Surface) of Hemoglobin S by Intramolecular, Low-O2-Affinity-Inducing Central Cavity Cross-Bridges

B. Manjula, A. Malavalli, J. Friedman, 2000, Journal of protein chemistry.

Sequence homology of group A streptococcal Pep M5 protein with other coiled-coil proteins.

B. Manjula, V. Fischetti, 1986, Biochemical and biophysical research communications.

transfusion with hemoglobin-based oxygen carriers Blood volume and cardiac index in rats after exchange

K. Ryan, B. Manjula, K. Vandegriff, 2015 .

Subunit interactions in mouse myeloma proteins with anti-galactan activity.

B. Manjula, M. Potter, C. Glaudemans, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Interchain disulfide bonds in immunoglobulins: analysis by two-dimensional polyacrylamide-gel electrophoresis.

B. Manjula, F. Richards, 1975, Analytical biochemistry.

Chapter 39 – Surface Decoration of Hemoglobin with Polyethylene Glycol

B. Manjula, S. Acharya, 2006 .

Extension Arm Facilitated PEGylation of Hemoglobin: Correlation of the Properties with the Extent of PEGylation

B. Manjula, A. Acharya, Dongxia Li, 2006, The protein journal.

Molecular Modeling Studies of Surface Decoration of Hemoglobin by Maleimide PEG

B. Manjula, M. Prabhakaran, S. Acharya, 2006, Artificial cells, blood substitutes, and immobilization biotechnology.

Influence of the chemistry of conjugation of poly(ethylene glycol) to Hb on the oxygen-binding and solution properties of the PEG-Hb conjugate.

B. Manjula, M. Prabhakaran, Tao Hu, 2005, The Biochemical journal.

Conjugation of Multiple Copies of Polyethylene Glycol to Hemoglobin Facilitated Through Thiolation: Influence on Hemoglobin Structure and Function

C. Ho, B. Manjula, K. Perumalsamy, 2005, The protein journal.

Domain structure and molecular flexibility of streptococcal M proteinIn Situ probed by limited proteolysis

B. Manjula, A. Acharya, T. Fairwell, 1990, Journal of protein chemistry.

Conformational characteristics of the complete cequence of group A streptococcal M6 protein

B. Trus, B. Manjula, D. Parry, 1988, Proteins.

Packing Density of the PEG-Shell in PEG-Albumins: PEGylation Induced Viscosity and COP are Inverse Correlate of Packing Density

B. Manjula, Fantao Meng, M. Intaglietta, 2012, Artificial cells, blood substitutes, and immobilization biotechnology.

Analysis of functionalization of methoxy-PEG as maleimide-PEG.

B. Manjula, S. Acharya, Paul K. Smith, 2008, Analytical biochemistry.

Modified Hemoglobin : Kinetic and Conformational Consequences †

B. Manjula, J. Friedman, A. Friedman, 2022 .

Influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated haemoglobin.

B. Manjula, M. Brenowitz, Tao Hu, 2007, The Biochemical journal.

Autoxidation of the site-specifically PEGylated hemoglobins: role of the PEG chains and the sites of PEGylation in the autoxidation.

B. Manjula, Tao Hu, Dongxia Li, 2008, Biochemistry.

Hexa-thiocarbamoyl Phenyl PEG5K Hb: Vasoactivity and Structure

B. Manjula, M. Prabhakaran, Fantao Meng, 2009, The protein journal.

Hemoglobin Einstein: Semisynthetic deletion in the B‐helix of the α‐chain

C. Ho, B. Manjula, M. Prabhakaran, 2004 .

Chimeric hemoglobins — hybrids of human and swine hemoglobin: Assembly and stability of interspecies hybrids

B. Manjula, Ramesh Kumar, M. Janardhan Rao, 1996, Protein science : a publication of the Protein Society.

Cys-93-ββ-Succinimidophenyl Polyethylene Glycol 2000 Hemoglobin A

B. Manjula, A. Malavalli, J. Friedman, 2000, The Journal of Biological Chemistry.

High-efficiency synthesis of human alpha-endorphin and magainin in the erythrocytes of transgenic mice: a production system for therapeutic peptides.

B. Manjula, W. Huang, A. Sharma, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Recombinant hemoglobin A produced in transgenic swine: structural equivalence with human hemoglobin A.

B. Chait, B. Manjula, A. Acharya, 1994, Artificial cells, blood substitutes, and immobilization biotechnology.

Purification and molecular analysis of hemoglobin by high-performance liquid chromatography.

B. Manjula, S. Acharya, 2003, Methods in Molecular Medicine.

Activation of the low oxygen affinity-inducing potential of the Asn108(β)→Lys mutation of Hb-Presbyterian on intramolecular αα-fumaryl cross-bridging

B. Manjula, A. Malavalli, J. Friedman, 2001 .

EARLY DIFFERENCE IN TISSUE PH AND MICROVASCULAR HEMODYNAMICS IN HEMORRHAGIC SHOCK RESUSCITATION USING POLYETHYLENE GLYCOL-ALBUMIN- AND HYDROXYETHYL STARCH-BASED PLASMA EXPANDERS

B. Manjula, P. Cabrales, M. Intaglietta, 2005, Shock.

OXYGEN CARRIERS VASOCONSTRICTION IN THE PRESENCE OF CELL-FREE HEMOGLOBIN DISSOCIATION OF LOCAL NITRIC OXIDE CONCENTRATION AND

B. Manjula, R. Winslow, P. Cabrales, 2013 .

Primary structure of streptococcal Pep M5 protein: Absence of extensive sequence repeats.

B. Manjula, V. Fischetti, S. Mische, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Unimpaired function of human phagocytes in the presence of phagocytosis-resistant group A streptococci

B. Manjula, V. Fischetti, M. Schmidt, 1985, Infection and immunity.

Difference in the structural features of streptococcal M proteins from nephritogenic and rheumatogenic serotypes

B. Manjula, T. Fairwell, K. Khandke, 1987, The Journal of experimental medicine.

Reversible Dihydroxypropylation of Amino Groups in Proteins: Application in Primary Structural Studies of Streptococcal M-Proteins

B. Manjula, A. Acharya, V. Fischetti, 1987 .

The amino-terminal region of group A streptococcal M protein determines its molecular state of assembly and function

B. Manjula, E. Braswell, T. Fairwell, 1991, Journal of Protein Chemistry.

Purification and Characterization of Polyphosphate Kinase from Neissenia meningitidis

B. Manjula, C. Tinsley, E. Gotschlich, 2003 .

Purification andCharacterization ofPolyphosphate Kinase fromNeissenia meningitidis

B. Manjula, C. Tinsley, E. Gotschlich, 1993 .

Influence of trifluoroacetic acid on retention times of histidine-containing tryptic peptides in reverse phase HPLC.

B. Manjula, A. Acharya, V. Fischetti, 2009, International journal of peptide and protein research.

Induced Plasma Expander-like Properties as a Function of PEG-chains on Extension Arm Facilitated PEGylation of Albumin: “Mushroom to Brush-Like” Conformational Transition of the PEG-albumin Conjugate

B. Manjula, R. Sahu, S. Acharya, 2009, Artificial cells, blood substitutes, and immobilization biotechnology.

Activation of the low oxygen affinity-inducing potential of the Asn108(beta)-->Lys mutation of Hb-Presbyterian on intramolecular alpha alpha-fumaryl cross-bridging.

B. Manjula, A. Malavalli, M. Prabhakaran, 2001, Protein Engineering.

Beta 93 modified hemoglobin: kinetic and conformational consequences.

B. Manjula, J. Friedman, A. Friedman, 2001, Biochemistry.

Intramolecular cross-linking of oxy hemoglobin by bis sulfosuccinimidyl suberate and sebacate: generation of cross-linked hemoglobin with reduced oxygen affinity.

P. K. Smith, B. Manjula, A. Malavalli, 1995, Artificial cells, blood substitutes, and immobilization biotechnology.

Probing the Conformation of Hemoglobin Presbyterian in the R-State

C. Ho, B. Manjula, A. Malavalli, 2003, Journal of Protein Chemistry.

Probing the diphosphoglycerate binding pocket of HbA and HbPresbyterian (beta 108Asn --> Lys).

B. Manjula, A. Malavalli, J. Friedman, 1999, Biochemistry.

Correct assembly of human normal adult hemoglobin when expressed in transgenic swine: chemical, conformational and functional equivalence with the human-derived protein.

D. P. Sun, B. Manjula, A. Malavalli, 1998, Protein engineering.

Influence of the chemical nature of side chain at beta 108 of hemoglobin A on the modulation of the oxygen affinity by chloride ions. Low oxygen affinity variants of human hemoglobin expressed in transgenic pigs: hemoglobins Presbyterian and Yoshizuka.

B. Manjula, A. Acharya, K. Sundarapandiyan, 1994, The Journal of biological chemistry.

PEGylation of human serum albumin: reaction of PEG-phenyl-isothiocyanate with protein.

B. Manjula, Fantao Meng, S. Acharya, 2008, Bioconjugate chemistry.

Microvascular Po2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(β) in hamster window chamber

B. Manjula, P. Cabrales, M. Intaglietta, 2004 .

UV resonance Raman study of beta93-modified hemoglobin A: chemical modifier-specific effects and added influences of attached poly(ethylene glycol) chains.

B. Manjula, J. Friedman, C. Bonaventura, 2002, Biochemistry.

β93 modified hemoglobin: Kinetic and conformational consequences

B. Manjula, J. Friedman, A. Friedman, 2001 .

Domain-specific effector interactions within the central cavity of human adult hemoglobin in solution and in porous sol-gel matrices: evidence for long-range communication pathways.

B. Manjula, J. Friedman, E. Peterson, 2004, Biochemistry.

A new, mouse-myeloma immunoglobulin a having specificity for β-D(1→6)-linked D-galactopyranosyl residues

B. Manjula, M. Potter, C. Glaudemans, 1975 .

Homogeneous, anti-galactan immunoglobulins. The question of specificity.

B. Manjula, C. P. Gluademans, 1976, Immunochemistry.

The binding of phosporylcholine-containing antigens from Streptococcus pneumoniae to myeloma immunoglobulins M-603 and H-8

B. Manjula, C. T. Bishop, C. Glaudemans, 1977 .

Non-hypertensive tetraPEGylated canine haemoglobin: correlation between PEGylation, O2 affinity and tissue oxygenation.

B. Manjula, M. Intaglietta, S. Acharya, 2007, The Biochemical journal.

Molecular Aspects of the High Oxygen Afinity of Non-Hypertensive Hexa Pegylated Hemoglobin, [(SP-PEG5K)6-Hb]

C. Ho, B. Manjula, A. Acharya, 2007, Artificial cells, blood substitutes, and immobilization biotechnology.

NH2-Terminal Sequence of the Clostripain and NBS Peptides of Streptococcal M5 Protein Purified in One Step by HPLC

B. Manjula, V. Fischetti, S. Mische, 1982 .