J. Hancox

发表

Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD.

S. Knapp, S. Harper, D. Bates, 2013, Investigative ophthalmology & visual science.

In silico study of action potential and QT interval shortening due to loss of inactivation of the cardiac rapid delayed rectifier potassium current.

J. Hancox, Henggui Zhang, 2004, Biochemical and biophysical research communications.

Plateau potentials drive axonal impulse bursts in insect motoneurons

J. Hancox, R. Pitman, 1991, Proceedings of the Royal Society of London. Series B: Biological Sciences.

Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling.

J. Hancox, Henggui Zhang, A. El Harchi, 2012, Cardiovascular research.

Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence

Gary R. Mirams, J. Hancox, G. Mirams, 2019, bioRxiv.

Rapid characterisation of hERG channel kinetics II: temperature dependence

J. Hancox, G. Mirams, D. Gavaghan, 2019, bioRxiv.

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

Gary R. Mirams, J. Skinner, B. Fermini, 2016, The Journal of physiology.

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

T. Colatsky, B. Fermini, G. Gintant, 2016, Journal of biomolecular screening.

Perspective: does ranolazine have potential for the treatment of atrial fibrillation?

J. Hancox, S. Doggrell, 2010, Expert opinion on investigational drugs.

Computer Three-Dimensional Reconstruction of the Atrioventricular Node

Henggui Zhang, Mitsuru Yamamoto, Shin Inada, 2008, Circulation research.

Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel.

J. Hancox, H. Witchel, J. Ridley, 2006, Journal of molecular and cellular cardiology.

Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia

J. Hancox, S. Doggrell, 2013, Expert opinion on drug safety.

Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial

J. Hancox, M. Varela, O. Aslanidi, 2016 .

: Mechanistic Insights from Canine Atrial Models

J. Hancox, M. Varela, O. Aslanidi, 2016 .

Abnormal calcium homeostasis in heart failure with preserved ejection fraction is related to both reduced contractile function and incomplete relaxation: an electromechanically detailed biophysical modeling study

J. Hancox, Henggui Zhang, D. MacIver, 2015, Front. Physiol..

Effect of cardiac ventricular mechanical contraction on the characteristics of the ECG: A simulation study

J. Hancox, Henggui Zhang, I. Adeniran, 2013 .

Gadolinium inhibits Na+‐Ca2+ exchanger current in guinea‐pig isolated ventricular myocytes

J. Hancox, J C Hancox, Y. H. Zhang, 2000, British journal of pharmacology.

Time course and voltage dependence of expressed HERG current compared with native ”rapid” delayed rectifier K current during the cardiac ventricular action potential

Harry J. Witchel, J. Hancox, H. Witchel, 1998, Pflügers Archiv.

Erythromycin block of the HERG K+ channel: accessibility to F656 and Y652.

J. Hancox, H. Witchel, C. Dempsey, 2006, Biochemical and biophysical research communications.

hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656.

J. Hancox, H. Witchel, D. Leishman, 2006, Biochemical and biophysical research communications.

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide.

Jules C Hancox, Derek J Leishman, Harry J Witchel, 2010, Journal of pharmacological and toxicological methods.

Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant

C. Du, J. Hancox, C. Dempsey, 2021, Cellular and molecular life sciences : CMLS.

Action Potential Clamp and Pharmacology of the Variant 1 Short QT Syndrome T618I hERG K+ Channel

Yi H. Zhang, J. Hancox, Henggui Zhang, 2012, PloS one.

Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin

Jules C Hancox, Derek J Leishman, Harry J Witchel, 2006, British journal of pharmacology.

Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome.

Jules C Hancox, Harry J Witchel, J. Hancox, 2006, Journal of molecular and cellular cardiology.

Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine

J. Hancox, H. Witchel, Jules C Hancox, 2002, British journal of pharmacology.

Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker

C. Du, J. Hancox, C. Dempsey, 2018, The Journal of Biological Chemistry.

An exploration of interactions between the antiarrhythmic drug dronedarone and hERG potassium channel pore

Charlotte K. Colenso, J. Hancox, C. Dempsey, 2018, Journal of Integrative Cardiology Open Access.

The Basis for Low-affinity hERG Potassium Channel Block by Sotalol

Yi H. Zhang, J. Hancox, C. Dempsey, 2017, Journal of pharmacology & pharmacotherapeutics.

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

Charlotte K. Colenso, J. Hancox, H. Witchel, 2016, Biochemical pharmacology.

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

J. Hancox, C. Dempsey, A. El Harchi, 2015, Journal of molecular and cellular cardiology.

Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants

C. Du, J. Hancox, C. Dempsey, 2014, Journal of molecular and cellular cardiology.

Molecular determinants of hERG potassium channel inhibition by disopyramide.

Yi H. Zhang, J. Hancox, C. Dempsey, 2012, Journal of molecular and cellular cardiology.

Refining Insights into High-Affinity Drug Binding to the Human Ether-à-go-go-Related Gene Potassium Channel

J. Hancox, A. James, 2008, Molecular Pharmacology.

Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656

J. Hancox, H. Witchel, A. James, 2006, FEBS letters.

The Low-Potency, Voltage-Dependent HERG Blocker Propafenone—Molecular Determinants and Drug Trapping

Jules C Hancox, Richard B Sessions, Harry J Witchel, 2004, Molecular Pharmacology.

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652

J. Hancox, O. Crociani, A. Arcangeli, 2003, British journal of pharmacology.

An Update on the Structure of hERG

J. Hancox, C. Dempsey, Yihong Zhang, 2020, Frontiers in Pharmacology.

Refining insights into high affinity drug binding to the hERG potassium channel

J. Hancox, A. James, 2008 .

Rapid communication Disopyramide is an effective inhibitor of mutant HERG K + channels involved in variant 1 short QT syndrome

J. Hancox, H. Witchel, R. S. Duncan, 2006 .

The short QT syndrome

Jules C Hancox, Harry J Witchel, J. Hancox, 2011, Journal of Interventional Cardiac Electrophysiology.

Lidoflazine is a high affinity blocker of the HERG K(+)channel.

J. Hancox, H. Witchel, J. Ridley, 2004, Journal of molecular and cellular cardiology.

High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656.

Jules C Hancox, Harry J Witchel, James T Milnes, 2004, Biochemical and biophysical research communications.

Pro-Arrhythmic Effects of Discontinuous Conduction at the Purkinje Fiber-Ventricle Junction Arising From Heart Failure-Induced Ionic Remodeling – Insights From Computational Modelling

Chen Li, J. Hancox, Henggui Zhang, 2022, Frontiers in Physiology.

Ionic mechanisms for electrical heterogeneity between rabbit Purkinje fiber and ventricular cells.

Henggui Zhang, Jules C Hancox, Mark R Boyett, 2010, Biophysical journal.

KCNE5 (KCNE1L) Variants Are Novel Modulators of Brugada Syndrome and Idiopathic Ventricular Fibrillation

J. Hancox, M. Horie, Tetsuhisa Hattori, 2011, Circulation. Arrhythmia and electrophysiology.

Identifying locations of re-entrant drivers from patient-specific distribution of fibrosis in the left atrium

T. Schaeffter, J. Hancox, R. Macleod, 2020, PLoS Comput. Biol..

Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes.

J. Hancox, N. Marrion, A. James, 2015, Heart rhythm.

Perception of validity of clinical and preclinical methods for assessment of torsades de pointes liability.

J. Hancox, M. Curtis, M. Pugsley, 2008, Pharmacology & therapeutics.

Methods for screening drugs for their pro-arrhythmic liability: does the rabbit ventricular wedge hold the key?

J. Hancox, M. Curtis, 2006, Journal of pharmacological and toxicological methods.

Preparation, preparation, preparation: The influence of adrenergic agonism in cardiac ventricular repolarisation assays used in preclinical drug development and drug safety pharmacology.

J. Hancox, M. Curtis, 2005, Journal of pharmacological and toxicological methods.

Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart

J. Hancox, Henggui Zhang, M. Boyett, 2020, Frontiers in Physiology.

Acidosis inhibits spontaneous activity and membrane currents in myocytes isolated from the rabbit atrioventricular node.

Godfrey L. Smith, J. Hancox, Hongwei Cheng, 2009, Journal of molecular and cellular cardiology.

Emerging therapeutic targets in the short QT syndrome

Dominic G. Whittaker, C. Du, J. Hancox, 2018, Expert opinion on therapeutic targets.

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome

Dominic G. Whittaker, J. Hancox, Henggui Zhang, 2019, Front. Physiol..

Acute desensitization of acetylcholine and endothelin-1 activated inward rectifier K+ current in myocytes from the cardiac atrioventricular node

J. Hancox, A. James, S. Choisy, 2012, Biochemical and biophysical research communications.

Antiarrhythmics—from cell to clinic: past, present, and future

J. Hancox, J. Jones, K. Patel, 2000, Heart.

Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome

C. Du, J. Hancox, Hongwei Cheng, 2019, Journal of molecular and cellular cardiology.

Long QT syndrome and left ventricular noncompaction in 4 family members across 2 generations with KCNQ1 mutation.

J. Hancox, V. Murday, D. Moore, 2017, European journal of medical genetics.

Increased Susceptibility to Atrial Tachyarrhythmia in Spontaneously Hypertensive Rat Hearts

J. Hancox, A. James, S. Choisy, 2007, Hypertension.

Back Matter

Bates, R. H. Ritchie, M. E. Coupland, 1999 .

Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome

Henggui Zhang, Jules C. Hancox, Mark J. McPate, 2009, Journal of molecular and cellular cardiology.

Learning from studying very rare cardiac conditions: the example of short QT syndrome

Dominic G. Whittaker, J. Hancox, Henggui Zhang, 2019, Journal of Congenital Cardiology.

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study

Dominic G. Whittaker, Craig P. Testrow, J. Hancox, 2020, Frontiers in Physiology.

Effects of BDF 9198 on action potentials and ionic currents from guinea‐pig isolated ventricular myocytes

J. Hancox, S. Doggrell, P. Dooley, 2000, British journal of pharmacology.

Reciprocal interaction between IK1 and If in biological pacemakers: A simulation study

Kuanquan Wang, Jules C. Hancox, Yacong Li, 2020, bioRxiv.

Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles

Dominic G. Whittaker, J. Hancox, Henggui Zhang, 2017, Front. Physiol..

Effects of cell swelling on intracellular calcium and membrane currents in bovine articular chondrocytes

J. Hancox, H. Donahue, C. Yellowley, 2002, Journal of cellular biochemistry.

The sodium channel Nav1.5a is the predominant isoform expressed in adult mouse dorsal root ganglia and exhibits distinct inactivation properties from the full-length Nav1.5 channel

J. Hancox, N. Kerr, D. Wynick, 2007, Molecular and Cellular Neuroscience.

Regulation of Kv4.3 and hERG potassium channels by KChIP2 isoforms and DPP6 and response to the dual K+ channel activator NS3623

J. Hancox, M. Cannell, S. Laínez, 2018, Biochemical pharmacology.

Functional evaluation of gene mutations in Long QT Syndrome: strength of evidence from in vitro assays for deciphering variants of uncertain significance

J. Hancox, S. Harmer, A. G. Stuart, 2020, Journal of Congenital Cardiology.

N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome.

J. Hancox, M. Horie, T. Kita, 2007, Heart rhythm.

Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform.

C. Du, J. Hancox, A. El Harchi, 2011, Biochemical and biophysical research communications.

hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome

J. Hancox, J. Cordeiro, H. Witchel, 2009, Biochemical and biophysical research communications.

Delayed Ventricular Repolarization and Sodium Channel Current Modification in a Mouse Model of Rett Syndrome

J. Hancox, A. Abdala, A. James, 2022, International journal of molecular sciences.

Phenanthrene impacts zebrafish cardiomyocyte excitability by inhibiting IKr and shortening action potential duration

J. Hancox, F. Brette, H. Shiels, 2021, The Journal of general physiology.

Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafficking impairment

J. Hancox, Henggui Zhang, C. Dempsey, 2020, Biochemical and biophysical research communications.

Rational prediction of pharmacological treatment options for a novel KCNH2-linked variant of the Short QT Syndrome

J. Hancox, A. G. Stuart, 2018 .

Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome

J. Hancox, C. Dempsey, Yihong Zhang, 2018, Physiological reports.

Primary carnitine deficiency as a potential cause of short QT syndrome

J. Hancox, 2018 .

hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes

J. Hancox, C. Dempsey, J. Mitcheson, 2015, Therapeutic advances in drug safety.

Selective serotonin reuptake inhibitors and torsade de pointes: new concepts and new directions derived from a systematic review of case reports

A. Baranchuk, J. Hancox, M. Hasnain, 2013, Therapeutic advances in drug safety.

A multicentre study of patients with Timothy syndrome

J. Hancox, R. Newbury-Ecob, K. Timothy, 2018, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Inhibition of sarcoplasmic reticulum Ca2+‐ATPase decreases atrioventricular node‐paced heart rate in rabbits

Godfrey L. Smith, J. Hancox, Hongwei Cheng, 2012, Experimental physiology.

Evidence for a modulatory effect of external potassium ions on ionic current mediated by the cardiac Na+-Ca2+ exchanger.

J. Hancox, Yin Hua Zhang, Y. H. Zhang, 2003, Cell calcium.

Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange

Jules C Hancox, J. Hancox, Hongwei Cheng, 2015, Physiological reports.

Multiple ion channel block by the cation channel inhibitor SKF‐96365 in myocytes from the rabbit atrioventricular node

J. Hancox, Hongwei Cheng, Alexander E. Curtis, 2016, Physiological reports.

Characterization and influence of cardiac background sodium current in the atrioventricular node

J. Hancox, Henggui Zhang, Hongwei Cheng, 2016, Journal of molecular and cellular cardiology.

Modulation by Endothelin-1 of Spontaneous Activity and Membrane Currents of Atrioventricular Node Myocytes from the Rabbit Heart

Godfrey L. Smith, J. Hancox, Hongwei Cheng, 2012, PloS one.

Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca2+ ATPase

Godfrey L. Smith, J. Hancox, Hongwei Cheng, 2011, Cell calcium.

A method for making rapid changes of superfusate whilst maintaining temperature at 37°C

J. Hancox, A. Levi, J. Croker, 1996, Pflügers Archiv.

Streptozotocin‐induced diabetes modulates action potentials and ion channel currents from the rat atrioventricular node

J. Hancox, D. Tosh, K. Yuill, 2010, Experimental physiology.

A TRPC-like non-selective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells.

Jules C Hancox, D. Bates, J. Hancox, 2006, Cell calcium.

VEGF‐Mediated Elevated Intracellular Calcium and Angiogenesis in Human Microvascular Endothelial Cells In Vitro are Inhibited by Dominant Negative TRPC6

D. Bates, J. Hancox, Anette L Magnussen, 2008, Microcirculation.

Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone.

Jules C Hancox, Yi H. Zhang, J. Hancox, 2010, Journal of electrocardiology.

Towards limiting QT interval prolongation and arrhythmia risk in citalopram use.

A. Baranchuk, J. Hancox, Yihong Zhang, 2014, Cardiology journal.

EFFECT OF PHOSPHORYLATION ON L‐TYPE CALCIUM CURRENT IN VENTRICULAR MYOCYTES DIALYSED WITH PROTEOLYTIC ENZYMES

J. Hancox, R. Chapman, P. Dooley, 1999, Clinical and experimental pharmacology & physiology.

Dronedarone: an amiodarone analogue

J. Hancox, S. Doggrell, 2004, Expert opinion on investigational drugs.

Triadin mutations - a cause of ventricular arrhythmias in children and young adults

J. Hancox, A. G. Stuart, A. James, 2017, Journal of Congenital Cardiology.

Inhibition by nickel of the L-type Ca channel in guinea pig ventricular myocytes and effect of internal cAMP.

J. Hancox, A. Levi, I. Hobai, 2000, American journal of physiology. Heart and circulatory physiology.

Effects of the Class III antiarrhythmic agent dofetilide (UK‐68,798) on L‐type calcium current from rabbit ventricular myocytes

J. Hancox, H. Witchel, D. Leishman, 2001, The Journal of pharmacy and pharmacology.

Modulation of the Na+/Ca2+ Exchanger by Isoprenaline, Adenosine, and Endothelin‐1 in Guinea Pig Ventricular Myocytes

J. Hancox, A. James, Yin Hua Zhang, 2002, Annals of the New York Academy of Sciences.

(2015). Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange. Physiological (11).

J. Hancox, C. Orchard, A. James, 2015 .

Acidosis slows electrical conduction through the atrio-ventricular node

Godfrey L. Smith, J. Hancox, Hongwei Cheng, 2014, Front. Physiol..

Nickel inhibits β-1 adrenoceptor mediated activation of cardiac CFTR chloride channels

J. Hancox, Hongwei Cheng, A. James, 2013, Biochemical and biophysical research communications.

Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101.

J. Hancox, A. James, S. Choisy, 2011, Biochemical and biophysical research communications.

Inhibition of L‐type calcium current by propafenone in single myocytes isolated from the rabbit atrioventricular node

J. Hancox, J. Mitcheson, 1997, British journal of pharmacology.

Acidosis delays conduction through the atrioventricular node

Godfrey L. Smith, J. Hancox, S. Cobbe, 2007 .

A method for making rapid changes of superfusate whilst maintaining temperature at 37 degrees C.

J. Hancox, A. Levi, J. Croker, 1996, Pflugers Archiv : European journal of physiology.

Na‐Ca Exchange Tail Current Indicates Voltage Dependence of the Cai Transient in Rabbit Ventricular Myocytes

J. Hancox, A. Levi, 1995, Journal of cardiovascular electrophysiology.

A novel genetic modifier for clarithromycin-related cardiac arrhythmia risk?

A. Baranchuk, C. Du, J. Hancox, 2014, Therapeutic advances in infectious disease.

Sex, drugs and arrhythmia: are gender differences in risk of torsades de pointes simply a matter of testosterone?

J. Hancox, A. James, 2003, Cardiovascular research.

Moderately elevated plasma homocysteine impairs functional endothelial recovery following denudation of mouse carotid arteries.

J. Hancox, H. Witchel, C. Jackson, 2004, Metabolism: clinical and experimental.

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling

Dominic G. Whittaker, J. Hancox, Henggui Zhang, 2018, Front. Physiol..

In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Dominic G. Whittaker, J. Hancox, Henggui Zhang, 2017, Scientific Reports.

Could ivabradine be a new treatment for the short QT syndrome?

J. Hancox, 2017, Clinical and experimental pharmacology & physiology.

A unique triadin exon deletion causing a null phenotype

J. Hancox, A. Hills, C. Dent, 2018, HeartRhythm case reports.

Compound Heterozygous Triadin Mutation Causing Cardiac Arrest in Two Siblings

J. Hancox, R. Newbury-Ecob, A. G. Stuart, 2016, Pacing and clinical electrophysiology : PACE.

Inhibitory Effects of the Antiestrogen Agent Clomiphene on Cardiac Sarcolemmal Anionic and Cationic Currents

J. Hancox, J. Borg, R. Kozlowski, 2002, Journal of Pharmacology and Experimental Therapeutics.

Actions of the anti‐oestrogen agent clomiphene on outward K+ currents in rat ventricular myocytes

J. Hancox, J. Borg, A. James, 2004, Clinical and experimental pharmacology & physiology.

Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant

C. Du, J. Hancox, C. Dempsey, 2021, Cellular and Molecular Life Sciences.

hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine

Jules C. Hancox, Christopher E. Dempsey, John S. Mitcheson, 2015, Journal of the American Heart Association.

Hancox, J. C. (2020). Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafcking

J. Hancox, Henggui Zhang, C. Dempsey, 2020 .

Letter by Melgari et al Regarding Article, "Ivabradine: Role in the Chronic Heart Failure Armamentarium".

J. Hancox, Dario Melgari, G. Ng, 2016, Circulation.

(2020). Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafﬁcking impairment.

J. Hancox, Henggui Zhang, C. Dempsey, 2022 .

Amiodarone blocks L-type calcium current in single myocytes isolated from the rabbit atrioventricular node.

J. Hancox, 1997, General pharmacology.

Complementarity between Arrhythmia Mechanisms Found in Silico and in Genetic Models of N588K-hERG Linked Short QT Syndrome

C. Du, J. Hancox, Henggui Zhang, 2020, Journal of Integrative Cardiology Open Access.

Tramadol linked QT interval prolongation and Torsades de pointes

J. Hancox, 2018 .

Methadone and torsade de pointes: how can we better understand the association?

J. Hancox, M. Hasnain, W. Vieweg, 2013, The American journal of medicine.

Activation of Glibenclamide-Sensitive ATP-Sensitive K+ Channels During &bgr;-Adrenergically Induced Metabolic Stress Produces a Substrate for Atrial Tachyarrhythmia

J. Hancox, Shang-Jin Kim, A. James, 2012, Circulation. Arrhythmia and electrophysiology.

Characteristics of a transient outward current (sensitive to 4-aminopyridine) in Ca2+-tolerant myocytes isolated from the rabbit atrioventricular node

John S. Mitcheson, J. Hancox, J. Mitcheson, 1999, Pflügers Archiv.

(2017). Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806. Physiological

J. Hancox, M. Cannell, H. Cheng, 2017 .

Cultured adult cardiac myocytes: future applications, culture methods, morphological and electrophysiological properties.

A J Levi, J. Hancox, J. Mitcheson, 1998, Cardiovascular research.

Role of Intracellular Sodium Overload in the Genesis of Cardiac Arrhythmias

A J Levi, S J Evans, J. Hancox, 1997, Journal of cardiovascular electrophysiology.

One hump or two? The triggering of calcium release from the sarcoplasmic reticulum and the voltage dependence of contraction in mammalian cardiac muscle.

J. Hancox, P. Brooksby, A. Levi, 1993, Cardiovascular research.

A role for depolarisation induced calcium entry on the Na-Ca exchange in triggering intracellular calcium release and contraction in rat ventricular myocytes.

J. Hancox, P. Brooksby, A. Levi, 1993, Cardiovascular research.

QTc interval and ventricular action potential prolongation in the Mecp2 Null/+ murine model of Rett syndrome

J. Hancox, A. Abdala, A. James, 2022, Physiological reports.

Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture

J. Hancox, J. Mitcheson, A. Levi, 1996, Pflügers Archiv.

Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture

J. Hancox, J. Mitcheson, A. Levi, 2006, Pflügers Archiv.

Actions of the selective serotonin re-uptake inhibitor fluvoxamine on HERG-mediated potassium current in a mammalian cell line

J. Hancox, H. Witchel, J. Milnes, 2002 .

The hERG potassium channel and hERG screening for drug-induced torsades de pointes.

Jules C Hancox, Yi H. Zhang, J. Hancox, 2008, Pharmacology & therapeutics.

Synthetic cannabinoids and potential cardiac arrhythmia risk: an important message for drug users

J. Hancox, N. Kalk, G. Henderson, 2020, Therapeutic advances in drug safety.

A basis for human QT interval prolongation and arrhythmia risk in type 2 diabetes?

J. Hancox, 2017, Experimental physiology.

Solifenacin linked QT interval prolongation and torsades de pointes

J. Hancox, J. Bray, 2017, Therapeutic advances in drug safety.

Hancox, J. C. (2017). A basis for human QT interval prolongation and arrhythmia risk in type 2 diabetes? Experimental Physiology, 102(11), 1395-

J. Hancox, 2017 .

QT interval prolongation and torsades de pointes with oxaliplatin

J. Hancox, R. Caves, A. James, 2016, Therapeutic advances in drug safety.

Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports

A. Baranchuk, J. Hancox, R. Howland, 2014, Therapeutic advances in psychopharmacology.

Azithromycin, cardiovascular risks, QTc interval prolongation, torsade de pointes, and regulatory issues: A narrative review based on the study of case reports

A. Baranchuk, J. Hancox, M. Hasnain, 2013, Therapeutic advances in infectious disease.

Inhibition of HERG K+ Current and Prolongation of the Guinea‐Pig Ventricular Action Potential by 4‐Aminopyridine

J. Hancox, H. Witchel, J. Milnes, 2003, The Journal of physiology.

Whole-Cell Membrane Currents from Human Osteoblast-like Cells

J. Hancox, T. Skerry, C. Yellowley, 1998, Calcified Tissue International.

Improved Ca2+ release synchrony following selective modification of Itof and phase 1 repolarization in normal and failing ventricular myocytes.

J. Hancox, M. Cannell, M. Hezzell, 2022, Journal of molecular and cellular cardiology.

Ion channel and exchange currents in single myocytes isolated from the rabbit atrioventricular node.

J. Hancox, J. Mitcheson, 1997, The Canadian journal of cardiology.

Actions of myristyl-FRCRCFa, a cell-permeant blocker of the cardiac sarcolemmal Na-Ca exchanger, tested in rabbit ventricular myocytes

J. Hancox, D. Khananshvili, A. Levi, 1998, Pflügers Archiv.

Na+-Ca2+ exchange current from rabbit isolated atrioventricular nodal and ventricular myocytes compared using action potential and ramp waveforms.

J. Hancox, J C Hancox, M K Convery, 2000, Acta physiologica Scandinavica.

β-Adrenoceptor/PKA-stimulation, Na+–Ca2+ exchange and PKA-activated Cl− currents in rabbit cardiomyocytes: A conundrum

J. Hancox, A. James, S. Choisy, 2011, Cell calcium.

Inhibition of Na/Ca exchange by external Ni in guinea-pig ventricular myocytes at 37 degrees C, dialysed internally with cAMP-free and cAMP-containing solutions.

J. Hancox, A. Levi, I. Hobai, 1999, Cell calcium.

Inhibition of L-type calcium current by flecainide in isolated single rabbit atrioventricular nodal myocytes

J. Hancox, M. Convery, M. K. Convery, 1998 .

Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation

Yi H. Zhang, C. Du, J. Hancox, 2010, Journal of cardiovascular electrophysiology.

Calcium transients which accompany the activation of sodium current in rat ventricular myocytes at 37°C: a trigger role for reverse Na-Ca exchange activated by membrane potential?

J. Hancox, A. Levi, 1995, Pflügers Archiv.

Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K+ channels: Validation with hERG

J. Hancox, C. Dempsey, S. Harmer, 2022, Frontiers in Pharmacology.

Stimulation of Na/Ca exchange by the beta-adrenergic/protein kinase A pathway in guinea-pig ventricular myocytes at 37 degrees C.

J. Hancox, A. Levi, L. Perchenet, 2000, Pflugers Archiv : European journal of physiology.

Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide.

J. Hancox, G. Popowicz, A. El Harchi, 2020, Bioorganic chemistry.

Modification of KCNH 2-Encoded Cardiac Potassium Channels by KCNE 1 Polymorphism LETTER TO THE

C. Du, J. Hancox, Henggui Zhang, 2014 .

Paradoxical effects of insulin on cardiac L-type calcium current and on contraction at physiological temperature

J. Hancox, M. Suleiman, V. Pabbathi, 2004, Diabetologia.

Psychotropic Drugs, Cardiac Arrhythmia, and Sudden Death

D. Nutt, J. Hancox, H. Witchel, 2003, Journal of clinical psychopharmacology.

Cardiac background sodium current: Elusive but important

J. Hancox, Hongwei Cheng, M. Boyett, 2017, Channels.

Is timing everything? Therapeutic potential of modulators of cardiac Na+ transporters

J. Hancox, S. Doggrell, 2003, Expert opinion on investigational drugs.

The Functional Role of Hyperpolarization Activated Current (If) on Cardiac Pacemaking in Human vs. in the Rabbit Sinoatrial Node: A Simulation and Theoretical Study

Kuanquan Wang, J. Hancox, Henggui Zhang, 2021, Frontiers in Physiology.

Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes.

Jules C Hancox, Harry J Witchel, James T Milnes, 2002, Journal of pharmacological and toxicological methods.

Therapeutic Advances in Infectious Disease

A. Baranchuk, J. Hancox, M. Hasnain, 2013 .

In silico Exploration of Interactions Between Potential COVID-19 Antiviral Treatments and the Pore of the hERG Potassium Channel—A Drug Antitarget

J. Hancox, Ehab Al-Moubarak, M. Sharifi, 2021, Frontiers in Cardiovascular Medicine.

Regulation of cardiac Na+-Ca2+ exchanger activity by protein kinase phosphorylation--still a paradox?

J. Hancox, Yin Hua Zhang, 2009, Cell calcium.

Interactions between Voltage Sensor and Pore Domains in a hERG K+ Channel Model from Molecular Simulations and the Effects of a Voltage Sensor Mutation

Jules C. Hancox, Christopher E. Dempsey, Charlotte K. Colenso, 2013, J. Chem. Inf. Model..

Development of a biophysically detailed model of the rapid-delayed rectifier potassium channel

J. Hancox, Henggui Zhang, I. Adeniran, 2010, 2010 Computing in Cardiology.

Inhibitory actions of the selective serotonin re‐uptake inhibitor citalopram on HERG and ventricular L‐type calcium currents

Jules C Hancox, Harry J Witchel, J. Hancox, 2002, FEBS letters.

Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin

J. Hancox, H. Witchel, D. Leishman, 2007, Biochemical pharmacology.

J. Hancox, A. James, L. A. Arberry, 2004, Basic Research in Cardiology.

Recent advances in understanding sex differences in cardiac repolarization.

J. Hancox, A. James, S. Choisy, 2007, Progress in biophysics and molecular biology.

Actions of pyrethroid insecticides on sodium currents, action potentials, and contractile rhythm in isolated mammalian ventricular myocytes and perfused hearts.

C. I. Spencer, J. Hancox, C. Spencer, 2001, The Journal of pharmacology and experimental therapeutics.

Differential pharmacology of the cardiac anionic background current I(AB).

J. Hancox, Henggui Zhang, Hongyu Li, 2007, European journal of pharmacology.

Tefluthrin modulates a novel anionic background conductance (I(AB)) in guinea-pig ventricular myocytes.

J. Hancox, C. Spencer, J. Borg, 2002, Biochemical and biophysical research communications.

Integration of Genetics into a Systems Model of Electrocardiographic Traits Using HumanCVD BeadChip

Henggui Zhang, Tom R. Gaunt, Fotios Drenos, 2012, Circulation. Cardiovascular genetics.

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm‐1 scorpion toxin

J. Hancox, O. Crociani, A. Arcangeli, 2003, FEBS letters.

Virtual Catheter Ablation of Target Areas Identified from Image-Based Models of Atrial Fibrillation

Tobias Schaeffter, Robert S. MacLeod, Aditi Roy, 2019, FIMH.

The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias.

P. Lambiase, D. Roden, A. Camm, 2013, Pharmacology & therapeutics.

Atrial proarrhythmia due to increased inward rectifier current (I(K1)) arising from KCNJ2 mutation--a simulation study.

Henggui Zhang, Shin Inada, Sanjay Kharche, 2008, Progress in biophysics and molecular biology.

COVID-19 Management and Arrhythmia: Risks and Challenges for Clinicians Treating Patients Affected by SARS-CoV-2

J. Hancox, A. El Harchi, A. Carpenter, 2020, Frontiers in Cardiovascular Medicine.

Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria

Henggui Zhang, Sanjay Kharche, Jules C Hancox, 2013, The Journal of physiology.

A New Algorithm to Diagnose Atrial Ectopic Origin from Multi Lead ECG Systems - Insights from 3D Virtual Human Atria and Torso

Erick A. Perez Alday, Michael A. Colman, Philip Langley, 2015, PLoS Comput. Biol..

Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics – Insights from a 3D Model of the Human Atria

Henggui Zhang, Jianqiao Ye, Ismail Adeniran, 2015, PloS one.

PALLAS: limiting indications for dronedarone treatment of atrial fibrillation?

J. Hancox, S. Doggrell, 2012, Expert Opinion on Pharmacotherapy.

Reduced density and altered regulation of rat atrial L-type Ca2+ current in heart failure.

S. Bryant, J. Hancox, C. Orchard, 2017, American journal of physiology. Heart and circulatory physiology.

Cardiac Excitation and Contraction Reduced density and altered regulation of rat atrial L-type Ca 2 current in heart failure

S. Bryant, J. Hancox, C. Orchard, 2017 .

Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models

Michael A. Colman, Marta Varela, Jules C. Hancox, 2016, PLoS Comput. Biol..

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats

J. Hancox, Shang-Jin Kim, A. James, 2015, Physiological reports.

Atrial Remodeling and the Substrate for Atrial Fibrillation in Rat Hearts With Elevated Afterload

Jules C Hancox, Shang-Jin Kim, J. Hancox, 2011, Circulation. Arrhythmia and electrophysiology.

left ventricle Electromechanical wavebreak in a model of the human

N. Trayanova, M. Nash, A. Panfilov, 2012 .

Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model

Michael A. Colman, Henggui Zhang, Marta Varela, 2014, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Inhibition of voltage-gated Na+ currents by eleclazine in rat atrial and ventricular myocytes

J. Hancox, Hongwei Cheng, B. Clennell, 2020, Heart rhythm O2.

Atrial-ventricular differences in rabbit cardiac voltage-gated Na+ currents: Basis for atrial-selective block by ranolazine

S. Bryant, J. Hancox, Hongwei Cheng, 2017, Heart rhythm.

Novel ion channel targets in atrial fibrillation

J. Hancox, N. Marrion, Henggui Zhang, 2016, Expert opinion on therapeutic targets.

Recent progress in multi-scale models of the human atria

Erick A. Perez Alday, Michael A. Colman, Henggui Zhang, 2014 .

Ibutilide – recent molecular insights and accumulating evidence for use in atrial flutter and fibrillation

J. Hancox, S. Doggrell, 2005, Expert opinion on investigational drugs.

Identification of a proton sensor that regulates conductance and open time of single hERG channels

J. Hancox, N. Marrion, C. Dempsey, 2019, Scientific Reports.

Polyaromatic hydrocarbons in pollution: a heart‐breaking matter

J. Hancox, J. Incardona, F. Brette, 2019, The Journal of physiology.

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.

Jules C Hancox, Stefan Knapp, Jennifer Batson, 2017, ACS chemical biology.

An investigation of the role played by the E-4031-sensitive (rapid delayed rectifier) potassium current in isolated rabbit atrioventricular nodal and ventricular myocytes

J. Hancox, J. Mitcheson, J. C. Hancox, 1999, Pflügers Archiv.

Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem

J. Hancox, R. Howland, T. Clausen, 2013, Therapeutic advances in psychopharmacology.

Role of SK channel activation in determining the action potential configuration in freshly isolated human atrial myocytes from the SKArF study.

J. Hancox, N. Marrion, L. Culliford, 2019, Biochemical and biophysical research communications.

Quetiapine and the Need for a Thorough QT/QTc Study

A. Baranchuk, J. Hancox, R. Howland, 2014, Journal of clinical psychopharmacology.

Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias.

Jules C Hancox, J. Hancox, Michael E O'Leary, 2010, British journal of clinical pharmacology.

Inhibition of a TREK-like K+ channel current by noradrenaline requires both β1- and β2-adrenoceptors in rat atrial myocytes

S. Bryant, J. Hancox, A. James, 2014, Cardiovascular research.

Evidence for a Novel K+ Channel Modulated by α1A-Adrenoceptors in Cardiac Myocytes

J. Hancox, M. Shattock, A. James, 2004, Molecular Pharmacology.

Pharmacological Inhibition of the hERG Potassium Channel Is Modulated by Extracellular But Not Intracellular Acidosis

C. Du, J. Hancox, A. El Harchi, 2011, Journal of cardiovascular electrophysiology.

Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome

J. Hancox, C. Dempsey, Yihong Zhang, 2019, Heliyon.

In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Henggui Zhang, Ismail Adeniran, Jules C Hancox, 2017, Scientific Reports.

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

Henggui Zhang, Jules C. Hancox, Dominic G. Whittaker, 2017, PLoS Comput. Biol..

Modelling the effects of disopyramide on short QT syndrome variant 1 in the human ventricles

Henggui Zhang, Jules C. Hancox, Alan P. Benson, 2016, 2016 Computing in Cardiology Conference (CinC).

Considering Ranolazine as a Potential Treatment for K+ Channel Linked Short QT Syndrome

J. Hancox, 2016, Cardiovascular Electrophysiology.

In silico investigation of short QT syndrome-linked potassium channel mutations on electro-mechanical function of human atrial cells

Michael A. Colman, Henggui Zhang, Jules C. Hancox, 2015, 2015 Computing in Cardiology Conference (CinC).

In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling

Henggui Zhang, Ismail Adeniran, Jules C. Hancox, 2013, Front. Physiol..

Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome

Henggui Zhang, Ismail Adeniran, Jules C. Hancox, 2011, PLoS Comput. Biol..

The hERG K+ channel S4 domain L532P mutation: Characterization at 37 °C

Charlotte K. Colenso, Yi H. Zhang, J. Hancox, 2011, Biochimica et biophysica acta.

POTENTIAL CLAMP AND MEFLOQUINE SENSITIVITY OF RECOMBINANT ' IKS ' CHANNELS INCORPORATING THE V 307 L KCNQ 1 MUTATION

J. Hancox, Y. H. Zhang, M. McPate, 2010 .

Pharmacology of the short QT syndrome N588K‐hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs

J. Hancox, H. Witchel, H J Witchel, 2008, British journal of pharmacology.

The N588K-HERG K+ channel mutation in the ‘short QT syndrome’: Mechanism of gain-in-function determined at 37 °C

Jules C. Hancox, Harry J. Witchel, Mark J. McPate, 2005 .

Pro‐arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation – insights from modelling

Henggui Zhang, Ismail Adeniran, Sanjay Kharche, 2012, The Journal of physiology.

Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation--a simulation study.

Henggui Zhang, Sanjay Kharche, Jules C Hancox, 2008, Progress in biophysics and molecular biology.

Inducing Ito,f and phase 1 repolarization of the cardiac action potential with a Kv4.3/KChIP2.1 bicistronic transgene

J. Hancox, M. Cannell, S. Harmer, 2021, Journal of molecular and cellular cardiology.

The hyperpolarisation-activated current,If, is not required for pacemaking in single cells from the rabbit atrioventricular node

J. Hancox, A. Levi, Jules Hancox, 1994, Pflügers Archiv.

A hERG mutation E1039X produced a synergistic lesion on IKs together with KCNQ1-R174C mutation in a LQTS family with three compound mutations

J. Hancox, M. Horie, F. Toyoda, 2018, Scientific Reports.

A Novel, Voltage‐Dependent Nonselective Cation Current Activated by Insulin in Guinea Pig Isolated Ventricular Myocytes

J. Hancox, Yin Hua Zhang, 2003, Circulation research.

Actions of the digitalis analogue strophanthidin on action potentials and L‐type calcium current in single cells isolated from the rabbit atrioventricular node

A J Levi, J. Hancox, J C Hancox, 1996, British journal of pharmacology.

Familial And Acquired Long QT Syndrome And The Cardiac Rapid Delayed Rectifier Potassium Current

J. Hancox, H. Witchel, Jules C Hancox, 2000, Clinical and experimental pharmacology & physiology.

Evidence for a novel K(+) channel modulated by alpha(1A)-adrenoceptors in cardiac myocytes.

J. Hancox, M. Shattock, A. James, 2004, Molecular Pharmacology.

Intracellular calcium transients recorded with Fura-2 in spontaneously active myocytes isolated from the atrioventricular node of the rabbit heart

A J Levi, J. Hancox, P. Brooksby, 1994, Proceedings of the Royal Society of London. Series B: Biological Sciences.

The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues.

B. Fermini, J. Hancox, A. Alexandrou, 2014, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Expansion and Characterization of Neonatal Cardiac Pericytes Provides a Novel Cellular Option for Tissue Engineering in Congenital Heart Disease

M. Caputo, G. Angelini, J. Hancox, 2015, Journal of the American Heart Association.

QT interval prolongation and Torsades de Pointes with donepezil, rivastigmine and galantamine

J. Hancox, Katie Malone, 2020, Therapeutic advances in drug safety.

Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline

J. Hancox, A. Teschemacher, H. Witchel, 1999, British journal of pharmacology.

Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine

J. Hancox, S. Doggrell, 2014, Expert opinion on drug safety.

Arrhythmogenic late Ca2+ sparks in failing heart cells and their control by action potential configuration

J. Hancox, M. Cannell, G. Chanoit, 2020, Proceedings of the National Academy of Sciences.

Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition

C. Du, J. Hancox, Henggui Zhang, 2013, Physiological reports.

Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome

C. Du, J. Hancox, Y. Zhang, 2023, Philosophical Transactions of the Royal Society B.

Preferential formation of human heteromeric SK2:SK3 channels limits homomeric SK channel assembly and function

J. Hancox, N. Marrion, A. Butler, 2022, The Journal of biological chemistry.

Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp

G. Bett, C. Du, J. Hancox, 2022, Frontiers in Pharmacology.

Investigation of hERG1b Influence on hERG Channel Pharmacology at Physiological Temperature

J. Hancox, Henggui Zhang, Dario Melgari, 2018 .

Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports

A. Baranchuk, J. Hancox, M. Hasnain, 2013, Psychopharmacology.

Progress and Gaps in Understanding the Electrophysiological Properties of Morphologically Normal Cells from the Cardiac atrioventricular Node

Jules C. Hancox, Kathryn H. Yuill, John S. Mitcheson, 2003, Int. J. Bifurc. Chaos.

Characteristics of single cells isolated from the atrioventricular node of the adult guinea-pig heart.

Jules C. Hancox, Kathryn H. Yuill, J. Hancox, 2002, Pflügers Archiv.

The actions of nickel on membrane currents activated by hyperpolarisation in single cells from the rabbit atrioventricular node.

J. Hancox, J C Hancox, C Howarth, 1995, General pharmacology.

Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation

Michael A. Colman, Henggui Zhang, Bruce H. Smaill, 2013, Interface Focus.

Application of Micro-Computed Tomography With Iodine Staining to Cardiac Imaging, Segmentation, and Computational Model Development

Henggui Zhang, Jonathan C. Jarvis, Jichao Zhao, 2013, IEEE Transactions on Medical Imaging.

High potency inhibition of hERG potassium channels by the sodium–calcium exchange inhibitor KB‐R7943

C. Du, J. Hancox, Hongwei Cheng, 2012, British journal of pharmacology.

Characteristics of the delayed rectifier K current compared in myocytes isolated from the atrioventricular node and ventricle of the rabbit heart

Jules C. Hancox, J. Hancox, F. Howarth, 1996, Pflügers Archiv.

Mechanistic Links Between Na+ Channel (SCN5A) Mutations and Impaired Cardiac Pacemaking in Sick Sinus Syndrome

Henggui Zhang, Shin Inada, Ming Lei, 2010, Circulation research.

Voltage Sensor Gating Charge Transfer in a hERG Potassium Channel Model

Charlotte K. Colenso, J. Hancox, R. Sessions, 2014, Biophysical journal.

hERG potassium channel inhibition by ivabradine requires channel gating.

J. Hancox, C. Dempsey, A. El Harchi, 2015, Journal of molecular and cellular cardiology.

Assessing hERG Pore Models As Templates for Drug Docking Using Published Experimental Constraints: The Inactivated State in the Context of Drug Block

Jules C. Hancox, Christopher E. Dempsey, Dominic Wright, 2014, J. Chem. Inf. Model..

Structural determinants for high-affinity block of hERG potassium channels.

Michael C Sanguinetti, Harry Witchel, J. Hancox, 2005, Novartis Foundation symposium.

Comparison of Na+-Ca2+ exchange current elicited from isolated rabbit ventricular myocytes by voltage ramp and step protocols

J. Hancox, M. K. Convery, 1999, Pflügers Archiv.

Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models

J. Hancox, Yizhou Liu, Henggui Zhang, 2023, Philosophical Transactions of the Royal Society B.

Cultured Adult Rabbit Myocytes:

J. Hancox, J. Mitcheson, A. Levi, 1997, Journal of cardiovascular electrophysiology.

Short QT Interval Linked to Androgen Misuse: Wider Significance and Possible Basis

J. Hancox, A. James, S. Choisy, 2009, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

Modeling the Chronotropic Effect of Isoprenaline on Rabbit Sinoatrial Node

A. Holden, J. Hancox, Henggui Zhang, 2012, Front. Physio..

In silico investigation of pro-arrhythmic effects of azithromycin on the human ventricle

J. Hancox, Henggui Zhang, Yizhou Liu, 2021, Biochemistry and biophysics reports.

hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction.

J. Hancox, A. E. Harchi, 2023, Journal of pharmacological and toxicological methods.

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806

J. Hancox, Hongwei Cheng, M. Cannell, 2017, Physiological reports.

42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Michael A. Colman, Bruce H. Smaill, Jichao Zhao, 2019, IEEE Transactions on Medical Imaging.

Short QT syndrome.

J. Hancox, H. Witchel, M. McPate, 2006, Future cardiology.

Erythromycin, QTc interval prolongation, and torsade de pointes: Case reports, major risk factors and illness severity

A. Baranchuk, J. Hancox, M. Hasnain, 2014, Therapeutic advances in infectious disease.

One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells.

M R Boyett, S Inada, H. Zhang, 2009, Biophysical journal.

Identification of a proton sensor that regulates conductance and open time of single hERG channels

J. Hancox, N. Marrion, C. Dempsey, 2019, Scientific Reports.

Stimulation of Na/Ca exchange by the β-adrenergic/protein kinase A pathway in guinea-pig ventricular myocytes at 37°C

J. Hancox, A. Levi, L. Perchenet, 2000, Pflügers Archiv.

”Voltage-activated Ca release” in rabbit, rat and guinea-pig cardiac myocytes, and modulation by internal cAMP

J. Hancox, S. Howlett, G. Ferrier, 1997, Pflügers Archiv.

Voltage dependence of the Fura-2 transient in rabbit left atrial myocytes at 37°C

J. Hancox, J. Mitcheson, A. Levi, 1997, Pflügers Archiv.

The Fura-2 transient can show two types of voltage dependence at 36°C in ventricular myocytes isolated from the rat heart

J. Hancox, S. Evans, A. Levi, 1996, Pflügers Archiv.

The effect of internal sodium and caesium on phasic contraction of patch‐clamped rabbit ventricular myocytes.

J. Hancox, J. Mitcheson, A. Levi, 1996, The Journal of physiology.

Comparison of Na(+)/Ca(2+) exchanger current and of its response to isoproterenol between acutely isolated and short-term cultured adult ventricular myocytes.

J. Hancox, J. Mitcheson, Y. H. Zhang, 2002, Biochemical and biophysical research communications.

Late Ca2+ Sparks and Ripples During the Systolic Ca2+ Transient in Heart Muscle Cells

J. Hancox, M. Cannell, C. Kong, 2017, Circulation research.

& M. (2018). Late Ca2+ Sparks and Ripples During the Systolic Ca2+ Transient in Heart Muscle Cells. Circulation Research , 122 , 473-478.

J. Hancox, M. Cannell, C. Kong, 2017 .

Sparks and Ripples During the Systolic Ca 2 + Transient in Heart Muscle Cells

J. Hancox, M. Cannell, C. Kong, 2017 .

(2022). QTc interval and ventricular action potential prolongation in the Mecp2Null/+ murine model of Rett syndrome. Physiological Reports, 10(19),

J. Hancox, Ana P. L. Abdala, Ian Charles, 2022 .

VEGF Activates Receptor-Operated Cation Channels in Human Microvascular Endothelial Cells

D. Bates, J. Hancox, R. Foster, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells

C. Du, J. Hancox, W. Fuller, 2023, Frontiers in Physiology.

Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia—A simulation study

Henggui Zhang, Wei Wang, Shanzhuo Zhang, 2018, PLoS Comput. Biol..

Electrophysiological characterization of the modified hERGT potassium channel used to obtain the first cryo‐EM hERG structure

J. Hancox, C. Dempsey, Yihong Zhang, 2020, Physiological reports.

Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports

A. Baranchuk, J. Hancox, M. Hasnain, 2013, Psychopharmacology.

Improved Ca2+ release synchrony following selective modification of Itof and phase 1 repolarization in normal and failing ventricular myocytes.

J. Hancox, M. Cannell, M. Hezzell, 2022, Journal of molecular and cellular cardiology.

SHORT COMMUNICATION PLATEAU POTENTIALS IN AN INSECT MOTONEURONE CAN BE DRIVEN BY SYNAPTIC STIMULATION

Jules C. Hancox, J. Hancox, M. Pitman, 1993 .

More types than one: multiple muscarinic receptor coupled K+ currents undergo remodelling in an experimental model of atrial fibrillation

J. Hancox, A. James, J. Hancox, 2007, British journal of pharmacology.

The short QT syndrome

M. Link, J. Hancox, Henggui Zhang, 2011, Journal of Interventional Cardiac Electrophysiology.

Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study.

Henggui Zhang, Kuanquan Wang, Yongfeng Yuan, 2017, Chaos.

Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration

C. Du, J. Hancox, A. El Harchi, 2014, Physiological reports.

The N588K-HERG K+ channel mutation in the 'short QT syndrome': mechanism of gain-in-function determined at 37 degrees C.

Jules C Hancox, Harry J Witchel, James T Milnes, 2005, Biochemical and biophysical research communications.

Emerging therapeutic targets in the short QT syndrome

Dominic G. Whittaker, C. Du, J. Hancox, 2018, Expert opinion on therapeutic targets.

Short QT Interval Linked to Androgen Misuse: Wider Significance and Possible Basis

J. Hancox, A. James, S. Choisy, 2009, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

Arrhythmogenic substrate for atrial fibrillation: Insights from an integrative computational model of pulmonary veins

Michael A. Colman, Henggui Zhang, Jichao Zhao, 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Ion currents, action potentials, and noradrenergic responses in rat pulmonary vein and left atrial cardiomyocytes

S. Bryant, J. Hancox, A. James, 2020, Physiological reports.

Measuring kinetics and potency of hERG block for CiPA.

Monique J Windley, Najah Abi-Gerges, Bernard Fermini, 2017, Journal of pharmacological and toxicological methods.

Nickel inhibits β-1 adrenoceptor mediated activation of cardiac CFTR chloride channels

J. Hancox, Hongwei Cheng, A. James, 2013, Biochemical and biophysical research communications.

Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide.

J. Hancox, H. Witchel, J. Ridley, 2003, Biochemical and biophysical research communications.

Molecular determinants of hERG potassium channel inhibition by disopyramide.

Yi H. Zhang, J. Hancox, C. Dempsey, 2012, Journal of molecular and cellular cardiology.

Comparative effects of the short QT N588K mutation at 37 degrees C on hERG K+ channel current during ventricular, Purkinje fibre and atrial action potentials: an action potential clamp study.

J. Hancox, J. Cordeiro, H. Witchel, 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.