D. Westaway

发表

C. Iadecola, S. Younkin, K. Niwa, 2000, Proceedings of the National Academy of Sciences of the United States of America.

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2000, Nature.

Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695*

S. Turner, D. Westaway, G. Carlson, 2001, The Journal of Biological Chemistry.

In vivo reduction of amyloid-beta by a mutant copper transporter.

P. S. St George-Hyslop, D. Westaway, G. Carlson, 2003, Proceedings of the National Academy of Sciences of the United States of America.

TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation.

D. Westaway, P. Fraser, T. Beach, 2007, Biochemistry.

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

G. Petsko, J. Buxbaum, D. Ringe, 2013, Molecular Psychiatry.

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Weiming Xia, Paul Fraser, J. Rommens, 1997, Nature Medicine.

A cellular gene encodes scrapie PrP 27-30 protein

Ruedi Aebersold, Paul Tempst, Charles Weissmann, 1985, Cell.

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

Stephen J. DeArmond, Stanley B. Prusiner, George A. Carlson, 1990, Cell.

Prionet Canada: A Network of Centres of Excellence for Research into Prions and Prion Diseases

D. Westaway, S. Moore, D. Krewski, 2009, Journal of toxicology and environmental health. Part A.

The Presenilin Proteins Are Components of Multiple Membrane-bound Complexes That Have Different Biological Activities*

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2004, Journal of Biological Chemistry.

Loss of nicastrin elicits an apoptotic phenotype in mouse embryos

R. Rozmahel, C. Hawkins, D. Westaway, 2006, Brain Research.

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2006, Nature.

Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high–molecular weight complexes

D. Westaway, H. Wille, L. Dorosh, 2022, The Journal of biological chemistry.

A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles

B. Sykes, G. Jansen, D. Westaway, 2018, PLoS pathogens.

Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes.

J. Nadeau, S. Schwartz, D. Westaway, 2000, Genomics.

Microglial activation in brain lesions with tau deposits: Comparison of human tauopathies and tau transgenic mice TgTauP301L

D. Westaway, P. George-Hyslop, E. Matsubara, 2008, Brain Research.

Enhanced accumulation of tau in doubly transgenic mice expressing mutant βAPP and presenilin-1

D. Westaway, E. Matsubara, M. Shoji, 2006, Brain Research.

Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy

D. Westaway, E. Matsubara, M. Shoji, 2011, Journal of neuroscience research.

Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters

D. Westaway, H. Wille, G. Schmitt-Ulms, 2009, PloS one.

Quaternary Structure Changes for PrPSc Predate PrPC Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease

D. Westaway, Jing Yang, V. Sim, 2020, Molecular neurobiology.

Genetics and polymorphism of the mouse prion gene complex: control of scrapie incubation time

M. Lovett, S. Prusiner, D. Westaway, 1988, Molecular and cellular biology.

Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2002, Neuroscience research.

Proviral deletions and oncogene base-substitutions in insertionally mutagenized c-myc alleles may contribute to the progression of avian bursal tumors.

H. Varmus, D. Westaway, G. Payne, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Interactome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones

D. Westaway, G. Carlson, Rebecca Young, 2009, PLoS pathogens.

Aberrant Presenilin-1 Expression Downregulates LDL Receptor-Related Protein (LRP): Is LRP Central to Alzheimer's Disease Pathogenesis?

E. Masliah, D. Westaway, G. Carlson, 1999, Molecular and Cellular Neuroscience.

Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2004, Neuroreport.

Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene

H. Varmus, M. Schwab, D. Westaway, 1985, Molecular and Cellular Biology.

The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease

P. Hof, D. Dickstein, D. Westaway, 2012, Molecular Neurodegeneration.

Prion-like strain effects in tauopathies

D. Westaway, Sang-Gyun Kang, Z. Han, 2022, Cell and Tissue Research.

Shadoo/PrP (Sprn0/0/Prnp0/0) double knockout mice

D. Westaway, N. Daude, 2012, Prion.

More than zeroes

D. Westaway, N. Daude, 2012 .

Enhanced accumulation of phosphorylated α‐synuclein in double transgenic mice expressing mutant β‐amyloid precursor protein and presenilin‐1

D. Westaway, E. Matsubara, M. Shoji, 2007 .

Aβ vaccination of a genetic model of Alzheimer's disease

D. Westaway, P. Fraser, P. George-Hyslop, 2003 .

Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation

E. Walter, D. Westaway, G. Millhauser, 2015, EMBO molecular medicine.

Prion disease tempo determined by host-dependent substrate reduction.

M. D. Di Bari, R. Nonno, D. Westaway, 2014, The Journal of clinical investigation.

Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrPSc Accumulation

Inyoul Y. Lee, L. Hood, D. Westaway, 2011, PLoS pathogens.

On safari with PrP: prion diseases of animals.

S. Prusiner, D. Westaway, G. Carlson, 1995, Trends in microbiology.

Genetics of prion diseases and prion diversity in mice.

S. Prusiner, D. Westaway, G. Carlson, 1994, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice

S. Prusiner, C. Ebeling, D. Westaway, 1991, Neuron.

Genetics of prion infections.

S. Prusiner, D. Westaway, G. Carlson, 1991, Trends in genetics : TIG.

Link between scrapie and BSE?

S. Prusiner, D. Westaway, 1990, Nature.

Unraveling prion diseases through molecular genetics

S. Prusiner, D. Westaway, G. Carlson, 1989, Trends in Neurosciences.

Genetics and polymorphism of the mouse prion gene complex: control of scrapie incubation time

M. Lovett, S. Prusiner, D. Westaway, 1988 .

Genetic control of prion incubation period in mice.

S. Prusiner, D. Westaway, G. Carlson, 1988, Ciba Foundation symposium.

OBSERVATION T 313 M PINK 1 Mutation in an Extended Highly Consanguineous Saudi Family With Early-Onset Parkinson Disease

D. Westaway, E. Rogaeva, P. George-Hyslop, 2006 .

T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease.

P. S. St George-Hyslop, D. Westaway, E. Rogaeva, 2006, Archives of neurology.

Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene

H. Varmus, M. Schwab, D. Westaway, 1985, Molecular and cellular biology.

Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis

D. Westaway, P. Fraser, P. George-Hyslop, 2002, Nature Medicine.

Mammalian prion proteins: enigma, variation and vaccination.

D. Westaway, G. Carlson, 2002, Trends in biochemical sciences.

Phosphatidylinositol as a Component of the Ice Nucleating Site of Pseudomonas syringae and Erwinia herbiola

D. Westaway, L. Kozloff, M. Lute, 1984, Science.

Developmental Expression of Wild-Type and Mutant Presenilin-1 in Hippocampal Neurons from Transgenic Mice: Evidence for Novel Species-Specific Properties of Human Presenilin-1

P. S. St George-Hyslop, B. Strooper, D. Westaway, 1999, Molecular medicine.

Susceptibility of Beavers to Chronic Wasting Disease

J. Aiken, D. Westaway, Jing Yang, 2022, Biology.

Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model

Christina M. Weaver, P. Hof, P. S. St George-Hyslop, 2014, The Journal of comparative neurology.

Actions of -Amyloid Protein on Human Neurons Are Expressed through the Amylin Receptor

D. Westaway, J. Jhamandas, Jing Yang, 2010 .

Infectious Prions Accumulate to High Levels in Non Proliferative C2C12 Myotubes

Camilo Duque Velásquez, J. Aiken, D. Westaway, 2013, PLoS pathogens.

Normal brain development in PS1 hypomorphic mice with markedly reduced γ-secretase cleavage of βAPP

R. Rozmahel, D. Westaway, P. George-Hyslop, 2002, Neurobiology of Aging.

An intron nucleotide sequence variant in a cloned β+-thalassaemia globin gene

D. Westaway, R. Williamson, 1981 .

Amyloid-β seeding effects are dependent on the presence of knock-in genes in the AppNL-G-F mice

R. Sutherland, D. Westaway, M. Mohajerani, 2022, bioRxiv.

Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP+PS1 transgenic mouse brains

D. Westaway, S. Kar, H. Mount, 2009, Neurobiology of Aging.

Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation.

P. S. St George-Hyslop, D. Westaway, G. Carlson, 2006, The American journal of pathology.

Presenilin 1 and Presenilin 2 Have Differential Effects on the Stability and Maturation of Nicastrin in Mammalian Brain*

D. Westaway, P. Fraser, P. George-Hyslop, 2003, Journal of Biological Chemistry.

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

R. Rozmahel, You-Qiang Song, P. S. St George-Hyslop, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.

R. Rozmahel, M. Memo, P. S. St George-Hyslop, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Presenilin 1 Controls (cid:103) -Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons

B. Strooper, D. Westaway, P. Fraser, 1999 .

Molecular Genetics of the Presenilins in Alzheimer's Disease

D. Westaway, G. Carlson, P. Fraser, 1998 .

Nascent β Structure in the Elongated Hydrophobic Region of a Gerstmann-Sträussler-Scheinker PrP Allele.

B. Sykes, D. Westaway, Ze-Lin Fu, 2019, Journal of molecular biology.

The PrP-like proteins Shadoo and Doppel.

D. Westaway, P. Harrison, N. Daude, 2011, Topics in current chemistry.

Investigating CRISPR/Cas9 gene drive for production of disease-preventing prion gene alleles

D. Westaway, A. Castle, Serene L. Wohlgemuth, 2022, PloS one.

Bridging Integrator 1 (BIN1, rs6733839) and Sex Are Moderators of Vascular Health Predictions of Memory Aging Trajectories.

R. Dixon, D. Westaway, J. Jhamandas, 2022, Journal of Alzheimer's disease : JAD.

An intron nucleotide sequence variant in a cloned beta +-thalassaemia globin gene.

D. Westaway, R. Williamson, 1981, Nucleic acids research.

Murine models of tauopathies

D. Westaway, Ghazaleh Eskandari-Sedighi, 2021 .

A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone

Inyoul Y. Lee, L. Hood, B. Sykes, 2016, PloS one.

Structure and polymorphism of the mouse prion protein gene.

S. Prusiner, S. Turner, D. Westaway, 1994, Proceedings of the National Academy of Sciences of the United States of America.

PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis.

D. Westaway, J. Laplanche, J. Launay, 1993, Genomics.

Infectious and genetic manifestations of prion diseases.

S. Prusiner, D. Westaway, 1991, Molecular plant-microbe interactions : MPMI.

Primary structure of prion protein may modify scrapie isolate properties.

S. Prusiner, D. Westaway, G. Carlson, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Teaching case 3-2019: Are nuclear clefts or invaginations the niche of intranuclear inclusions in FTLD-TDP?

D. Westaway, E. Gelpí, E. Pérez-Navarro, 2019, Clinical neuropathology.

Synergistic associations of COMT and BDNF with executive function in aging are selective and modified by APOE

D. Westaway, J. Jhamandas, Shraddha Sapkota, 2014 .

Carboxyl-terminal Fragments of Alzheimer β-Amyloid Precursor Protein Accumulate in Restricted and Unpredicted Intracellular Compartments in Presenilin 1-deficient Cells*

R. Rozmahel, P. S. St George-Hyslop, D. Westaway, 2000, The Journal of Biological Chemistry.

Interaction between Shadoo and PrP Affects the PrP-Folding Pathway

D. Westaway, J. Chapuis, M. Moudjou, 2015, Journal of Virology.

The P’s and Q’s of cellular PrP-Aβ interactions

D. Westaway, J. Jhamandas, 2012, Prion.

Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex*

Fabiana A. Caetano, D. Westaway, Jerson L. Silva, 2016, The Journal of Biological Chemistry.

Proteinase-Activated Receptor-2 Exerts Protective and Pathogenic Cell Type-Specific Effects in Alzheimer’s Disease

D. Westaway, M. Hollenberg, R. Dyck, 2007 .

Dissociated phenotypes in presenilin transgenic mice define functionally distinct γ-secretases

R. Rozmahel, C. Ebeling, D. Westaway, 2005 .

Toll‐like receptor‐mediated immune response inhibits prion propagation

J. Aiken, D. Westaway, H. Wille, 2016, Glia.

Prion Infectivity Plateaus and Conversion to Symptomatic Disease Originate from Falling Precursor Levels and Increased Levels of Oligomeric PrPSc Species

D. Westaway, Debbie McKenzie, Jacques Q van der Merwe, 2015, Journal of Virology.

Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrPC-deficiency

D. Westaway, G. Carlson, Rose Pitstick, 2012, Proceedings of the National Academy of Sciences.

Prion protein (PrPc) promotes beta-amyloid plaque formation.

D. Westaway, W. Paulus, K. Keyvani, 2005, Neurobiology of aging.

ThreeHamster Species withDifferent Scrapie Incubation Timesand Neuropathological Features EncodeDistinct PrionProteins

D. Westaway, 1990 .

Introduction and Oral presentations

Robert E. Mercer, S. Prusiner, D. Westaway, 2011 .

The effect of Aβ seeding is dependent on the presence of knock-in genes in the AppNL−G−F mice

R. Sutherland, D. Westaway, M. Mohajerani, 2022, Frontiers in Dementia.

University of Alberta “OMICs” Conference, June 17, 2013: Conference Program and Abstracts

Fang Wu, David S. Wishart, Sambasivarao Damaraju, 2013 .

Development of chemical isotope labeling LC-MS for tissue metabolomics and its application for brain and liver metabolome profiling in Alzheimer's disease mouse model.

D. Westaway, Jing Yang, Liang Li, 2019, Analytica chimica acta.

The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease

P. Hof, D. Dickstein, D. Westaway, 2012, Molecular Neurodegeneration.

Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study.

S. MacDonald, R. Dixon, D. Westaway, 2016, The journals of gerontology. Series B, Psychological sciences and social sciences.

ApoE and pulse pressure interactively influence level and change in the aging of episodic memory: Protective effects among ε2 carriers.

R. Dixon, D. Westaway, L. Bäckman, 2015, Neuropsychology.

Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid β42 from Isolated Intact Nerve Terminals

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2010, The Journal of Neuroscience.

Lipid Rafts Act as a Common Platform for Amyloid-β Oligomer-Induced Alzheimer's Disease Pathology.

D. Westaway, P. George-Hyslop, M. Takatama, 2022, Journal of Alzheimer's disease : JAD.

Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

D. Westaway, P. Fraser, P. George-Hyslop, 2006, Nature Medicine.

11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease.

Alan A. Wilson, J. Nobrega, H. Kung, 2003, Nuclear medicine and biology.

Transgenic mouse models of Alzheimer's disease.

D. Westaway, C. Janus, M. A. Chishti, 2000, Biochimica et biophysica acta.

Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease

D. Westaway, R. de Silva, A. Lerner, 2022, Science Translational Medicine.

Choices for tissue visualization with IR microspectroscopy

Adam D. Bookatz, D. Westaway, S. Mai, 2005 .

Interactions between β-amyloid and central cholinergic neurons: implications for Alzheimer’s disease

D. Westaway, S. Kar, H. Mount, 2004 .

Identification of a provirally activated c‐Ha‐ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral‐host transcript.

H. Varmus, D. Westaway, J. Papkoff, 1986, The EMBO journal.

Prion inhibition with multivalent PrPSc binding compounds.

D. Westaway, F. West, C. Mays, 2012, Biomaterials.

In vivo reduction of amyloid-β by a mutant copper transporter

D. Westaway, G. Carlson, P. George-Hyslop, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer’s disease mouse models with abundant Aβ in plasma

M. Hayden, D. Westaway, P. George-Hyslop, 2006, Neurobiology of Disease.

The prion gene complex encoding PrP(C) and Doppel: insights from mutational analysis.

D. Westaway, P. Mastrangelo, 2001, Gene.

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

D. Westaway, Sooyeon Lee, A. Cuervo, 2010, Cell.

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.

M. Ohno, P. S. St George-Hyslop, D. Wesson, 2011, Brain : a journal of neurology.

Isolation and partial sequence of recombinant plasmids containing human α-, β- and γ-globin cDNA fragments

D. Westaway, R. Dalgleish, R. Williamson, 1978, Nature.

Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein

Seo Jung Hong, D. Westaway, P. Stocki, 2016, Molecular biology of the cell.

Distinct prion proteins in short and long scrapie incubation period mice

S. Prusiner, D. Westaway, G. Carlson, 1987, Cell.

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.

Inyoul Y. Lee, L. Hood, F. Cohen, 1999, Journal of molecular biology.

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

S. Prusiner, D. Westaway, K. Basler, 1986, Cell.

Role of Cathepsin D in U18666A-induced Neuronal Cell Death

D. Westaway, S. Kar, Timothy J. Revett, 2012, The Journal of Biological Chemistry.

Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo

R. Rozmahel, D. Westaway, P. George-Hyslop, 2007, Neurobiology of Disease.

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex

R. Rozmahel, J. Woodgett, D. Westaway, 1999, Nature Medicine.

Family reunion – The ZIP/prion gene family

D. Westaway, E. Rogaeva, P. George-Hyslop, 2011, Progress in Neurobiology.

Aβ Inhibition of Ionic Conductance in Mouse Basal Forebrain Neurons Is Dependent upon the Cellular Prion Protein PrPC

D. Westaway, J. Jhamandas, Jing Yang, 2011, The Journal of Neuroscience.

Ionic mechanisms of action of prion protein fragment PrP(106–126) in rat basal forebrain neurons

D. Westaway, J. Jhamandas, Zongming Li, 2010, Journal of neuroscience research.

Complete genomic sequence and analysis of the prion protein gene region from three mammalian species.

Inyoul Y. Lee, L. Hood, S. Prusiner, 1998, Genome research.

Prion protein expression and release by mast cells after activation.

D. Westaway, M. Hughes, N. Cashman, 2009, The Journal of infectious diseases.

VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival

B. Winblad, D. Westaway, N. Bogdanovic, 2013, Scientific Reports.

McrA and McrB restriction phenotypes of some E. coli strains and implications for gene cloning.

D. Hanahan, R. Blumenthal, P. Rigby, 1988, Nucleic acids research.

Examining the zinc binding site of the amyloid-β peptide

D. Westaway, P. Fraser, K. Qin, 2000 .

Examining the zinc binding site of the amyloid-beta peptide.

D. Westaway, P. Fraser, K. Qin, 2000, European journal of biochemistry.

Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity*

D. Westaway, J. Jhamandas, W. Fu, 2015, The Journal of Biological Chemistry.

Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

Stephen J. DeArmond, Stanley B. Prusiner, S. Prusiner, 1989, Cell.

TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity

D. Westaway, P. Fraser, E. Rogaeva, 2006, Nature.

Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons

B. de Strooper, D. Westaway, P. Fraser, 1999, The Journal of cell biology.

Alzheimer's disease: Antibody clears senile plaques

D. Westaway, P. George-Hyslop, 1999, Nature.

Presenilin Proteins and the Pathogenesis of Early-Onset Familial Alzheimer’s Disease: β-Amyloid Production and Parallels to Prion Diseases

J. Rommens, J. Roder, R. Sherrington, 1998 .

The Expanding Universe of Prion Diseases

D. Westaway, J. Watts, A. Balachandran, 2006, PLoS pathogens.

The cellular prion protein binds copper in vivo

D. Westaway, P. Fraser, A. Giese, 1997, Nature.

Cellular Biology of Tau Diversity and Pathogenic Conformers

D. Westaway, L. Hromadkova, J. Safar, 2020, Frontiers in Neurology.

Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie.

S. Prusiner, D. Westaway, A. Jenny, 1994, Genes & development.

Three hamster species with different scrapie incubation times and neuropathological features encode distinct prion proteins

S. Prusiner, D. Westaway, S. DeArmond, 1990, Molecular and cellular biology.

Molecular cloning of a human prion protein cDNA.

S. Prusiner, D. Westaway, S. DeArmond, 1986, DNA.

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

David S. Park, Suneil K. Kalia, H. Anisman, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Doppel-induced cerebellar degeneration in transgenic mice

Richard C. Moore, L. Hood, S. Prusiner, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss.

F. Cohen, S. Prusiner, D. Westaway, 2000, The Journal of biological chemistry.

The prion protein family: diversity, rivalry, and dysfunction.

D. Westaway, J. Watts, 2007, Biochimica et biophysica acta.

Two different neurodegenerative diseases caused by proteins with similar structures

F. Cohen, S. Prusiner, H. Mo, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Endoproteolytic processing of the mammalian prion glycoprotein family

Robert E. Mercer, D. Westaway, G. Schmitt-Ulms, 2014, The FEBS journal.

The CNS glycoprotein Shadoo has PrPC-like protective properties and displays reduced levels in prion infections

Bob Strome, Gerold Schmitt-Ulms, Patrick Horne, 2007, The EMBO journal.

The PrP-like Protein Doppel Binds Copper*

S. Prusiner, D. Westaway, P. Fraser, 2003, The Journal of Biological Chemistry.

Mapping Cu(II) Binding Sites in Prion Proteins by Diethyl Pyrocarbonate Modification and Matrix-assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) Mass Spectrometric Footprinting*

D. Westaway, K. Qin, P. Mastrangelo, 2002, The Journal of Biological Chemistry.

Development of isotope labeling liquid chromatography mass spectrometry for mouse urine metabolomics: quantitative metabolomic study of transgenic mice related to Alzheimer's disease.

D. Wishart, D. Westaway, J. Xia, 2014, Journal of proteome research.

Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome

Jurg Ott, Mark Poulter, Harry F. Baker, 1989, Nature.

Tau conformers in FTLD-MAPT undergo liquid-liquid phase separation and perturb the nuclear envelope

D. Westaway, J. Safar, N. Daude, 2020, bioRxiv.

Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation

D. Westaway, H. Wille, Jing Yang, 2020, Acta Neuropathologica.

Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.

S. Prusiner, C. Ebeling, D. Westaway, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins

S. Prusiner, D. Westaway, G. Carlson, 1994, Cell.

Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse.

S. Prusiner, C. Ebeling, D. Westaway, 1993, Genetics.

Linkage of prion protein and scrapie incubation time genes

S. Prusiner, D. Kingsbury, D. Westaway, 1986, Cell.

Characterization of the NT2‐derived neuronal and astrocytic cell lines as alternative in vitro models for primary human neurons and astrocytes

Glen Baker, D. Westaway, J. Jhamandas, 2014, Journal of neuroscience research.

Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis

D. Westaway, J. Jhamandas, S. Kar, 2013, Molecular Neurobiology.

The in Vivo Brain Interactome of the Amyloid Precursor Protein*S

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2008, Molecular & Cellular Proteomics.

The Standard Scrapie Cell Assay: Development, Utility and Prospects

J. Aiken, D. Westaway, Debbie McKenzie, 2015, Viruses.

Biology of the prion gene complex.

D. Westaway, P. Mastrangelo, 2001, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Ralph A. Nixon, Paul M. Mathews, Patrick Horne, 2000, Nature.

Prion protein (PrPc) promotes β-amyloid plaque formation

D. Westaway, W. Paulus, K. Keyvani, 2005, Neurobiology of Aging.

Biological properties of the PrP-like Shadoo protein.

D. Westaway, N. Daude, 2011, Frontiers in bioscience.

Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease.

D. Westaway, S. Kar, H. Mount, 2004, Journal of psychiatry & neuroscience : JPN.

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

D. Westaway, L. Molina-Porcel, J. Safar, 2021, BMC Biology.

Large-Scale Sequencing of Human, Mouse, and Sheep Prion Protein Genes

Inyoul Y. Lee, L. Hood, S. Prusiner, 1998 .

The Effects of N-terminal Mutations on β-amyloid Peptide Aggregation and Toxicity

D. Westaway, S. Kar, V. Sim, 2018, Neuroscience.

Application of high-throughput, capillary-based Western analysis to modulated cleavage of the cellular prion protein

D. Westaway, S. Gilch, N. Daude, 2018, The Journal of Biological Chemistry.

Metabolomic study of disease progression in scrapie prion infected mice; validation of a novel method for brain metabolite extraction

B. Sykes, D. Westaway, P. Mercier, 2020, Metabolomics.

Transgenic mouse models of Alzheimer's disease

D. Westaway, C. Janus, David Westaway, 2001, Physiology & Behavior.

Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein

D. Westaway, D. Drucker, Erin E. Mulvihill, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Prion protein genes: evolutionary and functional aspects.

S. Prusiner, D. Westaway, B. Oesch, 1991, Current topics in microbiology and immunology.

Conservation of the cellular gene encoding the scrapie prion protein.

S. Prusiner, D. Westaway, 1986, Nucleic acids research.

Syrian hamster prion protein (PrPC) is expressed in photoreceptor cells of the adult retina

D. Westaway, G. Carlson, M. A. Chishti, 1997, Neuroscience Letters.

Genetic Mapping of Activity Determinants within Cellular Prion Proteins

F. Major, D. Westaway, P. Fraser, 2004, Journal of Biological Chemistry.

A cluster of familial Creutzfeldt–Jakob disease mutations recapitulate conserved residues in Doppel: a case of molecular mimicry?

A. Lesk, D. Westaway, L. Serpell, 2002, FEBS letters.

Proteasomal Inhibition Redirects the PrP-Like Shadoo Protein to the Nucleus

D. Westaway, S. Kar, Jing Yang, 2019, Molecular Neurobiology.

Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice

D. Westaway, A. Giese, H. Kretzschmar, 2017, PloS one.

Prionet Canada: A Network of Centres of Excellence for Research on Prion Diseases—Ongoing and Future Research Directions

D. Westaway, D. Krewski, N. Cashman, 2011, Journal of toxicology and environmental health. Part A.

Copper(II)-induced Conformational Changes and Protease Resistance in Recombinant and Cellular PrP

D. Westaway, P. Fraser, H. Kretzschmar, 2000, The Journal of Biological Chemistry.

Frequent Missense and Insertion/Deletion Polymorphisms in the Ovine Shadoo Gene Parallel Species-Specific Variation in PrP

D. Westaway, E. Rogaeva, N. Daude, 2009, PloS one.

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

B. Ghetti, D. Westaway, H. Wille, 2017, Molecular Neurodegeneration.

Establishment and characterization of Prnp knockdown neuroblastoma cells using dual microRNA-mediated RNA interference

J. Aiken, D. Westaway, Yong-Sun Kim, 2011, Prion.

Wild‐type Shadoo proteins convert to amyloid‐like forms under native conditions

D. Westaway, P. Fraser, J. McLaurin, 2010, Journal of neurochemistry.

Transgenic Approaches to Prion “Species-Barrier” Effects

D. Westaway, 1996 .

Multisite Interactions of Prions with Membranes and Native Nanodiscs.

D. Westaway, M. Overduin, H. Wille, 2021, Chemistry and physics of lipids.

MOLECULAR GENETICS OF THE MOUSE PRION GENE COMPLEX

S. Prusiner, D. Westaway, G. Carlson, 1988 .

Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts

R. Mayeux, L. Farrer, D. Westaway, 2013, Molecular Neurodegeneration.

Impaired conditioned taste aversion learning in APP transgenic mice

D. Westaway, P. George-Hyslop, H. Welzl, 2004, Neurobiology of Aging.

Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression.

S. Younkin, L. Younkin, C. Ebeling, 2004, Human molecular genetics.

Mouse models of Alzheimer's disease: The long and filamentous road

D. Westaway, C. Janus, P. Horne, 2003, Neurological research.

Object Recognition Memory and Cholinergic Parameters in Mice Expressing Human Presenilin 1 Transgenes

D. Westaway, E. Vaucher, S. Kar, 2002, Experimental Neurology.

Oleic Acid Ameliorates Amyloidosis in Cellular and Mouse Models of Alzheimer's Disease

R. Rozmahel, D. Westaway, D. Cechetto, 2011, Brain pathology.

Dense-core and diffuse Abeta plaques in TgCRND8 mice studied with synchrotron FTIR microspectroscopy.

D. Westaway, M. D. Del Bigio, S. Mai, 2007, Biopolymers.

Presenilin 1 Mutations Activate γ42-Secretase but Reciprocally Inhibit ε-Secretase Cleavage of Amyloid Precursor Protein (APP) and S3-Cleavage of Notch*

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2002, The Journal of Biological Chemistry.

DHA Supplemented in Peptamen Diet Offers No Advantage in Pathways to Amyloidosis: Is It Time to Evaluate Composite Lipid Diet?

R. Rozmahel, D. Westaway, Z. Amtul, 2011, PloS one.

RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine.

Xudong Huang, D. Westaway, S. Bandyopadhyay, 2006, Current Alzheimer research.

Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region.

Xudong Huang, D. Westaway, A. Bush, 2005, Current Alzheimer research.

Beta Amyloid-Induced Depression of Hippocampal Long-Term Potentiation Is Mediated through the Amylin Receptor

D. Westaway, J. Jhamandas, Jing Yang, 2012, The Journal of Neuroscience.

Dietary composition modulates brain mass and solubilizable Aβ levels in a mouse model of aggressive Alzheimer's amyloid pathology

Patrick R Hof, Lap Ho, J. Buxbaum, 2009, Molecular Neurodegeneration.

Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin.

D. Westaway, S. Kar, Jing Yang, 2012, Human molecular genetics.

Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against β‐amyloid‐toxicity

D. Westaway, S. Kar, Jing Yang, 2020, Neuropathology and applied neurobiology.

Proteinase-Activated Receptor-2 Exerts Protective and Pathogenic Cell Type-Specific Effects in Alzheimer’s Disease1

D. Westaway, M. Hollenberg, R. Dyck, 2007, The Journal of Immunology.

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

B. Ghetti, D. Westaway, H. Wille, 2017, Molecular Neurodegeneration.

Amyloid β accelerates phosphorylation of tau and neurofibrillary tangle formation in an amyloid precursor protein and tau double‐transgenic mouse model

D. Westaway, E. Matsubara, M. Shoji, 2010, Journal of neuroscience research.

Focally Elevated Creatine Detected in Amyloid Precursor Protein (APP) Transgenic Mice and Alzheimer Disease Brain Tissue*

D. Westaway, M. D. Del Bigio, R. Julian, 2006, Journal of Biological Chemistry.

Aβ-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Aβ pathology

D. Westaway, P. Fraser, P. George-Hyslop, 2002, Neuroscience Research.

Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.

Koji Abe, Mikio Shoji, Masato Hasegawa, 2005, The American journal of pathology.

Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2002, Nature medicine.

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2003, Journal of neurochemistry.

Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes

J. Roder, D. Westaway, G. Carlson, 2000, Neurobiology of Aging.

Lipid rafts act as a common platform for Aβ oligomer‐induced Alzheimer’s pathology

D. Westaway, P. George-Hyslop, M. Shoji, 2021, Alzheimer's & Dementia.

Evolutionary descent of prion genes from a ZIP metal ion transport ancestor

D. Westaway, H. Wille, G. Schmitt-Ulms, 2009 .

LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation.

L. Hazrati, D. Westaway, G. Carlson, 2012, Journal of molecular biology.

Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation

D. Westaway, J. Jhamandas, K. Kaur, 2017, Journal of Neuroinflammation.

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

M. Ohno, P. S. St George-Hyslop, D. Wesson, 2011, Autophagy.

Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo

D. Holtzman, M. Sano, D. Westaway, 2009, Molecular Neurodegeneration.

The Prion Protein Modulates A-type K+ Currents Mediated by Kv4.2 Complexes through Dipeptidyl Aminopeptidase-like Protein 6*

D. Westaway, M. Coulthart, J. Jhamandas, 2013, The Journal of Biological Chemistry.

Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease

R. Rozmahel, D. Westaway, L. Wang, 2010, Neuroscience.

Short amylin receptor antagonist peptides improve memory deficits in Alzheimer’s disease mouse model

D. Westaway, J. Jhamandas, Jing Yang, 2019, Scientific Reports.

Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation

D. Westaway, J. Jhamandas, K. Kaur, 2017, Journal of Neuroinflammation.

Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease

D. Westaway, J. Jhamandas, K. Kaur, 2016, Alzheimer's & dementia.

Pramlintide Antagonizes Beta Amyloid (Aβ)- and Human Amylin-Induced Depression of Hippocampal Long-Term Potentiation

D. Westaway, J. Jhamandas, R. Kimura, 2016, Molecular Neurobiology.

Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer’s Disease Mouse Models

D. Westaway, J. Jhamandas, Jing Yang, 2021, Molecular Neurobiology.

Association among Amyloid Plaque, Lipid, and Creatine in Hippocampus of TgCRND8 Mouse Model for Alzheimer Disease*

D. Westaway, M. D. Del Bigio, R. Julian, 2010, The Journal of Biological Chemistry.

IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults

R. Dixon, D. Westaway, J. Jhamandas, 2013, Neurobiology of Aging.

Neuroprotective properties of the PrP-like Shadoo glycoprotein assessed in the middle cerebral artery occlusion model of ischemia

D. Westaway, I. Winship, Bin Dong, 2015, Prion.

Immunization with amyloid-β using GM-CSF and IL-4 reduces amyloid burden and alters plaque morphology

D. Westaway, J. McLaurin, Kevin A. Dasilva, 2006, Neurobiology of Disease.

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.

R. Rozmahel, P. S. St George-Hyslop, C. Ebeling, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Isolation and partial sequence of recombinant plasmids containing human alpha-, beta- and gamma-globin cDNA fragments.

D. Westaway, R. Dalgleish, R. Williamson, 1978, Nature.

McrAandMcrBrestriction phenotypes ofsomeE.coli strains andimplications forgenecloning

R. Blumenthal, P. Rigby, D. Westaway, 1987 .

Phenotypic and functional changes in glial cells as a function of age

D. Westaway, P. Fraser, J. McLaurin, 2002, Neurobiology of Aging.

A b peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer ' s disease

D. Westaway, P. Fraser, P. George-Hyslop, 2022 .

APOE and COMT polymorphisms are complementary biomarkers of status, stability, and transitions in normal aging and early mild cognitive impairment

Stuart W. S. MacDonald, Roger A. Dixon, S. MacDonald, 2014, Front. Aging Neurosci..

Enhanced accumulation of phosphorylated alpha-synuclein in double transgenic mice expressing mutant beta-amyloid precursor protein and presenilin-1.

D. Westaway, E. Matsubara, M. Shoji, 2007, Journal of neuroscience research.

RGG repeats of PrP-like Shadoo protein bind nucleic acids.

D. Westaway, A. Lau, C. Mays, 2012, Biochemistry.

Doppel is an N-glycosylated, GPI-anchored protein: expression in testis and ectopic production in the brains of Prnp mice predisposed to Purkinje cell loss

Richard C. Moore, F. Cohen, S. Prusiner, 2000 .

Cytosolic Proteins Regulate α-Synuclein Dissociation from Presynaptic Membranes*

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2006, Journal of Biological Chemistry.

Synergistic associations of catechol-O-methyltransferase and brain-derived neurotrophic factor with executive function in aging are selective and modified by apolipoprotein E

R. Dixon, D. Westaway, J. Jhamandas, 2015, Neurobiology of Aging.

Cognitive Characteristics of TgAPP CRND8 Mice Immunised with Beta Amyloid Peptide

D. Westaway, P. George-Hyslop, J. McLaurin, 2003 .

Molecular biology and genetics of prions--implications for sheep scrapie, "mad cows" and the BSE epidemic. Historical background.

S. Prusiner, D. Westaway, M. Torchia, 1991, The Cornell veterinarian.

IDE (rs6583817) polymorphism and pulse pressure are independently and interactively associated with level and change in executive function in older adults.

R. Dixon, D. Westaway, J. Jhamandas, 2014, Psychology and aging.

Effects in Alzheimer's Disease Protective and Pathogenic Cell Type-Specific Proteinase-Activated Receptor-2 Exerts

D. Westaway, M. Hollenberg, R. Dyck, 2013 .

Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention.

D. Westaway, L. Serpell, P. Fraser, 2001, Amyloid: Journal of Protein Folding Disorders.

Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

R. Rozmahel, P. S. St George-Hyslop, D. Westaway, 2002, Neurobiology of aging.

Proteasomal Inhibition Redirects the PrP-Like Shadoo Protein to the Nucleus

D. Westaway, S. Kar, Jing Yang, 2019, Molecular Neurobiology.

Amyloid-β-(1-42) Increases Ryanodine Receptor-3 Expression and Function in Neurons of TgCRND8 Mice*

D. Westaway, C. Supnet, Jeff Grant, 2006, Journal of Biological Chemistry.

The CNS glycoprotein Shadoo has PrPC-like protective properties and displays reduced levels in prion infections

D. Westaway, G. Carlson, Rebecca Young, 2007, The EMBO journal.

Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease

D. Westaway, J. Jhamandas, K. Kaur, 2016, Alzheimer's & dementia.

Assignment of the human and mouse prion protein genes to homologous chromosomes.

T. Mohandas, S. Prusiner, D. Westaway, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Plasmacytoid Dendritic Cells Sequester High Prion Titres at Early Stages of Prion Infection

J. Collinge, D. Westaway, T. Sweeting, 2012, PLoS pathogens.

New developments in animal models of Alzheimer’s disease

D. Westaway, C. Janus, M. A. Chishti, 2001, Current neurology and neuroscience reports.

Two homologous genes causing early-onset familial Alzheimer's disease.

J. Rommens, P. S. St George-Hyslop, D. Westaway, 1996, Cold Spring Harbor symposia on quantitative biology.

Correction: Interactome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones

D. Westaway, G. Carlson, Rebecca Young, 2009, PLoS Pathogens.

Presenilin function: connections to Alzheimer's disease and signal transduction.

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2001, Biochemical Society symposium.