C. Benoist

发表

The Human Cell Atlas

Fabian J Theis, Jay W. Shin, D. Pe’er, 2017, bioRxiv.

Gene expression microarrays: glimpses of the immunological genome

R. Melamed, C. Benoist, G. Hyatt, 2006, Nature Immunology.

The Immunological Genome Project: networks of gene expression in immune cells

D. Koller, D. Laidlaw, R. Jianu, 2008, Nature Immunology.

Genetic determinants of co-accessible chromatin regions in activated T cells across humans

Howard Y. Chang, Neva C. Durand, Erez Lieberman Aiden, 2018, Nature Genetics.

Parsing the Interferon Transcriptional Network and Its Disease Associations

Chun Jimmie Ye, N. Hacohen, A. Regev, 2016, Cell.

Transcriptomes of the B and T Lineages Compared by Multiplatform Microarray Profiling

Christophe Benoist, C. Benoist, D. Mathis, 2011, The Journal of Immunology.

Theory and Practice of Using Polycationic Amphiphiles and polymers for In Vitro and In Vivo Gene Transfer

C. Benoist, J. Behr, B. Demeneix, 1998 .

Polyethylenimine-based intravenous delivery of transgenes to mouse lung

G. Merlo, C. Benoist, G. Levi, 1998, Gene Therapy.

Lipospermine-based gene transfer into the newborn mouse brain is optimized by a low lipospermine/DNA charge ratio.

D. Scherman, C. Benoist, J. Behr, 1995, Human gene therapy.

Regulatory T cells: recommendations to simplify the nomenclature

A. Rudensky, S. Ziegler, C. Benoist, 2013, Nature Immunology.

Consortium biology in immunology: the perspective from the Immunological Genome Project

C. Benoist, M. Merad, D. Mathis, 2012, Nature Reviews Immunology.

Conservation and divergence in the transcriptional programs of the human and mouse immune systems

D. Koller, A. Regev, V. Jojic, 2013, Proceedings of the National Academy of Sciences.

Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.

C. Benoist, D. Mathis, J. Katz, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

Mark S. Anderson, C. Benoist, R. Bronson, 2002, Science.

Correcting an immune-response deficiency by creating Eα gene transgenic mice

C. Benoist, D. Mathis, P. Gerlinger, 1985, Nature.

Mice lacking the MHC class II-associated invariant chain

C. Benoist, V. Lotteau, H. Ploegh, 1993, Cell.

Imputing gene expression from optimally reduced probe sets

D. Koller, C. Benoist, Yoni Donner, 2012, Nature Methods.

Cell Death Mediators in Autoimmune Diabetes—No Shortage of Suspects

C. Benoist, D. Mathis, 1997, Cell.

The cis-Regulatory Atlas of the Mouse Immune System

Jason D. Buenrostro, S. Mostafavi, C. Lareau, 2019, Cell.

Evolutionary variation of the CCAAT-binding transcription factor NF-Y.

C. Benoist, D. Mathis, R. Mantovani, 1992, Nucleic acids research.

Intersection of population variation and autoimmunity genetics in human T cell activation

Chun Jimmie Ye, N. Hacohen, A. Regev, 2014, Science.

The cellular mechanism of Aire control of T cell tolerance.

Mark S. Anderson, C. Benoist, Emily S. Venanzi, 2005, Immunity.

B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients

C. Benoist, D. Mathis, I. Gavanescu, 2008, Proceedings of the National Academy of Sciences.

Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance

C. Benoist, D. Mathis, Siyoung Yang, 2015, Science.

A Plaidoyer for ‘Systems Immunology’

Christophe Benoist, R. Germain, C. Benoist, 2006, Immunological reviews.

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.

I. Weissman, C. Benoist, A. Goldrath, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Accurate measurement of pancreatic islet β-cell mass using a second-generation fluorescent exendin-4 analog

Greg M. Thurber, J. Gaglia, R. Weissleder, 2011, Proceedings of the National Academy of Sciences.

Aire controls gene expression in the thymic epithelium with ordered stochasticity

David Zemmour, Christophe Benoist, C. Benoist, 2015, Nature Immunology.

How much TCR does a T cell need?

C Benoist, C. Benoist, R. Obst, 2001, Immunity.

The Human Cell Atlas

Roland Eils, Alexander van Oudenaarden, Hans Clevers, 2017, bioRxiv.

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

Daphne Koller, Aviv Regev, Nir Hacohen, 2014, Science.

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.

J. Gaglia, R. Weissleder, M. Harisinghani, 2011, The Journal of clinical investigation.

The K/BxN Arthritis Model

Christophe Benoist, C. Benoist, D. Mathis, 2008, Current protocols in immunology.

A Shared Gene-Expression Signature in Innate-Like Lymphocytes.

C. Benoist, T. Yamagata, D. Mathis, 2005 .

Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis

C. Benoist, D. Mathis, Haochu Huang, 2010, Proceedings of the National Academy of Sciences.

LAG-3 is not responsible for selecting T helper cells in CD4-deficient mice.

C. Benoist, D. Mathis, A. Dierich, 1996, International immunology.

Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients

Ralph Weissleder, Iman Aganj, Christophe Benoist, 2015, Proceedings of the National Academy of Sciences.

A Special Population of Regulatory T Cells Potentiates Muscle Repair

C. Benoist, D. Mathis, A. Wagers, 2013, Cell.

Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny

C. Benoist, D. Mathis, K. Bittinger, 2017, Proceedings of the National Academy of Sciences.

Modifier loci condition autoimmunity provoked by Aire deficiency

Mark S. Anderson, C. Benoist, D. Mathis, 2005, The Journal of experimental medicine.

Gene transfer by naked DNA into adult mouse brain.

D. Scherman, C. Benoist, B. Demeneix, 1996, Gene therapy.

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Christophe Benoist, Laura Herrero, A. Goldfine, 2009, Nature Medicine.

Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

K. Garcia, C. Benoist, D. Mathis, 2020, eLife.

Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: Age, diet, and PPARγ effects

B. Spiegelman, C. Benoist, D. Mathis, 2014, Proceedings of the National Academy of Sciences.

The immune system's involvement in obesity-driven type 2 diabetes.

C. Benoist, D. Mathis, C. Shu, 2012, Seminars in immunology.

A multiply redundant genetic switch ‘ locks in ’ the transcriptional signature of regulatory T cells

J. Collins, T. Lu, C. Benoist, 2012 .

Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism.

C. Benoist, D. Mathis, D. Kolodin, 2011, Seminars in immunology.

Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations

F. Rieux-Laucat, C. Benoist, T. Chatila, 2020, Nature Immunology.

Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells

C. Benoist, D. Mathis, Alvin Pratama, 2019, The Journal of experimental medicine.

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2

K. Garcia, C. Benoist, D. Mathis, 2013, The Journal of experimental medicine.

CD4+ teff cell heterogeneity: the perspective from single-cell transcriptomics.

C. Benoist, D. Zemmour, Evgeny Kiner, 2020, Current opinion in immunology.

Interleukin-4 can be a key positive regulator of inflammatory arthritis.

C. Benoist, R. Locksley, L. Nguyen, 2005, Arthritis and rheumatism.

Mice lacking all conventional MHC class II genes.

C. Benoist, L. Fugger, D. Mathis, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Flow Cytometry, Amped Up

Nir Hacohen, Christophe Benoist, N. Hacohen, 2011, Science.

Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis.

C. Benoist, J. Jacobs, D. Mathis, 2004, Arthritis and rheumatism.

Another view of the selective model of thymocyte selection

C. Benoist, D. Mathis, C. Waltzinger, 1993, Cell.

The thymic compartment responsible for positive selection of CD4+ T cells.

C. Benoist, D. Mathis, C. Waltzinger, 1992, International immunology.

How defects in central tolerance impinge on a deficiency in regulatory T cells.

C. Benoist, D. Mathis, Zhibin Chen, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The molecular program induced in T cells undergoing homeostatic proliferation.

Richard Park, Christophe Benoist, C. Benoist, 2004, Proceedings of the National Academy of Sciences of the United States of America.

T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow.

C. Benoist, C. Hunter, M. Cancro, 2017, Cell reports.

Transgenic mice: 'new wave' immunogenetics.

C. Benoist, D. Mathis, M. Lemeur, 1986, Immunology today.

Different modes of pathogenesis in T‐cell‐dependent autoimmunity: clues from two TCR transgenic systems

C. Benoist, L. Poirot, D. Mathis, 1999, Immunological reviews.

Arthritogenic Monoclonal Antibodies from K/BxN Mice

C. Benoist, D. Mathis, M. V. Van Regenmortel, 2002, The Journal of experimental medicine.

Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity

C. Benoist, D. Mathis, M. Martinic, 2009, The Journal of experimental medicine.

Modeling CTLA4-linked autoimmunity with RNA interference in mice

C. Benoist, D. Mathis, Zhibin Chen, 2006, Proceedings of the National Academy of Sciences.

Response to Letter from Mucida et al.

P. Chambon, Y. Belkaid, C. Benoist, 2009 .

Author response: The Human Cell Atlas

Fabian J Theis, Jay W. Shin, D. Pe’er, 2017 .

Tissue Tregs.

C. Benoist, D. Mathis, Marisella Panduro, 2016, Annual review of immunology.

The same genomic region conditions clonal deletion and clonal deviation to the CD8αα and regulatory T cell lineages in NOD versus C57BL/6 mice

C. Benoist, T. Yamagata, D. Mathis, 2007, Proceedings of the National Academy of Sciences.

Environmental modulation of the autonomy of cytotoxic T lymphocytes

C. Benoist, D. Mathis, Susan Chan, 1993, European journal of immunology.

Sperm cells as vectors for transferring DNA into mouse eggs: a breakthrough for immunologists?

C. Benoist, D. Mathis, 1989, Immunology today (Amsterdam. Regular ed.).

Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes.

R. Weissleder, C. Benoist, D. Mathis, 2005, The Journal of clinical investigation.

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

C. Benoist, N. Geva-Zatorsky, XiMei Sun, 2019, Nature.

Critical Roles for Interleukin 1 and Tumor Necrosis Factor α in Antibody-induced Arthritis

C. Benoist, D. Mathis, K. Ohmura, 2002, The Journal of experimental medicine.

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

C. Benoist, D. Mathis, D. Gray, 2007, The Journal of experimental medicine.

OX40 Ligand Self-Reactivity but Promotion of Diabetes by Paradoxical Dampening of Anti-Islet

C. Benoist, L. Poirot, D. Mathis, 2003 .

Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes

Ansuman T. Satpathy, C. Benoist, D. Mathis, 2007, Proceedings of the National Academy of Sciences.

Positive selection of T cells: fastidious or promiscuous?

C. Benoist, D. Mathis, 1997, Current opinion in immunology.

The influence of invariant chain on the positive selection of single T cell receptor specificities

C. Benoist, D. Mathis, S. Viville, 1995, European journal of immunology.

The virtue of complexity

C. Benoist, D. Mathis, 1993, Current Biology.

Delineation of antigen contact residues on an MHC class II molecule.

C. Benoist, J. Peccoud, D. Mathis, 1990, The EMBO journal.

Treg cells: guardians for life

C. Benoist, D. Mathis, Jonathan A Hill, 2007, Nature Immunology.

Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection.

R. Zinkernagel, C. Benoist, A. Oxenius, 1997, Journal of immunology.

The phenotype of H‐2M‐deficient mice is dependent on the MHC class II molecules expressed

C. Benoist, H. Ploegh, D. Mathis, 1998, European journal of immunology.

Independent Modes of Natural Killing Distinguished in Mice Lacking Lag3

C. Benoist, D. Mathis, A. Dierich, 1996, Science.

Checkpoints in the progression of autoimmune disease: lessons from diabetes models.

C. Benoist, D. Mathis, J. Katz, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Differential splicing across immune system lineages

Henry H. Paik, J. Collins, J. Costello, 2013, Proceedings of the National Academy of Sciences.

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

C. Benoist, T. Kaisho, D. Mathis, 2022, Cell.

Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes

C. Benoist, D. Mathis, M. Bogue, 1992, The Journal of experimental medicine.

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability

C. Benoist, V. Baud, A. Rouers, 2019, Front. Immunol..

b-Cell death during progression to diabetes

C. Benoist, D. Mathis, L. Vence, 2001 .

Inbred Mouse Strains Expression in Primary Immunocytes across Variation and Genetic Control of Gene

D. Koller, A. Regev, V. Jojic, 2014 .

Good riddance: Thymocyte clonal deletion prevents autoimmunity.

C. Benoist, Emily S. Venanzi, D. Mathis, 2004, Current opinion in immunology.

Major Histocompatibility Complex Class II Molecules Can Protect from Diabetes by Positively Selecting T Cells with Additional Specificities

C. Benoist, D. Mathis, J. Katz, 1998, The Journal of experimental medicine.

Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase.

C. Benoist, K. O'hare, R. Breathnach, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Inflammatory arthritis can be reined in by CpG-induced DC–NK cell cross talk

J. Carulli, R. Weissleder, C. Benoist, 2007, The Journal of experimental medicine.

Monoclonal antibodies toNF-Ydefine itsfunction in MHC class 11andalbumin gene transcription

C. Benoist, R. Mantovani, U. Pessara, 1992 .

Activation of adenosine receptor A2a by gut symbionts promotes immune tolerance

A. Kostic, C. Benoist, G. Phillips, 2021 .

Virofection: a new procedure to achieve stable expression of genes transferred into early embryos.

C. Benoist, B. Demeneix, J. Samarut, 1994, The International journal of developmental biology.

Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet beta-cell-reactive T-cells.

C. Benoist, D. Mathis, L. Vence, 2004, Diabetes.

1527 Physiological (cid:2) Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes

C. Benoist, L. Poirot, D. Mathis, 2003 .

Promiscuity Promotes Tolerance

C. Benoist, D. Mathis, 2016, The Journal of Immunology.

Evidence for a single-niche model of positive selection.

C. Benoist, D. Mathis, M. Merkenschlager, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis.

Christophe Benoist, C. Benoist, L. Nguyen, 2007, Arthritis and rheumatism.

The Human Cell Atlas White Paper

Roland Eils, Hans Clevers, Mary Carmichael, 2018, 1810.05192.

A multiple redundant genetic switch locks in the transcriptional signature of T regulatory cells

James J. Collins, Philippe Kastner, Ting Lu, 2012, Nature Immunology.

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells.

Christophe Benoist, C. Benoist, D. Mathis, 2010, Immunity.

Rapid, high efficiency isolation of pancreatic ß-cells

R. Weissleder, Y. Iwamoto, C. Benoist, 2015, Scientific Reports.

Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut

R. Weissleder, C. Benoist, D. Mathis, 2014, Proceedings of the National Academy of Sciences.

A shared gene‐expression signature in innate‐like lymphocytes

Tetsuya Yamagata, Christophe Benoist, C. Benoist, 2006, Immunological reviews.

β-Cell death during progression to diabetes

Christophe Benoist, C. Benoist, D. Mathis, 2001, Nature.

Structural Basis for the Transition from Initiation to Elongation Transcription in T 7 RNA Polymerase

Christophe Benoist, C. Benoist, R. Bronson, 2022 .

Positive selection of the T cell repertoire: Where and when does it occur?

Christophe Benoist, C. Benoist, D. Mathis, 1989, Cell.

Brief De 6 nltive Report Evaluation of the Functional Equivalence of Major Histocompatibility Complex Class H A and E Complexes

C. Benoist, D. Mathis, M. Bogue, 2003 .

A Challenge to the Instructive Model of Positive Selection

C. Benoist, D. Mathis, Susan Chan, 1993, Immunological reviews.

Why is clonal deletion of neonatal thymocytes defective?

C. Benoist, D. Mathis, K. Signorelli, 1992, European journal of immunology.

MHC-linked protection from diabetes dissociated from clonal deletion of T cells.

C. Benoist, D. Mathis, J. Böhme, 1990, Science.

Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins.

C. Benoist, D. Mathis, M. L. Meur, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Arthritis critically dependent on innate immune system players.

Ralph Weissleder, Umar Mahmood, Christophe Benoist, 2002, Immunity.

The neuropeptide neuromedin U promotes autoantibody-mediated arthritis

R. Weissleder, C. Benoist, D. Mathis, 2012, Arthritis Research & Therapy.

Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model

C. Benoist, J. Jacobs, D. Mathis, 2007, Arthritis and rheumatism.

The K/BxN mouse model of inflammatory arthritis: theory and practice.

C. Benoist, L. Nguyen, D. Mathis, 2007, Methods in molecular medicine.

Green TR Cells

C. Benoist, D. Mathis, M. Feuerer, 2005 .

B-cell control region at the 5' end of a major histocompatibility complex class II gene: sequences and factors

C. Benoist, D. Mathis, P. Gerlinger, 1988, Molecular and cellular biology.

B-Cell Control Region atthe5'Endofa MajorHistocompatibili ty ComplexClass II Gene:Sequences andFactors

C. Benoist, D. Mathis, M. Lemeur, 1988 .

Transgenic Mice: New Systems for Studying the Function of MHC Class II Molecules

C. Benoist, D. Mathis, M. L. Meur, 1987 .

Generation of the αβ T-cell repertoire

C. Benoist, D. Mathis, 1992 .

Visualization of CD4/CD8 T Cell Commitment

C. Benoist, D. Mathis, A. Dierich, 1998, The Journal of experimental medicine.

Transgenic mice carrying the rearranged T cell receptor of a diabetogenic T cell clone

C. Benoist, D. Mathis, J. Katz, 1994 .

Major histocompatibility complex class I molecules are required for the development of insulitis in non‐obese diabetic mice

C. Benoist, D. Mathis, J. Katz, 1993, European journal of immunology.

Regulatory T‐cell differentiation: Committed to control: a precocious choice?

C. Benoist, D. Mathis, S. Haxhinasto, 2007, Immunology and cell biology.

Different molecular complexes that mediate transcriptional induction and repression by FoxP3

C. Benoist, D. Mathis, Ho-Keun Kwon, 2017, Nature Immunology.

Unstable FoxP3+ T regulatory cells in NZW mice

C. Benoist, D. Mathis, Ho-Keun Kwon, 2016, Proceedings of the National Academy of Sciences.

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

C. Benoist, D. Mathis, M. Feuerer, 2008, Proceedings of the National Academy of Sciences.

Back to central tolerance.

C. Benoist, D. Mathis, 2004, Immunity.

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity

C. Benoist, H. Ploegh, D. Mathis, 2007, Proceedings of the National Academy of Sciences.

The arthritogenic T cell receptor and its ligand in a model of spontaneous arthritis.

V. Kouskoff, C. Benoist, D. Mathis, 1999, Arthritis and rheumatism.

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes

C. Benoist, J. Allison, D. Mathis, 1998, The Journal of experimental medicine.

Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor–specified peripheral niche constraints

C. Benoist, D. Mathis, M. Feuerer, 2010, The Journal of experimental medicine.

Interleukin-4 Deficiency Does Not Exacerbate Disease in NOD Mice

C. Benoist, D. Mathis, J. Katz, 1998, Diabetes.

Nodes The Dendritic Cell Populations of Mouse Lymph

C. Benoist, A. Kamath, S. Henri, 2012 .

Lymph Nodes The Dendritic Cell Populations of Mouse

Burnham, C. Benoist, A. Kamath, 2001 .

The Dendritic Cell Populations of Mouse

Burnham, C. Benoist, A. Kamath, 2001 .

The role of CD8+ T cells in the initiation of insulin‐dependent diabetes mellitus

C. Benoist, D. Mathis, Antonio Gonzalez, 1996, European journal of immunology.

Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.

V. E. Williams, H. Mcdevitt, C. Benoist, 1983, Proceedings of the National Academy of Sciences of the United States of America.

CD4+ T cell responses in mice lacking MHC class II molecules specifically on B cells

C. Benoist, A. Oxenius, D. Mathis, 1998, European journal of immunology.

Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy.

C. Benoist, D. Mathis, D. Gray, 2008, The American journal of pathology.

Graft rejection by T cells not restricted by conventional major histocompatibility complex molecules

C. Benoist, D. Mathis, A. Dierich, 1993, European journal of immunology.

Fine-tuning of MHC class II gene expression in defined microenvironments.

C. Benoist, D. Mathis, S. Viville, 1989, Trends in genetics : TIG.

CD4/CD8 lineage commitment: matching fate with competence

C. Benoist, D. Mathis, Susan Chan, 1998, Immunological reviews.

Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus

C. Benoist, D. Mathis, N. Nakano, 1997, Science.

Mice lacking the transcription factor CIITA--a second look.

C. Benoist, C. Chang, D. Mathis, 1998, International immunology.

Anatomy of a new B-cell-specific enhancer

C. Benoist, D. Mathis, W. Koch, 1989, Molecular and cellular biology.

New B-lymphocyte-specific enhancer-binding protein

C. Benoist, D. Mathis, A. Dorn, 1989, Molecular and cellular biology.

An enhancer factor defect in a mutant Burkitt lymphoma cell line

C. Benoist, D. Mathis, S. Candéias, 1988, The Journal of experimental medicine.

A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?

C. Benoist, D. Mathis, 2000, Arthritis research.

Fluorescent exendin-4 derivatives for pancreatic β-cell analysis.

R. Weissleder, C. Benoist, D. Mathis, 2014, Bioconjugate chemistry.

Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells.

C. Benoist, J. Allison, D. Mathis, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Cellular and molecular changes accompanying the progression from insulitis to diabetes

C. Benoist, D. Mathis, I. André-Schmutz, 1999, European journal of immunology.

The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis.

A. Rudensky, C. Benoist, R. Ramirez, 2022, Immunity.

Lack of Foxp3 function and expression in the thymic epithelium

A. Rudensky, C. Benoist, N. Manley, 2007, The Journal of experimental medicine.

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.

R. Maehr, C. Benoist, H. Ploegh, 2005, The Journal of clinical investigation.

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages the Immunological

A. Regev, V. Jojic, D. Laidlaw, 2012 .

Selection of a Broad Repertoire of CD 4 1 T Cells in H-2 Ma 0 / 0 Mice

C. Benoist, A. Oxenius, D. Mathis, 1997 .

An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk

Yan Zhou, David A. Weitz, Christophe Benoist, 2017, Cell.

Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells.

C. Benoist, T. Yamagata, D. Mathis, 2004, Nature immunology.

T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo.

C. Benoist, D. Mathis, L. Vivien, 2001, International immunology.

Singular role for T-BET+CXCR3+ regulatory T cells in protection from autoimmune diabetes

C. Benoist, D. Mathis, T. G. Tan, 2016, Proceedings of the National Academy of Sciences.

Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

David A. Relman, Sünje J. Pamp, Christophe Benoist, 2012, Cell.

The immunosuppressant 15-deoxyspergualin [correction of 1,5- deoxyspergualin] reveals commonality between preT and preB cell differentiation

C. Benoist, D. Mathis, B. Wang, 1996, The Journal of experimental medicine.

The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology.

V. E. Williams, H. Mcdevitt, C. Benoist, 1983, Proceedings of the National Academy of Sciences of the United States of America.

A single amino acid substitution in the Ak molecule fortuitously provokes an alloresponse

C. Benoist, D. Mathis, P. Dellabona, 1991, European journal of immunology.

I-Ak polymorphisms define a functionally dominant region for the presentation of hen egg lysozyme peptides.

J. Freed, J. Buerstedde, C. Benoist, 1989, Journal of immunology.

I-A alpha polymorphic residues that determine alloreactive T cell recognition

C. Benoist, J. Peccoud, D. Mathis, 1989, The Journal of experimental medicine.

Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes.

C. Benoist, H. Ploegh, D. Mathis, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain.

C. Benoist, D. Mathis, S. Viville, 1994, Science.

Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation

R. Melamed, C. Benoist, A. Kamphorst, 2007, Proceedings of the National Academy of Sciences.

Aire’s plant homeodomain(PHD)-2 is critical for induction of immunological tolerance

C. Benoist, D. Mathis, Siyoung Yang, 2013, Proceedings of the National Academy of Sciences.

A new mouse model of rheumatoid arthritis: organ-specific disease provoked by systemic autoimmunity.

V. Kouskoff, C. Benoist, D. Mathis, 1997, Ryumachi. [Rheumatism].

Autoimmunity: The pathogen connection

C. Benoist, D. Mathis, 1998, Nature.

Antiviral immune responses of mice lacking MHC class II or its associated invariant chain.

R. Zinkernagel, C. Benoist, M. Battegay, 1996, Cellular immunology.

Yes, it does

C. Benoist, D. Mathis, 2007, Nature Reviews Immunology.

Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice.

C. Benoist, H. Ploegh, D. Mathis, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Global relevance of Aire binding to hypomethylated lysine-4 of histone-3

R. Kingston, C. Benoist, D. Mathis, 2010, Proceedings of the National Academy of Sciences.

An influence of CD5 on the selection of CD4‐lineage T cells

A. Tarakhovsky, C. Benoist, D. Mathis, 1999, European journal of immunology.

Demystification of the alloresponse

C. Benoist, D. Mathis, 1991, Current Biology.

Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells

C. Benoist, D. Mathis, E. Wakamatsu, 2012, Proceedings of the National Academy of Sciences.

Tregs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis

C. Benoist, M. Lazar, D. Mathis, 2022, Science Immunology.

The transcriptional landscape of αβ T cell differentiation

G. Nolan, C. Benoist, D. Mathis, 2013, Nature Immunology.

Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts

C. Benoist, D. Mathis, A. ortiz-lopez, 2022, Proceedings of the National Academy of Sciences of the United States of America.

MHC Control of the Naive TCR a-Chain Repertoire’

C. Benoist, D. Mathis, M. Merkenschlager, 2001 .

MHC control of the naive TCR alpha-chain repertoire.

C. Benoist, D. Mathis, M. Merkenschlager, 1994, Journal of immunology.

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

C. Benoist, D. Mathis, C. Waltzinger, 1999, The Journal of experimental medicine.

A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice.

V. Kouskoff, C. Benoist, D. Mathis, 1993, Journal of immunological methods.

One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes.

J. Nadeau, C. Benoist, D. Mathis, 1991, Genomics.

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

C. Benoist, D. Mathis, S. Haxhinasto, 2008, The Journal of experimental medicine.

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes

Maxim N. Artyomov, F. Ginhoux, V. Narang, 2020, bioRxiv.

Following a diabetogenic T cell from genesis through pathogenesis

C. Benoist, D. Mathis, J. Katz, 1993, Cell.

The influence of positive selection on RAG expression in thymocytes

J. Vonesch, V. Kouskoff, C. Benoist, 1995, European journal of immunology.

FUNCTIONAL SITES ON THE A,-CHAIN Polymorphic Residues Involved in Antigen Presentation to Insulin-Specific, A,b:A,k- Restricted T Cells'

C. Benoist, J. Peccoud, A. Reske-Kunz, 1989 .

Toxic MHC class II beta chains.

C. Benoist, L. Fugger, D. Mathis, 1999, Immunity.

Functional sites on Ia molecules: a molecular dissection of A alpha immunogenicity.

C. Benoist, D. Mathis, D. Landais, 1986, Cell.

E alpha u and E beta u chain association: where lies the anomaly?

H. Mcdevitt, C. Benoist, D. Mathis, 1986, Journal of immunology.

Properties of a CCAAT box-binding protein.

C. Benoist, D. Mathis, R. Hooft van Huijsduijnen, 1987, Nucleic acids research.

Structure and Expression of the Murine Ia α Chains

V. E. Williams, H. Mcdevitt, C. Benoist, 1983 .

Restricted assembly of MHC class II molecules in transgenic mice.

C. Benoist, D. Mathis, C. Waltzinger, 1989, Journal of immunology.

BCL6 deletion in CD4 T cells does not affect Th2 effector mediated immunity in the skin

C. Benoist, Samuel I Old, F. Ronchese, 2022, Immunology and cell biology.

Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis

C. Benoist, C. Degott, E. Gravallese, 2019 .

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion

C. Benoist, D. Mathis, M. Fassett, 2012, Proceedings of the National Academy of Sciences.

Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice.

Christine M. Miller, R. Germain, C. Benoist, 2015, Cell metabolism.

Imaging inflammation of the pancreatic islets in type 1 diabetes.

R. Weissleder, C. Benoist, D. Mathis, 2004, Proceedings of the National Academy of Sciences of the United States of America.

T helper cell subsets in insulin-dependent diabetes.

C Benoist, C. Benoist, D. Mathis, 1995, Science.

Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?

C. Benoist, D. Mathis, 2001, Nature Immunology.

Role of coreceptors in positive selection and lineage commitment.

C. Benoist, D. Mathis, C. Waltzinger, 1994, The EMBO journal.

The enhancer in an MHC class II gene, in vitro and in mouso.

C. Benoist, D. Mathis, C. Waltzinger, 1988, Biochimie.

Anatomy of a new B-cell-specific enhancer.

C. Benoist, D. Mathis, W. Koch, 1989, Molecular and cellular biology.

The murine E alpha immune response gene.

V. E. Williams, H. Mcdevitt, C. Benoist, 1983, Cell.

Several mechanisms can account for defective E gene expression in different mouse haplotypes (Ia antigens/major histocompatibility complex/immune response genes/recombinant DNA/Southern blotting)

V. E. Williams, C. Benoist, D. Mathis, 2016 .

Inbred and wild mice carry identical deletions in their E alpha MHC genes.

C. Benoist, D. Mathis, M. Steinmetz, 1985, The EMBO journal.

Correcting an immune-response deficiency by creating E alpha gene transgenic mice.

C. Benoist, D. Mathis, P. Gerlinger, 1985, Nature.

A dynamic atlas of immunocyte migration from the gut

C. Benoist, D. Mathis, Bola S Hanna, 2022, bioRxiv.

Intrathymic delivery of MHC genes using recombinant adenoviruses.

C. Benoist, D. Mathis, R. Rooke, 2000, Methods in molecular biology.

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity

Or Gozani, Christophe Benoist, Jakub Abramson, 2008, Proceedings of the National Academy of Sciences.

Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain.

C. Benoist, D. Mathis, R. Mantovani, 1992, The Journal of biological chemistry.

Mast cells jump start K/BxN serum transfer arthritis via IL-1

C. Benoist, D. Mathis, Y. Iwakura, 2007, Arthritis Research & Therapy.

The Immunosuppressant 1 , 5-deoxyspergualin Reveals

C. Benoist, D. Mathis, Bo Wang, 2003 .

The Immunosuppressan t lin Reveals Commonality between PreT and PreB Cell Differentiation

C. Benoist, D. Mathis, Bo Wang, 1996 .

T-Cell Co-Receptors: The end of a frustrating search

C. Benoist, D. Mathis, 1994, Current Biology.

TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis.

A R Pettit, C Benoist, R Müller, 2001, The American journal of pathology.

A broad analysis of IL1 polymorphism and rheumatoid arthritis.

Vincent L. Butty, P. Gregersen, R. Plenge, 2008, Arthritis and rheumatism.

The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease.

C. Benoist, D. Mathis, P. Monach, 2004, Advances in immunology.

Mining the Human Gut Microbiota for Immunomodulatory Organisms

C. Benoist, N. Geva-Zatorsky, D. Mathis, 2017, Cell.

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

C. Benoist, L. Poirot, D. Mathis, 2003, The Journal of experimental medicine.

How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease

C. Benoist, D. Mathis, I. Matsumoto, 2002, Nature Immunology.

Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells

Liza Konnikova, David Zemmour, Christophe Benoist, 2015, Science.

Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

Manolis Kellis, Aviv Regev, Nir Hacohen, 2014, Science.

Human Dendritic Cells Common Genetic Variants Modulate Pathogen-Sensing Responses in

N. Hacohen, A. Regev, Manolis Kellis, 2014 .

A decade of AIRE

C. Benoist, D. Mathis, 2007, Nature Reviews Immunology.

Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.

C. Benoist, D. Mathis, H. Fehling, 2011, Immunity.

Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.

C Benoist, P Chambon, P. Chambon, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Mice lacking MHC class II molecules

D. Gray, J. Kaufman, C. Benoist, 1991, Cell.

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice

C. Benoist, D. Mathis, M. Kronenberg, 1995, The Journal of experimental medicine.

Treg cells limit IFN-γ production to control macrophage accrual and phenotype during skeletal muscle regeneration

C. Benoist, D. Mathis, Marisella Panduro, 2018, Proceedings of the National Academy of Sciences.

Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet.

C. Benoist, D. Mathis, 1990, Annual review of immunology.

TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype

C. Benoist, D. Mathis, D. Zemmour, 2018, Cell.

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells.

C. Benoist, D. Mathis, A. Wagers, 2016, Immunity.

In vivo sequence requirements of the SV40 early promoter region

Pierre Chambon, Christophe Benoist, P. Chambon, 1981, Nature.

The murine Eα immune response gene

V. E. Williams, H. Mcdevitt, C. Benoist, 1983, Cell.

A microRNA expression and regulatory element activity atlas of the mouse immune system

Jason D. Buenrostro, A. Regev, E. Kenigsberg, 2021, Nature Immunology.

PPARγ is a major driver of the accumulation and phenotype of adipose-tissue Treg cells

C. Benoist, D. Mathis, M. Feuerer, 2012, Nature.

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

R. Young, C. Benoist, D. Mathis, 2011, Proceedings of the National Academy of Sciences.

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice

C. Benoist, D. Mathis, Esen Sefik, 2011, Proceedings of the National Academy of Sciences.

Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes.

S. Mostafavi, C. Benoist, D. Mathis, 2020, Nature immunology.

Deep learning of immune cell differentiation

S. Mostafavi, C. Benoist, Alexandra Maslova, 2020, Proceedings of the National Academy of Sciences.

Learning immune cell differentiation

S. Mostafavi, C. Benoist, Alexandra Maslova, 2019, bioRxiv.

Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice

C. Benoist, N. Geva-Zatorsky, D. Mathis, 2016, Proceedings of the National Academy of Sciences.

Stability of the Regulatory T Cell Lineage in Vivo

Christophe Benoist, A. Rudensky, C. Benoist, 2010, Science.

Molecular diversification of regulatory T cells in nonlymphoid tissues

Allon M. Klein, C. Benoist, R. Zilionis, 2018, Science Immunology.

Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice.

J. Flint, W. Valdar, C. Benoist, 2011, Arthritis and rheumatism.

Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity

C. Benoist, D. Mathis, D. Zemmour, 2017, Proceedings of the National Academy of Sciences.

Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand1

C. Benoist, L. Poirot, D. Mathis, 2003, The Journal of Immunology.

Inhibition of thymocyte positive selection by natural MHC: peptide ligands

C Benoist, V. Kouskoff, C. Benoist, 1999, European journal of immunology.

Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.

Kenji Yoshida, Christophe Benoist, Laurent Poirot, 2003, The Journal of clinical investigation.

Thymic negative selection is functional in NOD mice

C. Benoist, D. Mathis, M. Feuerer, 2012, The Journal of experimental medicine.

Transcriptional impact of Aire varies with cell type

C. Benoist, D. Mathis, M. Guerau-de-Arellano, 2008, Proceedings of the National Academy of Sciences.

Genetic determinants of co-accessible chromatin regions in activated T cells across humans

Howard Y. Chang, Neva C. Durand, Chun Jimmie Ye, 2018, Nature Genetics.

Population dynamics of islet-infiltrating cells in autoimmune diabetes

Greg M. Thurber, R. Weissleder, C. Benoist, 2015, Proceedings of the National Academy of Sciences.

Dominant negative analogs of NF-YA.

C. Benoist, D. Mathis, R. Mantovani, 1994, The Journal of biological chemistry.

How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets.

C. Benoist, D. Mathis, M. Feuerer, 2009, Immunity.

The Dendritic Cell Populations of Mouse Lymph Nodes1

C. Benoist, K. Burnham, A. Kamath, 2001, The Journal of Immunology.

The transcriptional regulator Aire binds to and activates super-enhancers

C. Benoist, D. Mathis, H. Yoshida, 2017, Nature Immunology.

Aire's Partners in the Molecular Control of Immunological Tolerance

C. Benoist, D. Mathis, M. Giraud, 2010, Cell.

Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant.

C. Benoist, D. Mathis, M. Lemeur, 1989, Science.

IL-17A–producing γδT cells promote muscle regeneration in a microbiota-dependent manner

C. Benoist, D. Mathis, I. Prinz, 2022, The Journal of experimental medicine.

PPARγ marks splenic precursors of multiple nonlymphoid-tissue Treg compartments

C. Benoist, D. Mathis, A. Muñoz-Rojas, 2021, Proceedings of the National Academy of Sciences.

Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle

Omar K. Yaghi, C. Benoist, D. Mathis, 2020, Proceedings of the National Academy of Sciences.

T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle

C. Benoist, D. Mathis, Wilson Kuswanto, 2019, Proceedings of the National Academy of Sciences.

Amino acid residues on the I-Ak alpha-chain required for the binding and stability of two antigenic peptides.

E. Unanue, C. Nelson, N. Viner, 1996, Journal of immunology.

Interindividual variation in human T regulatory cells

B. Stranger, T. Raj, C. Benoist, 2014, Proceedings of the National Academy of Sciences.

Genetic Influences on the End-Stage Effector Phase of Arthritis

D. Gauguier, M. Lathrop, C. Benoist, 2001, The Journal of experimental medicine.

ImmGen microarray gene expression data: Data Generation and Quality Control pipeline

Christophe Benoist, C. Benoist, D. Mathis, 2012 .

Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells1

C. Benoist, R. Obst, D. Mathis, 2007, The Journal of Immunology.

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

J. Stroud, S. Ziegler, C. Benoist, 2006, Cell.

The transcriptional landscape of αβ T cell differentiation

Charles C. Kim, G. Nolan, D. Koller, 2013, Nature Immunology.

Transgenes and knock-outs in autoimmunity.

C. Benoist, D. Mathis, 1993, Current opinion in immunology.

Commercially Available Outbred Mice for Genome-Wide Association Studies

Laurent Farinelli, David J. Adams, Jonathan Flint, 2010, PLoS genetics.

The ovalbumin gene-sequence of putative control regions

C Benoist, K O'Hare, R Breathnach, 1980, Nucleic Acids Res..

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

R. Weissleder, C. Benoist, R. Prinjha, 2014, eLife.

Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.

C. Benoist, D. Mathis, J. Katz, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes

Vincent L. Butty, Pardis C Sabeti, C. Benoist, 2007, Proceedings of the National Academy of Sciences.

Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.

Omar K. Yaghi, S. Itzkovitz, C. Benoist, 2021, Immunity.

Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells

C. Benoist, T. Yamagata, D. Mathis, 2004, Nature Immunology.

ImmGen at 15

Jason D. Buenrostro, E. Amir, A. Regev, 2020, Nature Immunology.

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

C. Benoist, M. Bevan, A. Goldrath, 2002, The Journal of experimental medicine.

Role of the forkhead transcription family member, FKHR, in thymocyte differentiation

C. Benoist, D. Mathis, H. Leenders, 2000, European journal of immunology.

The shaping of the T cell repertoire.

C. Benoist, D. Mathis, C. Waltzinger, 2001, Immunity.

Amino Acids Specifying MHC Class Preference in TCR Vα2 Regions

C. Benoist, D. Mathis, C. Waltzinger, 1999, The Journal of Immunology.

Cassette vectors directing expression of T cell receptor genes in transgenic mice.

V. Kouskoff, C. Benoist, D. Mathis, 1995, Journal of immunological methods.

A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis

C. Benoist, H. Ploegh, W. Robinson, 2009, Proceedings of the National Academy of Sciences.

Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells

Mark S. Anderson, A. Tarakhovsky, C. Benoist, 2015, Proceedings of the National Academy of Sciences.

T cell receptor specificity and diabetes in nonobese diabetic mice.

C. Benoist, D. Mathis, 1993, Science.

Defective central tolerance induction in NOD mice: genomics and genetics.

C. Benoist, S. Zucchelli, T. Yamagata, 2005, Immunity.

Organ-Specific Disease Provoked by Systemic Autoimmunity

V. Kouskoff, C. Benoist, D. Mathis, 1996, Cell.

Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1.

C. Benoist, D. Mathis, P. Nigrovic, 2010, Arthritis and rheumatism.

Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1

C. Benoist, D. Mathis, Y. Iwakura, 2007, Proceedings of the National Academy of Sciences.

Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

C. Benoist, D. Mathis, D. Friend, 2002, Science.

Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme.

C. Benoist, D. Mathis, I. Matsumoto, 1999, Science.

From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins.

K. Rajewsky, C. Benoist, D. Mathis, 1999, Immunity.

CD4 CD25 T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion

G. Freeman, C. Benoist, A. Herman, 2004 .

An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint

A. Kostic, C. Benoist, D. Mathis, 2020, Cell.

FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression

C. Benoist, D. Mathis, Ricardo N. Ramirez, 2021, bioRxiv.

The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries.

C. Benoist, D. Mathis, Gang Wang, 2023, Immunity.

The influence of the microbiota on type‐1 diabetes: on the threshold of a leap forward in our understanding

C. Benoist, D. Mathis, 2012, Immunological reviews.

Microbiota and autoimmune disease: the hosted self.

C. Benoist, D. Mathis, 2011, Cell host & microbe.

Organisation and sequences at the 5′ end of a cloned complete ovalbumin gene

P. Chambon, C. Benoist, K. O'hare, 1979, Nature.

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.

C. Benoist, D. Hafler, V. Kuchroo, 2014, Immunity.

A multiplicity of CCAAT box-binding proteins

C. Benoist, D. Mathis, A. Dorn, 1987, Cell.

Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers

C. Benoist, R. Levine, D. Mathis, 2021, Proceedings of the National Academy of Sciences.

A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine.

C. Benoist, J. Behr, B. Demeneix, 1996, Human gene therapy.

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated

C. Benoist, D. Mathis, Whitney Besse, 2008, Proceedings of the National Academy of Sciences.

Profound Treg perturbations correlate with COVID-19 severity

B. Walker, C. Benoist, Xu G. Yu, 2020, bioRxiv.

Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.

M. Yaffe, R. Weissleder, L. Josephson, 2009, Arthritis and rheumatism.

Danger-free autoimmune disease in Aire-deficient mice

C. Benoist, D. Mathis, D. Gray, 2007, Proceedings of the National Academy of Sciences.

A common polymorphism near PER1 and the timing of human behavioral rhythms

A. Myers, C. Saper, J. Shulman, 2012, Annals of neurology.

A combination of cyclophosphamide and interleukin-2 allows CD4+ T cells converted to Tregs to control scurfy syndrome.

A. Schambach, C. Benoist, Mario Amendola, 2021, Blood.

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

Mark M. Davis, C. Benoist, D. Mathis, 1989, Cell.

Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements

P. Chambon, C. Benoist, J. Jongstra, 1984, Nature.

Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice.

Forest M White, Christophe Benoist, C. Benoist, 2010, Journal of proteome research.

The immune system of mice lacking conventional MHC class II molecules.

C. Benoist, D. Mathis, M. Merkenschlager, 1994, Advances in immunology.

Compartmentalization of MHC class II gene expression in transgenic mice

C. Benoist, P. Marrack, Y. Ron, 1988, Cell.

Antigen persistence is required throughout the expansion phase of a CD4+ T cell response

Christophe Benoist, C. Benoist, R. Obst, 2005, The Journal of experimental medicine.

A cassette vector for high-level reporter expression driven by a hybrid invariant chain promoter in transgenic mice.

C. Benoist, D. Mathis, H. V. van Santen, 2000, Journal of immunological methods.

Deletions covering the putative promoter region of early mRNAs of simian virus 40 do not abolish T-antigen expression.

P. Chambon, C. Benoist, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.

Christophe Benoist, R. Melamed, C. Benoist, 2007, Immunity.

Endocrine self and gut non-self intersect in the pancreatic lymph nodes.

C. Benoist, D. Mathis, S. Turley, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface

C. Benoist, E. Crestani, D. Knipe, 2021, Proceedings of the National Academy of Sciences.

Profound Treg perturbations correlate with COVID-19 severity

B. Walker, C. Benoist, Xu G. Yu, 2021, Proceedings of the National Academy of Sciences.

Mice lacking TdT: mature animals with an immature lymphocyte repertoire.

C. Benoist, D. Mathis, A. Dierich, 1993, Science.

Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model.

C. Benoist, J. Jacobs, D. Mathis, 2010, Arthritis and rheumatism.

Chromosomal clustering of genes controlled by the aire transcription factor.

C. Benoist, Emily S. Venanzi, D. Mathis, 2005, Proceedings of the National Academy of Sciences of the United States of America.

AIRE and APECED: molecular insights into an autoimmune disease

C. Benoist, D. Mathis, J. Villaseñor, 2005, Immunological reviews.

Lymphotoxin Pathway and Aire Influences on Thymic Medullary Epithelial Cells Are Unconnected1

C. Benoist, Emily S. Venanzi, D. Mathis, 2007, The Journal of Immunology.

Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types

R. Weissleder, C. Benoist, D. Mathis, 2018, Proceedings of the National Academy of Sciences.

Differential Response of Regulatory and Conventional CD4+ Lymphocytes to CD3 Engagement: Clues to a Possible Mechanism of Anti-CD3 Action?

C. Benoist, D. Mathis, J. Nishio, 2013, The Journal of Immunology.

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

C. Benoist, D. Mathis, M. Feuerer, 2010, Proceedings of the National Academy of Sciences.

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

C. Benoist, D. Mathis, M. Feuerer, 2009, Nature Immunology.

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

C. Benoist, Michael Matos, A. Herman, 2005, The Journal of experimental medicine.

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Jason D. Buenrostro, A. Regev, E. Kenigsberg, 2021, Nature Communications.

ImmVar project: Insights and design considerations for future studies of "healthy" immune variation.

N. Hacohen, A. Regev, B. Stranger, 2015, Seminars in immunology.

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

Allon M Klein, Allon M. Klein, David Zemmour, 2018, Nature Immunology.

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets

C. Benoist, D. Mathis, J. Wong, 2007, The Journal of experimental medicine.

Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.

P. Chambon, Y. Belkaid, C. Benoist, 2008, Immunity.

Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2

Michael D Healy, Kelsey K. Finn, Benjamin P. Roscoe, 2021, Science Immunology.

Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8+ T cell repertoire upon viral exposure

Benjamin P. Roscoe, A. Shalek, J. Francis, 2021, bioRxiv.

Mast cells in autoimmune disease

C. Benoist, D. Mathis, 2002, Nature.

Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes

Maxim N. Artyomov, F. Ginhoux, V. Narang, 2023, Cell reports.

An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription

N. Hacohen, D. Root, C. Benoist, 2014, Proceedings of the National Academy of Sciences.

The variable immunological self: Genetic variation and nongenetic noise in Aire-regulated transcription

R. Melamed, C. Benoist, Emily S. Venanzi, 2008, Proceedings of the National Academy of Sciences.

Unconnected on Thymic Medullary Epithelial Cells Are Lymphotoxin Pathway and Aire Influences and Diane

C. Benoist, Emily S. Venanzi, D. Gray, 2007 .

Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells.

J. Stroud, C. Benoist, D. Mathis, 2011, Immunity.

Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase‐, CD23‐, interleukin‐4‐, IgD‐ and CD30‐deficient mouse mutants

K. Rajewsky, T. Mak, C. Benoist, 1996, European journal of immunology.

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

C. Benoist, H. Ploegh, D. Mathis, 1996, Cell.

Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen.

J. Kearney, C. Benoist, D. Mathis, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The Regulation of Ia Gene Transcription

C. Benoist, D. Mathis, M. Lemeur, 1986 .

Treg cells, life history, and diversity.

C. Benoist, D. Mathis, 2012, Cold Spring Harbor perspectives in biology.

Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity.

Christophe Benoist, Laurent Poirot, C. Benoist, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Spotting a killer's target in autoimmune diabetes

C. Benoist, D. Mathis, 1999, Nature Medicine.

Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny.

C. Benoist, D. Mathis, M. Bogue, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Genetic determinants of chromatin accessibility and gene regulation in T cell activation across human individuals

Aviv Regev, Howard Y. Chang, Neva C. Durand, 2016 .

FoxP3 can fold into two distinct dimerization states with divergent functional implications for T cell homeostasis

A. Rudensky, C. Benoist, S. Hur, 2022, bioRxiv.

FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes

C. Benoist, D. Mathis, Ho-Keun Kwon, 2017, Proceedings of the National Academy of Sciences.

In favor of the selective model of positive selection.

C. Benoist, D. Mathis, S. Chan, 1994, Seminars in immunology.

Results The Pancreatic Lesion Includes CD 4 T Cell Subpopulations with Both Effector and Regulatory Phenotypes

G. Freeman, C. Benoist, A. Herman, 2004 .

STRUCTURE AND EXPRESSION OF OVALBUMIN AND CLOSELY RELATED CHICKEN GENES

P. Chambon, R. Heilig, C. Benoist, 1979 .

Regulatory T cells in nonlymphoid tissues

C. Benoist, D. Mathis, Dalia Burzyn, 2013, Nature Immunology.

Disease The Immunogenetic Architecture of Autoimmune An Goris and Adrian Liston Self-Control ? Natural Killer Cell Tolerance : Control by Self or

Baptiste N. Jaeger, C. Benoist, R. Locksley, 2012 .

Fat T reg cells : a liaison between the immune and metabolic systems

Christophe Benoist, Laura Herrero, A. Goldfine, 2011 .

Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview.

C. Benoist, R. Park, Michael Matos, 2004, Diabetes.

Regions of allelic hypervariability in the murine Aα immune response gene

V. E. Williams, H. Mcdevitt, C. Benoist, 1983, Cell.

Superantigens interact with MHC class II molecules outside of the antigen groove

C. Benoist, P. Marrack, J. Peccoud, 1990, Cell.

A Broad Analysis of IL 1 Polymorphism and Rheumatoid Arthritis

Vincent L. Butty, P. Gregersen, R. Plenge, 2008 .

beta-Cell death during progression to diabetes.

C Benoist, C. Benoist, D. Mathis, 2001, Nature.

Engagement: Clues to a Possible Mechanism Lymphocytes to CD3 + Conventional CD4 Differential Response of Regulatory and

C. Benoist, D. Mathis, Li Li, 2013 .

Revised nomenclature of mouseH-2 genes

S. Tonegawa, H. Mcdevitt, C. Benoist, 2005, Immunogenetics.

Nomenclature Revised nomenclature of mouse B-2 genes

L. Hood, S. Tonegawa, H. Mcdevitt, 1993 .

Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders.

P. Schur, C. Benoist, M. Weinblatt, 2003, Arthritis and rheumatism.

Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice.

C. Benoist, A. Oxenius, D. Mathis, 1997, Immunity.

Functional sites on la molecules: A molecular dissection of Aα immunogenicity

C. Benoist, D. Mathis, D. Landais, 1986, Cell.

T-cell compartments of prediabetic NOD mice.

C. Benoist, Emily S. Venanzi, D. Mathis, 2003, Diabetes.

Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice.

M. Lathrop, C. Benoist, D. Mathis, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Co‐evolution from yeast to mouse: cDNA cloning of the two NF‐Y (CP‐1/CBF) subunits.

C. Benoist, D. Mathis, R. Hooft van Huijsduijnen, 1990, The EMBO journal.

Variation and Genetic Control of Gene Expression in Primary Immunocytes across Inbred Mouse Strains

D. Koller, S. Mostafavi, C. Benoist, 2014, The Journal of Immunology.

Molecular definition of the identity and activation of natural killer cells

Charles C. Kim, A. Regev, V. Jojic, 2012, Nature Immunology.

Monoclonal antibodies to NF‐Y define its function in MHC class II and albumin gene transcription.

C. Benoist, D. Mathis, R. Mantovani, 1992, The EMBO journal.

Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity.

C. Benoist, D. Mathis, Ricardo N. Ramirez, 2021, Cell metabolism.

Correction: A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

R. Mott, J. Flint, P. Klenerman, 2011, PLoS Biology.

A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

R. Mott, J. Flint, P. Klenerman, 2010, PLoS biology.

Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells

C. Benoist, D. Mathis, H. V. van Santen, 2004, The Journal of experimental medicine.

An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes.

A. Rudensky, C. Benoist, D. Mathis, 2012, Immunity.

Revised nomenclature of mouse H-2 genes.

L. Hood, C. Benoist, R. Flavell, 1990, Immunogenetics.

Functional consequences of overexpressed Ia antigens in Aαk/Aβk transgenic mice.

C. Benoist, D. Mathis, C. Waltzinger, 1990 .

Antigen‐presenting Function of the TL Antigen and Mouse CD1 Molecules

P. A. Peterson, C. Benoist, W. Huse, 1995, Immunological reviews.

The V beta 17+ T cell repertoire: skewed J beta usage after thymic selection; dissimilar CDR3s in CD4+ versus CD8+ cells

C. Benoist, D. Mathis, C. Waltzinger, 1991, The Journal of experimental medicine.

Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes

C. Benoist, D. Mathis, C. Carnaud, 2001, Nature Immunology.

Genetic determinants of co-accessible chromatin regions in T cell activation across humans

Aviv Regev, Howard Y. Chang, Philip L. De Jager, 2016, bioRxiv.

A cluster of coregulated genes determines TGF-β–induced regulatory T-cell (Treg) dysfunction in NOD mice

C. Benoist, D. Mathis, A. D’Alise, 2011, Proceedings of the National Academy of Sciences.

STRUCTURAL ORGANIZATION AND EXPRESSION OF OVALBUMIN AND RELATED CHICKEN GENES

P. Chambon, C. Benoist, K. O'hare, 1979 .

Regions of allelic hypervariability in the murine A alpha immune response gene.

V. E. Williams, H. Mcdevitt, C. Benoist, 1983, Cell.

NF-X, a transcription factor implicated in MHC class II gene regulation.

V. Kouskoff, C. Benoist, C. Griscelli, 1991, Journal of immunology.

The E alpha promoter: a linker-scanning analysis.

C. Benoist, D. Mathis, R. Mantovani, 1991, Journal of immunology.

Particularities of the vasculature can promote the organ specificity of autoimmune attack

R. Weissleder, C. Benoist, D. Mathis, 2006, Nature Immunology.

No more than seven interruptions in the ovalbumin gene: comparison of genomic and double-stranded cDNA sequences.

C Benoist, P Chambon, P. Chambon, 1979, Nucleic acids research.

The level of N‐region diversity in T cell receptors is not pre‐ordained in the stem cell

C. Benoist, D. Mathis, M. Bogue, 1993, European journal of immunology.

Network pharmacology of JAK inhibitors

S. Mostafavi, C. Benoist, D. Mathis, 2016, Proceedings of the National Academy of Sciences.

Consortium biology in immunology: the perspective from the Immunological Genome Project

C. Benoist, M. Merad, D. Mathis, 2014, Nature Reviews Immunology.

Mice Lacking Terminal Deoxynucleotidyl Transferase: Adult Mice with a Fetal Antigen Receptor Repertoire

C. Benoist, D. Mathis, S. Gilfillan, 1995, Immunological reviews.

Efficient immune responses in mice lacking N‐region diversity

R. Zinkernagel, C. Benoist, D. Mathis, 1995, European journal of immunology.

More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase.

C. Benoist, D. Mathis, C. Waltzinger, 1994, International immunology.

Microbiome induced complement synthesized in the gut protects against enteric infections

C. Benoist, J. Moffitt, J. Mekalanos, 2023, bioRxiv.

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas

C. Benoist, J. Flier, R. Kulkarni, 2016, PloS one.

A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice

C. Benoist, D. Mathis, Hirotsugu Suwanai, 2010, Proceedings of the National Academy of Sciences.

Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses.

C. Benoist, D. Mathis, C. Waltzinger, 1997, Immunity.

A molecular chart of thymocyte positive selection

C Benoist, C. Benoist, D. Mathis, 2001, European journal of immunology.

T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33

C. Benoist, D. Mathis, J. Tuncel, 2019, The Journal of experimental medicine.

Altered Natural Killer Cells in Type 1 Diabetic Patients

Vincent L. Butty, C. Benoist, D. Mathis, 2007, Diabetes.

Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors

C. Benoist, D. Mathis, D. Zemmour, 2019, Science Immunology.

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3

C. Benoist, D. Mathis, M. Mingueneau, 2015, Proceedings of the National Academy of Sciences.

Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature

R. Weissleder, C. Benoist, D. Mathis, 2014, Proceedings of the National Academy of Sciences.

CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance

C. Benoist, D. Mathis, Daniel A. Michelson, 2022, Proceedings of the National Academy of Sciences of the United States of America.

A special repertoire of alpha:beta T cells in neonatal mice.

C. Benoist, D. Mathis, M. Bogue, 1991, The EMBO journal.

Imaging the emergence and natural progression of spontaneous autoimmune diabetes

R. Weissleder, C. Benoist, D. Mathis, 2017, Proceedings of the National Academy of Sciences.

The Effect of Ethnicity in the Rate of Beta Cell Functional Loss in the First 3 Years After Type 1 Diabetes Diagnosis.

Kathleen C. Fraser, Mark S. Anderson, Renee A. Davis, 2020, The Journal of clinical endocrinology and metabolism.

Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing γδ T Cells to Promote Immunologic Tolerance.

C. Benoist, D. Mathis, S. Rosenzweig, 2016, Immunity.

Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging

R. Weissleder, G. Wojtkiewicz, C. Benoist, 2012, Nature Immunology.

Open-source ImmGen: mononuclear phagocytes

Christophe Benoist, C. Benoist, 2016, Nature Immunology.

Autoimmune diabetes: Retrovirus as trigger, precipitator or marker?

C. Benoist, D. Mathis, 1997, Nature.

Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation

Charles C. Kim, D. Koller, A. Regev, 2013 .

Impact of Diabetes Susceptibility Loci on Progression From Pre-Diabetes to Diabetes in At-Risk Individuals of the Diabetes Prevention Trial–Type 1 (DPT-1)

Vincent L. Butty, C. Benoist, D. Mathis, 2008, Diabetes.

Impact of diabetes susceptibility loci on progression from prediabetes to diabetes in at-risk individuals of the DPT 1 trial

Vincent L. Butty, C. Benoist, D. Mathis, 2008 .

A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity

T. Raj, H. Weiner, C. Benoist, 2015, Annals of neurology.

Genomic responses to inflammation in mouse models mimic humans: We concur, apples to oranges comparisons won’t do

C. Benoist, T. Shay, J. Lederer, 2014, Proceedings of the National Academy of Sciences.

Transcriptomes of the B and T Lineages Compared by Multiplatform Microarray Profiling

C. Benoist, D. Mathis, Michio W. Painter, 2011, Journal of Immunology.

Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules.

C Benoist, C. Benoist, D. Mathis, 2000, The Journal of experimental medicine.

Structure of the TCR-Ag-MHC Complex

C. Benoist, J. Peccoud, D. Mathis, 1992 .

Levees of immunological tolerance

C. Benoist, D. Mathis, 2010, Nature Immunology.

A variegated model of transcription factor function in the immune system.

C. Benoist, Kaitavjeet Chowdhary, 2023, Trends in immunology.

An interwoven network of transcription factors, with divergent influences from FoxP3, underlies Treg diversity

C. Benoist, D. Mathis, Deepshika Ramanan, 2023, bioRxiv.

Nonregulatory CD 4 Self-Peptides in Regulatory and Adaptation of TCR Repertoires to

C. Benoist, R. Obst, D. Mathis, 2007 .

Islet Recovery and Reversal of Murine Type 1 Diabetes in the Absence of Any Infused Spleen Cell Contribution

J. Gaglia, C. Benoist, D. Mathis, 2006, Science.

IL-17-producing T cells can augment autoantibody-induced arthritis

C. Benoist, J. Jacobs, D. Mathis, 2009, Proceedings of the National Academy of Sciences.

T-cell development: A new marker of differentiation state

C. Benoist, D. Mathis, 1999, Current Biology.

Amino Acids Specifying MHC Class Preference in TCR V a 2 Regions 1

C. Benoist, D. Mathis, C. Waltzinger, 1999 .

Positive selection of thymocytes induced by gene transfer: MHC class II-mediated selection of CD8 lineage cells.

C Benoist, C. Benoist, D. Mathis, 1999, International immunology.

Regulatory T cells in the face of the intestinal microbiota

C. Benoist, D. Mathis, Deepshika Ramanan, 2023, Nature Reviews Immunology.

R. Weissleder, C. Benoist, M. Pittet, 2018, JCI insight.

Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus

C. Benoist, D. Mathis, M. Verzi, 2023, The Journal of experimental medicine.

The major histocompatibility complex (MHC) Ea promoter: sequences and factors at the initiation site.

C. Benoist, D. Mathis, L. Tora, 1993, Nucleic acids research.

Selection for Survival?

C Benoist, C. Benoist, D. Mathis, 1997, Science.

C ritical R oles for Interleukin 1 and Tum or N ecrosis Factor in A ntibody-induced A rthritis

C. Benoist, C. Degott, E. Gravallese, 2015 .

Establishment of an Inactivation Method for Ebola Virus and SARS-CoV-2 Suitable for Downstream Sequencing of Low Cell Numbers

C. Benoist, E. Mühlberger, Judith Olejnik, 2023, Pathogens.

Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

Allon M. Klein, C. Benoist, R. Zilionis, 2018, Nature Immunology.

Altered I-J phenotype in E alpha transgenic mice.

C. Benoist, D. Mathis, D. Murphy, 1986, Proceedings of the National Academy of Sciences of the United States of America.

The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice.

C. Benoist, T. Yamagata, D. Mathis, 2007, Proceedings of the National Academy of Sciences of the United States of America.

The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms

C. Benoist, R. Bronson, D. Mathis, 2009, Proceedings of the National Academy of Sciences.

TOXIC MHC CLASS II BETA CHAINS. AUTHORS' REPLY

C. Benoist, L. Fugger, D. Mathis, 1999 .

T-cell recognition of superantigens: inside or outside the groove?

C. Benoist, J. Peccoud, D. Mathis, 1989, Cold Spring Harbor symposia on quantitative biology.

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets

C. Benoist, D. Mathis, Deepshika Ramanan, 2023, bioRxiv.

Ladder-like multimerization of FoxP3 enables microsatellite recognition and DNA bridging

C. Benoist, S. Hur, Ricardo N. Ramirez, 2023, bioRxiv.

The Shaping of the T Cell Repertoire segments

C. Benoist, D. Mathis, C. Waltzinger, 2001 .

The Human Cell Atlas

Fabian J Theis, Jay W. Shin, Michael J. T. Stubbington, 2017, bioRxiv.

Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet.

C. Benoist, D. Mathis, 1990 .

Expression profiling of constitutive mast cells reveals a unique identity within the immune system

A. Regev, C. Benoist, M. Merad, 2016, Nature Immunology.

ImmGen Report: Molecular definition of Natural Killer cell identity and activation

Charles C. Kim, A. Regev, V. Jojic, 2012, Nature Immunology.

Mutations from patients with IPEX ported to mice reveal different patterns of FoxP3 and Treg dysfunction

C. Benoist, D. Mathis, S. Hur, 2023, Cell reports.

Phase I Solicitation

E. Lander, B. Wold, J. Sanes, 2020 .

Conservation and divergence in modules of the transcriptional programs of the human and mouse immune systems

Charles C. Kim, D. Koller, A. Regev, 2018, bioRxiv.

Conservation and divergence in modules of the transcriptional programs of the human and mouse immune systems [preprint]

A. Regev, V. Jojic, O. Zuk, 2020 .

Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes

Jason D. Buenrostro, A. Regev, E. Kenigsberg, 2021, Nature Immunology.

Genetic control of diabetes progression.

M. Mattéi, C. Benoist, D. Mathis, 1997, Immunity.

Conservation and divergence in the transcriptional programs of the human and mouse immune systems

D. Koller, A. Regev, V. Jojic, 2013, Proceedings of the National Academy of Sciences.

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells.

C. Benoist, D. Mathis, A. Wagers, 2016, Immunity.

Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

Chun Jimmie Ye, N. Hacohen, A. Regev, 2014, Science.

Unstable FoxP3+ T regulatory cells in NZW mice

C. Benoist, D. Mathis, Ho-Keun Kwon, 2016, Proceedings of the National Academy of Sciences of the United States of America.

Treg cells, life history, and diversity.

C. Benoist, D. Mathis, 2012, Cold Spring Harbor perspectives in biology.

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated

C. Benoist, D. Mathis, Whitney Besse, 2008, Proceedings of the National Academy of Sciences.

A combination of cyclophosphamide and interleukin-2 allows CD4+ T cells converted to Tregs to control scurfy syndrome.

A. Schambach, C. Benoist, Mario Amendola, 2021, Blood.

A cluster of coregulated genes determines TGF-β–induced regulatory T-cell (Treg) dysfunction in NOD mice

C. Benoist, D. Mathis, A. D’Alise, 2011, Proceedings of the National Academy of Sciences.

Functional sites on the A alpha-chain. Polymorphic residues involved in antigen presentation to insulin-specific, Ab alpha:Ak beta-restricted T cells.

C. Benoist, J. Peccoud, D. Mathis, 1989, Journal of immunology.

The Human Cell Atlas White Paper

Evan Z. Macosko, Jay W. Shin, Allon M. Klein, 2018, 1810.05192.

Network pharmacology of JAK inhibitors

S. Mostafavi, C. Benoist, D. Mathis, 2016, Proceedings of the National Academy of Sciences.

The Human Cell Atlas

Fabian J Theis, Jay W. Shin, Michael J. T. Stubbington, 2017, bioRxiv.

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

C. Benoist, D. Mathis, C. Waltzinger, 1999, The Journal of experimental medicine.

Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.

P. Chambon, Y. Belkaid, C. Benoist, 2008, Immunity.

Genomics of Tolerance

C. Benoist, 2009 .

Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity

C. Benoist, D. Mathis, M. Martinic, 2009, The Journal of experimental medicine.

Knock-out mice: a new tool for transplantation immunologists.

C. Benoist, D. Mathis, S. Cardell, 1993, Transplantation proceedings.

Visualization of CD4/CD8 T Cell Commitment

C. Benoist, D. Mathis, A. Dierich, 1998, The Journal of experimental medicine.

Visualization of Cd4/cd8 T Cell Commitment

C. Benoist, D. Mathis, A. Dierich, 2022 .

Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise

C. Benoist, P. K. Langston, Amber L Mueller, 2023, Science Immunology.

Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin

C. Benoist, D. Mathis, Y. Hsu, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Parsing the Interferon Transcriptional Network and Its Disease Associations

Chun Jimmie Ye, N. Hacohen, A. Regev, 2016, Cell.

Differential Response of Regulatory and Conventional CD4+ Lymphocytes to CD3 Engagement: Clues to a Possible Mechanism of Anti-CD3 Action?

C. Benoist, D. Mathis, J. Nishio, 2013, The Journal of Immunology.

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.

J. Gaglia, R. Weissleder, M. Harisinghani, 2011, The Journal of clinical investigation.

R. Weissleder, C. Benoist, M. Pittet, 2018, JCI insight.

The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease.

C. Benoist, D. Mathis, P. Monach, 2004, Advances in immunology.

FOXP3 recognizes microsatellites and bridges DNA through multimerization

C. Benoist, Ricardo N. Ramirez, Fangwei Leng, 2023, Nature.

Regulatory T‐cell differentiation: Committed to control: a precocious choice?

C. Benoist, D. Mathis, S. Haxhinasto, 2007, Immunology and cell biology.

CD4 CD25 T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion

C. Benoist, A. Herman, D. Mathis, 2004 .

Modifier loci condition autoimmunity provoked by Aire deficiency

Mark S. Anderson, C. Benoist, D. Mathis, 2005, The Journal of experimental medicine.

The interweaved signatures of common-gamma-chain cytokines across immunologic lineages

C. Benoist, T. Shay, S. Nutt, 2023, The Journal of experimental medicine.

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

C. Benoist, Michael Matos, A. Herman, 2005, The Journal of experimental medicine.

Inhibition of thymocyte positive selection by natural MHC: peptide ligands

V. Kouskoff, C. Benoist, D. Mathis, 1999, European journal of immunology.

Local structure of a peptide contact site on Ak alpha.

C. Benoist, D. Mathis, G. Mer, 1991, International immunology.

The immunosuppressant 15-deoxyspergualin [correction of 1,5- deoxyspergualin] reveals commonality between preT and preB cell differentiation

C. Benoist, D. Mathis, Bo Wang, 1996, The Journal of experimental medicine.

The Immunosuppressant 1,5-deoxyspergualin Reveals Commonality between Pret and Preb Cell Differentiation

C. Benoist, D. Mathis, Bo Wang, 1996 .

Lymph node stromal cell responses to perinatal T cell waves, a temporal atlas.

C. Benoist, Teshika Jayewickreme, Diane Mathis, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Molecular diversification of regulatory T cells in nonlymphoid tissues

Allon M. Klein, C. Benoist, R. Zilionis, 2018, Science Immunology.

An enhancer factor defect in a mutant Burkitt lymphoma cell line

C. Benoist, Diane Mathis, Serge M. Candéias, 1988, The Journal of experimental medicine.

Inflammatory arthritis can be reined in by CpG-induced DC–NK cell cross talk

J. Carulli, R. Weissleder, C. Benoist, 2007, The Journal of experimental medicine.

Antigen persistence is required throughout the expansion phase of a CD4+ T cell response

C. Benoist, R. Obst, D. Mathis, 2005, The Journal of experimental medicine.

Transformation ofmousefibroblasts tomethotrexate resistance by arecombinant plasmid expressing aprokaryotic dihydrofolate

Christophe Benoist, C. Benoist, K. O'hare, 1981 .

Interleukin-4 Deficiency Does Not Exacerbate Disease in NOD Mice

C. Benoist, D. Mathis, J. Katz, 1998, Diabetes.

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

C. Benoist, D. Mathis, D. Gray, 2007, The Journal of experimental medicine.

Temporal and spatial expression of lipospermine-compacted genes transferred into chick embryos in vivo.

C. Benoist, J. Behr, B. Demeneix, 1994, BioTechniques.

Gut complement induced by the microbiota combats pathogens and spares commensals

C. Benoist, J. Moffitt, J. Mekalanos, 2024, Cell.

FoxP3 recognizes microsatellites and bridges DNA through multimerization

C. Benoist, S. Hur, Ricardo N. Ramirez, 2023, bioRxiv.

Adipose-tissue Treg cells restrain differentiation of stromal adipocyte precursors to promote insulin sensitivity and metabolic homeostasis.

C. Benoist, A. Muñoz-Rojas, Gangqiang Wang, 2024, Immunity.

AIRE relies on Z-DNA to flag gene targets for thymic T cell tolerization.

C. Benoist, Sara Mostafavi, Diane Mathis, 2024, Nature.

Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice.

J. Flint, W. Valdar, C. Benoist, 2011, Arthritis and rheumatism.

A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue

Omar K. Yaghi, C. Benoist, Bola S Hanna, 2023, Nature Immunology.

IL-17-producing T cells can augment autoantibody-induced arthritis

C. Benoist, J. Jacobs, D. Mathis, 2009, Proceedings of the National Academy of Sciences.

Positive selection of T cells: fastidious or promiscuous?

C. Benoist, D. Mathis, 1997, Current opinion in immunology.

An integrated transcription factor framework for Treg identity and diversity.

C. Benoist, Kaitavjeet Chowdhary, Diane Mathis, 2024, Proceedings of the National Academy of Sciences of the United States of America.

Genetic determinants of chromatin accessibility and gene regulation in T cell activation across human individuals

Howard Y. Chang, Neva C. Durand, Chun Jimmie Ye, 2016 .

Adipose-tissue regulatory T cells are a consortium of subtypes that evolves with age and diet

C. Benoist, A. Muñoz-Rojas, Gangqiang Wang, 2024, Proceedings of the National Academy of Sciences of the United States of America.

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets

C. Benoist, D. Mathis, Deepshika Ramanan, 2023, Proceedings of the National Academy of Sciences of the United States of America.

The major histocompatibility complex (MHC) Ea promoter: sequences and factors at the initiation site.

C. Benoist, D. Mathis, L. Tora, 1993, Nucleic acids research.

A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control.

C. Benoist, G. Randolph, Jonathan C. Kagan, 2024, Immunity.