H. Leonhardt

H. Leonhardt, M. C. Cardoso, H. Easwaran, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Direct protein transfer to terminally differentiated muscle cells

H. Leonhardt, M. C. Cardoso, H. Easwaran, 1999, Journal of Molecular Medicine.

Chromatin domains and the interchromatin compartment form structurally defined and functionally interacting nuclear networks

Karl Rohr, Thomas Cremer, Christoph Cremer, 2006, Chromosome Research.

Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells

H. Leonhardt, E. Wagner, J. Rädler, 2016, Pharmaceutical Research.

CPT1alpha over-expression increases long-chain fatty acid oxidation and reduces cell viability with incremental palmitic acid concentration in 293T cells.

H. Leonhardt, M. C. Cardoso, W. Langhans, 2005, Biochemical and biophysical research communications.

CPT 1 a over-expression increases long-chain fatty acid oxidation and reduces cell viability with incremental palmitic acid concentration in 293 T cells q

H. Leonhardt, M. C. Cardoso, W. Langhans, 2005 .

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia

W. Hiddemann, K. Metzeler, H. Leonhardt, 2017, Leukemia.

MeCP2 Rett mutations affect large scale chromatin organization.

H. Leonhardt, M. C. Cardoso, B. K. Thakur, 2011, Human molecular genetics.

Reversal of terminal differentiation and control of DNA replication: Cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication

H. Leonhardt, M. C. Cardoso, B. Nadal-Ginard, 1993, Cell.

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver

A. Hoeflich, R. Wanke, E. Wolf, 2018, Molecular metabolism.

Front Cover: N ‐Hydroxysuccinimide‐Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates (ChemBioChem 1‐2/2020)

Anselm F. L. Schneider, H. Leonhardt, C. Hackenberger, 2020 .

DNA labeling in living cells

Heinrich Leonhardt, M Cristina Cardoso, H. Leonhardt, 2005, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Diurnality and Nocturnality in Primates: An Analysis from the Rod Photoreceptor Nuclei Perspective

L. Peichl, A. Hendrickson, H. Leonhardt, 2013, Evolutionary Biology.

CDK9-dependent RNA polymerase II pausing controls transcription initiation

P. Cramer, H. Leonhardt, B. Schwalb, 2017, eLife.

Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control

H. Leonhardt, A. Lamond, M. Chagot, 2014, The Journal of cell biology.

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes

Heinrich Leonhardt, Lothar Schermelleh, Erich A. Nigg, 2012, Biology Open.

Histone acetylation controls the inactive X chromosome replication dynamics

H. Leonhardt, H. Rahn, T. Cremer, 2011, Nature communications.

Studies of Mechanisms Controlling Dna Methyltransferase 1 Studies of Mechanisms Controlling Dna Methyltransferase 1

H. Leonhardt, P. Becker, Carina Frauer, 2022 .

H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization

M. Mann, J. Michaelis, E. Kremmer, 2012, Nucleic acids research.

Stable chromosomal units determine the spatial and temporal organization of DNA replication

H. Leonhardt, D. Zink, M. C. Cardoso, 2004, Journal of Cell Science.

Methyl CpG–binding proteins induce large-scale chromatin reorganization during terminal differentiation

Thomas Cremer, M. Cristina Cardoso, Heinrich Leonhardt, 2005, The Journal of cell biology.

Differentiation and large scale spatial organization of the genome.

H. Leonhardt, I. Solovei, B. Joffe, 2010, Current opinion in genetics & development.

Epigenetics of eu- and heterochromatin in inverted and conventional nuclei from mouse retina

G. Schotta, H. Leonhardt, H. Kimura, 2013, Chromosome Research.

Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene.

R. Jaenisch, H. Leonhardt, D. Talbot, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Functional nuclear organization of transcription and DNA replication: a topographical marriage between chromatin domains and the interchromatin compartment.

L. Schermelleh, C. Cremer, M. Heidemann, 2010, Cold Spring Harbor symposia on quantitative biology.

L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins

I. Hellmann, Martha Smets, H. Leonhardt, 2017, Nucleus.

Recruitment of DNA methyltransferase I to DNA repair sites.

H. Leonhardt, M. C. Cardoso, L. Schermelleh, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency

H. Leonhardt, T. Carell, S. Bultmann, 2018, Scientific Reports.

Small chromosomal regions position themselves autonomously according to their chromatin class.

Wouter Meuleman, Ludo Pagie, Peter Marynen, 2017, Genome research.

DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation

Martha Smets, H. Leonhardt, Daniela Meilinger, 2017, Human molecular genetics.

Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain

Iris Antes, M. Cristina Cardoso, Heinrich Leonhardt, 2011, PloS one.

Uncoupling the replication machinery: Replication fork progression in the absence of processive DNA synthesis

H. Leonhardt, A. Sporbert, M. C. Cardoso, 2008, Cell cycle.

Restriction of AID activity and somatic hypermutation by PARP-1

B. Jungnickel, H. Leonhardt, T. Helleday, 2019, Nucleic acids research.

Induction of Tumors in Mice by Genomic Hypomethylation

R. Jaenisch, J. Gray, J. Hodgson, 2003, Science.

Loss of KDM6A confers drug resistance in acute myeloid leukemia

W. Hiddemann, K. Metzeler, G. Schotta, 2018, Leukemia.

Global DNA Hypomethylation Prevents Consolidation of Differentiation Programs and Allows Reversion to the Embryonic Stem Cell State

H. Leonhardt, Benedikt Zacher, A. Tresch, 2012, PloS one.

Cohesin depleted cells rebuild functional nuclear compartments after endomitosis

Erez Lieberman Aiden, Volker J Schmid, Kyle N. Klein, 2019, Nature Communications.

Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci

Thomas Cremer, Justin Demmerle, Felix Kraus, 2014, Epigenetics & Chromatin.

Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation

H. Leonhardt, M. C. Cardoso, L. Schermelleh, 2007, Nucleic acids research.

Replication and translation of epigenetic information.

H. Leonhardt, M. C. Cardoso, A. Brero, 2006, Current topics in microbiology and immunology.

Smoothelin contains a novel actin cytoskeleton localization sequence with similarity to troponin T

H. Leonhardt, Christina Quensel, M. Cardoso, 2002, Journal of cellular biochemistry.

Nuclear architecture: Is it important for genome function and can we prove it?

Thomas Cremer, Sandra Goetze, Heinrich Leonhardt, 2007, Journal of cellular biochemistry.

Dnmt1 Expression in Pre- and Postimplantation Embryogenesis and the Maintenance of IAP Silencing

R. Jaenisch, H. Leonhardt, A. Meissner, 2004, Molecular and Cellular Biology.

Maintenance of IAP Silencing Postimplantation Embryogenesis and the Dnmt 1 Expression in Pre-and

R. Jaenisch, H. Leonhardt, A. Meissner, 2004 .

Developmental differences in genome replication program and origin activation

Corella S. Casas-Delucchi, Vadim O. Chagin, H. Leonhardt, 2020, Nucleic acids research.

Different Binding Properties and Function of CXXC Zinc Finger Domains in Dnmt1 and Tet1

Johannes Söding, Heinrich Leonhardt, Weihua Qin, 2011, PloS one.

Myb-binding Protein 1a (Mybbp1a) Regulates Levels and Processing of Pre-ribosomal RNA*

H. Leonhardt, G. Längst, L. Schermelleh, 2012, The Journal of Biological Chemistry.

DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters.

Heinrich Leonhardt, Richard Ankerhold, M Cristina Cardoso, 2002, Molecular cell.

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation

L. Peichl, H. Blum, H. Leonhardt, 2013, Cell.

Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML

Lucas E. Wange, W. Hiddemann, K. Metzeler, 2021, Scientific Reports.

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

H. Leonhardt, V. Hornung, D. Kostrewa, 2017, Nature.

Phosphorylation of TET Proteins Is Regulated via O-GlcNAcylation by the O-Linked N-Acetylglucosamine Transferase (OGT)*

E. Kremmer, H. Leonhardt, Nagarjuna Nagaraj, 2015, The Journal of Biological Chemistry.

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

C. Plass, C. Buske, H. Leonhardt, 2018, Genome Biology.

Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise

I. Hellmann, H. Leonhardt, M. C. Cardoso, 2016, Nucleic acids research.

Distribution of DNA replication proteins in Drosophila cells

H. Leonhardt, M. C. Cardoso, H. Easwaran, 2007, BMC Cell Biology.

Mapping and Use of a Sequence that Targets DNA Ligase I to Sites of DNA Replication In Vivo

H. Leonhardt, H. Rahn, M. C. Cardoso, 1997, The Journal of cell biology.

Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen

H. Leonhardt, M. C. Cardoso, M. Savio, 2006, Journal of Cell Science.

Analysis of centriole elimination during C. elegans oogenesis

G. Knott, P. Gönczy, H. Leonhardt, 2012, Development.

Epiblast morphogenesis is controlled by selective mRNA decay triggered by LIN28A relocation

J. Ule, N. Luscombe, H. Leonhardt, 2021, bioRxiv.

Visualization and characterization of RNA–protein interactions in living cells

H. Leonhardt, M. C. Cardoso, Ningjun Duan, 2021, Nucleic acids research.

Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways

H. Leonhardt, Daniela Meilinger, G. Pichler, 2011, Journal of cellular biochemistry.

FUS-dependent liquid–liquid phase separation is important for DNA repair initiation

H. Leonhardt, M. C. Cardoso, O. Mühlemann, 2021, The Journal of cell biology.

Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells.

Martha Smets, H. Leonhardt, S. Bultmann, 2017, Journal of molecular biology.

Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells

H. Leonhardt, Daniela Meilinger, S. Bultmann, 2009, EMBO reports.

recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen

H. Leonhardt, M. C. Cardoso, M. Savio, 2006 .

Characterization of H 3 K 56 me 3 , a novel histone core modification

H. Leonhardt, K. Jung, D. Eick, 2014 .

XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions

Heinrich Leonhardt, H. Leonhardt, O. Mortusewicz, 2007, BMC Molecular Biology.

Quantitative 3D structured illumination microscopy of nuclear structures

Atsushi Matsuda, Justin Demmerle, Felix Kraus, 2017, Nature Protocols.

Modulation of protein properties in living cells using nanobodies

Corella S. Casas-Delucchi, S. Muyldermans, H. Leonhardt, 2010, Nature Structural &Molecular Biology.

Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering.

H. Leonhardt, C. Stewart, I. Solovei, 2017, Differentiation; research in biological diversity.

Identification of the elementary structural units of the DNA damage response

M. Durante, H. Leonhardt, M. C. Cardoso, 2017, Nature Communications.

Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5–hydroxymethylcytosine

H. Leonhardt, A. Szwagierczak, A. Brachmann, 2011, Nucleic acids research.

Functional links between nuclear structure, gene expression, DNA replication, and methylation.

H. Leonhardt, H. Rahn, M. C. Cardoso, 1999, Critical reviews in eukaryotic gene expression.

DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

Martha Smets, H. Leonhardt, A. Imhof, 2015, Cell Research.

MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid–liquid phase separation and restricted by DNA methylation

H. Leonhardt, M. C. Cardoso, T. Meckel, 2022, Nucleus.

Structure, function and dynamics of nuclear subcompartments.

H. Leonhardt, M. C. Cardoso, Robert M Martin, 2012, Current opinion in cell biology.

Regulation of DNA methyltransferase 1 by interactions and modifications

H. Leonhardt, G. Pichler, Weihua Qin, 2011, Nucleus.

Probing Intranuclear Environments at the Single-Molecule Level

H. Leonhardt, M. C. Cardoso, V. Buschmann, 2007, Biophysical journal.

Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase.

Heinrich Leonhardt, M Cristina Cardoso, Dominik Schumacher, 2015, Angewandte Chemie.

Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system

Heinrich Leonhardt, Yolanda Markaki, H. Leonhardt, 2014, Nucleus.

Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA

J. Hackermüller, U. Dianzani, H. Leonhardt, 2018, Nature Communications.

Replication‐independent chromatin loading of Dnmt1 during G2 and M phases

H. Leonhardt, L. Schermelleh, H. Easwaran, 2004, EMBO reports.

Systematic analysis of the binding behaviour of UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads

H. Leonhardt, M. C. Cardoso, A. Szwagierczak, 2020, PloS one.

Heterochromatin organization and phase separation

H. Leonhardt, M. C. Cardoso, Weihua Qin, 2023, Nucleus.

CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin

G. Schotta, H. Leonhardt, S. Diekmann, 2012, Nucleus.

Determination of local chromatin composition by CasID

H. Leonhardt, F. Herzog, Pascaline Rombaut, 2016, Nucleus.

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1

Marco Y. Hein, M. Mann, H. Hermeking, 2016, Proceedings of the National Academy of Sciences.

Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells

H. Leonhardt, C. Josenhans, M. Griffioen, 2020, Frontiers in Immunology.

Trapped in action: direct visualization of DNA methyltransferase activity in living cells

Heinrich Leonhardt, Lothar Schermelleh, M Cristina Cardoso, 2005, Nature Methods.

Role for hACF1 in the G2/M damage checkpoint

H. Leonhardt, A. Friedl, P. Becker, 2011, Nucleic acids research.

Probing protein ubiquitination in live cells

H. Leonhardt, M. C. Cardoso, A. Imhof, 2022, bioRxiv.

The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation

H. Leonhardt, R. Hilgenfeld, A. von Brunn, 2021, The EMBO journal.

Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation

H. Aburatani, H. Leonhardt, Akinori Endo, 2020, Nature Communications.

Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair

H. Leonhardt, M. C. Cardoso, A. Rapp, 2019, Nucleus.

The CENP-T C-Terminus Is Exclusively Proximal to H3.1 and not to H3.2 or H3.3

H. Leonhardt, S. Diekmann, A. Hofmeister, 2015, International journal of molecular sciences.

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation

H. Leonhardt, Christina Bauer, U. Müller, 2014, Nucleic acids research.

A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle

K. Sullivan, H. Leonhardt, M. C. Cardoso, 2014, Open Biology.

Visualization and targeted disruption of protein interactions in living cells

H. Leonhardt, M. C. Cardoso, H. D. Herce, 2013, Nature Communications.

The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization.

H. Leonhardt, Monica Mantri, L. Schermelleh, 2013, The Biochemical journal.

A bacterial-two-hybrid selection system for one-step isolation of intracellularly functional Nanobodies.

S. Muyldermans, K. Hertogs, H. Leonhardt, 2012, Archives of biochemistry and biophysics.

Step-Wise Assembly, Maturation and Dynamic Behavior of the Human CENP-P/O/R/Q/U Kinetochore Sub-Complex

H. Leonhardt, M. C. Cardoso, P. Meraldi, 2012, PloS one.

The fluorescent two-hybrid (F2H) assay for direct analysis of protein-protein interactions in living cells.

H. Leonhardt, Kourosh Zolghadr, U. Rothbauer, 2012, Methods in molecular biology.

Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain

H. Leonhardt, G. Längst, Max Felle, 2009, Journal of cellular biochemistry.

A Fluorescent Two-hybrid Assay for Direct Visualization of Protein Interactions in Living Cells*S

E. Wanker, H. Goehler, H. Leonhardt, 2008, Molecular & Cellular Proteomics.

Locus-Specific Chromatin Proteome Revealed by Mass Spectrometry-Based CasID.

H. Leonhardt, M. Bartoschek, Enes Ugur, 2020, Methods in molecular biology.

Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells

Heinrich Leonhardt, H. Leonhardt, V. Schreiber, 2007, Nucleic acids research.

Differential recruitment of DNA Ligase I and III to DNA repair sites

H. Leonhardt, M. C. Cardoso, U. Rothbauer, 2006, Nucleic Acids Research.

Super-resolution in situ analysis of active ribosomal DNA chromatin organization in the nucleolus

H. Leonhardt, G. Längst, L. Schermelleh, 2020, Scientific Reports.

DNA methylation, nuclear structure, gene expression and cancer

H. Leonhardt, M. Cardoso, 2000, Journal of cellular biochemistry. Supplement.

Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers

H. Leonhardt, T. Lahaye, S. Bultmann, 2012, Nucleic acids research.

Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma.

W. Klapper, R. Kridel, C. Steidl, 2020, Cell reports.

Roquin Suppresses the PI3K‐mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells

Joao C. Guimaraes, M. Zavolan, H. Leonhardt, 2017, Immunity.

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells

E. Kremmer, H. Leonhardt, G. Längst, 2007, The Journal of cell biology.

MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos

H. Leonhardt, R. Meehan, B. Shorning, 2009, Development.

MBD 4 and MLH 1 are required for apoptotic induction in xDNMT 1-depleted embryos

H. Leonhardt, R. Meehan, B. Shorning, 2009 .

A modular open platform for systematic functional studies under physiological conditions

E. Kremmer, Martha Smets, H. Leonhardt, 2015, Nucleic acids research.

Interactions within the mammalian DNA methyltransferase family

H. Leonhardt, A. Ehrenhofer-Murray, J. Margot, 2003, BMC Molecular Biology.

Visualization of Genomic Loci in Living Cells with a Fluorescent CRISPR/Cas9 System.

H. Leonhardt, Y. Markaki, Tobias Anton, 2016, Methods in molecular biology.

DNA Methyltransferase Is Actively Retained in the Cytoplasm during Early Development

H. Leonhardt, M. C. Cardoso, 1999, The Journal of cell biology.

The PHD domain of Np95 (mUHRF1) is involved in large-scale reorganization of pericentromeric heterochromatin.

H. Leonhardt, S. Cogliati, L. Brino, 2008, Molecular biology of the cell.

Construction of a shuttle vector for inducible gene expression in Escherichia coli and Bacillus subtilis.

H. Leonhardt, J. Alonso, 1988, Journal of general microbiology.

Nanobodies: Chemical Functionalization Strategies and Intracellular Applications

Anselm F. L. Schneider, H. Leonhardt, C. Hackenberger, 2018, Angewandte Chemie.

Fluorescent protein specific Nanotraps to study protein-protein interactions and histone-tail peptide binding.

H. Leonhardt, G. Pichler, U. Rothbauer, 2012, Methods in molecular biology.

Novel antibody derivatives for proteome and high-content analysis

H. Leonhardt, Kourosh Zolghadr, U. Rothbauer, 2010, Analytical and bioanalytical chemistry.

Expression of an alternative Dnmt1 isoform during muscle differentiation.

H. Leonhardt, M. C. Cardoso, I. Grunewald, 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution

L. Peichl, A. Bird, H. Leonhardt, 2014, Epigenetics & Chromatin.

PCNA acts as a stationary loading platform for transiently interacting Okazaki fragment maturation proteins

H. Leonhardt, A. Sporbert, M. C. Cardoso, 2005, Nucleic acids research.

Regulation of DNA methyltransferase 1.

H. Leonhardt, L. Schermelleh, Kourosh Zolghadr, 2006, Advances in enzyme regulation.

Structure and function of the mouse DNA methyltransferase gene: Dnmt1 shows a tripartite structure.

R. Roberts, H. Leonhardt, M. C. Cardoso, 2000, Journal of molecular biology.

Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans

A. Feuchtinger, H. Leonhardt, S. Schneider, 2019, Journal of Cell Science.

Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans

A. Feuchtinger, H. Leonhardt, H. Zischka, 2019 .

Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure*

H. Leonhardt, M. C. Cardoso, V. Schreiber, 2016, The Journal of Biological Chemistry.

Measurement of replication structures at the nanometer scale using super-resolution light microscopy

U. Birk, H. Leonhardt, M. C. Cardoso, 2009, Nucleic acids research.

Cell Cycle Markers for Live Cell Analyses

Heinrich Leonhardt, M Cristina Cardoso, H. Leonhardt, 2005, Cell cycle.

Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin

Corella S. Casas-Delucchi, H. Leonhardt, M. C. Cardoso, 2011, Nucleic acids research.

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells.

Anselm F. L. Schneider, H. Leonhardt, M. C. Cardoso, 2017, Nature chemistry.

Premier Lecture Series

H. Leonhardt, A. Bolzer, I. Solovei, 2005, Cellular Oncology : the Official Journal of the International Society for Cellular Oncology.

Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency

Martha Smets, H. Leonhardt, M. C. Cardoso, 2021, Nucleic acids research.

HP1β carries an acidic linker domain and requires H3K9me3 for phase separation

H. Leonhardt, M. C. Cardoso, J. Ryan, 2021, Nucleus.

Targeting and tracing of specific DNA sequences with dTALEs in living cells

Heinrich Leonhardt, Irina Solovei, H. Leonhardt, 2013, Nucleic acids research.

4D Visualization of replication foci in mammalian cells corresponding to individual replicons

Corella S. Casas-Delucchi, A Bensimon, H. Leonhardt, 2016, Nature Communications.

Replisome loading reduces chromatin motion independent of DNA synthesis

D. Loerke, H. Leonhardt, M. C. Cardoso, 2023, bioRxiv.

Regulation and spatial organization of PCNA in Trypanosoma brucei.

H. Leonhardt, A. Maiser, C. Janzen, 2012, Biochemical and biophysical research communications.

Intranuclear targeting of DNA replication factors

H. Leonhardt, H. Rahn, M. Cardoso, 1998, Journal of cellular biochemistry.

Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites

H. Leonhardt, M. C. Cardoso, M. Meisterernst, 2008, The Journal of cell biology.

Physical and biochemical characterization of recombination-dependent synthesis of linear plasmid multimers in Bacillus subtilis.

H. Leonhardt, J. Alonso, R. Lurz, 1991, Nucleic acids research.

Identification and Characterization of Novel Smoothelin Isoforms in Vascular Smooth Muscle

H. Leonhardt, M. C. Cardoso, Christina Quensel, 2001, Journal of Vascular Research.

Discontinuous movement of mRNP particles in nucleoplasmic regions devoid of chromatin

H. Leonhardt, U. Kubitscheck, B. Daneholt, 2008, Proceedings of the National Academy of Sciences.

A unified multi-kingdom Golden Gate cloning platform

H. Leonhardt, M. Parniske, M. Boshart, 2019, Scientific Reports.

Heterochromatin drives compartmentalization of inverted and conventional nuclei

L. Mirny, J. Dekker, H. Leonhardt, 2019, Nature.

Heterochromatin drives organization of conventional and inverted nuclei

L. Mirny, J. Dekker, H. Leonhardt, 2018, bioRxiv.

Parameters affecting plasmid stability in Bacillus subtilis.

H. Leonhardt, J. Alonso, 1991, Gene.

A novel isoform of the smooth muscle cell differentiation marker smoothelin

H. Leonhardt, M. C. Cardoso, R. Dietz, 1999, Journal of Molecular Medicine.

Current Status: Site-Specific Antibody Drug Conjugates

H. Leonhardt, C. Hackenberger, J. Helma, 2016, Journal of Clinical Immunology.

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms

H. Leonhardt, V. Schreiber, O. Mortusewicz, 2011, Nucleic acids research.

Characterization of the sebocyte lipid droplet proteome reveals novel potential regulators of sebaceous lipogenesis.

H. Leonhardt, U. Müller, C. Zouboulis, 2015, Experimental cell research.

Cristae-dependent quality control of the mitochondrial genome

H. Leonhardt, P. Walter, Christof Osman, 2021, Science advances.

Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesis.

K. Metzeler, H. Leonhardt, Anne-Kathrin Garz, 2018, Blood advances.

Magnetosome Expression of Functional Camelid Antibody Fragments (Nanobodies) in Magnetospirillum gryphiswaldense

D. Schüler, H. Leonhardt, U. Rothbauer, 2011, Applied and Environmental Microbiology.

Tunable light and drug induced depletion of target proteins

H. Leonhardt, M. Bartoschek, B. Conradt, 2020, Nature Communications.

Parallel Force Assay for Protein-Protein Interactions

H. Gaub, H. Leonhardt, Diana A Pippig, 2014, PloS one.

Direct and Dynamic Detection of HIV-1 in Living Cells

H. Leonhardt, H. Kräusslich, U. Rothbauer, 2012, PloS one.

Top-down de Novo protein sequencing of a 13.6 kDa camelid single heavy chain antibody by matrix-assisted laser desorption ionization-time-of-flight/time-of-flight mass spectrometry.

Bettina Warscheid, Heinrich Leonhardt, Anja Resemann, 2010, Analytical chemistry.

Controlling The Mobility Of Oligonucleotides In The Nanochannels Of Mesoporous Silica

H. Leonhardt, T. Bein, C. Bräuchle, 2012 .

Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase

H. Leonhardt, J. Waschke, N. Schlegel, 2017, Scientific Reports.

Generation and characterization of a rat monoclonal antibody specific for PCNA.

E. Kremmer, H. Leonhardt, M. C. Cardoso, 2008, Hybridoma.

Epigenetics of eu- and heterochromatin in inverted and conventional nuclei from mouse retina

G. Schotta, H. Leonhardt, H. Kimura, 2013, Chromosome Research.

Reliable detection of epigenetic histone marks and nuclear proteins in tissue cryosections

H. Leonhardt, H. Kimura, I. Solovei, 2012, Chromosome Research.

Energy profile of nanobody–GFP complex under force

H. Gaub, H. Leonhardt, Philip M. D. Severin, 2015, Physical biology.

Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters

Volker J Schmid, J. Stamatoyannopoulos, I. Hellmann, 2017, Epigenetics & Chromatin.

Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation

M. Mann, H. Leonhardt, E. Bernstein, 2017, The EMBO journal.

Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network

H. Leonhardt, B. Habermann, D. Lamb, 2016, The Journal of cell biology.

CRISPR‐assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes

H. Leonhardt, Y. Yarden, S. Bultmann, 2017, The FEBS journal.

Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA

J. Hackermüller, U. Dianzani, H. Leonhardt, 2018, Nature Communications.

EGFR/ERBB receptors differentially modulate sebaceous lipogenesis

H. Leonhardt, E. Camera, M. Ludovici, 2015, FEBS letters.

An Intracellular Nanotrap Redirects Proteins and Organelles in Live Bacteria

D. Schüler, H. Leonhardt, U. Rothbauer, 2015, mBio.

Identification and characterization of two novel primate-specific histone H 3 variants , H 3 . X and H 3 . Y

E. Kremmer, H. Leonhardt, R. Merkl, 2022 .

Generation and characterization of a rat monoclonal antibody specific for multiple red fluorescent proteins.

E. Kremmer, H. Leonhardt, M. C. Cardoso, 2008, Hybridoma.

Diffusion and binding properties investigated by Fluorescence Correlation Spectroscopy (FCS).

H. Leonhardt, M. C. Cardoso, V. Buschmann, 2005, Current pharmaceutical biotechnology.

Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML

H. Leonhardt, T. Straub, C. Seitz, 2023, Leukemia.

Replisome loading reduces chromatin motion independent of DNA synthesis

D. Loerke, H. Leonhardt, M. C. Cardoso, 2023, bioRxiv.

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

C. Plass, C. Buske, H. Leonhardt, 2018, Genome Biology.

Functional analysis of the leading strand replication origin of plasmid pUB110 in Bacillus subtilis.

H. Leonhardt, J. Alonso, C. A. Stiege, 1988, Nucleic acids research.

Engineering antibodies and proteins for molecular in vivo imaging.

H. Leonhardt, U. Rothbauer, Tina Romer, 2011, Current opinion in biotechnology.

Tunable light and drug induced depletion of target proteins

H. Leonhardt, M. Bartoschek, B. Conradt, 2020, Nature Communications.

Restriction of AID activity and somatic hypermutation by PARP-1

B. Jungnickel, H. Leonhardt, T. Helleday, 2019, Nucleic acids research.

A unified multi-kingdom Golden Gate cloning platform

Heinrich Leonhardt, Michael Boshart, Joel Ryan, 2019, Scientific Reports.

Nanobodys: Strategien zur chemischen Funktionalisierung und intrazelluläre Anwendungen

Anselm F. L. Schneider, H. Leonhardt, C. Hackenberger, 2018 .

Nanobodys: Strategien zur chemischen Funktionalisierung und intrazelluläre Anwendungen

Christian P. R. Hackenberger, Dominik Schumacher, Jonas Helma, 2018 .

Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy

M. Gustafsson, D. Agard, J. Sedat, 2008, Science.

Dynamics of DNA Replication Factories in Living Cells

H. Leonhardt, H. Rahn, P. Weinzierl, 2000, The Journal of cell biology.

EGFR/ERBB receptors differentially modulate sebaceous lipogenesis

H. Leonhardt, E. Camera, M. Ludovici, 2015, FEBS letters.

Diurnality and Nocturnality in Primates: An Analysis from the Rod Photoreceptor Nuclei Perspective

L. Peichl, A. Hendrickson, H. Leonhardt, 2014, Evolutionary Biology.

Energy profile of nanobody–GFP complex under force

H. Gaub, H. Leonhardt, Philip M. D. Severin, 2015, Physical biology.

A mutagenesis strategy combining systematic alanine scanning with larger mutations to study protein interactions.

H. Leonhardt, Fabio Spada, K. Fellinger, 2008, Analytical biochemistry.

Tyrosin Kinase Inhibition Restores the Membrane Localization of FLT3-ITD

H. Leonhardt, B. Vick, P. Greif, 2015 .

XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions

H. Leonhardt, O. Mortusewicz, 2007, BMC Molecular Biology.

DNA Methyltransferase Is Actively Retained in the Cytoplasm during Early Development

H. Leonhardt, M. C. Cardoso, 1999, The Journal of cell biology.

Small chromosomal regions position themselves autonomously according to their chromatin class.

P. Marynen, Parveen Kumar, T. Voet, 2017, Genome research.

Visualization of Genomic Loci in Living Cells with a Fluorescent CRISPR/Cas9 System.

H. Leonhardt, Tobias Anton, Yolanda Markaki, 2016, Methods in molecular biology.

An Unexpected Link Between Energy Metabolism, Calcium, Chromatin Condensation and Cell Cycle

Heinrich Leonhardt, M Cristina Cardoso, H. Leonhardt, 2007, Cell cycle.

The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes

H. Blum, H. Leonhardt, I. Solovei, 2023, bioRxiv.