C. Kiel

发表

Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes.

D. Case, H. Gohlke, C. Kiel, 2003, Journal of molecular biology.

Structures in systems biology.

C. Kiel, P. Beltrão, Luis Serrano, 2007, Current opinion in structural biology.

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

Gabriëlle H S Buitendijk, Alan M. Kwong, R. T. Smith, 2020, Scientific Reports.

Cell Type–Specific Importance of Ras–c-Raf Complex Association Rate Constants for MAPK Signaling

Christina Kiel, C. Kiel, Luis Serrano, 2009, Science Signaling.

Interaction Dynamics Determine Signaling and Output Pathway Responses.

E. Klipp, C. Kiel, L. Serrano, 2017, Cell reports.

Systems level expression correlation of Ras GTPase regulators

C. Kiel, N. Blüthgen, Luis Serrano, 2018, Cell Communication and Signaling.

Engineering Signal Transduction Pathways

L. Serrano, C. Kiel, E. Yus, 2010, Cell.

A Comprehensive View of the β-Arrestinome

Martin H. Schaefer, Luis Serrano, Anne Poupon, 2017, Front. Endocrinol..

Complexities in Quantitative Systems Analysis of Signaling Networks

L. Serrano, C. Kiel, 2014 .

Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration.

Peter Nürnberg, Steffen Schmitz-Valckenberg, Christina Kiel, 2019, JAMA ophthalmology.

Analyzing protein interaction networks using structural information.

Christina Kiel, Pedro Beltrao, C. Kiel, 2008, Annual review of biochemistry.

Structural data in synthetic biology approaches for studying general design principles of cellular signaling networks.

Christina Kiel, C. Kiel, Luis Serrano, 2012, Structure.

Recognizing and defining true Ras binding domains II: in silico prediction based on homology modelling and energy calculations.

Joost Schymkowitz, Frederic Rousseau, Jesper Ferkinghoff-Borg, 2005, Journal of molecular biology.

The ubiquitin domain superfold: structure-based sequence alignments and characterization of binding epitopes.

Christina Kiel, C. Kiel, Luis Serrano, 2006, Journal of molecular biology.

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

Nicola B Quinn, A. Peters, K. Stark, 2020, BMC Medical Genomics.

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

Nicola B Quinn, A. Peters, K. Stark, 2019, bioRxiv.

The yin–yang of kinase activation and unfolding explains the peculiarity of Val600 in the activation segment of BRAF

C. Kiel, Luis Serrano, H. Benisty, 2016, eLife.

The Impact of Structural Proteomics on the Prediction of Protein– Protein Interactions

C. Kiel, Luis Serrano, 2008 .

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Oleksii S. Rukhlenko, B. Kholodenko, I. Jurisica, 2020, Nature Communications.

Vitronectin and Its Interaction with PAI-1 Suggests a Functional Link to Vascular Changes in AMD Pathobiology

C. Kiel, Tobias Strunz, U. Friedrich, 2022, Cells.

Advancing Precision Vaccinology by Molecular and Genomic Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 in Germany, 2021

C. Kiel, W. Haas, S. Fuchs, 2022, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Edinburgh Research Explorer Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D in

Oleksii S. Rukhlenko, B. Kholodenko, I. Jurisica, 2020 .

Article Pleiotropic locus 15q

C. Kiel, F. Grassmann, Tobias Strunz, 2020 .

Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells

C. Kiel, S. Catozzi, K. Wynne, 2022, bioRxiv.

Structure-based prediction of Ras-effector binding affinities and design of ‘branchegetic’ interface mutations

C. Kiel, Philipp Junk, 2022, bioRxiv.

Tuneable endogenous mammalian target complementation via multiplexed plasmid-based recombineering

C. Kiel, Luis Serrano, H. Benisty, 2015, Scientific Reports.

Structure-based prediction of Ras-effector binding affinities and design of ‘branchegetic’ interface mutations

C. Kiel, Philipp Junk, 2022, bioRxiv.

Structural and functional protein network analyses predict novel signaling functions for rhodopsin

Andrew Chatr-aryamontri, Gianni Cesareni, Marius Ueffing, 2011, Molecular systems biology.

Disease–Gene Networks of Skin Pigmentation Disorders and Reconstruction of Protein–Protein Interaction Networks

C. Kiel, M. Halasz, K. Wynne, 2022, Bioengineering.

Network pharmacology: curing causal mechanisms instead of treating symptoms.

Harald H. H. W. Schmidt, C. Kiel, M. List, 2021, Trends in pharmacological sciences.

Association Rate Constants of Ras-Effector Interactions Are Evolutionarily Conserved

Luis Serrano, Christina Kiel, Dorothee Aydin, 2008, PLoS Comput. Biol..

Combining Gene–Disease Associations with Single-Cell Gene Expression Data Provides Anatomy-Specific Subnetworks in Age-Related Macular Degeneration

C. Kiel, P. Luthert, 2020, Network and systems medicine.

Cell Adhesion Molecules in Normal Skin and Melanoma

C. Kiel, Cian D'Arcy, 2021, Biomolecules.

Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa

C. Kiel, P. Rakoczy, M. Wikstrom, 2014, Molecular vision.

Analysis of disease-linked rhodopsin mutations based on structure, function, and protein stability calculations.

François Stricher, Richard McKeone, Christina Kiel, 2011, Journal of molecular biology.

Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP.

C. Kiel, M. Ahmadian, K. Scheffzek, 2003, Journal of molecular biology.

Phylogeographic and evolutionary history analyses of the warty crab Eriphia verrucosa (Decapoda, Brachyura, Eriphiidae) unveil genetic imprints of a late Pleistocene vicariant event across the Gibraltar Strait, erased by postglacial expansion and admixture among refugial lineages

C. Kiel, C. Schubart, T. Deli, 2019, BMC Evolutionary Biology.

Signaling pathways in intestinal homeostasis and colorectal cancer: KRAS at centre stage

C. Kiel, Camille Ternet, 2021, Cell communication and signaling : CCS.

A RAC-GEF network critical for early intestinal tumourigenesis

C. Kiel, M. Drysdale, E. McGhee, 2021, Nature communications.

Y chromosome mosaicism is associated with age-related macular degeneration

D. Weeks, A. D. den Hollander, C. Kiel, 2018, European Journal of Human Genetics.

Whole-cell energy modeling reveals quantitative changes of predicted energy flows in RAS mutant cancer cell lines

C. Kiel, P. Luthert, S. Catozzi, 2023, iScience.

Structure‐energy‐based predictions and network modelling of RASopathy and cancer missense mutations

Christina Kiel, C. Kiel, Luis Serrano, 2014, Molecular systems biology.

Recognizing and defining true Ras binding domains I: biochemical analysis.

Christina Kiel, C. Kiel, Luis Serrano, 2005, Journal of molecular biology.

The Ins and Outs of RAS Effector Complexes

C. Kiel, W. Kolch, D. Matallanas, 2021, Biomolecules.

Assigning Co-Regulated Human Genes and Regulatory Gene Clusters

C. Kiel, Tobias Strunz, M. Kellner, 2021, Cells.

Learning from Fifteen Years of Genome-Wide Association Studies in Age-Related Macular Degeneration

C. Kiel, Tobias Strunz, B. Weber, 2020, Cells.

Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD)

C. Kiel, F. Grassmann, Tobias Strunz, 2020, Cells.

Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits

Gabriëlle H S Buitendijk, Alan M. Kwong, R. T. Smith, 2017, Genome Medicine.

Protein Conservation and Variation Suggest Mechanisms of Cell Type-Specific Modulation of Signaling Pathways

Martin H. Schaefer, Luis Serrano, Jae-Seong Yang, 2014, PLoS Comput. Biol..

Analysis of Ras-effector interaction competition in large intestine and colorectal cancer context

C. Kiel, P. Luthert, S. Catozzi, 2020, Small GTPases.

Predicted ‘wiring landscape’ of Ras-effector interactions in 29 human tissues

C. Kiel, S. Catozzi, M. Halasz, 2021, npj Systems Biology and Applications.

Improved Binding of Raf to Ras·GDP Is Correlated with Biological Activity*

H. Kalbitzer, C. Kiel, G. Schreiber, 2009, The Journal of Biological Chemistry.

Simple and complex retinal dystrophies are associated with profoundly different disease networks

Christina Kiel, Philip J. Luthert, C. Kiel, 2017, Scientific Reports.

Shaping dots and lines: Adding modularity into protein interaction networks using structural information

Christina Kiel, Luis Serrano, Anne Campagna, 2008, FEBS letters.

Dissecting the Calcium-Induced Differentiation of Human Primary Keratinocytes Stem Cells by Integrative and Structural Network Analyses

Luis Serrano, Ben Lehner, Jae-Seong Yang, 2015, PLoS Comput. Biol..

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.

M. Vidal, C. Kiel, P. Lehner, 2009, Genome research.

Protein design in biological networks: from manipulating the input to modifying the output.

Luis Serrano, Christina Kiel, Almer M Van der Sloot, 2009, Protein engineering, design & selection : PEDS.

A Circulating MicroRNA Profile in a Laser-Induced Mouse Model of Choroidal Neovascularization

C. Kiel, F. Grassmann, T. Langmann, 2020, International journal of molecular sciences.

VarQ: A Tool for the Structural and Functional Analysis of Human Protein Variants

Luis Serrano, Javier Delgado, Leandro G. Radusky, 2018, Front. Genet..

Integration of Protein Abundance and Structure Data Reveals Competition in the ErbB Signaling Network

Erik Verschueren, Jae-Seong Yang, Christina Kiel, 2013, Science Signaling.

Quantification of ErbB network proteins in three cell types using complementary approaches identifies cell-general and cell-type-specific signaling proteins.

Ruedi Aebersold, Eduard Sabidó, Christina Kiel, 2014, Journal of proteome research.

In vitro modeling of the complex retinal condition age-related macular degeneration

C. Kiel, F. Grassmann, C. Brandl, 2022, Journal of Translational Genetics and Genomics.

Wide-field optical coherence tomography in ABCA4-associated inherited retinal dystrophies

C. Kiel, H. Stöhr, U. Kellner, 2021, Journal of Translational Genetics and Genomics.

interaction network Analysis of the human E 2 ubiquitin conjugating enzyme protein

M. Vidal, C. Kiel, P. Lehner, 2009 .

Analysis of the human E 2 ubiquitin conjugating enzyme protein interaction network

M. Vidal, C. Kiel, P. Lehner, 2009 .

The Activation of RalGDS Can Be Achieved Independently of Its Ras Binding Domain

C. Kiel, C. Herrmann, P. Herter, 2002, The Journal of Biological Chemistry.

Challenges ahead in signal transduction: MAPK as an example.

Christina Kiel, Luis Serrano, L. Serrano, 2012, Current opinion in biotechnology.

Pleiotropic Effects of Risk Factors in Age-Related Macular Degeneration and Seemingly Unrelated Complex Diseases.

C. Kiel, F. Grassmann, B. Weber, 2018, Advances in experimental medicine and biology.

An Eye on Age-Related Macular Degeneration: The Role of MicroRNAs in Disease Pathology

C. Kiel, F. Grassmann, B. Weber, 2016, Molecular Diagnosis & Therapy.

From oncogenic mutation to dynamic code

C. Kiel, W. Kolch, 2018, Science.

Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex.

G Schreiber, C. Kiel, G. Schreiber, 2004, Proceedings of the National Academy of Sciences of the United States of America.

An Eye on Age-Related Macular Degeneration: The Role of MicroRNAs in Disease Pathology

C. Kiel, F. Grassmann, B. Weber, 2016, Molecular Diagnosis & Therapy.

Reconstruction and analysis of a large-scale binary Ras-effector signaling network

C. Kiel, S. Catozzi, K. Wynne, 2022, Cell communication and signaling : CCS.

Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain

C. Kiel, M. Ueffing, Mingjie Zhang, 2014, Molecular and Cellular Biology.

A genome-wide Ras-effector interaction network.

Christina Kiel, Mathilde Foglierini, Luis Serrano, 2007, Journal of molecular biology.

VarQ: a tool for the structural analysis of Human Protein Variants

Javier Delgado, Leandro G. Radusky, Juan P. Bustamante, 2018, bioRxiv.

A mega-analysis of expression quantitative trait loci in retinal tissue

A. Swaroop, C. Kiel, F. Grassmann, 2020, PLoS genetics.

Epistatic interactions of genetic loci associated with age-related macular degeneration

C. Kiel, Tobias Strunz, B. Weber, 2021, Scientific Reports.

Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration

C. Kiel, Luis Serrano, P. Luthert, 2020, npj Aging and Mechanisms of Disease.

Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration

C. Kiel, Luis Serrano, P. Luthert, 2020, npj Aging and Mechanisms of Disease.

Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits

Gabriëlle H S Buitendijk, Alan M. Kwong, R. T. Smith, 2017, Genome Medicine.

Opportunities and Challenges of Whole-Cell and -Tissue Simulations of the Outer Retina in Health and Disease

C. Kiel, Luis Serrano, P. Luthert, 2018, Annual Review of Biomedical Data Science.

Seed sequence polymorphism rs2168518 and allele-specific target gene regulation of hsa-miR-4513

G. Meister, C. Kiel, F. Grassmann, 2021, Human molecular genetics.

A detailed thermodynamic analysis of ras/effector complex interfaces.

Christina Kiel, Luis Serrano, L. Serrano, 2004, Journal of molecular biology.

Prediction of Ras-effector interactions using position energy matrices

Luis Serrano, Christina Kiel, L. Serrano, 2007, Bioinform..

SnapShot: APC/T Cell Immune Checkpoints

C. Kiel, Scott H. Shrager, 2020, Cell.

Systems level expression correlation of Ras GTPase regulators

C. Kiel, N. Blüthgen, Luis Serrano, 2018, Cell communication and signaling : CCS.

QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration

D. Hernandez, Jayshree Advani, A. Swaroop, 2023, Research square.

Simple and complex retinal dystrophies are associated with profoundly different disease networks

C. Kiel, Luis Serrano, P. Luthert, 2017, Scientific Reports.

SAPIN: A framework for the structural analysis of protein interaction networks

Javier Delgado Blanco, Luis Serrano, Jae-Seong Yang, 2012, Bioinform..

Analysis of context-specific KRAS–effector (sub)complexes in Caco-2 cells

C. Kiel, K. Wynne, J. Heldin, 2023, Life Science Alliance.

C. Kiel, C. Schubart, T. Deli, 2019, BMC Evolutionary Biology.

TAPAS: tools to assist the targeted protein quantification of human alternative splice variants

Luis Serrano, Jae-Seong Yang, Eduard Sabidó, 2014, Bioinform..