J. Otlewski

发表

Predicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases.

S. Anderson, I. Apostol, S. Lu, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Canonical protein inhibitors of serine proteases

J. Otlewski, T. Cierpicki, D. Krowarsch, 2003, Cellular and Molecular Life Sciences CMLS.

Amide proton temperature coefficients as hydrogen bond indicators in proteins

J. Otlewski, T. Cierpicki, 2001, Journal of biomolecular NMR.

Structure-function relationship of serine protease-protein inhibitor interaction.

J Otlewski, M. Jaskólski, J. Otlewski, 2001, Acta biochimica Polonica.

Interscaffolding additivity: binding of P1 variants of bovine pancreatic trypsin inhibitor to four serine proteases.

J Otlewski, J. Otlewski, M. Dadlez, 1999, Journal of molecular biology.

Expression, purification and catalytic activity of Lupinus luteus asparagine beta-amidohydrolase and its Escherichia coli homolog.

M. Jaskólski, D. Bonthron, J. Otlewski, 2004, European journal of biochemistry.

Ultrahigh-resolution structure of a BPTI mutant.

J Otlewski, S. Krzywda, M. Jaskólski, 2001, Acta crystallographica. Section D, Biological crystallography.

Determination of the complete three-dimensional structure of the trypsin inhibitor from squash seeds in aqueous solution by nuclear magnetic resonance and a combination of distance geometry and dynamical simulated annealing.

J Otlewski, T. Holak, J. Otlewski, 1989, Journal of molecular biology.

Design and In Vitro Evaluation of a Cytotoxic Conjugate Based on the Anti-HER2 Affibody Fused to the Fc Fragment of IgG1

J. Otlewski, Alicja M. Sochaj-Gregorczyk, Patryk Ludzia, 2017, International journal of molecular sciences.

A Novel Affibody-Auristatin E Conjugate With a Potent and Selective Activity Against HER2+ Cell Lines

J. Otlewski, Alicja M. Sochaj-Gregorczyk, Anna Serwotka-Suszczak, 2016, Journal of immunotherapy.

High-Yield Site-Specific Conjugation of Fibroblast Growth Factor 1 with Monomethylauristatin E via Cysteine Flanked by Basic Residues.

J. Otlewski, A. Szlachcic, M. Zakrzewska, 2017, Bioconjugate chemistry.

Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors

J. Otlewski, M. Miączyńska, M. Zakrzewska, 2021, Journal of biomedical science.

Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy

J. Otlewski, A. Szlachcic, M. Zakrzewska, 2016, Drug design, development and therapy.

Identification of a peptide antagonist of the FGF1–FGFR1 signaling axis by phage display selection

J. Otlewski, A. Szlachcic, Magdalena Lipok, 2019, FEBS open bio.

Novel peptide recognized by RhoA GTPase.

J. Otlewski, F. Jeleń, A. Oleksy, 2006, Acta biochimica Polonica.

Femtomolar Zn2+ affinity of LIM domain of PDLIM1 protein uncovers crucial contribution of protein-protein interactions to protein stability.

J. Otlewski, A. Krężel, M. Sikorska, 2012, Journal of inorganic biochemistry.

The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications.

J. Otlewski, O. Reiner, Z. Derewenda, 2004, Structure.

Selection and characterization of human antibody fragments specific for psoriasin - a cancer associated protein.

J. Otlewski, S. Wulhfard, D. Neri, 2012, Biochemical and biophysical research communications.

Tyrosine hydrogen-bonding and environmental effects in proteins probed by ultraviolet resonance Raman spectroscopy.

M Laskowski, J Otlewski, J. Otlewski, 1988, Biochemistry.

Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule

J. Otlewski, Aleksandra Sokołowska-Wędzina, Edyta Petters, 2015, International journal of molecular sciences.

Selection of specific interactors from phage display library based on sea lamprey variable lymphocyte receptor sequences.

J. Otlewski, Magdalena Wezner-Ptasińska, 2015, Biochimica et biophysica acta.

Design and characteristics of a stable protein scaffold for specific binding based on variable lymphocyte receptor sequences.

J. Otlewski, D. Krowarsch, Magdalena Wezner-Ptasińska, 2011, Biochimica et biophysica acta.

Instability restricts signaling of multiple fibroblast growth factors

J. Otlewski, J. Damborský, A. Kozubík, 2015, Cellular and Molecular Life Sciences.

The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2021, Molecular medicine.

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

J. Otlewski, M. Miączyńska, M. Zakrzewska, 2020, Molecular oncology.

Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors

J. Otlewski, M. Zakrzewska, D. Krowarsch, 2017, ACS omega.

Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling

J. Otlewski, M. Zakrzewska, E. M. Haugsten, 2019, International journal of molecular sciences.

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2018, International journal of molecular sciences.

A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells

J. Otlewski, D. Krowarsch, F. Jeleń, 2017, International journal of molecular sciences.

FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1

J. Otlewski, A. Szlachcic, Łukasz Opaliński, 2020, Cancers.

Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells

J. Otlewski, A. Corsini, S. Bellosta, 2021, Biology.

FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1

J. Otlewski, A. Szlachcic, M. Zakrzewska, 2018, International journal of molecular sciences.

Inhibition of Six Serine Proteinases of the Human Coagulation System by Mutants of Bovine Pancreatic Trypsin Inhibitor*

J. Otlewski, M. Dadlez, O. Buczek, 2000, The Journal of Biological Chemistry.

Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF

J. Otlewski, Z. Dauter, Z. Derewenda, 2004 .

Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI)

J. Otlewski, O. Buczek, D. Krowarsch, 2002, Protein science : a publication of the Protein Society.

Amino-acid sequences of trypsin inhibitors from watermelon (Citrullus vulgaris) and red bryony (Bryonia dioica) seeds.

J. Otlewski, H. Whatley, T. Wilusz, 1987, Biological chemistry Hoppe-Seyler.

Phage Display Selection of P1 Mutants of BPTI Directed against Five Different Serine Proteinases

J. Otlewski, M. Dadlez, L. Kiczak, 1999, Biological chemistry.

Nucleolin Regulates Phosphorylation and Nuclear Export of Fibroblast Growth Factor 1 (FGF1)

J. Otlewski, M. Zakrzewska, S. Olsnes, 2014, PloS one.

Synthesis, cloning and expression in Escherichia coli of a gene coding for the Met8 → Leu CMTI I — a representative of the squash inhibitors of serine proteinases

J. Otlewski, L. Jaroszewski, A. Bierzyński, 1995, FEBS letters.

Site-specific conjugation of fibroblast growth factor 2 (FGF2) based on incorporation of alkyne-reactive unnatural amino acid.

J. Otlewski, A. Szlachcic, M. Zakrzewska, 2017, Bioorganic & medicinal chemistry.

FGF1 protects FGFR1-overexpressing cancer cells against drugs targeting tubulin polymerization by activating AKT via two independent mechanisms

J. Otlewski, M. Zakrzewska, Martyna Sochacka, 2022, Frontiers in Oncology.

Letter to the Editor: Assignment of 1H, 13C and 15N resonances of the N-terminal microtubule-binding domain of human doublecortin

J. Otlewski, T. Cierpicki, J. Bushweller, 2003, Journal of biomolecular NMR.

Trypsin inhibitors in summer squash (Cucurbita pepo) seeds. Isolation, purification and partial characterization of three inhibitors.

J. Leluk, J. Otlewski, T. Wilusz, 1984, Acta biochimica Polonica.

Preparation and characteristics of trypsin inhibitors from the seeds of squash (Cucurbita maxima) and zucchini (Cucurbita pepo var. Giromontia).

J. Leluk, J. Otlewski, T. Wilusz, 1983, Acta biochimica Polonica.

Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2017, Scientific Reports.

Inhibition of serine proteinases from human blood clotting system by squash inhibitor mutants.

J. Otlewski, Z. Szewczuk, O. Buczek, 2000, Biochimica et biophysica acta.

Structural and energetic determinants of the S1-site specificity in serine proteases.

J. Otlewski, H. Czapinska, 1999, European journal of biochemistry.

Hydrogen bonds in human ubiquitin reflected in temperature coefficients of amide protons.

J. Otlewski, T. Cierpicki, I. Zhukov, 2002, Journal of magnetic resonance.

The refined 2.0 Å X‐ray crystal structure of the complex formed between bovine β‐trypsin and CMTI‐I, a trypsin inhibitor from squash seeds (Cucurbita maxima) Topological similarity of the squash seed inhibitors with the carboxypeptidase A inhibitor from potatoes

J Otlewski, R. Huber, J. Otlewski, 1989, FEBS letters.

Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity.

J. Otlewski, J. Grembecka, J. Potempa, 2006, Journal of medicinal chemistry.

Co-ordination ability towards CuII of the 29-amino acid residue trypsin inhibitor of squash and two of its analogues

J. Otlewski, P. Młynarz, H. Kozłowski, 2001 .

Novel Method for Preparation of Site-Specific, Stoichiometric-Controlled Dual Warhead Conjugate of FGF2 via Dimerization Employing Sortase A-Mediated Ligation.

J. Otlewski, Łukasz Opaliński, M. A. Krzyścik, 2019, Molecular pharmaceutics.

Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action.

Malgorzata Zakrzewska, Jacek Otlewski, J. Otlewski, 2005, Journal of molecular biology.

The squash family of serine proteinase inhibitors. Amino acid sequences and association equilibrium constants of inhibitors from squash, summer squash, zucchini, and cucumber seeds.

J Otlewski, J. Leluk, J. Cook, 1985, Biochemical and biophysical research communications.

Current methods for the synthesis of homogeneous antibody-drug conjugates.

J. Otlewski, Alicja M. Sochaj, K. Swiderska, 2015, Biotechnology advances.

New analogues of Cucurbita maxima trypsin inhibitor III (CMTI III) with simplified structure.

J. Otlewski, U. Ragnarsson, K. Rolka, 1992, Biological chemistry Hoppe-Seyler.

NMR solution structure of Apis mellifera chymotrypsin/cathepsin G inhibitor‐1 (AMCI‐1): Structural similarity with Ascaris protease inhibitors

J. Otlewski, T. Cierpicki, J. Bania, 2000, Protein science : a publication of the Protein Society.

Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.

J. Otlewski, Z. Dauter, D. Sherman, 2002, Structure.

Aptamers: molecules of great potential.

Jacek Otlewski, Filip Radom, J. Otlewski, 2013, Biotechnology advances.

Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions.

J. Otlewski, M. Zakrzewska, J. Sławski, 2020, Cytokine & growth factor reviews.

Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity

J. Otlewski, T. Holak, A. Szlachcic, 2018, International journal of molecular sciences.

Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2019, Cells.

Structure of small G proteins and their regulators.

J Otlewski, J. Otlewski, M. Paduch, 2001, Acta biochimica Polonica.

Single peptide bond hydrolysis/resynthesis in squash inhibitors of serine proteinases. 2. Limited proteolysis of Curcurbita maxima trypsin inhibitor I by pepsin.

J. Otlewski, T. Wilusz, G. Bulaj, 1994, Biochemistry.

The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle.

J. Otlewski, Z. Dauter, Z. Derewenda, 2004, Structure.

PDZ domains - common players in the cell signaling.

Jacek Otlewski, J. Otlewski, K. Śmietana, 2003, Acta biochimica Polonica.

High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer

J. Otlewski, M. Zakrzewska, G. Chodaczek, 2017, Molecular Cancer Research.

High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR 1-overexpressing Lung Cancer Running Title : scFv-Fc for Targeting FGFR 1-positive Lung Cancer Cells

J. Otlewski, G. Chodaczek, Aleksandra Sokołowska-Wędzina, 2017 .

Biophysical properties of the eukaryotic ribosomal stalk.

J. Otlewski, C. Robinson, D. Krokowski, 2010, Biochemistry.

Chemical synthesis of new trypsin, chymotrypsin and elastase inhibitors by amino-acid substitutions in a trypsin inhibitor from squash seeds (CMTI III).

J. Otlewski, T. Wilusz, U. Ragnarsson, 1991, Biological chemistry Hoppe-Seyler.

The squash inhibitor family of serine proteinases.

J Otlewski, J. Otlewski, 1990, Biological chemistry Hoppe-Seyler.

Synthesis of an elastase inhibitor by monosubstitution of arginine-5 with valine at the reactive site in a trypsin inhibitor from squash seeds (CMTI III).

J. Otlewski, T. Wilusz, U. Ragnarsson, 1989, Biological chemistry Hoppe-Seyler.

Monitoring protein cleavage and concurrent disulfide bond assignment using thermospray LC/MS.

J. Otlewski, A. Polanowski, K. Stachowiak, 1990, Peptide research.

Nuclear magnetic resonance solution and X-ray structures of squash trypsin inhibitor exhibit the same conformation of the proteinase binding loop.

R. Huber, T. Holak, J. Otlewski, 1989, Journal of molecular biology.

Galectins as modulators of receptor tyrosine kinases signaling in health and disease.

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2021, Cytokine & growth factor reviews.

FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex

J. Otlewski, M. Zakrzewska, D. Krowarsch, 2022, Cell Communication and Signaling.

Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells

J. Otlewski, M. Zakrzewska, A. Wiedlocha, 2022, Cells.

Identification of new FGF1 binding partners—Implications for its intracellular function

J. Otlewski, M. Zakrzewska, S. Olsnes, 2016, IUBMB life.

ERK-Mediated Phosphorylation of Fibroblast Growth Factor Receptor 1 on Ser777 Inhibits Signaling

J. Otlewski, Yixin Jin, B. Hausott, 2013, Science Signaling.

Longer action means better drug: tuning up protein therapeutics.

Anna Szlachcic, Malgorzata Zakrzewska, Jacek Otlewski, 2011, Biotechnology advances.

Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2017, Scientific Reports.

FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance

J. Otlewski, M. Zakrzewska, K. Sluzalska, 2021, Cancers.

Dissecting the thermodynamics of GAP-RhoA interactions.

J. Otlewski, Z. Derewenda, A. Mateja, 2009, Journal of structural biology.

Expression, purification and crystallization of cysteine-rich human protein muskelin in Escherichia coli.

J. Otlewski, K. Śmietana, A. Kiedzierska, 2008, Protein expression and purification.

Amyloid‐forming peptides selected proteolytically from phage display library

J. Otlewski, K. Kościelska-Kasprzak, 2003, Protein science : a publication of the Protein Society.

Variability of the canonical loop conformations in serine proteinases inhibitors and other proteins

J. Otlewski, W. Apostoluk, 1998, Proteins.

PDZ tandem of human syntenin: crystal structure and functional properties.

Jacek Otlewski, Zbigniew Dauter, David R Cooper, 2003, Structure.

The many faces of protease–protein inhibitor interaction

J. Otlewski, M. Zakrzewska, F. Jeleń, 2005, The EMBO journal.

Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model

J. Otlewski, G. Mælandsmo, M. Zakrzewska, 2021, Biomacromolecules.

Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2018, Journal of clinical medicine.

Structural and energetic aspects of protein-protein recognition.

J. Otlewski, W. Apostoluk, 1997, Acta biochimica Polonica.

Structure of single-disulfide variants of bovine pancreatic trypsin inhibitor (BPTI) as probed by their binding to bovine beta-trypsin.

J. Otlewski, M. Dadlez, I. Krokoszynska, 1998, Journal of molecular biology.

Serine proteinase from Cucurbita ficifolia seeds.

J. Otlewski, T. Wilusz, M. Dryjański, 1990, Acta biochimica Polonica.

The DCX-domain tandems of doublecortin and doublecortin-like kinase

C. Walsh, J. Otlewski, Z. Dauter, 2003, Nature Structural Biology.

Importance of α–helix N–capping motif in stabilization of ββα fold

Jacek Otlewski, J. Otlewski, T. Cierpicki, 2003 .

Importance of (cid:1) -helix N-capping motif in stabilization of (cid:2)(cid:2)(cid:1) fold

J. Otlewski, T. Cierpicki, K. Kościelska-Kasprzak, 2003 .

Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2020, International journal of molecular sciences.

J. Otlewski, K. Śmietana, A. Kiedzierska, 2007, Biochimica et biophysica acta.

Efficient production and purification of extracellular domain of human FGFR-Fc fusion proteins from Chinese hamster ovary cells.

Malgorzata Zakrzewska, Jacek Otlewski, J. Otlewski, 2014, Protein expression and purification.

Bivalent Peptides as Models for Multimeric Targets of PDZ Domains

J. Otlewski, Z. Derewenda, M. Paduch, 2007, Chembiochem : a European journal of chemical biology.

Cyclic and dimeric fibroblast growth factor 2 variants with high biomedical potential.

J. Otlewski, Łukasz Opaliński, M. A. Krzyścik, 2022, International journal of biological macromolecules.

Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers.

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2021, Biomacromolecules.

FGF1 Fusions with the Fc Fragment of IgG1 for the Assembly of GFPpolygons-Mediated Multivalent Complexes Recognizing FGFRs

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2021, Biomolecules.

Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1.

J. Otlewski, M. Zakrzewska, M. A. Krzyścik, 2021, International journal of biological macromolecules.

Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation.

J. Otlewski, A. Szlachcic, M. Zakrzewska, 2021, Journal of visualized experiments : JoVE.

Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1)

J. Otlewski, M. Zakrzewska, M. A. Krzyścik, 2020, Molecular pharmaceutics.

Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2019, Cell Communication and Signaling.

Ligand-induced changes in the conformational stability of bovine trypsinogen and their implications for the protein function.

J. Otlewski, G. Bulaj, 1995, Journal of molecular biology.

High-resolution structure of bovine pancreatic trypsin inhibitor with altered binding loop sequence.

J Otlewski, S. Krzywda, M. Jaskólski, 2000, Journal of molecular biology.

Design, expression and characterization of a highly stable tetratricopeptide-based protein scaffold for phage display application.

J. Otlewski, D. Krowarsch, Edyta Petters, 2013, Acta biochimica Polonica.

Denaturation of free and complexed bovine trypsinogen with the calcium ion, dipeptide Ile-Val and basic pancreatic trypsin inhibitor (Kunitz).

J. Otlewski, G. Bulaj, 1994, European journal of biochemistry.

Review Canonical protein inhibitors of serine proteases

J. Otlewski, T. Cierpicki, D. Krowarsch, 2003 .

NMR structures of two variants of bovine pancreatic trypsin inhibitor (BPTI) reveal unexpected influence of mutations on protein structure and stability.

Jacek Otlewski, J. Otlewski, T. Cierpicki, 2002, Journal of molecular biology.

Analysis of serine proteinase–inhibitor interaction by alanine shaving

Jacek Otlewski, Michał Dadlez, J. Otlewski, 2002, Protein science : a publication of the Protein Society.

Amino‐acid substitutions at the fully exposed P1 site of bovine pancreatic trypsin inhibitor affect its stability

J. Otlewski, D. Krowarsch, 2001, Protein science : a publication of the Protein Society.

Structure-activity relationships for the interaction of bovine pancreatic trypsin inhibitor with an intracellular site on a large conductance Ca(2+)-activated K(+) channel.

J. Otlewski, D. Goldenberg, G. Moss, 2000, Biochemistry.

The crystal structures of the complexes between bovine beta-trypsin and ten P1 variants of BPTI.

J Otlewski, J. Otlewski, R. Helland, 2000, Journal of molecular biology.

High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes.

J. Otlewski, N. Willassen, R. Helland, 1999, Acta crystallographica. Section D, Biological crystallography.

Protein inhibitors of serine proteinases.

J. Otlewski, D. Krowarsch, W. Apostoluk, 1999, Acta biochimica Polonica.

Phage display of proteins.

K Kościelska, L Kiczak, M Kasztura, 1998, Acta biochimica Polonica.

Single peptide bond hydrolysis/resynthesis in squash inhibitors of serine proteinases. 1. Kinetics and thermodynamics of the interaction between squash inhibitors and bovine beta-trypsin.

J Otlewski, J. Otlewski, T Zbyryt, 1994, Biochemistry.

Interaction between squash inhibitors and bovine trypsinogen.

J. Otlewski, T. Zbyryt, 1991, Biological Chemistry Hoppe-Seyler.

Structures of proteins in solution derived from homonuclear three-dimensional NOE-NOE nuclear magnetic resonance spectroscopy. High-resolution structure of squash trypsin inhibitor

J. Otlewski, T. Holak, H. Oschkinat, 1991 .

Inhibition of serine proteinases by squash inhibitors.

J. Otlewski, T. Wilusz, I. Krokoszynska, 1990, Biological chemistry Hoppe-Seyler.

Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin.

J. Otlewski, H. Czapinska, R. Helland, 2004, Journal of molecular biology.

Specificity of human cathepsin G.

J. Otlewski, H. Czapinska, J. Polanowska, 1998, Biochimica et biophysica acta.

Structure of hisactophilin is similar to interleukin-1β and fibroblast growth factor

T. Holak, J. Otlewski, M. Schleicher, 1994, Nature.

Homonuclear three-dimensional NOE-NOE nuclear magnetic resonance/spectra for structure determination of proteins in solution.

T. Holak, J. Otlewski, M. Schleicher, 1992, Journal of Molecular Biology.

A new family of serine proteinase inhibitors from squash seeds

J. Leluk, J. Otlewski, T. Wilusz, 1988 .

The autoinhibitory function of D1 domain of FGFR1 goes beyond the inhibition of ligand binding.

J. Otlewski, M. Zakrzewska, Aleksandra Sokołowska-Wędzina, 2017, The international journal of biochemistry & cell biology.

Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF.

J. Otlewski, Z. Derewenda, M. Purdy, 2004, Acta crystallographica. Section D, Biological crystallography.

Crystal Structure of Vigna radiata Cytokinin-Specific Binding Protein in Complex with Zeatin[OA]

M. Jaskólski, J. Otlewski, Y. Hashimoto, 2006, The Plant Cell Online.

Trypsin specificity as elucidated by LIE calculations, X‐ray structures, and association constant measurements

Jacek Otlewski, B. Brandsdal, J. Otlewski, 2004, Protein science : a publication of the Protein Society.

Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers

J. Otlewski, G. Chodaczek, Aleksandra Sokołowska-Wędzina, 2018, PloS one.

Anti-FGFR1 aptamer-tagged superparamagnetic conjugates for anticancer hyperthermia therapy

Urszula N. Wasko, J. Otlewski, F. Jeleń, 2017, International journal of nanomedicine.

Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants.

J. Otlewski, H. Czapinska, R. Helland, 2004, Journal of molecular biology.

The dimerization mechanism of LIS1 and its implication for proteins containing the LisH motif.

J. Otlewski, T. Cierpicki, Z. Derewenda, 2006, Journal of molecular biology.

A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin.

J. Otlewski, W. Fairbrother, J. Burnier, 1994, Proceedings of the National Academy of Sciences of the United States of America.

The High ZnII Affinity of the Tetracysteine Tag Affects Its Fluorescent Labeling with Biarsenicals

J. Otlewski, A. Krężel, Adam Pomorski, 2010, Chembiochem : a European journal of chemical biology.

Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity

J. Otlewski, A. Szlachcic, M. Zakrzewska, 2019, Cells.

Translocation of Exogenous FGF1 and FGF2 Protects the Cell against Apoptosis Independently of Receptor Activation.

J. Otlewski, M. Zakrzewska, D. Krowarsch, 2018, Journal of molecular biology.

Instability restricts signaling of multiple fibroblast growth factors

J. Otlewski, J. Damborský, A. Kozubík, 2015, Cellular and Molecular Life Sciences.

Pdz Domain from Dishevelled — a Specificity Study

J. Otlewski, A. Krężel, A. Mateja, 2022 .

Quantitative measurement of Au and Fe in ferromagnetic nanoparticles with Laser Induced Breakdown Spectroscopy using a polymer-based gel matrix

J. Otlewski, T. Borowik, M. Przybyło, 2011 .

Immobilized Bowman-Birk inhibitor for selective isolation of chymotrypsin B from bovine pancreas.

J. Leluk, J. Otlewski, T. Wilusz, 1983, Journal of chromatography.

FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner

J. Otlewski, M. Zakrzewska, D. Krowarsch, 2020, Cell Communication and Signaling.

Correction: Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling

J. Otlewski, M. Zakrzewska, D. Krowarsch, 2023, Cell Communication and Signaling.

Short report galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling

J. Otlewski, M. Zakrzewska, D. Krowarsch, 2023, Cell Communication and Signaling.

Peptibody Based on FGFR1-Binding Peptides From the FGF4 Sequence as a Cancer-Targeting Agent

J. Otlewski, A. Szlachcic, Jakub Szymczyk, 2021, Frontiers in Pharmacology.

Structural requirements of FGF-1 for receptor binding and translocation into cells.

J. Otlewski, M. Zakrzewska, D. Krowarsch, 2006, Biochemistry.

Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling

J. Otlewski, M. Zakrzewska, D. Krowarsch, 2023, Cellular and Molecular Life Sciences.

Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2019, Cell Communication and Signaling.

Increased Protein Stability of FGF1 Can Compensate for Its Reduced Affinity for Heparin*

J. Otlewski, A. Szlachcic, M. Zakrzewska, 2009, The Journal of Biological Chemistry.

Cytokinin‐induced structural adaptability of a Lupinus luteus PR‐10 protein

M. Jaskólski, J. Otlewski, A. Bujacz, 2009, The FEBS journal.

Substitutions at the P(1) position in BPTI strongly affect the association energy with serine proteinases.

J. Otlewski, R. Helland, M. Dadlez, 2000, Journal of molecular biology.

Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling

J. Otlewski, M. Zakrzewska, D. Krowarsch, 2023, Cell Communication and Signaling.

Dual-Warhead Conjugate Based on Fibroblast Growth Factor 2 Dimer Loaded with α-Amanitin and Monomethyl Auristatin E Exhibits Superior Cytotoxicity towards Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1

J. Otlewski, K. Sluzalska, D. Nawrocka, 2023, International journal of molecular sciences.

Drug Conjugation via Maleimide–Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies

J. Otlewski, Anna Kocyła, A. Szlachcic, 2022, Molecular pharmaceutics.

The impact of Glu-->Ala and Glu-->Asp mutations on the crystallization properties of RhoGDI: the structure of RhoGDI at 1.3 A resolution.

K. Longenecker, J. Otlewski, Z. Dauter, 2002, Acta crystallographica. Section D, Biological crystallography.

Multivalent protein-drug conjugates - An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells.

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2023, Biotechnology advances.

The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2022, International Journal of Molecular Sciences.

Design of fully active FGF-1 variants with increased stability.

Malgorzata Zakrzewska, Jacek Otlewski, J. Otlewski, 2004, Protein engineering, design & selection : PEDS.

Serine proteinase from Cucurbita ficifolia seed; purification, properties, substrate specificity and action on native squash trypsin inhibitor (CMTI I).

J. Otlewski, T. Wilusz, M. Dryjański, 1990, Biological chemistry Hoppe-Seyler.

The synthesis of multifunctional nanoparticles conjugated with anti-Her2 affibody and monomethylauristatin E

J. Otlewski, Anna Cyranka-Czaja, P. Jakimowicz, 2015 .

Degenerate specificity of PDZ domains from RhoA-specific nucleotide exchange factors PDZRhoGEF and LARG.

J. Otlewski, Z. Derewenda, M. Paduch, 2008, Acta biochimica Polonica.

Tumor-specific hyperthermia with aptamer-tagged superparamagnetic nanoparticles

J. Otlewski, F. Jeleń, P. Jakimowicz, 2013, International journal of nanomedicine.

FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation

J. Otlewski, A. Szlachcic, M. Zakrzewska, 2012, International journal of nanomedicine.

The Molecular Basis of RhoA Specificity in the Guanine Nucleotide Exchange Factor PDZ-RhoGEF*

J. Otlewski, Z. Derewenda, U. Derewenda, 2006, Journal of Biological Chemistry.

Selection of potent chymotrypsin and elastase inhibitors from M13 phage library of basic pancreatic trypsin inhibitor (BPTI).

J. Otlewski, M. Dadlez, K. Kościelska-Kasprzak, 2001, Biochimica et biophysica acta.

Determination of a high precision structure of a novel protein, Linum usitatissimum trypsin inhibitor (LUTI), using computer-aided assignment of NOESY cross-peaks.

J Otlewski, J. Otlewski, T. Cierpicki, 2000, Journal of molecular biology.

FGF homologous factors are secreted from cells to induce FGFR‐mediated anti‐apoptotic response

J. Otlewski, M. Zakrzewska, D. Krowarsch, 2023, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Pdz Domains — Common Players in the Cell Signaling Jacek Otlewski Was Supported by a Scholarship from the Foundation for Polish Science

J. Otlewski, K. Śmietana, A. Oleksy, 2022 .

Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity

J. Otlewski, T. Holak, A. Szlachcic, 2018, International journal of molecular sciences.

New synthetic analogues of trypsin inhibitor CMTI-III from squash seeds

J. Otlewski, T. Wilusz, U. Ragnarsson, 1991 .

N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope

J. Otlewski, M. Zakrzewska, Łukasz Opaliński, 2023, Cell Communication and Signaling.

Dissecting the thermodynamics of GAP-RhoA interactions.

J. Otlewski, Z. Derewenda, A. Mateja, 2009, Journal of structural biology.

Intracellular FGF1 protects cells from apoptosis through direct interaction with p53

J. Otlewski, M. Zakrzewska, D. Krowarsch, 2023, Cellular and Molecular Life Sciences.

The impact of Lys-->Arg surface mutations on the crystallization of the globular domain of RhoGDI.

J. Otlewski, Z. Derewenda, Y. Devedjiev, 2004, Acta crystallographica. Section D, Biological crystallography.

A novel, stable, helical scaffold as an alternative binder - construction of phage display libraries.

J. Otlewski, Anna Cyranka-Czaja, 2012, Acta biochimica Polonica.

PDZ domains - common players in the cell signaling.

J. Otlewski, K. Śmietana, A. Oleksy, 2003, Acta biochimica Polonica.

Anti-FGFR1 aptamer-tagged superparamagnetic conjugates for anticancer hyperthermia therapy

Urszula N. Wasko, J. Otlewski, Maciej P. Mazurek, 2017, International journal of nanomedicine.