M. O’Connor-McCourt

发表

Simo V. Zhang, Q. Cui, E. Purisima, 2007, Molecular systems biology.

Identification of high-quality cancer prognostic markers and metastasis network modules

Q. Cui, E. Purisima, E. Wang, 2010, Nature communications.

Transforming Growth Factor‐β: Multifunctional Regulator of Cell Growth and Phenotype

M. Sporn, M. O’Connor-McCourt, L. Wakefield, 1988, Annals of the New York Academy of Sciences.

Transforming growth factor-β receptors on human endometrial cells: identification of the type I, II, and III receptors and glycosylphosphatidylinositol anchored TGF-β binding proteins

M. O’Connor-McCourt, N. Dumont, A. Philip, 1995, Molecular and Cellular Endocrinology.

Lack of responsiveness to transforming growth factor-β (TGF-β)-induced growth arrest and fibronectin synthesis in BeWo choriocarcinoma cells

M. O’Connor-McCourt, K. Lee, E. Mitchell, 1994 .

Predictive genomics: a cancer hallmark network framework for predicting tumor clinical phenotypes using genome sequencing data.

E. Wang, M. O’Connor-McCourt, A. Masoudi-Nejad, 2014, Seminars in cancer biology.

Fetal and adult human skin fibroblasts display intrinsic differences in contractile capacity

Lucie Germain, M. O’Connor-McCourt, L. Germain, 2001, Journal of cellular physiology.

Up-regulation of E-cadherin by an anti-epidermal growth factor receptor monoclonal antibody in lung cancer cell lines.

M. O’Connor-McCourt, A. Al Moustafa, M. Alaoui-Jamali, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Paip1 Interacts with Poly(A) Binding Protein through Two Independent Binding Motifs

Nahum Sonenberg, Gregory De Crescenzo, N. Sonenberg, 2002, Molecular and Cellular Biology.

Kinetic analysis of the interactions between troponin C and the C-terminal troponin I regulatory region and validation of a new peptide delivery/capture system used for surface plasmon resonance.

R. Hodges, M. O’Connor-McCourt, G. De Crescenzo, 2002, Journal of molecular biology.

Glycoproteomic comparison of clinical triple-negative and luminal breast tumors.

E. Wang, M. O’Connor-McCourt, Jie Li, 2015, Journal of proteome research.

Molecular Characterization of the Vasculature of Patients with Infiltrating Ductal Carcinoma Generates a Gene Signature Predictive of Breast Cancer Survival

E. Wang, M. O’Connor-McCourt, J. Li, 2015 .

Kinetic analysis of novel mono‐ and multivalent VHH‐fragments and their application for molecular imaging of brain tumours

G. Sutherland, B. Tomanek, M. O’Connor-McCourt, 2010, British journal of pharmacology.

Differential tumor-targeting abilities of three single-domain antibody formats.

M. Jaramillo, M. O’Connor-McCourt, J. Baardsnes, 2010, Cancer letters.

The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning.

M. O’Connor-McCourt, J. Wrana, V. Luga, 2009, The Biochemical journal.

Transforming growth factor-beta (TGF-beta) binding to the extracellular domain of the type II TGF-beta receptor: receptor capture on a biosensor surface using a new coiled-coil capture system demonstrates that avidity contributes significantly to high affinity binding.

M. O’Connor-McCourt, Y. Durocher, G. De Crescenzo, 2003, Journal of molecular biology.

Genetic studies of diseases

E. Wang, M. O’Connor-McCourt, A. Lenferink, 2007, Cellular and Molecular Life Sciences.

Real-time monitoring of the interactions of two-stranded de novo designed coiled-coils: effect of chain length on the kinetic and thermodynamic constants of binding.

R. Hodges, M. O’Connor-McCourt, J. Litowski, 2003, Biochemistry.

Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates

M. Jaramillo, M. O’Connor-McCourt, T. Sulea, 2019, PloS one.

Adenovirus-delivered antisense RNA and shRNA exhibit different silencing efficiencies for the endogenous transforming growth factor-beta (TGF-beta) type II receptor.

M. O’Connor-McCourt, C. Collins, Christel Dias, 2006, Oligonucleotides.

Site‐directed mutagenesis of the type II TGF‐β receptor indicates a ligand‐binding site distinct from that of the type II activin receptor

M. O’Connor-McCourt, T. Sulea, A. Guimond, 2002, FEBS letters.

Therapeutic Discovery Engineering and Therapeutic Application of Single-Chain Bivalent TGF-b Family Traps

M. O’Connor-McCourt, A. Lenferink, C. Collins, 2012 .

A transforming growth factor beta (TGF-beta) receptor from human placenta exhibits a greater affinity for TGF-beta 2 than for TGF-beta 1.

M. O’Connor-McCourt, E. Mitchell, E. J. Mitchell, 1991, Biochemistry.

Three key residues underlie the differential affinity of the TGFbeta isoforms for the TGFbeta type II receptor.

A. Hinck, Luzhe Sun, M. O’Connor-McCourt, 2006, Journal of molecular biology.

Development of reverse phase protein microarrays for the validation of clusterin, a mid-abundant blood biomarker

M. O’Connor-McCourt, A. Nantel, M. Basik, 2009, Proteome Science.

A mass spectrometry-based plasma protein panel targeting the tumor microenvironment in patients with breast cancer.

E. Wang, M. O’Connor-McCourt, K. Chisholm, 2013, Journal of proteomics.

Cancer systems biology: exploring cancer-associated genes on cellular networks.

E. Wang, M. O’Connor-McCourt, A. Lenferink, 2007, Cellular and molecular life sciences : CMLS.

What ' sNewinHumanWound-HealingMyofibroblastsl

M. O’Connor-McCourt, G. Castilloux, D. G. V. MOULIN, 2009 .

What's new in human wound-healing myofibroblasts?

M. O’Connor-McCourt, L. Germain, F. Auger, 1999, Current topics in pathology. Ergebnisse der Pathologie.

Substrate cleavage by caspases generates protein fragments with Smac/Diablo-like activities

M. O’Connor-McCourt, M. Saleh, G. D. Crescenzo, 2003, Cell Death and Differentiation.

Transforming growth factor-beta receptor expression on endothelial cells: heterogeneity of type III receptor expression.

M. O’Connor-McCourt, B. Meyrick, R. Hoover, 1995, Journal of cellular physiology.

Specific binding of endocrine transforming growth factor-beta 1 to vascular endothelium.

M. O’Connor-McCourt, J. Bergeron, A. Philip, 1995, The Journal of clinical investigation.

Regulation of signal transduction pathways by peptide toxins

M. O’Connor-McCourt, R. Andersen, C. Holmes, 1994 .

Localization of specific binding sites for125I-TGF-β1 to fenestrated endothelium in bone and anastomosing capillary networks in enamel organ suggests a role for TGF-β1 in angiogenesis

M. O’Connor-McCourt, J. Bergeron, A. Philip, 2001, Calcified Tissue International.

Distinct functional domains of TGF-beta bind receptors on endothelial cells.

M. O’Connor-McCourt, N. Dumont, J. Burmester, 1999, Growth factors.

Mutagenesis analysis of the membrane‐proximal ligand binding site of the TGF‐β receptor type III extracellular domain

M. O’Connor-McCourt, C. Collins, M. Beauchemin, 1995, FEBS letters.

Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX

S. C. Chafe, F. Bénard, M. Jaramillo, 2021, mAbs.

Ectodomain cleavage and shedding of the type III transforming growth factor‐β receptor in lung membranes

M. O’Connor-McCourt, A. Philip, R. Hannah, 1999 .

Characterization of recombinant soluble human transforming growth factor-beta receptor type II (rhTGF-beta sRII).

M. O’Connor-McCourt, M. Tsang, J. Weatherbee, 1995, Cytokine.

IGFBP-4 anti-angiogenic and anti-tumorigenic effects are associated with anti-cathepsin B activity.

M. O’Connor-McCourt, Y. Durocher, D. L'abbe, 2013, Neoplasia.

A ligand‐pseudoreceptor system based on de novo designed peptides for the generation of adenoviral vectors with altered tropism

M. O’Connor-McCourt, L. Bourget, B. Massie, 2008, The journal of gene medicine.

Characterization of transforming growth factor-beta (TGF-beta) receptors on BeWo choriocarcinoma cells including the identification of a novel 38-kDa TGF-beta binding glycoprotein.

K. Lee, M. O’Connor-McCourt, E. Mitchell, 1992, Molecular Biology of the Cell.

Subtypes of betaglycan and of type I and type II transforming growth factor‐β (TGF‐β) receptors with different affinities for TGF‐β1 and TGF‐β2 are exhibited by human placental trophoblast cells

M. O’Connor-McCourt, E. Mitchell, L. Fitz‐Gibbon, 1992 .

Real-time kinetic studies on the interaction of transforming growth factor alpha with the epidermal growth factor receptor extracellular domain reveal a conformational change model.

M. O’Connor-McCourt, G. De Crescenzo, S. Grothé, 2000, Biochemistry.

Expression of P185erbB-2, P160erbB-3, P180erbB-4, and heregulin alpha in human normal bronchial epithelial and lung cancer cell lines.

M. O’Connor-McCourt, A. Al Moustafa, M. Alaoui-Jamali, 1999, Anticancer research.

Black cellular spreading and motility assay.

M. O’Connor-McCourt, A. Al Moustafa, N. Urbani, 1999, BioTechniques.

Characterization of transforming growth factor‐β growth regulatory effects and receptors on bovine mammary cells

M. O’Connor-McCourt, N. Dumont, A. Philip, 1995, Journal of cellular physiology.

Assisted Design of Antibody and Protein Therapeutics (ADAPT)

E. Purisima, M. Jaramillo, M. O’Connor-McCourt, 2017, PloS one.

Real-time Monitoring of the Interactions of Transforming Growth Factor-β (TGF-β) Isoforms with Latency-associated Protein and the Ectodomains of the TGF-β Type II and III Receptors Reveals Different Kinetic Models and Stoichiometries of Binding*

M. O’Connor-McCourt, M. Tsang, G. De Crescenzo, 2001, The Journal of Biological Chemistry.

A fusion plasmid for the synthesis of lipopeptide-antigen chimeras in Escherichia coli.

M. O’Connor-McCourt, P. Lau, L. Lin, 1992, Gene.

Interaction of transforming growth factor-beta 1 with alpha 2-macroglobulin. Role in transforming growth factor-beta 1 clearance.

M. O’Connor-McCourt, A. Philip, Anie Philip, 1991, The Journal of biological chemistry.

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

M. O’Connor-McCourt, L. Wakefield, L. Wakefield, 1987, The Journal of biological chemistry.

Amass spectrometry-based plasma protein panel targeting the tumor microenvironment in patients with breast cancer☆

E. Wang, M. O’Connor-McCourt, K. Chisholm, 2013 .

The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand.

H. Lodish, M. O’Connor-McCourt, A. Moustakas, 1993, The Journal of biological chemistry.

Mitochondrion-dependent N-terminal Processing of Outer Membrane Mcl-1 Protein Removes an Essential Mule/Lasu1 Protein-binding Site*

Jason C. Young, M. Warr, M. O’Connor-McCourt, 2011, The Journal of Biological Chemistry.

The extracellular domain of the epidermal growth factor receptor. Studies on the affinity and stoichiometry of binding, receptor dimerization and a binding-domain mutant.

M. O’Connor-McCourt, D. Bergsma, C. Kay, 1994, European journal of biochemistry.

Kinetic analysis of the interactions between Troponin C (TnC) and Troponin I (TnI) binding peptides: evidence for separate binding sites for the ‘structural’ N‐terminus and the ‘regulatory’ C‐terminus of TnI on TnC

Brian Tripet, Gregory De Crescenzo, R. Hodges, 2003, Journal of molecular recognition : JMR.

Investigation of three new mouse mammary tumor cell lines as models for transforming growth factor (TGF)-β and Neu pathway signaling studies: identification of a novel model for TGF-β-induced epithelial-to-mesenchymal transition

Christiane Cantin, M. O’Connor-McCourt, A. Lenferink, 2004, Breast Cancer Research.

Correction: A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

C. Zwieb, A. Hinck, Luzhe Sun, 2016, Oncotarget.

A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

C. Zwieb, A. Hinck, Luzhe Sun, 2016, Oncotarget.

A Direct Interaction between Transforming Growth Factor (TGF)-βs and Amyloid-β Protein Affects Fibrillogenesis in a TGF-βReceptor-independent Manner*

Gregory De Crescenzo, M. O’Connor-McCourt, M. Kirkitadze, 2003, Journal of Biological Chemistry.

Identification and Construction of Combinatory Cancer Hallmark-Based Gene Signature Sets to Predict Recurrence and Chemotherapy Benefit in Stage II Colorectal Cancer.

Jinfeng Zou, Chabane Tibiche, Mark Trifiro, 2016, JAMA oncology.

Adenovirus-Delivered Antisense RNA and shRNA Exhibit Different Silencing Efficiencies for the Endogenous Transforming Growth Factor-β (TGF-β) Type II Receptor

M. O’Connor-McCourt, C. Collins, Christel Dias, 2006 .

Differential sensitivity of A549 non small lung carcinoma cell responses to epidermal growth factor receptor pathway inhibitors

M. Jaramillo, M. O’Connor-McCourt, C. Collins, 2008, Cancer biology & therapy.

Adenovirus-based libraries: efficient generation of recombinant adenoviruses by positive selection with the adenovirus protease

M. O’Connor-McCourt, B. Massie, S. M. Elahi, 2002, Gene Therapy.

Transcriptome profiling of a TGF-β-induced epithelial-to-mesenchymal transition reveals extracellular clusterin as a target for therapeutic antibodies

M. O’Connor-McCourt, A. Lenferink, A. Nantel, 2010, Oncogene.

Structural basis of ligand recognition by PABC, a highly specific peptide‐binding domain found in poly(A)‐binding protein and a HECT ubiquitin ligase

Kalle Gehring, Nahum Sonenberg, Irena Ekiel, 2004, The EMBO journal.

Analysis of acquired resistance to metronomic oral topotecan chemotherapy plus pazopanib after prolonged preclinical potent responsiveness in advanced ovarian cancer

M. Jaramillo, M. O’Connor-McCourt, C. Collins, 2014, Angiogenesis.

Genetic studies of diseases

M. O’Connor-McCourt, A. Lenferink, E. Wang, 2007, Cellular and Molecular Life Sciences.

Evidence of a major neutralizable conformational epitope region on VP2 of infectious pancreatic necrosis virus.

M. O’Connor-McCourt, S. Grothé, J. Heppell, 1995, The Journal of general virology.

TGF-β1 protein trap AVID200 beneficially affects hematopoiesis and bone marrow fibrosis in myelofibrosis

M. O’Connor-McCourt, R. Hoffman, R. Mesa, 2021, JCI insight.

NMR study of the differential contributions of residues of transforming growth factor alpha to association with its receptor.

B. Sykes, M. O’Connor-McCourt, C. McInnes, 2000, Protein engineering.

The crystal structure and dimerization interface of GADD45γ

M. Jaramillo, M. O’Connor-McCourt, J. Schrag, 2008, Proceedings of the National Academy of Sciences.

Engineering and Therapeutic Application of Single-Chain Bivalent TGF-β Family Traps

M. O’Connor-McCourt, A. Lenferink, C. Collins, 2012, Molecular Cancer Therapeutics.

TbetaR-II discriminates the high- and low-affinity TGF-beta isoforms via two hydrogen-bonded ion pairs.

Jason Baardsnes, A. Hinck, M. O’Connor-McCourt, 2009, Biochemistry.

P856 AVID200, first-in-class TGF-beta1 and beta3 selective inhibitor: results of a phase 1 monotherapy dose escalation study in solid tumors and evidence of target engagement in patients

M. O’Connor-McCourt, T. Yap, T. Gruosso, 2020, Journal of Immunotherapy for Cancer.

Structures of TGF-β receptor complexes: implications for function and therapeutic intervention using ligand traps.

A. Hinck, M. O’Connor-McCourt, 2011, Current pharmaceutical biotechnology.

Glycoproteomic analysis of two mouse mammary cell lines during transforming growth factor (TGF)-β induced epithelial to mesenchymal transition

Christiane Cantin, John F Kelly, M. O’Connor-McCourt, 2009, Proteome Science.

Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling

Troy C. Krzysiak, Morkos A. Henen, A. Hinck, 2016, Biochemistry.

Engineering TGF-β Traps: Artificially Dimerized Receptor Ectodomains as High-affinity Blockers of TGF-β Action

M. O’Connor-McCourt, Y. Durocher, G. D. Crescenzo, 2008 .

NMR Study of the Transforming Growth Factor-α (TGF-α)-Epidermal Growth Factor Receptor Complex

D. Hoyt, B. Sykes, M. O’Connor-McCourt, 1996, The Journal of Biological Chemistry.

Interaction of transforming growth factor alpha with the epidermal growth factor receptor: binding kinetics and differential mobility within the bound TGF-alpha.

D. Hoyt, B. Sykes, M. O’Connor-McCourt, 1994, Biochemistry.

Molecular imaging of breast tumors using a near‐infrared fluorescently labeled clusterin binding peptide

Feng Ni, Ping Xu, Christiane Cantin, 2012, International journal of cancer.

Modulated response to cytokines of human wound healing myofibroblasts compared to dermal fibroblasts.

F A Auger, M. O’Connor-McCourt, L. Germain, 1998, Experimental cell research.

Autoantibodies to the epidermal growth factor receptor in systemic sclerosis, lupus, and autoimmune mice

M. O’Connor-McCourt, F. Arnett, M. Sinha, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Corrigendum: Identification of high-quality cancer prognostic markers and metastasis network modules

Q. Cui, E. Purisima, E. Wang, 2012, Nature Communications.

Signaling network assessment of mutations and copy number variations predict breast cancer subtype-specific drug targets.

Edwin Wang, Catherine Collins, Chabane Tibiche, 2013, Cell reports.

Structural basis of the regulation of the CbpA co-chaperone by its specific modulator CbpM.

M. O’Connor-McCourt, J. Baardsnes, I. Ekiel, 2010, Journal of molecular biology.

Three Key Residues Underlie the Differential Affinity of the TGFβ Isoforms for the TGFβ Type II Receptor

Gregory De Crescenzo, Jason Baardsnes, A. Hinck, 2006 .

Protein Repressor Paip2 with Poly(A) Binding Dual Interactions of the Translational

N. Sonenberg, M. O’Connor-McCourt, Y. Svitkin, 2014 .

Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein

Nahum Sonenberg, Gregory De Crescenzo, N. Sonenberg, 2001, Molecular and Cellular Biology.

Predominant intracellular localization of the type I transforming growth factor-beta receptor and increased nuclear accumulation after growth arrest.

M. O’Connor-McCourt, A. Guimond, J. Zwaagstra, 2000, Experimental cell research.

Receptors, acceptors, and the action of polypeptide hormones: illustrative studies with epidermal growth factor (urogastrone).

M. O’Connor-McCourt, M. Hollenberg, 1983, Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire.

AVID200, a Potent Trap for TGF-β Ligands Inhibits TGF-β1 Signaling in Human Myelofibrosis

M. O’Connor-McCourt, R. Hoffman, A. Migliaccio, 2018, Blood.

Abstract 4688: AVID200: a novel computationally-designed TGF beta trap promoting anti-tumor T cell activity

M. O’Connor-McCourt, A. Lenferink, C. Collins, 2017 .

Enhancement of the Antagonistic Potency of Transforming Growth Factor-β Receptor Extracellular Domains by Coiled Coil-induced Homo- and Heterodimerization*

M. O’Connor-McCourt, Y. Durocher, G. De Crescenzo, 2004, Journal of Biological Chemistry.

Functional Roles for the Cytoplasmic Domain of the Type III Transforming Growth Factor β Receptor in Regulating Transforming Growth Factor β Signaling*

Harvey F. Lodish, Michel Beauchemin, William P. Schiemann, 2001, The Journal of Biological Chemistry.

Mapping of putative binding sites on the ectodomain of the type II TGF‐β receptor by scanning‐deletion mutagenesis and knowledge‐based modeling

M. O’Connor-McCourt, T. Sulea, A. Guimond, 1999, FEBS letters.

Analysis of the Interaction between Two TGF‐β‐binding Proteins and Three TGF‐β Isoforms Using Surface Plasmon Resonance

M. O’Connor-McCourt, M. Tsang, J. Weatherbee, 1995 .

Roles for endothelin receptor B and BCL2A1 in spontaneous CNS metastasis of melanoma.

M. Jaramillo, M. O’Connor-McCourt, C. Collins, 2012, Cancer research.

Transforming growth factor-β1 is the predominant isoform required for breast cancer cell outgrowth in bone

M. O’Connor-McCourt, P. Siegel, Z. Dong, 2009, Oncogene.

Analysis of the contribution of receptor subdomains to the cooperative binding and internalization of transforming growth factor-beta (TGF-beta) type I and type II receptors.

M. O’Connor-McCourt, C. Collins, M. Langlois, 2008, Experimental cell research.

Transforming Growth Factor (TGF)-β1 Internalization

M. O’Connor-McCourt, J. Zwaagstra, M. El‐Alfy, 2001, The Journal of Biological Chemistry.

Down-regulation of transforming growth factor-beta receptors: cooperativity between the types I, II, and III receptors and modulation at the cell surface.

M. O’Connor-McCourt, Z. Kassam, J. Zwaagstra, 1999, Experimental cell research.

Binding of transforming growth factor-β (TGF-β) to pregnancy zone protein (PZP)

M. O’Connor-McCourt, A. Philip, T. Stigbrand, 1994 .

Binding of transforming growth factor-beta (TGF-beta) to pregnancy zone protein (PZP). Comparison to the TGF-beta-alpha 2-macroglobulin interaction.

M. O’Connor-McCourt, A. Philip, T. Stigbrand, 1994, European Journal of Biochemistry.

Transforming growth factor (TGF)-beta 1 internalization: modulation by ligand interaction with TGF-beta receptors types I and II and a mechanism that is distinct from clathrin-mediated endocytosis.

M. O’Connor-McCourt, J. Zwaagstra, M. El‐Alfy, 2001, The Journal of biological chemistry.

Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling.

H. Lodish, M. O’Connor-McCourt, A. Moustakas, 2001, The Journal of biological chemistry.

Link Protein Has Greater Affinity for Versican than Aggrecan*

M. O’Connor-McCourt, P. Roughley, S. Shi, 2004, Journal of Biological Chemistry.

Fetal and postnatal sera differentially modulate human dermal fibroblast phenotypic and functional features in vitro

M. O’Connor-McCourt, L. Germain, F. Auger, 1997, Journal of cellular physiology.

Kinetic study on the formation of a de novo designed heterodimeric coiled-coil: use of surface plasmon resonance to monitor the association and dissociation of polypeptide chains.

R. Hodges, M. O’Connor-McCourt, C. Kay, 1996, Biochemistry.

Differential tumor-targeting abilities of three single-domain antibody formats.

M. Jaramillo, M. O’Connor-McCourt, J. Baardsnes, 2010, Cancer letters.

Identification of vascular breast tumor markers by laser capture microdissection and label-free LC-MS.

E. Wang, M. O’Connor-McCourt, A. Lenferink, 2011, Journal of proteome research.

Construction of transforming growth factor alpha (TGF-alpha) phage library and identification of high binders of epidermal growth factor receptor (EGFR) by phage display.

D. Hoyt, B. Sykes, M. O’Connor-McCourt, 1997, Journal of biochemistry.

Characterization of recombinant soluble human transforming growth factor-β receptor Type II (rhTGF-βsRII)

M. O’Connor-McCourt, John M Smith, M. Tsang, 1995 .

Computational selection of antibody-drug conjugate targets for breast cancer

Sieu Phan, Fazel Famili, Youlian Pan, 2015, Oncotarget.

Abstract 1467: AB-16B5, a therapeutic monoclonal antibody against human clusterin that blocks the epithelial-to-mesenchymal transition

M. O’Connor-McCourt, A. Lenferink, T. Sulea, 2010 .

Corrigendum: Identification of high-quality cancer prognostic markers and metastasis network modules

Q. Cui, E. Purisima, E. Wang, 2012, Nature Communications.

Analysis of acquired resistance to metronomic oral topotecan chemotherapy plus pazopanib after prolonged preclinical potent responsiveness in advanced ovarian cancer

M. Jaramillo, M. O’Connor-McCourt, C. Collins, 2014, Angiogenesis.

Identification of a functional site on the type I TGF‐β receptor by mutational analysis of its ectodomain

M. O’Connor-McCourt, T. Sulea, A. Guimond, 2002, FEBS letters.

Expression of TGF‐β type II receptor antisense RNA impairs TGF‐β signaling in vitro and promotes mammary gland differentiation in vivo

M. O’Connor-McCourt, A. Lenferink, A. Guimond, 2003, International journal of cancer.

Abstract 1759: AVID200, a highly potent TGF-beta trap, exhibits optimal isoform selectivity for enhancing anti-tumor T-cell activity, without promoting metastasis or cardiotoxicity

M. O’Connor-McCourt, A. Lenferink, T. Sulea, 2018 .

Transforming growth factor-beta receptors on human endometrial cells: identification of the type I, II, and III receptors and glycosyl-phosphatidylinositol anchored TGF-beta binding proteins.

M. O’Connor-McCourt, N. Dumont, A. Philip, 1995, Molecular and cellular endocrinology.

Design of a novel small peptide targeted against a tumor-specific receptor.

D. Bigner, M. O’Connor-McCourt, M. Campa, 2000, Biochemical and biophysical research communications.

(TCF-P) Receptors With Different Affinities for JGF-P1 and TCF-P2 Are Exhibited by Human Placental Trophoblast Cells

M. O’Connor-McCourt, L. Fitz‐Gibbon, E. J. Mitchell, 2004 .

Mapping of the ligand binding domain of the transforming growth factor beta receptor type III by deletion mutagenesis.

M. O’Connor-McCourt, M. Beauchemin, M. Pépin, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Differential tumor-targeting abilities of three single-domain antibody formats.

M. Jaramillo, M. O’Connor-McCourt, J. Baardsnes, 2010, Cancer letters.

Structure-based Minimization of Transforming Growth Factor-α (TGF-α) through NMR Analysis of the Receptor-bound Ligand

B. Sykes, M. O’Connor-McCourt, C. McInnes, 1998, The Journal of Biological Chemistry.

Down-regulation of Transforming Growth Factor-β Receptors: Cooperativity between the Types I, II, and III Receptors and Modulation at the Cell Surface

M. O’Connor-McCourt, Z. Kassam, J. Zwaagstra, 1999 .

Escherichia coli expression and refolding of E/K-coil-tagged EGF generates fully bioactive EGF for diverse applications.

M. O’Connor-McCourt, A. Lenferink, J. Baardsnes, 2009, Protein expression and purification.

A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

C. Zwieb, A. Hinck, Luzhe Sun, 2016, Oncotarget.

Differential tumor-targeting abilities of three single-domain antibody formats.

M. Jaramillo, M. O’Connor-McCourt, J. Baardsnes, 2010, Cancer letters.

Subtypes of betaglycan and of type I and type II transforming growth factor-beta (TGF-beta) receptors with different affinities for TGF-beta 1 and TGF-beta 2 are exhibited by human placental trophoblast cells.

M. O’Connor-McCourt, L. Fitz‐Gibbon, E. J. Mitchell, 1992, Journal of cellular physiology.

Purification of the extracellular domain of the epidermal growth factor receptor produced by recombinant baculovirus-infected insect cells in a 10-L reactor.

M. O’Connor-McCourt, M. Pacheco-Oliver, M. Debanne, 1995, Methods in molecular biology.

Superagonistic activation of ErbB-1 by EGF-related growth factors with enhanced association and dissociation rate constants.

M. O’Connor-McCourt, A. Lenferink, E. J. V. van Zoelen, 2000, The Journal of biological chemistry.

M. O’Connor-McCourt, Y. Durocher, G. De Crescenzo, 2003, Journal of molecular biology.

Chemical modification and hybrid enzyme formation as probes of the active site and subunit interactions in Escherichia coli succinyl-CoA synthetase.

M. O’Connor-McCourt, W. A. Bridger, 1985, Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire.

Down-regulation of transforming growth factor-beta receptors: cooperativity between the types I, II, and III receptors and modulation at the cell surface.

M. O’Connor-McCourt, Z. Kassam, J. Zwaagstra, 1999, Experimental cell research.