J. Wells

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A hot spot of binding energy in a hormone-receptor interface

T. Clackson, J. Wells, J. Wells, 1995, Science.

Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

Christopher L. McClendon, J. Wells, J. Wells, 2007, Nature.

Systematic mutational analyses of protein-protein interfaces.

J. Wells, J. Wells, 1991, Methods in enzymology.

Dissecting the catalytic triad of a serine protease

J. Wells, P. Carter, J. Wells, 1988, Nature.

Hormone phage: An enrichment method for variant proteins with altered binding properties

J. Wells, S. Bass, R. Greene, 1990, Proteins.

Structural and mutational analysis of affinity-inert contact residues at the growth hormone-receptor interface.

J. Wells, K. Pearce, M. Ultsch, 1996, Biochemistry.

Discovery of an allosteric site in the caspases.

J. Wells, J. Hardy, Joni W. Lam, 2004, Proceedings of the National Academy of Sciences of the United States of America.

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

Frank von Delft, James S Fraser, Daniel A Keedy, 2018, eLife.

New routes for PTP1B allosteric inhibition by multitemperature crystallography, fragment screening and covalent tethering

J. Wells, F. von Delft, J. Fraser, 2017, bioRxiv.

CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.

Julie C. Mitchell, Andrej Sali, Dina Schneidman-Duhovny, 2016, Journal of molecular biology.

Convergent solutions to binding at a protein-protein interface.

W. Delano, J. Wells, M. Ultsch, 2000, Science.

Comparison of a structural and a functional epitope.

J. Wells, B. Cunningham, B C Cunningham, 1993, Journal of molecular biology.

Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.

T. Clackson, J. Wells, M. Ultsch, 1998, Journal of molecular biology.

A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor.

J. Wells, S. Bass, M. Mulkerrin, 1991, Proceedings of the National Academy of Sciences of the United States of America.

High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis.

J. Wells, B. Cunningham, J. Wells, 1989, Science.

Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.

J. Wells, M. Arkin, Yinyan Tang, 2014, Chemistry & biology.

Methods for the proteomic identification of protease substrates.

J. Wells, Nicholas J Agard, Nicholas J. Agard, 2009, Current opinion in chemical biology.

Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking.

A. Sali, B. Shoichet, Hao Fan, 2015, Journal of medicinal chemistry.

Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases.

Kathryn A. Porter, S. Vajda, J. Wells, 2019, Journal of medicinal chemistry.

Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast *

V. Mootha, Hongying Shen, J. Wells, 2017, Molecular & Cellular Proteomics.

Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

C. Craik, J. Wells, G. Knudsen, 2016, Proceedings of the National Academy of Sciences.

The DegraBase: A Database of Proteolysis in Healthy and Apoptotic Human Cells*

Julia E. Seaman, E. Crawford, J. Wells, 2012, Molecular & Cellular Proteomics.

Global Sequencing of Proteolytic Cleavage Sites in Apoptosis by Specific Labeling of Protein N Termini

David T. Barkan, A. Burlingame, A. Sali, 2008, Cell.

Site-directed ligand discovery.

R. Stroud, J. Wells, E. Gordon, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

S. Lipton, A. Ciechanover, T. Luedde, 2018, Cell Death & Differentiation.

Caspase substrates and cellular remodeling.

E. Crawford, J. Wells, J. Wells, 2011, Annual review of biochemistry.

Global kinetic analysis of proteolysis via quantitative targeted proteomics

A. Burlingame, J. Wells, J. Trinidad, 2012, Proceedings of the National Academy of Sciences.

Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

S. Gygi, T. Xie, J. Wells, 2014, Molecular cell.

Phage display for selection of novel binding peptides.

S. Sidhu, J. Wells, B. Cunningham, 2000, Methods in enzymology.

Additivity of mutational effects in proteins.

J. Wells, J A Wells, J. Wells, 1990, Biochemistry.

Substrate phage: selection of protease substrates by monovalent phage display.

J. Wells, D. J. Matthews, J A Wells, 1993, Science.

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Kevan M. Shokat, James A. Wells, K. Shokat, 2013, Nature.

Binding of small molecules to an adaptive protein–protein interface

Michelle R. Arkin, Jennifer Hyde, Robert S. McDowell, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Substrate and Inhibitor-induced Dimerization and Cooperativity in Caspase-1 but Not Caspase-3*

Christopher L. McClendon, J. Wells, M. Jacobson, 2013, The Journal of Biological Chemistry.

An allosteric circuit in caspase-1.

Debajyoti Datta, J. Wells, James A Wells, 2008, Journal of molecular biology.

Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface

Bih-Rong Wei, R. Stephens, J. Wells, 2016, Oncotarget.

Searching for new allosteric sites in enzymes.

J. Wells, J. Hardy, James A Wells, 2004, Current opinion in structural biology.

In vitro selection of zinc fingers with altered DNA-binding specificity.

S H Kim, Sung-Hou Kim, J. Wells, 1994, Biochemistry.

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

N. Krogan, D. Agard, R. Stroud, 2020, Nature Chemical Biology.

Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike

J. Wells, Jie Zhou, D. P. Nguyen, 2020, bioRxiv.

Hot-spot mimicry of a cytokine receptor by a small molecule

Christopher D. Thanos, James A. Wells, W. Delano, 2006, Proceedings of the National Academy of Sciences.

Structure and function of human growth hormone: implications for the hematopoietins.

J. Wells, A. D. de Vos, J A Wells, 1993, Annual review of biophysics and biomolecular structure.

Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library.

J. Wells, S. Atwell, J. Ridgway, 1997, Journal of molecular biology.

National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions

Richard D. Smith, E. Ruppin, J. Yates, 2020 .

Production of an atrial natriuretic peptide variant that is specific for type A receptor.

J. Wells, B. Cunningham, B. Bennett, 1994, The EMBO journal.

Synthesis of proteins by subtiligase.

J. Wells, J. Judice, A. Braisted, 1997, Methods in enzymology.

A small molecule inhibitor of Caspase 1

J. Wells, D. Auld, M. Boxer, 2011 .

Malonate-assisted purification of human caspases.

J. Wells, M. J. Romanowski, J. Scheer, 2005, Protein expression and purification.

A common allosteric site and mechanism in caspases

J. Wells, James A Wells, M. J. Romanowski, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Ordering a dynamic protein via a small-molecule stabilizer.

Jessica K. Gagnon, Chinmay Y. Majmudar, C. Brooks, 2013, Journal of the American Chemical Society.

Mutational analysis and protein engineering of receptor-binding determinants in human placental lactogen.

J. Wells, B. Cunningham, H. Lowman, 1991, The Journal of biological chemistry.

Identifying and antagonizing the interactions between layilin and glycosylated collagens.

J. Wells, M. Rosenblum, J. R. Byrnes, 2022, Cell chemical biology.

Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity.

J. Wells, K. Pearce, T. Teeri, 1999, Biochemistry.

Engineering enzyme specificity by "substrate-assisted catalysis".

J. Wells, P. Carter, J A Wells, 1987, Science.

Reply to Liu et al.: Specific mutations matter in specificity and catalysis in ACE2

T. Kortemme, J. Wells, J. Glasgow, 2021, Proceedings of the National Academy of Sciences.

Engineering Antibodies Targeting p16 MHC-Peptide Complexes.

J. Wells, J. Campisi, Nicholas J. Rettko, 2022, ACS chemical biology.

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

T. Kortemme, J. Wells, T. Hobman, 2020, bioRxiv.

Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis

J. Wells, R. Moriggl, C. Mayhew, 2019, Life Science Alliance.