A. Tomida

发表

Drug resistance mediated by cellular stress response to the microenvironment of solid tumors.

A. Tomida, T. Tsuruo, 1999, Anti-cancer drug design.

Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal

Takashi Tsuruo, Naoya Fujita, Hiroshi Sakamoto, 2003, Cancer science.

BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.

A. Tomida, Y. Sugimoto, Y. Kato, 2018, Biochemical and biophysical research communications.

BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib.

A. Tomida, Kazuhiro Kunimasa, Ikuko Nagasawa, 2017, Biochemical and biophysical research communications.

Neoadjuvant CAPOX and bevacizumab alone for locally advanced rectal cancer: long-term results from the N-SOG 03 trial

A. Tomida, M. Nagino, G. Nakayama, 2018, International Journal of Clinical Oncology.

GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress

A. Tomida, Y. Sugimoto, Y. Kato, 2020, Molecular Pharmacology.

InDePTH: detection of hub genes for developing gene expression networks under anticancer drug treatment

A. Tomida, Satomi Tsukahara, M. Koido, 2018, Oncotarget.

Identification of Chrysoplenetin from Vitex negundo as a Potential Cytotoxic Agent against PANC‐1 and a Panel of 39 Human Cancer Cell Lines (JFCR‐39)

A. Tomida, H. Esumi, T. Yamori, 2011, Phytotherapy research : PTR.

Prevention of carbon nanohorn agglomeration using a conjugate composed of comb-shaped polyethylene glycol and a peptide aptamer.

A. Tomida, T. Tsuruo, Shigeo Sato, 2009, Molecular pharmaceutics.

Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells

A. Tomida, K. Ikeda, T. Soga, 2014, International journal of cancer.

Glucose-regulated stresses cause decreased expression of cyclin D1 and hypophosphorylation of retinoblastoma protein in human cancer cells.

A. Tomida, T. Tsuruo, H. Suzuki, 1996, Oncogene.

Cellular sensitization to cisplatin and carboplatin with decreased removal of platinum-DNA adduct by glucose-regulated stress

Y. Taketani, A. Tomida, T. Tsuruo, 1999, Cancer Chemotherapy and Pharmacology.

2‐deoxyglucose inhibits chemotheapeutic drug‐induced apoptosis in human monocytic leukemia U937 cells ith inhibition of c‐Jun N‐terminal kinase 1/stress‐activated protein kinase activation

A. Tomida, T. Tsuruo, M. Naito, 1998, International journal of cancer.

Preventing the unfolded protein response via aberrant activation of 4E‐binding protein 1 by versipelostatin

K. Shin‐ya, A. Tomida, T. Tsuruo, 2009, Cancer science.

Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact.

A. Tomida, K. Ikeda, T. Soga, 2013, The American journal of pathology.

Alteration in Copy Numbers of Genes as a Mechanism for Acquired Drug Resistance

J. Inazawa, A. Tomida, T. Tsuruo, 2004, Cancer Research.

Nucleobindin 1 Controls the Unfolded Protein Response by Inhibiting ATF6 Activation*

Yusuke Nakamura, O. Kitahara, A. Tomida, 2007, Journal of Biological Chemistry.

Resistance to antitumor agent-induced apoptosis in a mutant of human myeloid leukemia U937 cells.

A. Tomida, T. Tsuruo, M. Naito, 1994, Experimental cell research.

Glucose‐regulated stresses cause degradation of DNA topoisomerase IIα by inducing nuclear proteasome during G1 cell cycle arrest in cancer cells

A. Tomida, T. Tsuruo, H. Kim, 1999, Journal of cellular physiology.

Immunological Quantitation of DT‐Diaphorase in Carcinoma Cell Lines and Clinical Colon Cancers: Advanced Tumors Express Greater Levels of DT‐Diaphorase

A. Tomida, T. Tsuruo, M. Naito, 1998, Japanese journal of cancer research : Gann.

A new evaluation method for quantifying PI3K activity by HTRF assay.

A. Tomida, S. Dan, Dexin Kong, 2008, Biochemical and biophysical research communications.

Bioactive cardenolides from the stems and twigs of Nerium oleander.

Takashi Tsuruo, Tomokazu Mitsui, Ming Zhao, 2007, Journal of natural products.

A Novel Endoplasmic Reticulum Export Signal

A. Tomida, T. Tsuruo, S. Saito, 2009, The Journal of Biological Chemistry.

Glucose‐regulated protein 78: A new partner of p53 in trophoblast

A. Tomida, T. Tsuruo, P. Bischof, 2009, Proteomics.

Biodistribution and ultrastructural localization of single-walled carbon nanohorns determined in vivo with embedded Gd2O3 labels.

T. Ichihashi, A. Tomida, T. Tsuruo, 2009, ACS nano.

Glucose‐regulated stresses induce resistance to camptothecin in human cancer cells

A. Tomida, T. Tsuruo, J. Yun, 1996, International journal of cancer.

A 12-mm carcinoid tumor of the minor duodenal papilla with lymph node metastases.

A. Tomida, M. Narita, Y. Kurumiya, 2013, Japanese journal of clinical oncology.

Enhancement of Reversing Effect of Cyclosporin A on Vincristine Resistance by Anti‐P‐glycoprotein Monoclonal Antibody MRK‐16

A. Tomida, T. Tsuruo, M. Naito, 1993, Japanese journal of cancer research : Gann.

Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines.

Y. Taketani, A. Tomida, T. Tsuruo, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

A Novel Mutant from Apoptosis‐resistant Colon Cancer HT‐29 Cells Showing Hyper‐apoptotic Response to Hypoxia, Low Glucose and Cisplatin

A. Tomida, T. Tsuruo, Hiroyuki Suzuki, 1998, Japanese journal of cancer research : Gann.

Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance.

A. Tomida, T. Tsuruo, M. Naito, 1993, Journal of the National Cancer Institute.

Intrabiliary Growth of Metastatic Adenocarcinoma 11 Years after Curative Operation of Colon Cancer

A. Tomida, S. Kawai, H. Matsunaga, 2016 .

Ultrastructural localization of intravenously injected carbon nanohorns in tumor

T. Ichihashi, A. Tomida, Shigeo Sato, 2014, International journal of nanomedicine.

Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation

A. Tomida, S. Dan, Kazuhiro Kunimasa, 2022, Scientific Reports.

IL12RB2 and ABCA1 Genes Are Associated with Susceptibility to Radiation Dermatitis

Y. Miki, T. Noda, Y. Nishimura, 2008, Clinical Cancer Research.

SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin

Y. Taketani, A. Tomida, T. Tsuruo, 2002, Oncogene.

Novel Mechanism of N‐Solanesyl‐N,N′‐bis(3,4‐dimethoxybenzyl)ethylenediamine in Potentiation of Antitumor Drug Action on Multidrug‐resistant and Sensitive Chinese Hamster Cells

A. Tomida, T. Tatsuta, Hideo Suzuki, 1991, Japanese journal of cancer research : Gann.

Production of biologically active taxoids by a callus culture of Taxus cuspidata.

A. Tomida, T. Tsuruo, T. Yamori, 2004, Journal of natural products.

Effect on tumor cells of blocking survival response to glucose deprivation.

Takashi Tsuruo, Hae-Ryong Park, Kazuo Shin-ya, 2004, Journal of the National Cancer Institute.

The polar neutral and basic taxoids isolated from needles and twigs of Taxus cuspidata and their biological activity

A. Tomida, T. Tsuruo, T. Yamori, 2008, Journal of Wood Science.

Bioactive triterpene saponins from the roots of Phytolacca americana.

Takashi Tsuruo, Liyan Wang, Takao Kataoka, 2008, Journal of natural products.

Two Taxoids from Taxus cuspidata as Modulators of Multidrag Resistant Tumor Cells

A. Tomida, T. Tsuruo, Shu-jun Zhang, 2001 .

Neutral taxoids from Taxus cuspidata as modulators of multidrug-resistant tumor cells.

A. Tomida, T. Tsuruo, J. Sakai, 2000, Phytochemistry.

Synergistic Effect in Culture of Bleomycin‐group Antibiotics and N‐Solanesyl‐N, N’‐bis(3,4‐dimethoxybenzyl)ethylenediamine, a Synthetic Isoprenoid

A. Tomida, Hideo Suzuki, 1990, Japanese journal of cancer research : Gann.

Bioactive lignans from Peperomia duclouxii.

A. Tomida, T. Tsuruo, T. Kataoka, 2007, Journal of natural products.

Cullin 3 Promotes Proteasomal Degradation of the Topoisomerase I-DNA Covalent Complex

A. Tomida, T. Tsuruo, Y. Ogiso, 2004, Cancer Research.

Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation.

K. Shin‐ya, A. Tomida, T. Tsuruo, 2009, Cancer research.

A BRIEF HISTORY OF CANCER CHEMOTHERAPY

Takashi Tsuruo, David J. Kerr, Qiang Yu, 2002 .

Cytocidal Activity of a Synthetic Isoprenoid, N‐Solanesyl‐N, N′‐bis(3,4‐dimethoxy‐benzyl)ethylenediamine, and Its Potentiation of Antitumor Drugs against Multidrug‐resistant and Sensitive Cells in vitro

A. Tomida, Hideo Suzuki, T. Nishimura, 1990, Japanese journal of cancer research : Gann.

Antitumor activity and novel DNA‐self‐strand‐breaking mechanism of CNDAC (1‐(2‐C‐cyano‐2‐deoxy‐β‐d‐ARABINO‐Pentofuranosyl) cytosine) and its N4‐palmitoyl derivative (CS‐682)

A. Tomida, T. Tsuruo, Y. Wataya, 1999, International journal of cancer.

Inhibition of P-glycoprotein and recovery of drug sensitivity of human acute leukemic blast cells by multidrug resistance gene (mdr1) antisense oligonucleotides.

A. Tomida, T. Tsuruo, H. Mizoguchi, 1998, Blood.

Overexpression of thioredoxin does not confer resistance to cisplatin in transfected human ovarian and colon cancer cell lines

Y. Taketani, A. Tomida, T. Tsuruo, 1997, Cancer Chemotherapy and Pharmacology.

Acute Induction of Adriamycin‐resistance in Human Colon Carcinoma HT‐29 Cells Exposed to a Sublethal Dose of Adriamycin

A. Tomida, T. Tsuruo, M. Naito, 1995, Japanese journal of cancer research : Gann.

Proteasome inhibition circumvents solid tumor resistance to topoisomerase II-directed drugs.

A. Tomida, T. Tsuruo, Y. Ogiso, 2000, Cancer research.

Prediction of Sensitivity to STI571 among Chronic Myeloid Leukemia Patients by Genome‐wide cDNA Microarray Analysis

Yusuke Nakamura, Tatsuhiko Tsunoda, Ryuzo Ohno, 2002, Japanese journal of cancer research : Gann.

Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation

A. Tomida, S. Saito, S. Dan, 2015, Cancer science.

DRUG RESISTANCE PATHWAYS AS TARGETS

A. Tomida, T. Tsuruo, 2002 .

Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia

A. Tomida, T. Tsuruo, Hiroyuki Suzuki, 2001, Oncogene.

Functional Interaction of DNA Topoisomerase IIα With the β-Catenin and T-Cell Factor-4 Complex

S. Hirohashi, A. Tomida, T. Tsuruo, 2007 .

DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines.

A. Tomida, T. Tsuruo, M. Naito, 1996, Cancer research.

Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II.

A. Tomida, T. Tsuruo, J. Yun, 1995, Oncology research.

TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress

A. Tomida, T. Natsume, S. Iemura, 2016, Journal of cellular biochemistry.

Reversal of Multidrug Resistance by Novel Nitrophenyl Pyrones, SNF4435C and D

A. Tomida, T. Tsuruo, Kosaku Takahashi, 2001, Japanese journal of cancer research : Gann.

Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor

A. Tomida, S. Dan, H. Seimiya, 2021, Cancer science.

The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.

A. Tomida, T. Natsume, S. Iemura, 2015, Biochemical and biophysical research communications.

Nuclear localization of proteasomes participates in stress-inducible resistance of solid tumor cells to topoisomerase II-directed drugs.

A. Tomida, T. Tsuruo, Y. Ogiso, 2002, Cancer research.

Hypoxia up-regulates telomerase activity via mitogen-activated protein kinase signaling in human solid tumor cells.

A. Tomida, T. Tsuruo, H. Seimiya, 1999, Biochemical and biophysical research communications.

Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity

K. Shin‐ya, A. Tomida, Ju-Young Kim, 2010, Journal of cellular physiology.

Development of a gene expression database and related analysis programs for evaluation of anticancer compounds

A. Tomida, S. Saito, S. Dan, 2013, Cancer science.

Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy

A. Tomida, Kazuhiro Kunimasa, Ikuko Nagasawa, 2020, iScience.

Etoposide‐resistant HT‐29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down‐regulator

K. Shin‐ya, A. Tomida, Ju-Young Kim, 2008, Journal of cellular physiology.

Topoisomerase IDNA Covalent Complex Cullin 3 Promotes Proteasomal Degradation of the Updated

A. Tomida, T. Tsuruo, Y. Ogiso, 2004 .

Interaction between Glucose-regulated Destruction Domain of DNA Topoisomerase IIα and MPN Domain of Jab1/CSN5*

A. Tomida, T. Tsuruo, T. Andoh, 2004, Journal of Biological Chemistry.

TBL2 Is a Novel PERK-Binding Protein that Modulates Stress-Signaling and Cell Survival during Endoplasmic Reticulum Stress

A. Tomida, S. Iemura, Satomi Tsukahara, 2014, PloS one.

POTENTIATION OF ANTITUMOR DRUGS AND ITS MECHANISM OF ACTION

A. Tomida, M. Tahara, Hideo Suzuki, 2006 .

Correction: IL12RB2 and ABCA1 Genes Are Associated with Susceptibility to Radiation Dermatitis

T. Noda, Y. Nishimura, A. Tomida, 2010, Clinical Cancer Research.

AP-1-Dependent miR-21 expression contributes to chemoresistance in cancer stem cell-like SP cells.

A. Tomida, Ryohei Katayama, N. Fujita, 2010, Oncology research.

Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation

A. Tomida, Shigeo Sato, S. Saito, 2012, Molecular Cancer Therapeutics.

Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions

A. Tomida, T. Tsuruo, S. Saito, 2010, Cancer science.

Glucose starvation and hypoxia induce nuclear accumulation of proteasome in cancer cells.

A. Tomida, T. Tsuruo, H. Kim, 1999, Biochemical and biophysical research communications.

Use of chemical genomics in assessment of the UPR.

A. Tomida, S. Saito, 2011, Methods in enzymology.

Modulation of multidrug resistance in tumor cells by taxinine derivatives.

A. Tomida, T. Tsuruo, J. Kobayashi, 1999, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells.

A. Tomida, T. Tsuruo, T. Yamori, 2007, Bioorganic & medicinal chemistry letters.

Activating mutations in EGFR and PI3K promote ATF4 induction for NSCLC cell survival during amino acid deprivation.

A. Tomida, Hitomi Shirahama, Y. Sugimoto, 2023, Heliyon.

Down‐regulation of epidermal growth factor receptor‐signaling pathway by binding of GRP78/BiP to the receptor under glucose‐starved stress conditions

A. Tomida, T. Tsuruo, K. Mikami, 1998, Journal of cellular physiology.

Taxoids and abietanes from callus cultures of Taxus cuspidata.

A. Tomida, T. Tsuruo, Shu-jun Zhang, 2005, Journal of natural products.

Mitochondrial deficiency impairs hypoxic induction of HIF-1 transcriptional activity and retards tumor growth

A. Tomida, Shigeo Sato, N. Haga, 2017, Oncotarget.

Compound C Prevents the Unfolded Protein Response during Glucose Deprivation through a Mechanism Independent of AMPK and BMP Signaling

K. Shin‐ya, A. Tomida, S. Saito, 2012, PloS one.

Regulation of DNA topoisomerase IIalpha stability by the ECV ubiquitin ligase complex.

A. Tomida, C. Choi, J. Yun, 2009, Biochemical and biophysical research communications.

A new taxoid from a callus culture of Taxus cuspidata as an MDR reversal agent.

A. Tomida, T. Tsuruo, J. Sakai, 2006, Chemical & pharmaceutical bulletin.

Structure-activity relationships of some taxoids as multidrug resistance modulator.

A. Tomida, T. Tsuruo, Shu-jun Zhang, 2007, Bioorganic & medicinal chemistry letters.

The kinase PERK represses translation of the G-protein–coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells

A. Tomida, Takuya Saito, M. Koido, 2020, The Journal of Biological Chemistry.

Bioactive tetrahydrofuran lignans from Peperomia dindygulensis.

A. Tomida, T. Tsuruo, T. Kataoka, 2005, Journal of natural products.

Bioactive polyketides from Peperomia duclouxii.