R. Joseph

发表

Identification of an allosteric signaling network within Tec family kinases.

R. Joseph, Q. Xie, A. Andreotti, 2010, Journal of molecular biology.

T-cell signaling regulated by the Tec family kinase, Itk.

R. Joseph, A. Andreotti, P. Schwartzberg, 2010, Cold Spring Harbor perspectives in biology.

Disrupting the Intermolecular Self-Association of Itk Enhances T Cell Signaling

R. Joseph, A. Andreotti, L. Berg, 2010, The Journal of Immunology.

Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1.

P. Vyas, R. Joseph, P. Majerus, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.

R. Joseph, A. Andreotti, S. Boyken, 2009, Journal of molecular biology.

SignalingSelf-Association of Itk Enhances T Cell Disrupting the Intermolecular

R. Joseph, A. Andreotti, L. Berg, 2010 .

Dynamics of the Tec‐family tyrosine kinase SH3 domains

R. Joseph, A. Andreotti, T. Smithgall, 2016, Protein science : a publication of the Protein Society.

Assignment1 of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization

R. Joseph, F. Norris, J. Walker, 2000, Cytogenetic and Genome Research.

An autoinhibitory role for the Pleckstrin Homology domain of ITK and its interplay with canonical phospholipid recognition

R. Joseph, A. Andreotti, S. Boyken, 2018 .

Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation.

R. Joseph, A. Andreotti, Lie Min, 2015, Journal of molecular biology.

Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases

R. Joseph, A. Andreotti, N. Kannan, 2019, Proceedings of the National Academy of Sciences.

Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK

R. Joseph, A. Andreotti, Lauren Kueffer, 2021, Frontiers in Cell and Developmental Biology.

Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts.

R. Joseph, A. Andreotti, T. Wales, 2017, Structure.

A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.

R. Jernigan, R. Joseph, Q. Xie, 2014, Journal of molecular biology.

An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition.

R. Joseph, A. Andreotti, S. Boyken, 2017, Biochemistry.

Substrate Specificity and Recognition Is Conferred by the Pleckstrin Homology Domain of the Dbl Family Guanine Nucleotide Exchange Factor P-Rex2*

R. Joseph, F. Norris, 2005, Journal of Biological Chemistry.

Insights into the working of P-Rex2: an inositol polyphosphate 4-phosphatase domain containing guanine nucleotide exchange factor

R. Joseph, 2004 .

Activation Loop Dynamics Determine the Different Catalytic Efficiencies of B Cell– and T Cell–Specific Tec Kinases

R. Joseph, Q. Xie, A. Andreotti, 2013, Science Signaling.

Substrate recognition of PLCγ1 via a specific docking surface on Itk.

R. Joseph, Q. Xie, A. Andreotti, 2013, Journal of molecular biology.

Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue.

R. Joseph, A. Andreotti, 2011, Biochemistry.

Conformational snapshots of Tec kinases during signaling

R. Joseph, A. Andreotti, 2009, Immunological reviews.

Differential impact of BTK active site inhibitors on the conformational state of full-length BTK

R. Joseph, A. Andreotti, T. Wales, 2020, eLife.

The conformational state of the BTK substrate PLCγ contributes to Ibrutinib resistance.

R. Joseph, A. Andreotti, T. Wales, 2021, Journal of molecular biology.

Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures.

R. Joseph, A. Andreotti, J. Nix, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCγ1

R. Joseph, A. Andreotti, Lie Min, 2009, Proceedings of the National Academy of Sciences.

Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response.

R. Joseph, A. Andreotti, J. Iwasa, 2018, Annual review of immunology.

Conformational switches that control the TEC kinase – PLCγ signaling axis

R. Joseph, A. Andreotti, Jacques Lowe, 2022, Journal of structural biology: X.

Bacterial expression and purification of interleukin-2 tyrosine kinase: single step separation of the chaperonin impurity.

R. Joseph, A. Andreotti, 2008, Protein expression and purification.

A remote substrate docking mechanism for the tec family tyrosine kinases.

R. Joseph, A. Andreotti, Lie Min, 2007, Biochemistry.

Mechanism and functional significance of Itk autophosphorylation.

R. Joseph, A. Andreotti, D. Fulton, 2007, Journal of molecular biology.

SH2-dependent autophosphorylation within the Tec family kinase Itk.

R. Joseph, A. Andreotti, A. Severin, 2009, Journal of molecular biology.

The linker between SH2 and kinase domains positively regulates catalysis of the Tec family kinases.

R. Joseph, A. Andreotti, Lie Min, 2007, Biochemistry.

Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases

Robert L. Jernigan, Nikita Chopra, Thomas E. Wales, 2016, PLoS Comput. Biol..

A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.

R. Jernigan, R. Joseph, Q. Xie, 2014, Journal of molecular biology.

Screening and Characterization of Allosteric Small Molecules Targeting Bruton's Tyrosine Kinase.

R. Joseph, A. Andreotti, N. Amatya, 2023, Biochemistry.

Dynamics of the Tec‐family tyrosine kinase SH3 domains

R. Joseph, A. Andreotti, T. Smithgall, 2016, Protein science : a publication of the Protein Society.