A. Andreotti

发表

Identification of an allosteric signaling network within Tec family kinases.

R. Joseph, Q. Xie, A. Andreotti, 2010, Journal of molecular biology.

T-cell signaling regulated by the Tec family kinase, Itk.

R. Joseph, A. Andreotti, P. Schwartzberg, 2010, Cold Spring Harbor perspectives in biology.

Disrupting the Intermolecular Self-Association of Itk Enhances T Cell Signaling

R. Joseph, A. Andreotti, L. Berg, 2010, The Journal of Immunology.

Positive Regulation of Itk PH Domain Function by Soluble IP4

A. Andreotti, M. Cooke, Stephen Soonthornvacharin, 2007, Science.

Calicheamicin−DNA Recognition: An Analysis of Seven Different Drug−DNA Complexes

A. Andreotti, S. Walker, D. Kahne, 2000 .

NMR characterization of calicheamicin γ1I bound to DNA

A. Andreotti, S. Walker, D. Kahne, 1994 .

The effects of glycosylation on peptide backbone conformation

A. Andreotti, D. Kahne, 1993 .

Defining a Two-Pronged Structural Model for PB1 Domain Interaction in Plant Auxin Responses*

A. Andreotti, L. Strader, G. Amarasinghe, 2015 .

Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.

R. Joseph, A. Andreotti, S. Boyken, 2009, Journal of molecular biology.

SignalingSelf-Association of Itk Enhances T Cell Disrupting the Intermolecular

R. Joseph, A. Andreotti, L. Berg, 2010 .

Dynamics of the Tec‐family tyrosine kinase SH3 domains

R. Joseph, A. Andreotti, T. Smithgall, 2016, Protein science : a publication of the Protein Society.

An autoinhibitory role for the Pleckstrin Homology domain of ITK and its interplay with canonical phospholipid recognition

R. Joseph, A. Andreotti, S. Boyken, 2018 .

Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation.

R. Joseph, A. Andreotti, Lie Min, 2015, Journal of molecular biology.

T Cell Specific Adapter Protein (TSAd) Interacts with Tec Kinase ITK to Promote CXCL12 Induced Migration of Human and Murine T Cells

A. Andreotti, A. Spurkland, M. Inngjerdingen, 2010, PloS one.

Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases

R. Joseph, A. Andreotti, N. Kannan, 2019, Proceedings of the National Academy of Sciences.

The HIV-1 protein Nef activates the Tec family kinase Btk by stabilizing an intermolecular SH3-SH2 domain interaction

A. Andreotti, S. Du, T. Smithgall, 2022, Science Signaling.

Determinants of intra versus intermolecular self-association within the regulatory domains of Rlk and Itk.

Kendall W. Cradic, A. Laederach, A. Andreotti, 2003, Journal of Molecular Biology.

Competing modes of self‐association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization

Kendall W. Cradic, A. Laederach, A. Andreotti, 2002, Protein science : a publication of the Protein Society.

Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK

R. Joseph, A. Andreotti, Lauren Kueffer, 2021, Frontiers in Cell and Developmental Biology.

SENSITIVITY OF GLYCOPEPTIDE CONFORMATION TO CARBOHYDRATE CHAIN LENGTH

A. Andreotti, D. Kahne, R. Liang, 1995 .

Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk.

A. Andreotti, J. Luban, J. Colgan, 2004, Immunity.

Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts.

R. Joseph, A. Andreotti, T. Wales, 2017, Structure.

A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.

R. Jernigan, R. Joseph, Q. Xie, 2014, Journal of molecular biology.

The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell–specific adapter protein

A. Andreotti, S. Boyken, A. Spurkland, 2019, The Journal of Biological Chemistry.

An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition.

R. Joseph, A. Andreotti, S. Boyken, 2017, Biochemistry.

A Selective NMR Probe to Monitor the Conformational Transition from Inactive to Active Kinase

Q. Xie, A. Andreotti, D. Fulton, 2014, ACS chemical biology.

Activation Loop Dynamics Determine the Different Catalytic Efficiencies of B Cell– and T Cell–Specific Tec Kinases

R. Joseph, Q. Xie, A. Andreotti, 2013, Science Signaling.

Substrate recognition of PLCγ1 via a specific docking surface on Itk.

R. Joseph, Q. Xie, A. Andreotti, 2013, Journal of molecular biology.

Dynamic regulatory features of the protein tyrosine kinases.

A. Andreotti, D. Y. Lin, N. Amatya, 2019, Biochemical Society transactions.

Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue.

R. Joseph, A. Andreotti, 2011, Biochemistry.

Conformational snapshots of Tec kinases during signaling

R. Joseph, A. Andreotti, 2009, Immunological reviews.

Editorial: Targeting Bruton Tyrosine Kinase

A. Andreotti, E. Grassilli, C. Brunner, 2022, Frontiers in Cell and Developmental Biology.

Differential impact of BTK active site inhibitors on the conformational state of full-length BTK

R. Joseph, A. Andreotti, T. Wales, 2020, eLife.

Regulatory intramolecular association in a tyrosine kinase of the Tec family

S. Schreiber, A. Andreotti, S. Bunnell, 1997, Nature.

The conformational state of the BTK substrate PLCγ contributes to Ibrutinib resistance.

R. Joseph, A. Andreotti, T. Wales, 2021, Journal of molecular biology.

Calmodulin and PI(3,4,5)P3 cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production

M. A. Shea, A. Andreotti, S. Boyken, 2014, Science Signaling.

A case study of proline isomerization in cell signaling.

A. Andreotti, Lie Min, D. Fulton, 2005, Frontiers in bioscience : a journal and virtual library.

Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures.

R. Joseph, A. Andreotti, J. Nix, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Molecular details of Itk activation by prolyl isomerization and phospholigand binding: the NMR structure of the Itk SH2 domain bound to a phosphopeptide.

A. Andreotti, E. Pletneva, M. Sundd, 2006, Journal of molecular biology.

Ligand specificity modulated by prolyl imide bond Cis/Trans isomerization in the Itk SH2 domain: a quantitative NMR study.

A. Laederach, A. Andreotti, P. Breheny, 2003, Journal of the American Chemical Society.

Structural characterization of a proline-driven conformational switch within the Itk SH2 domain

A. Andreotti, R. J. Mallis, K. Brazin, 2002, Nature Structural Biology.

Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A

A. Andreotti, R. J. Mallis, K. Brazin, 2002, Proceedings of the National Academy of Sciences of the United States of America.

A specific intermolecular association between the regulatory domains of a Tec family kinase.

A. Andreotti, K. Brazin, D. Fulton, 2000, Journal of molecular biology.

Native state proline isomerization: an intrinsic molecular switch.

A. Andreotti, Amy H Andreotti, 2003, Biochemistry.

Role of Reversible Histidine Coordination in Hydroxylamine Reduction by Plant Hemoglobins (Phytoglobins).

A. Andreotti, M. Hargrove, N. S. Athwal, 2016, Biochemistry.

Solution structure and backbone dynamics of Calsensin, an invertebrate neuronal calcium‐binding protein

A. Andreotti, K. Johansen, J. Johansen, 2005, Protein science : a publication of the Protein Society.

In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell Kinase

Amy H. Andreotti, Constantine D. Tsoukas, A. Andreotti, 2012, Journal of signal transduction.

Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec

A. Andreotti, S. Boyken, D. Fulton, 2012, Protein science : a publication of the Protein Society.

Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCγ1

R. Joseph, A. Andreotti, Lie Min, 2009, Proceedings of the National Academy of Sciences.

Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response.

R. Joseph, A. Andreotti, J. Iwasa, 2018, Annual review of immunology.

Conformational switches that control the TEC kinase – PLCγ signaling axis

R. Joseph, A. Andreotti, Jacques Lowe, 2022, Journal of structural biology: X.

Electron self-exchange in hemoglobins revealed by deutero-hemin substitution.

A. Andreotti, M. Hargrove, D. Fulton, 2015, Journal of inorganic biochemistry.

Solubility of recombinant Src homology 2 domains expressed in E. coli can be predicted by TANGO

A. Andreotti, A. Spurkland, L. Skjeldal, 2014, BMC Biotechnology.

Bacterial expression and purification of interleukin-2 tyrosine kinase: single step separation of the chaperonin impurity.

R. Joseph, A. Andreotti, 2008, Protein expression and purification.

Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR.

W Richter, B. Farmer, W. Richter, 1993, Science.

A remote substrate docking mechanism for the tec family tyrosine kinases.

R. Joseph, A. Andreotti, Lie Min, 2007, Biochemistry.

Defining a Two-pronged Structural Model for PB1 (Phox/Bem1p) Domain Interaction in Plant Auxin Responses*

A. Andreotti, L. Strader, J. Jez, 2015, The Journal of Biological Chemistry.

Opening the pore hinges on proline

A. Andreotti, Amy H Andreotti, 2006, Nature chemical biology.

Solution and micelle-bound structures of tachyplesin I and its active aromatic linear derivatives.

A. Laederach, A. Andreotti, D. Fulton, 2002, Biochemistry.

Mechanism and functional significance of Itk autophosphorylation.

R. Joseph, A. Andreotti, D. Fulton, 2007, Journal of molecular biology.

SH2-dependent autophosphorylation within the Tec family kinase Itk.

R. Joseph, A. Andreotti, A. Severin, 2009, Journal of molecular biology.

Mapping the Ca2+ -dependent binding of an invertebrate homolog of protein phosphatase 4 regulatory subunit 2 to the small EF-hand protein, calsensin.

A. Andreotti, K. Johansen, J. Johansen, 2006, Biochimica et biophysica acta.

Murine Itk SH3 domain

A. Andreotti, A. Severin, D. Fulton, 2008, Journal of biomolecular NMR.

The linker between SH2 and kinase domains positively regulates catalysis of the Tec family kinases.

R. Joseph, A. Andreotti, Lie Min, 2007, Biochemistry.

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

A. Andreotti, D. Y. Lin, T. Wales, 2023, bioRxiv.

Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases

Robert L. Jernigan, Nikita Chopra, Thomas E. Wales, 2016, PLoS Comput. Biol..

A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.

R. Jernigan, R. Joseph, Q. Xie, 2014, Journal of molecular biology.

Screening and Characterization of Allosteric Small Molecules Targeting Bruton's Tyrosine Kinase.

R. Joseph, A. Andreotti, N. Amatya, 2023, Biochemistry.

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states.

A. Andreotti, T. Wales, Puneet Juneja, 2024, eLife.

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

A. Andreotti, D. Y. Lin, T. Wales, 2023, bioRxiv.

Dynamics of the Tec‐family tyrosine kinase SH3 domains

R. Joseph, A. Andreotti, T. Smithgall, 2016, Protein science : a publication of the Protein Society.