S. Benkovic

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Allosteric regulation and catalysis emerge via a common route.

N. Goodey, S. Benkovic, 2008, Nature chemical biology.

Surface Sites for Engineering Allosteric Control in Proteins

W. P. Russ, R. Ranganathan, M. Socolich, 2008, Science.

Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. 1989.

R. Lerner, D. Burton, S. Benkovic, 1992, Biotechnology.

IPRO: an iterative computational protein library redesign and optimization procedure.

C. Maranas, N. Goodey, S. Benkovic, 2006, Biophysical journal.

A Perspective on Enzyme Catalysis

S. Benkovic, S. Hammes-Schiffer, S. Hammes‐Schiffer, 2003, Science.

A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase.

H. Jane Dyson, Sung-Hun Bae, Brendan M. Duggan, 2013, Biochemistry.

Network of coupled promoting motions in enzyme catalysis

P. Agarwal, S. Benkovic, S. Hammes-Schiffer, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant.

C. Cameron, S. Benkovic, S J Benkovic, 1997, Biochemistry.

Strength of an interloop hydrogen bond determines the kinetic pathway in catalysis by Escherichia coli dihydrofolate reductase.

G. Miller, S. Benkovic, Stephen J. Benkovic, 1998, Biochemistry.

Deletion of a highly motional residue affects formation of the Michaelis complex for Escherichia coli dihydrofolate reductase.

G. Miller, S. Benkovic, 1998, Biochemistry.

Interloop contacts modulate ligand cycling during catalysis by Escherichia coli dihydrofolate reductase.

G. Miller, S. Benkovic, D. Wahnon, 2001, Biochemistry.

Free-energy landscape of enzyme catalysis.

S. Benkovic, S. Hammes-Schiffer, G. Hammes, 2008, Biochemistry.

Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda.

D R Burton, R. Lerner, D. Burton, 1989, Science.

Colloidal Au-Enhanced Surface Plasmon Resonance for Ultrasensitive Detection of DNA Hybridization

Lin He, Christine D. Keating, Sheila R. Nicewarner, 2000 .

Subcloning, characterization, and affinity labeling of Escherichia coli glycinamide ribonucleotide transformylase.

S. Benkovic, James Inglese, D. Johnson, 1990, Biochemistry.

The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans.

S. Benkovic, Hong Zhao, Ye Fang, 2013, Chemical communications.

Structure-reactivity correlation for the hydrolysis of phosphoramidate monoanions

S. Benkovic, E. Sampson, 1971 .

Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.

C. Barbas, R. Lerner, S. Benkovic, 1991, Proceedings of the National Academy of Sciences of the United States of America.

DNA polymerase as a molecular motor and pump.

R. Astumian, S. Benkovic, Ayusman Sen, 2014, ACS nano.

Chemical basis for enzyme catalysis.

S. Benkovic, T. C. Bruice, 2000, Biochemistry.

Flexibility, diversity, and cooperativity: pillars of enzyme catalysis.

S. Benkovic, S. Hammes-Schiffer, G. Hammes, 2011, Biochemistry.

Relating protein motion to catalysis.

S. Benkovic, S. Hammes-Schiffer, S. Hammes‐Schiffer, 2006, Annual review of biochemistry.

A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis

Wei Li, H. Dyson, P. Wright, 2011, Science.

Anomerization rates and enzyme specificity for biologically important sugars and sugar phosphates

S. Benkovic, K. Schray, 1978 .

Magnetic resonance studies of the anomeric distribution and manganese binding properties of fructose phosphates.

S. Benkovic, A. Mildvan, J. L. Engle, 1972, Biochemical and biophysical research communications.

Anomeric specificity of the alkaline form of fructose 1,6-diphosphatase from rabbit liver.

S. Benkovic, J. J. Steffens, K. Schray, 1974, The Journal of biological chemistry.

Anomeric specificity of phosphofructokinase from rabbit muscle.

S. Benkovic, J. J. Steffens, K. Schray, 1974, The Journal of biological chemistry.

The anomeric form of D-fructose 1,6-bisphosphate used as substrate in the muscle and yeast aldolase reactions.

S. Benkovic, K. Schray, W. Bullard, 1975, The Journal of biological chemistry.

Finding Cinderella's slipper—proteins that fit

Marc Ostermeier, Stephen J. Benkovic, S. Benkovic, 1999, Nature Biotechnology.

Enhanced crossover SCRATCHY: construction and high-throughput screening of a combinatorial library containing multiple non-homologous crossovers.

Stephen J Benkovic, George Georgiou, Karl E Griswold, 2003, Nucleic acids research.

Evolution of highly active enzymes by homology-independent recombination.

Stephen J Benkovic, George Georgiou, Karl E Griswold, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A combinatorial approach to hybrid enzymes independent of DNA homology

Marc Ostermeier, Stephen J. Benkovic, S. Benkovic, 1999, Nature Biotechnology.

Creating multiple-crossover DNA libraries independent of sequence identity

C D Maranas, C. Maranas, S. Benkovic, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Rapid generation of incremental truncation libraries for protein engineering using alpha-phosphothioate nucleotides.

S. Benkovic, M. Ostermeier, S. Lutz, 2001, Nucleic acids research.

Synthesis and application of derivatizable oligonucleotides.

S. Benkovic, K. Gibson, K. Gibson, 1987, Nucleic acids research.

Fluorescent oligonucleotides and deoxynucleotide triphosphates: preparation and their interaction with the large (Klenow) fragment of Escherichia coli DNA polymerase I.

S. Benkovic, P. Darke, D. Allen, 1989, Biochemistry.

On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves

I-Kao Chiang, Hongjun Yue, Jinjie Shi, 2012, Proceedings of the National Academy of Sciences.

An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site

Vincent Hernandez, Stephen J Benkovic, Lucy Shapiro, 2007, Science.

Controlling cell–cell interactions using surface acoustic waves

Peng Li, Nitesh Nama, Feng Guo, 2014, Proceedings of the National Academy of Sciences.

LOVely enzymes – towards engineering light‐controllable biocatalysts

Stephen J. Benkovic, Ulrich Krauss, S. Benkovic, 2009, Microbial biotechnology.

A clamp-like biohybrid catalyst for DNA oxidation.

Stephen J Benkovic, Tom G Bloemberg, Joost Clerx, 2013, Nature chemistry.

Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.

C. Barbas, R. Lerner, S. Benkovic, 1991, Proceedings of the National Academy of Sciences of the United States of America.

PurT-encoded Glycinamide Ribonucleotide Transformylase

Stephen J Benkovic, S. Benkovic, J. Thoden, 2002, The Journal of Biological Chemistry.

Production of cyclic peptides and proteins in vivo.

S. Benkovic, D. Wahnon, E. Abel-Santos, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Split-intein mediated circular ligation used in the synthesis of cyclic peptide libraries in E. coli

Stephen J Benkovic, Ali Tavassoli, S. Benkovic, 2007, Nature Protocols.

Evolution of protein function by domain swapping.

S. Benkovic, M. Ostermeier, M Ostermeier, 2000, Advances in protein chemistry.

Recognition of a Key Anchor Residue by a Conserved Hydrophobic Pocket Ensures Subunit Interface Integrity in DNA Clamps.

S. Benkovic, Xiaojun Xu, Chunli Yan, 2019, Journal of molecular biology.

Probing DNA clamps with single-molecule force spectroscopy

S. Benkovic, Xiaojun Xu, I. Ivanov, 2013, Nucleic acids research.

The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer.

S. Benkovic, Zhihao Zhuang, P. Burgers, 2006, Proceedings of the National Academy of Sciences of the United States of America.

'Screw-cap' clamp loader proteins that thread

S. Benkovic, Zhihao Zhuang, M. Trakselis, 2004, Nature Structural &Molecular Biology.

Building a Replisome Solution Structure by Elucidation of Protein-Protein Interactions in the Bacteriophage T4 DNA Polymerase Holoenzyme* 210

S. Benkovic, A. D. Jones, M. Trakselis, 2001, The Journal of Biological Chemistry.

Intricacies in ATP-dependent clamp loading: variations across replication systems.

S. Benkovic, M. Trakselis, 2001, Structure.

Assembly and disassembly of DNA polymerase holoenzyme.

S. Benkovic, D J Sexton, S J Benkovic, 1997, Current opinion in chemical biology.

The carboxyl terminus of the bacteriophage T4 DNA polymerase is required for holoenzyme complex formation.

S. Benkovic, A. Berdis, P. Soumillion, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Glossary of Coined Names & Terms Used in Science

Lord Kelvin, S. Benkovic, J. Andraos, 2011 .

Chemistry and biochemistry of folates

Stephen J. Benkovic, S. Benkovic, Raymond L. Blakley, 1984 .

Characterization of the T 4 Mre 11 / Rad 50 complex and investigation of the Mre 11 dimeric interface

S. Benkovic, S. Nelson, T. Herdendorf, 2017 .

Active-site mapping and site-specific mutagenesis of glycinamide ribonucleotide transformylase from Escherichia coli.

S. Benkovic, James Inglese, J. Smith, 1990, Biochemistry.

Cloning and characterization of a new purine biosynthetic enzyme: a non-folate glycinamide ribonucleotide transformylase from E. coli.

S. Benkovic, J. Smith, A. Marolewski, 1994, Biochemistry.

Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: Temporal order and the roles of Asp27 and Tyr100

S. Benkovic, S. Hammes-Schiffer, A. Kohen, 2014, Proceedings of the National Academy of Sciences.

A multisubstrate adduct inhibitor of a purine biosynthetic enzyme with a picomolar dissociation constant.

S. Benkovic, James Inglese, R. Blatchly, 1989, Journal of medicinal chemistry.

Quantitative Analysis of Purine Nucleotides Indicates Purinosome s Increase de N ovo Purine Biosynthesis

S. Benkovic, Hong Zhao, Anthony M. Pedley, 2015 .

Quantitative Analysis of Purine Nucleotides Indicates That Purinosomes Increase de Novo Purine Biosynthesis*♦

S. Benkovic, Hong Zhao, Anthony M. Pedley, 2015, The Journal of Biological Chemistry.

Kinetic relationships between the various activities of the formyl-methenyl-methylenetetrahydrofolate synthetase.

S. Benkovic, P. Benkovic, G. Wasserman, 1983, Biochemistry.

Coupled motions in enzyme catalysis.

S. Benkovic, V. Nashine, S. Hammes-Schiffer, 2010, Current opinion in chemical biology.

Multisubstrate adduct inhibitors of glycinamide ribonucleotide transformylase : synthetic and enzyme-assembled

S. Benkovic, James Inglese, 1991 .

Human de novo purine biosynthesis

S. Benkovic, Anthony M. Pedley, V. Pareek, 2020, Critical reviews in biochemistry and molecular biology.

A two-phagemid system for the creation of non-phage displayed antibody libraries approaching one trillion members.

S. Benkovic, M. Ostermeier, 2000, Journal of immunological methods.

The kinetic mechanism of wild-type and mutant mouse dihydrofolate reductases.

S. Benkovic, J. Adams, J. Thillet, 1990, Biochemistry.

Acoustofluidic Chemical Waveform Generator and Switch

A. Manz, T. Huang, S. Benkovic, 2014, Analytical chemistry.

Collaborative coupling between polymerase and helicase for leading-strand synthesis

Fangyuan Ding, Stephen J. Benkovic, Vincent Croquette, 2012, Nucleic acids research.

Understanding DNA replication by the bacteriophage T4 replisome

S. Benkovic, M. M. Spiering, 2017, The Journal of Biological Chemistry.

DNA Replication by the Bacteriophage T 4 Replisome 1 Understanding DNA Replication by the Bacteriophage T 4 Replisome

S. Benkovic, M. M. Spiering, 2017 .

Coordinated DNA Replication by the Bacteriophage T4 Replisome

S. Benkovic, M. M. Spiering, E. Noble, 2015, Viruses.

Construction and characterization of a bacteriophage T4 DNA polymerase deficient in 3'-->5' exonuclease activity.

S. Benkovic, T. Capson, N. Nossal, 1993, Proceedings of the National Academy of Sciences of the United States of America.

A zinc ribbon protein in DNA replication: primer synthesis and macromolecular interactions by the bacteriophage T4 primase.

S. Benkovic, A. Valentine, F. Ishmael, 2001, Biochemistry.

Dynamic protein interactions in the bacteriophage T4 replisome.

S. Benkovic, R. Roccasecca, M. Trakselis, 2001, Trends in biochemical sciences.

Protein-Protein Interactions in the Bacteriophage T4 Replisome

S. Benkovic, M. Trakselis, F. Ishmael, 2003, The Journal of Biological Chemistry.

RNA Primer Handoff in Bacteriophage T4 DNA Replication

S. Benkovic, S. Nelson, Ravindra Kumar, 2008, Journal of Biological Chemistry.

Antibody-catalyzed rearrangement of the peptide bond.

R. Gibbs, S. Benkovic, S. Taylor, 1992, Science.

A nonradioactive DNA methyltransferase assay adaptable to high-throughput screening.

S. Benkovic, P. Rajagopalan, Y. Woo, 2005, Analytical biochemistry.

Macrocycles and Antibodies as Catalysts

S. Benkovic, D. Smithrud, 2007 .

Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation.

Jared L. Johnson, L. Cantley, S. Benkovic, 2019, Journal of proteome research.

Processive and unidirectional translocation of monomeric UvsW helicase on single-stranded DNA.

S. Benkovic, S. Nelson, S. Perumal, 2009, Biochemistry.

Clinical severity in Lesch-Nyhan disease: the role of residual enzyme and compensatory pathways.

S. Benkovic, D. Schretlen, Hong Zhao, 2015, Molecular genetics and metabolism.

Probing the Electrostatics of Active Site Microenvironments along the Catalytic Cycle for Escherichia coli Dihydrofolate Reductase

S. Benkovic, S. Hammes-Schiffer, J. Asbury, 2014, Journal of the American Chemical Society.

X-ray absorption studies of the Cu-dependent phenylalanine hydroxylase from Chromobacterium violaceum. Comparison of the copper coordination in oxidized and dithionite-reduced enzymes.

S. Benkovic, R. Strange, R. Carr, 1992, Biochemistry.

Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.

D. Boger, I. Wilson, S. Benkovic, 2001, Biochemistry.

Unexpected Formation of an Epoxide Derived Multisubstrate Adduct Inhibitor on the Active Site of GAR Transformylase

D. Boger, I. Wilson, S. Benkovic, 2001 .

Construction and characterization of a single-chain catalytic antibody.

R. Gibbs, S. Benkovic, B. Posner, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The enzymic nature of antibody catalysis: development of multistep kinetic processing.

R. Lerner, S. Benkovic, K. Janda, 1990, Science.

Structural basis for amide hydrolysis catalyzed by the 43C9 antibody.

E. Getzoff, V. Roberts, S. Benkovic, 1999, Journal of molecular biology.

Dynamic Regulation of a Metabolic Multi-enzyme Complex by Protein Kinase CK2

K. Shokat, S. Benkovic, S. An, 2010, The Journal of Biological Chemistry.

Expanding the 43C9 class of catalytic antibodies using a chain-shuffling approach.

G. Miller, S. Benkovic, B. Posner, 1997, Bioorganic & medicinal chemistry.

A universal, vector-based system for nucleic acid reading-frame selection.

S. Benkovic, W. Fast, S. Lutz, 2002, Protein engineering.

Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons

Moriah L. Szpara, W. Freeman, S. Benkovic, 2018, Journal of neurochemistry.

[14] Anomeric specificity of carbohydrate-utilizing enzymes

S. Benkovic, 1979 .

Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase.

D. Boger, S. Benkovic, L. T. Gooljarsingh, 1997, Bioorganic & medicinal chemistry.

10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase.

D. Boger, S. Benkovic, M. S. Warren, 1997, Bioorganic & medicinal chemistry.

Combinatorial approaches to engineering hybrid enzymes

S. Benkovic, J. D. Stevenson, 2002 .

Catalytic antibodies: perusing combinatorial libraries.

S. Benkovic, J. Smiley, B. Posner, 1994, Trends in biochemical sciences.

Recent developments in catalytic antibodies.

S. Benkovic, J. Stewart, 1993, International reviews of immunology.

Dark-Field Illumination on Zero-Mode Waveguide/Microfluidic Hybrid Chip Reveals T4 Replisomal Protein Interactions

Yanhui Zhao, T. Huang, S. Benkovic, 2014, Nano letters.

The unique chemistry of benzoxaboroles: current and emerging applications in biotechnology and therapeutic treatments.

S. Benkovic, C. Liu, J. Tomsho, 2014, Bioorganic & medicinal chemistry.

Capturing a sulfenic acid with arylboronic acids and benzoxaborole.

S. Benkovic, C. Liu, 2013, Journal of the American Chemical Society.

Examination of the reactivity of benzoxaboroles and related compounds with a cis-diol.

S. Benkovic, J. Tomsho, 2012, The Journal of organic chemistry.

Elucidation of the mechanism of the reaction between phenylboronic acid and a model diol, Alizarin Red S.

S. Benkovic, J. Tomsho, 2012, The Journal of organic chemistry.

Boron-containing inhibitors of synthetases.

S. Benkovic, S. Baker, J. Tomsho, 2011, Chemical Society reviews.

A cell cycle-regulated adenine DNA methyltransferase from Caulobacter crescentus processively methylates GANTC sites on hemimethylated DNA.

L. Shapiro, S. Benkovic, C. Stephens, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Rapid assembly of the bacteriophage T4 core replication complex on a linear primer/template construct.

S. Benkovic, B. F. Kaboord, 1993, Proceedings of the National Academy of Sciences of the United States of America.

5,10-Methylene-5,6,7,8-tetrahydrofolate. Conformation of the tetrahydropyrazine and imidazolidine rings.

S. Benkovic, M. Poe, L. M. Jackman, 1979, Biochemistry.

On the physical properties and mechanism of action of arylsulfate sulfohydrolase II from Aspergillus oryzae.

M. Funk, S. Benkovic, E. Sampson, 1975, Archives of Biochemistry and Biophysics.

Phenylalanine hydroxylase. Correlation of the iron content with activity and the preparation and reconstitution of the apoenzyme.

S. Benkovic, R. Shiman, D. Gottschall, 1982, The Journal of biological chemistry.

Studies in sulfate esters. V. The mechanism of hydrolysis of phenyl phosphosulfate, a model system for 3'-phosphoadenosine 5'-phosphosulfate.

S. Benkovic, R. Hevey, 1970, Journal of the American Chemical Society.

Mapping protein - Protein interactions in the bacteriophage T4 DNA polymerase holoenzyme using a novel trifunctional photo-cross-linking and affinity reagent [11]

S. Benkovic, A. D. Jones, S. Alley, 2000 .

Catalytic antibodies: mechanistic and practical considerations

S. Benkovic, J. Stewart, 1993 .

Antibody‐Catalyzed Rearrangement of the Peptide Bond.

Scott D. Taylor, R. Gibbs, S. Benkovic, 1993 .

Probing cell-cell communication with microfluidic devices.

Chung Yu Chan, Jarrod B French, Stephen J Benkovic, 2013, Lab on a chip.

The anomeric specificity of glycolytic enzymes.

S. Benkovic, K. Schray, 1976, Advances in enzymology and related areas of molecular biology.

Anomeric specificity of yeast pyruvate kinase toward activation by D-fructose 1,6-bisphosphate

S. Benkovic, P. Benkovic, R. Fishbein, 1975 .

Catalytic reactions of phosphoglucose isomerase with cyclic forms of glucose 6-phosphate and fructose 6-phosphate.

S. Benkovic, I. A. Rose, K. Schray, 1973, The Journal of biological chemistry.

Multimeric Structure of the Secreted Meprin A Metalloproteinase and Characterization of the Functional Protomer*

S. Benkovic, F. Ishmael, M. T. Norcum, 2001, The Journal of Biological Chemistry.

Structural requirements for the biosynthesis of backbone cyclic peptide libraries.

S. Benkovic, A. D. Jones, E. Abel-Santos, 2001, Chemistry & biology.

The T4 Phage UvsW Protein Contains Both DNA Unwinding and Strand Annealing Activities*

S. Benkovic, S. Nelson, 2007, Journal of Biological Chemistry.

Expression of rat liver phenylalanine hydroxylase in insect cells and site-directed mutagenesis of putative non-heme iron-binding sites.

S. Benkovic, D. Wojchowski, B. S. Gibbs, 1993, The Journal of biological chemistry.

Synthesis of two bi-functional ligands for the QUEST three-hybrid system

S. Benkovic, F. Salinas, S. Baker, 2000 .

Single-molecule mechanical identification and sequencing

S. Benkovic, J. Allemand, V. Croquette, 2012, Nature Methods.

Regulation of polymerase exchange between Polη and Polδ by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme

Robert E. Johnson, S. Benkovic, Zhihao Zhuang, 2008, Proceedings of the National Academy of Sciences.

RNA primer–primase complexes serve as the signal for polymerase recycling and Okazaki fragment initiation in T4 phage DNA replication

S. Benkovic, M. M. Spiering, Philip Hanoian, 2017, Proceedings of the National Academy of Sciences.

Insights into Okazaki Fragment Synthesis by the T4 Replisome

S. Benkovic, M. M. Spiering, Hongjun Yue, 2013, The Journal of Biological Chemistry.

T4 Phage Replisome

S. Benkovic, Zhihao Zhuang, M. M. Spiering, 2009 .

The Application of a Minicircle Substrate in the Study of the Coordinated T4 DNA Replication*

S. Benkovic, R. Roccasecca, M. Trakselis, 2003, Journal of Biological Chemistry.

Repetitive lagging strand DNA synthesis by the bacteriophage T4 replisome.

S. Benkovic, M. M. Spiering, S. Nelson, 2008, Molecular bioSystems.

Response of the bacteriophage T4 replisome to noncoding lesions and regression of a stalled replication fork.

S. Benkovic, S. Nelson, 2010, Journal of molecular biology.

Dissociative Properties of the Proteins within the Bacteriophage T4 Replisome*

S. Benkovic, R. Roccasecca, M. Trakselis, 2003, Journal of Biological Chemistry.

Characterization of bacteriophage T4-coordinated leading- and lagging-strand synthesis on a minicircle substrate.

S. Benkovic, F. Salinas, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Protein-DNA cross-linking demonstrates stepwise ATP-dependent assembly of T4 DNA polymerase and its accessory proteins on the primer-template

S. Benkovic, T. Capson, N. Nossal, 1991, Cell.

Analysis of the DNA translocation and unwinding activities of T4 phage helicases.

S. Benkovic, K. Raney, Senthil K. Perumal, 2010, Methods.

Simultaneous formation of functional leading and lagging strand holoenzyme complexes on a small, defined DNA substrate.

S. Benkovic, A. Berdis, 1998, Proceedings of the National Academy of Sciences of the United States of America.

The dynamic processivity of the T4 DNA polymerase during replication.

S. Benkovic, Zhihao Zhuang, R. Roccasecca, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Bacteriophage T4 Dda Helicase Translocates in a Unidirectional Fashion on Single-stranded DNA (*)

S. Benkovic, K. Raney, 1995, The Journal of Biological Chemistry.

Reductive activation of phenylalanine hydroxylase and its effect on the redox state of the non-heme iron.

S. Benkovic, L. Bloom, B. J. Gaffney, 1984, Biochemistry.

On the mechanism of action of folate- and biopterin-requiring enzymes.

S. Benkovic, 1980, Annual review of biochemistry.

Evaluation of the kinetic mechanism of Escherichia coli glycinamide ribonucleotide transformylase.

J. H. Shim, S. Benkovic, 1998, Biochemistry.

Cytochrome P 450 enzymes : understanding the biochemical hieroglyphs

S. Benkovic, S. Sligar, 2019 .

Cytochrome P 450 enzymes : understanding the biochemical

S. Benkovic, S. Sligar, 2018 .

A bio-hybrid rotaxane catalyst

S. Benkovic, R. Nolte, A. Rowan, 2017 .

Catecholate LMCT bands as probes for the active sites of nonheme iron oxygenases

S. Benkovic, L. Que, L. Bloom, 1988 .

Mechanism of oxygen activation by tyrosine hydroxylase.

S. Benkovic, T. Dix, D. Kuhn, 1987, Biochemistry.

Phenylalanine hydroxylase: absolute configuration and source of oxygen of the 4a-hydroxytetrahydropterin species.

S. Benkovic, G. Bollag, P. Domanico, 1985, Biochemistry.

On the mechanism of action of phenylalanine hydroxylase.

S. Benkovic, L. Bloom, P. Domanico, 1981, Biochemical Society transactions.

Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase.

C. Cameron, S. Benkovic, S. L. Le Grice, 1995, Methods in enzymology.

Assignment of a third purine biosynthetic gene (glycinamide ribonucleotide transformylase) to human chromosome 21.

S. Benkovic, D. Patterson, H. Drabkin, 1986, American journal of human genetics.

Mechanisms Research highlights at the chemistry/biology interface

C. Walsh, S. Benkovic, 1997 .

The Mechanism of Phosphoryl Transfer

S. Benkovic, K. Schray, 1978 .

Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis.

S. Benkovic, P. Rajagopalan, A. Kohen, 2004, Journal of the American Chemical Society.

Affinity labeling of the active site and the reactive sulfhydryl associated with activation of rat liver phenylalanine hydroxylase.

S. Benkovic, B. S. Gibbs, 1991, Biochemistry.

Characterization of phenylalanine hydroxylase.

S. Benkovic, L. Bloom, B. J. Gaffney, 1986, Biochemistry.

ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease

S. Benkovic, J. Asara, Guangyu Wu, 2022, Circulation.

Characterization of the metal-binding sites of the beta-lactamase from Bacteroides fragilis.

S. Benkovic, M. Crowder, E. Zovinka, 1996, Biochemistry.

Stereochemical course of the reaction catalyzed by 5'-nucleotide phosphodiesterase from snake venom.

S. Benkovic, F. R. Bryant, 1979, Biochemistry.

Use of inteins for the in vivo production of stable cyclic peptide libraries in E. coli.

S. Benkovic, E. Abel-Santos, C. Scott, 2003, Methods in molecular biology.

Stepwise loading of yeast clamp revealed by ensemble and single-molecule studies

S. Benkovic, V. Nashine, Ravindra Kumar, 2010, Proceedings of the National Academy of Sciences.

Investigation of Stoichiometry of T4 Bacteriophage Helicase Loader Protein (gp59)*

S. Benkovic, S. Arumugam, Tae-Hee Lee, 2009, The Journal of Biological Chemistry.

Cloning and expression of Chromobacterium violaceum phenylalanine hydroxylase in Escherichia coli and comparison of amino acid sequence with mammalian aromatic amino acid hydroxylases.

S. Benkovic, L. Liotta, A. Onishi, 1991, The Journal of biological chemistry.

Investigations of an Antibody Ligase

S. Benkovic, Carol M. Taylor, J. Witherington, 1997 .

The Human Lagging Strand DNA Polymerase δ Holoenzyme Is Distributive*

S. Benkovic, Hongjun Yue, S. Perumal, 2012, The Journal of Biological Chemistry.

Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling

S. Benkovic, Jingxuan He, V. Pareek, 2022, The Journal of biological chemistry.

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.

D. Boger, I. Wilson, S. Benkovic, 2002, Bioorganic & medicinal chemistry.

Interaction of DNA with the Klenow fragment of DNA polymerase I studied by time-resolved fluorescence spectroscopy.

S. Benkovic, D. Millar, R. Hochstrasser, 1991, Biochemistry.

Formyl phosphate: a proposed intermediate in the reaction catalyzed by Escherichia coli PurT GAR transformylase.

S. Benkovic, M. S. Warren, A. Marolewski, 1997, Biochemistry.

Phenylalanine Hydroxylase Stimulator Protein Is a 4α-Carbinolamine Dehydratase

S. Benkovic, S. Kaufman, R. Lazarus, 1983 .

Spatial colocalization and functional link of purinosomes with mitochondria

Ye Fang, Chung Yu Chan, Tony Jun Huang, 2016, Science.

Detecting Purinosome Metabolon Formation with Fluorescence Microscopy.

S. Benkovic, Anthony M. Pedley, 2018, Methods in molecular biology.

Molecular basis for nonadditive mutational effects in Escherichia coli dihydrofolate reductase.

S. Benkovic, S. Singleton, C. Wagner, 1995, Biochemistry.

Control of Enzyme Activity by a Light-Sensing Signaling Domain

Rama Ranganathan, Natarajan, Tina Vo, 2011 .

Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome

Stephen J. Benkovic, Vincent Croquette, S. Benkovic, 2009, Nature chemical biology.

The Oligomeric T4 Primase Is the Functional Form during Replication*

S. Benkovic, Zhihao Zhuang, J. Xi, 2005, Journal of Biological Chemistry.

Assembly of the bacteriophage T4 primosome: single-molecule and ensemble studies.

S. Benkovic, G. Hammes, M. Trakselis, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Assembly of the Bacteriophage T4 Helicase

S. Benkovic, S. Alley, F. Ishmael, 2002, The Journal of Biological Chemistry.

Accessory proteins function as matchmakers in the assembly of the T4 DNA polymerase holoenzyme

S. Benkovic, B. F. Kaboord, 1995, Current Biology.

A Comparison of the Bimolecular and Intramolecular Nucleophilic Catalysis of the Hydrolysis of Substituted Phenyl Acylates by the Dimethylamino Group

Stephen J. Benkovic, S. Benkovic, T. C. Bruice, 1963 .

Catalysis of phosphoryl group transfer. The role of divalent metal ions in the hydrolysis of lactic acid O-phenyl phosphate and salicylic acid O-aryl phosphates.

S. Benkovic, J. J. Steffens, I. J. Siewers, 1975, Biochemistry.

Evolution of cyclic peptide protease inhibitors

Peter G. Schultz, Stephen J. Benkovic, John M. Louis, 2011, Proceedings of the National Academy of Sciences.

Isothermal DNA amplification using the T4 replisome: circular nicking endonuclease-dependent amplification and primase-based whole-genome amplification

Viktor Stein, Stephen J. Benkovic, Florian Hollfelder, 2010, Nucleic acids research.

Identification and Mapping of Protein-Protein Interactions between gp32 and gp59 by Cross-linking*

S. Benkovic, S. Alley, F. Ishmael, 2001, The Journal of Biological Chemistry.

Creation of a novel biosensor for zinc(II)

Victoria A. Roberts, Elizabeth D. Getzoff, Stephen J. Benkovic, 1994 .

Metallo-β-lactamase: structure and mechanism

Stephen J. Benkovic, S. Benkovic, W. Fast, 1999 .

Direct observation of an enzyme-bound intermediate in the catalytic cycle of the metallo-β-lactamase from Bacteroides fragilis [15]

S. Benkovic, W. Fast, Zhigang Wang, 1998 .

Understanding Enzyme Mechanism through Protein Chimeragenesis

Nina M. Goodey, Stephen J. Benkovic, N. Goodey, 2009 .

Engineering Protein Evolution

S. Benkovic, S. Lutz, 2003 .

Photochemical cross-linking of DNA replication proteins at primer terminus.

S. Benkovic, T. Capson, N. Nossal, 1995, Methods in enzymology.

Behavior of a cross-linked attachment site: testing the role of branch migration in site-specific recombination.

S. Benkovic, H. Nash, M. Cowart, 1991, Journal of molecular biology.

Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis.

S. Benkovic, W. T. Mueller, G. Wasserman, 1980, Biochemistry.

Purfication of glycineamide ribonucleotide transformylase.

S. Benkovic, L. Y. Lin, C. Caperelli, 1978, Biochemical and biophysical research communications.

Fructose 1,6-bisphosphate. Kinetics of hydrolysis catalyzed by rabbit liver neutral fructose-1,6-bisphosphatase with Mn2+.

S. Benkovic, N. Dudman, M. Demaine, 1978, The Journal of biological chemistry.

Substrate form of D-frutose 1,6-bisphosphate utilized by fructose 1,6-bisphosphatase.

S. Benkovic, M. D. de Maine, R. Fishbein, 1977, Biochemistry.

The role of tryptophan in neutral fructose diphosphatase.

S. Benkovic, J. Villafranca, W. A. Frey, 1974, Biochemical and Biophysical Research Communications - BBRC.

Detection of dihydrofolate reductase conformational change by FRET using two fluorescent amino acids.

S. Benkovic, Lin Wang, S. Hecht, 2013, Journal of the American Chemical Society.

Characterization of mammalian phosphoribosylglycineamide formyltransferase from transformed cells.

S. Benkovic, S. Daubner, 1985, Cancer research.

The Unexpected Catalytic Properties of a Heterodimer of GAR Transformylase.

S. Benkovic, J. Shim, C. Liu, 2000, Bioorganic chemistry.

Mechanistic studies on phenylalanine hydroxylase from Chromobacterium violaceum. Evidence for the formation of an enzyme-oxygen complex.

S. Benkovic, J. Villafranca, K. Johnson, 1989, Biochemistry.

Serine transhydroxymethylase: evidence for a sequential random mechanism.

S. Benkovic, C. Tatum, L. Schirch, 1977, Biochemistry.

Role of HSP90 in the Regulation of de Novo Purine Biosynthesis.

S. Lindquist, S. Benkovic, Anthony M. Pedley, 2018, Biochemistry.

GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis

Ye Fang, Songon An, Stephen J. Benkovic, 2011, Nature chemical biology.

Microtubule-assisted mechanism for functional metabolic macromolecular complex formation

S. Benkovic, Yijun Deng, J. Tomsho, 2010, Proceedings of the National Academy of Sciences.

The Compensation in ΔH[UNK] and ΔS[UNK] Accompanying the Conversion of Lower Order Nucleophilic Displacement Reactions to Higher Order Catalytic Processes. The Temperature Dependence of the Hydrazinolysis and Imidazole-Catalyzed Hydrolysis of Substituted Phenyl Acetates

S. Benkovic, T. C. Bruice, 1964 .

Biocatalysts — the next generation

S. Benkovic, A. Ballesteros, 1997 .

Reaction Mechanisms Displayed by Catalytic Antibodies

S. Benkovic, L. Liotta, J. Stewart, 1993 .

Stepwise assembly of the human replicative polymerase holoenzyme

S. Benkovic, Senthil K. Perumal, S. Perumal, 2013, eLife.

Role of adenosine 5'-triphosphate hydrolysis in the assembly of the bacteriophage T4 DNA replication holoenzyme complex.

S. Benkovic, A. Berdis, 1996, Biochemistry.

Mechanistic aspects of DNA polymerases: Escherichia coli DNA polymerase I (Klenow fragment) as a paradigm

S. Benkovic, S. Carroll, 1990 .

A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis.

S. Henikoff, S. Benkovic, J. Stubbe, 1985, Biochemistry.

A new chemical synthesis of 2-amino-(N-D-ribofuranosyl)acetamide 5'-phosphate.

S. Benkovic, G. Chettur, 1977, Carbohydrate research.

Binding of hapten to a single-chain catalytic antibody demonstrated by electrospray mass spectrometry

G. Siuzdak, H. Dyson, S. Benkovic, 1994 .

Analysis of the Stoichiometry of the T4 Gene 45 Protein by Ion Spray Mass Spectrometry

B. Ganem, J. Henion, S. Benkovic, 1994 .

Sliding clamp of the bacteriophage T4 polymerase has open and closed subunit interfaces in solution.

S. Benkovic, E. Abel-Santos, S. Alley, 1999, Biochemistry.

Purification, Characterization, and Kinetic Studies of a SolubleBacteroides fragilis Metallo-β-lactamase That Provides Multiple Antibiotic Resistance*

S. Benkovic, Zhigang Wang, 1998, The Journal of Biological Chemistry.

A revised strategy for cloning antibody gene fragments in bacteria.

J. Pyati, S. Benkovic, I. Lee, 1993, Gene.

Familial mutations and zinc stoichiometry determine the rate-limiting step of nitrocefin hydrolysis by metallo-beta-lactamase from Bacteroides fragilis.

S. Benkovic, W. Fast, Z. Wang, 2001, Biochemistry.

Tracking sliding clamp opening and closing during bacteriophage T4 DNA polymerase holoenzyme assembly.

S. Benkovic, E. Abel-Santos, S. Alley, 2000, Biochemistry.

Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA.

S. Benkovic, M. Aitha, Mark Hedglin, 2017, Biochemistry.

Models for the tetrahydrofolic acid. IV. Reactions of amines with formamidinium tetrahydroquinoxaline analogs

S. Benkovic, T. Barrows, P. Farina, 1973 .

Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids.

S. Benkovic, Carol M. Taylor, R. Hirschmann, 1994, Science.

Stereoselective synthesis and biological activity of .beta.- and .alpha.-D-arabinose 1,5-diphosphate: analogs of a potent metabolic regulator

S. Benkovic, S. Pilkis, A. Reitz, 1984 .

Phenylalanine hydroxylase from Chromobacterium violaceum is a copper-containing monooxygenase. Kinetics of the reductive activation of the enzyme.

S. Benkovic, J. Villafranca, S. Pember, 1986, Biochemistry.

On the mechanisms of folate cofactors

S. Benkovic, 1978 .

The mechanism of formylation of five-membered cyclic phosphorodiamidates.

S. Benkovic, B. Amato, 1975, Biochemistry.

STUDIES ON MODELS FOR TETRAHYDROFOLIC ACID PART 4, REACTIONS OF AMINES WITH FORMAMIDINIUM TETRAHYDROQUINOXALINE ANALOGS

S. Benkovic, T. Barrows, P. Farina, 1974 .

Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten

S. Benkovic, Carol M. Taylor, R. Hirschmann, 1994 .

Mechanism of metal-independent hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase.

P. Hawkins, S. Benkovic, S. Balasubramanian, 1995, Biochemistry.

Identification of metal ligands in Cu(II)-inhibited Chromobacterium violaceum phenylalanine hydroxylase by electron spin echo envelope modulation analysis of histidine to serine mutations.

S. Benkovic, C. Bender, J. Peisach, 1994, Biochemistry.

Histidines 138 and 143 are copper binding ligands in Chromobacterium violaceum phenylalanine hydroxylase.

S. Benkovic, C. Bender, J. Peisach, 1993, Advances in experimental medicine and biology.

A re-examination of the metal requirement of Chromobacterium violaceum phenylalanine hydroxylase.

S. Benkovic, R. Carr, 1993, Advances in experimental medicine and biology.

Mechanism of oxygen activation by pteridine-dependent monooxygenases

S. Benkovic, T. Dix, 1988 .

Adduct formation between the cupric site of phenylalanine hydroxylase from Chromobacterium violaceum and 6,7-dimethyltetrahydropterin.

S. Benkovic, J. Villafranca, M. Pasenkiewicz-Gierula, 1987, Biochemistry.

[6] Chromobacterium violaceum phenylalanine 4-monooxygenase

S. Benkovic, J. Villafranca, S. Pember, 1987 .

Tautomeric nature of quinonoid 6,7-dimethyl-7,8-dihydro-6H-pterin in aqueous solution: a nitrogen-15 NMR study

S. Benkovic, R. Inners, W. Armarego, 1985 .

Phenylalanine hydroxylase: structural determination of the tetrahydropterin intermediates by carbon-13 NMR spectroscopy

S. Benkovic, R. Lazarus, C. Debrosse, 1982 .

On the mechanism of action of phenylalanine hydroxylase.

S. Benkovic, R. Lazarus, R. Dietrich, 1985, Biochemistry.

Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors.

D. Boger, S. Benkovic, L. T. Gooljarsingh, 1998, Bioorganic & medicinal chemistry.

Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH.

L. Shapiro, S. Benkovic, P. Rajagopalan, 2005, Journal of medicinal chemistry.

At the crossroads of chemistry and immunology: catalytic antibodies.

P G Schultz, R. Lerner, P. Schultz, 1991, Science.

Human AICAR transformylase: role of the 4-carboxamide of AICAR in binding and catalysis.

S. Benkovic, J. Shim, M. Wall, 2000, Biochemistry.

Chapter 1 Hydrolytic Reactions of Inorganic Esters

S. Benkovic, 1972 .

Studies on models for tetrahydrofolic acid. 8. Hydrolysis and methoxyaminolysis of amidines

S. Benkovic, P. Benkovic, B. Burdick, 1977 .

Kinetic detection of the imminium cation in formaldehyde-amine condensations in neutral aqueous solution

S. Benkovic, P. Benkovic, D. Comfort, 1969 .

Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase.

J. H. Shim, D. Boger, S. Benkovic, 2000, Bioorganic & medicinal chemistry.

Electron spin-echo studies of the copper binding site in phenylalanine hydroxylase from Chromobacterium violaceum

S. Benkovic, J. Villafranca, J. Peisach, 1988 .

Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase.

C. Cameron, S. Benkovic, S. L. Le Grice, 1995, Biochemistry.

Dependence of mechanism on pH for deuterium-hydrogen exchange in 1-methyltetrazole-5-d. Transition metal ion catalysis of a deprotonation process.

S. Benkovic, H. Kohn, R. A. Olofson, 1972, Journal of the American Chemical Society.

A highly efficient chemical synthesis of Rp and Sp adenyl(3′-5′)adenyl-o,o-phosphorothioate

S. Benkovic, J. Marlier, 1980 .

Models for tetrahydrofolic acid. I. Condensation of formaldehyde with tetrahydroquinoxaline analogs

S. Benkovic, P. Benkovic, D. Comfort, 1969 .

Engineering specificity for folate into dihydrofolate reductase from Escherichia coli.

S. Benkovic, B. Posner, R. Bethell, 1996, Biochemistry.

Hydrolytic mechanisms of phosphoramidates of aromatic amino acids.

S. Benkovic, P. Benkovic, 1967, Journal of the American Chemical Society.

Studies on models for tetrahydrofolic acid. 7. Reactions and mechanisms of tetrahydroquinoxaline derivatives at the formaldehyde level of oxidation.

S. Benkovic, L. Chrzanowski, P. Benkovic, 1976, Journal of the American Chemical Society.

The effect of arabinose 1,5-bisphosphate on rat hepatic 6-phosphofructo-1-kinase and fructose-1,6-bisphosphatase.

S. Benkovic, S. Pilkis, J. Pilkis, 1986, Biochemical and biophysical research communications.

On the mechanism of action of fructose 1,6-diphosphatase. Inhibition by structural analogs of fructose 1,6-diphosphate.

S. Benkovic, I. J. Siewers, M. Demaine, 1971, Biochemistry.

On the mechanism of fructose 1,6-diphosphatase: inhibition by methyl D-fructoside 1,6-diphosphate.

S. Benkovic, M. D. de Maine, J. J. Kleinschuster, 1970, Archives of biochemistry and biophysics.

STEREOSELECTIVE SYNTHESIS AND BIOLOGICAL ACTIVITY OF β- AND α-D-ARABINOSE 1,5-DIPHOSPHATE: ANALOGS OF A POTENT METABOLIC REGULATOR

S. Benkovic, S. Pilkis, A. Reitz, 1985 .

Cyclic peptide formation catalyzed by an antibody ligase.

S. Benkovic, J. Liu, S. Iwama, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Catalytic antibodies with acyl-transfer capabilities: mechanistic and kinetic investigations

R. Gibbs, R. Lerner, S. Benkovic, 1991 .

Catalytic antibodies with lipase activity and R or S substrate selectivity.

R. Lerner, S. Benkovic, K. Janda, 1989, Science.

Induction of an antibody that catalyzes the hydrolysis of an amide bond.

R. Lerner, S. Benkovic, K. Janda, 1988, Science.

A stereospecific cyclization catalyzed by an antibody.

R. Lerner, S. Benkovic, A. Napper, 1987, Science.

Studies on models for tetrahydrofolic acid. II. Additional observations on the mechanism for condensation of formaldehyde with tetrahydroquinoxaline analogs

S. Benkovic, R. Chrzanowski, P. Benkovic, 1970 .

Effect of divalent metal ions on the intramolecular nucleophilic catalysis of phosphate diester hydrolysis

S. Benkovic, J. J. Steffens, E. Sampson, 1973 .

Metal ion catalysis of phosphoryl hydrolysis from thiolphosphate monoesters

S. Benkovic, E. M. Miller, 1972 .

An Unusual Rate Enhancement in Metal Ion Catalysis of Phosphate Transfer

S. Benkovic, L. Dunikoski, 1971 .

Studies on Sulfate Esters. I. Nucleophilic Reactions of Amines with p-Nitrophenyl Sulfate

S. Benkovic, P. Benkovic, 1966 .

Studies on Sulfate Esters. II. Carboxyl Group Catalysis in the Hydrolysis of Salicyl Sulfate

S. Benkovic, 1966 .

Models for tetrahydrofolic acid. III. Hydrolytic interconversions of the tetrahydroquinoxaline analogs at the formate level of oxidation

S. Benkovic, P. Benkovic, W. Bullard, 1972 .

Additions and Correcitons - Mechanisms of Hydrolysis of Phosphate Ester Derivatives of Phosphoenolpyruvic Acid

S. Benkovic, K. Schray, 1971 .

Mechanisms of hydrolysis of phosphate ester derivatives of phosphoenolpyruvic acid.

S. Benkovic, K. Schray, 1971, Journal of the American Chemical Society.

Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer

S. Benkovic, M. Trakselis, E. Abel-Santos, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Replisome-mediated DNA replication.

S. Benkovic, F. Salinas, A. Valentine, 2001, Annual review of biochemistry.

Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction.

S. Benkovic, S. Hecht, M. M. Spiering, 2015, Biochemistry.

Tryptophan-based fluorophores for studying protein conformational changes.

S. Benkovic, S. Hecht, Poulami Talukder, 2014, Bioorganic & medicinal chemistry.

Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification.

S. Benkovic, Lin Wang, S. Hecht, 2013, Biochemistry.

Two pyrenylalanines in dihydrofolate reductase form an excimer enabling the study of protein dynamics.

S. Benkovic, Lin Wang, S. Hecht, 2012, Journal of the American Chemical Society.

Ring Structure and Aromatic Substituent Effects on the pK a of the Benzoxaborole Pharmacophore.

Stephen J Benkovic, Dennis G Hall, Arnab Pal, 2012, ACS medicinal chemistry letters.

Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells

S. Benkovic, Hua Tian, N. Winograd, 2020, Science.

Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome

S. Benkovic, Hong Zhao, Sherry L. Niessen, 2013, Proceedings of the National Academy of Sciences.

Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells

Stephen J Benkovic, Songon An, Erin D Sheets, 2008, Science.

5-Formyl- and 10-formyl-5,6,7,8-tetrahydrofolate. Conformation of the tetrahydropyrazine ring and formyl group in solution.

S. Benkovic, M. Poe, 1980, Biochemistry.

Folates and pterins

S. Benkovic, Raymond L. Blakley, 1984 .

Biotin and the nucleophilicity of 2-methoxy-2-imidazoline toward the sp2 carbonyl carbon

S. Benkovic, T. C. Bruice, A. F. Hegarty, 1969 .

Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity.

S. Benkovic, R. Kuchta, P. Benkovic, 1988, Biochemistry.

Kinetic mechanism of DNA polymerase I (Klenow).

S. Benkovic, V. Mizrahi, K. Johnson, 1987, Biochemistry.

Kinetic mechanism of DNA polymerase I

S. Benkovic, Kenneth A. Johnson, V. Mizrahi, 1987 .

Nutritional, pharmacological, and physiological aspects

S. Benkovic, Raymond L. Blakley, V. Whitehead, 1986 .

DNA polymerase fidelity: kinetics, structure, and checkpoints

S. Benkovic, C. M. Joyce, 2004 .

Kinetic mechanism of DNA polymerase I (Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant.

S. Benkovic, S J Benkovic, M E Dahlberg, 1991, Biochemistry.

Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli.

S. Benkovic, C. M. Joyce, N. Grindley, 1992, The Journal of biological chemistry.

Rate-limiting steps in the DNA polymerase I reaction pathway.

S. Benkovic, V. Mizrahi, K. Johnson, 1985, Biochemistry.

Interaction of dihydrofolate reductase with methotrexate: Ensemble and single-molecule kinetics

Stephen J Benkovic, Zhiquan Zhang, M. Dwyer, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Chapter 10 Transformations involving folate and biopterin cofactors

S. Benkovic, R. Lazarus, 1984 .

The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer.

S. Benkovic, Jeeyeon Lee, A. Kohen, 2010, Chemical communications.

Stereochemistry of methylene transfer involving 5,10-methylenetetrahydrofolate.

E. Schleicher, S. Benkovic, P. Benkovic, 1977, Biochemistry.

The reaction of nucleophilic species with quinonoid 6,6,7,7-tetramethyldihydropterin

S. Benkovic, T. C. Bruice, G. Bollag, 1986 .

The mechanism of oxidation of 6-methyl-5-carba-5-deazatetrahydropterin. Evidence for the involvement cf a 4a-adduct in the oxidation of tetrahydropterins.

S. Benkovic, G. Moad, C. Luthy, 1978 .

An unexpectedly efficient catalytic antibody operating by ping-pong and induced fit mechanisms.

R. Lerner, S. Benkovic, P. Wirsching, 1991, Science.

Mechanism of action of fructose 1,6-bisphosphatase.

S. Benkovic, M. Demaine, Stephen J. Benkovic, 1982, Advances in enzymology and related areas of molecular biology.

A kinetic study of wild-type and mutant dihydrofolate reductases from Lactobacillus casei.

S. Benkovic, C. Fierke, J. Feeney, 1989, Biochemistry.

Purification of a complex catalyzing folate cofactor synthesis and transformylation in de novo purine biosynthesis.

S. Benkovic, P. Benkovic, C. Caperelli, 1980, The Journal of biological chemistry.

Synthesis of 5,11-methenyltetrahydrohomofolate and its antifolate activity in vitro.

S. Benkovic, P. Domanico, C. Caperelli, 1981, Journal of medicinal chemistry.

Synthesis of [4a‐13C]‐6‐methyltetrahydropterin

S. Benkovic, R. Lazarus, M. Sulewski, 1982 .

Additions and Corrections - Stereoselective Chemical Reduction of 5,10-Methenyltetrahydrofolate

S. Benkovic, P. Farina, L. Farina, 1975 .

Stereoselective chemical reduction of 5,10-methenyltetrahydrofolate

S. Benkovic, P. Farina, L. Farina, 1973 .

The Interconversion of the 5,6,7,8-Tetrahydro-, 7,8-Dihydro-, and Radical Forms of 6,6,7,7-Tetramethyldihydropterin. A Model for the Biopterin Center of Aromatic Amino Acid Mixed Function Oxidases

S. Benkovic, T. C. Bruice, R. Lazarus, 1984 .

Phenylalanine hydroxylase: structural determination of the tetrahydropterin intermediates by carbon-13 NMR spectroscopy

S. Benkovic, R. Lazarus, C. Debrosse, 1982 .

Assembly of an active enzyme by the linkage of two protein modules.

S. Benkovic, A. Nixon, M. S. Warren, 1997, Proceedings of the National Academy of Sciences of the United States of America.

STUDIES ON 6-METHYL-5-DEAZATETRAHYDROPTERIN AND ITS 4A ADDUCTS

S. Benkovic, G. Moad, P. Benkovic, 1979 .

Solvation, Reorganization Energy, and Biological Catalysis*

S. Benkovic, W. R. Cannon, W. Cannon, 1998, The Journal of Biological Chemistry.

Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations.

J. H. Shim, K. Merz, S. Benkovic, 2001, Journal of the American Chemical Society.

Phosphorothioate substrates for T4 RNA ligase.

S. Benkovic, F. R. Bryant, 1982, Biochemistry.

Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.

D. Boger, I. Wilson, S. Benkovic, 2005, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.

D. Boger, I. Wilson, S. Benkovic, 2005, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.

D. Boger, I. Wilson, S. Benkovic, 2003, Bioorganic & Medicinal Chemistry.

Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.

D. Boger, I. Wilson, S. Benkovic, 2003, Bioorganic & medicinal chemistry.

Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase.

D. Boger, S. Benkovic, M. S. Warren, 1997, Bioorganic & medicinal chemistry.

Fructose 1,6-bisphosphatase from rabbit liver. [18O]Phosphate-H2O exchange as a probe of the catalytic mechanism.

S. Benkovic, T. Sharp, 1979, Biochemistry.

Distances between structural metal ion, substrates, and allosteric modifier of fructose bisphosphatase.

F. Raushel, S. Benkovic, J. Villafranca, 1981, Biochemistry.

Stereochemical course of the 3'----5'-exonuclease activity of DNA polymerase I.

S. Benkovic, A. Gupta, A. Gupta, 1984, Biochemistry.

Stereochemical and kinetic investigation of 32P-labeled inorganic phosphate exchange reaction catalyzed by primer-independent and primer-dependent polynucleotide phosphorylase from Micrococcus luteus.

S. Benkovic, F. R. Bryant, J. Marlier, 1981, Biochemistry.

Targeting Tumour Proliferation with a Small‐Molecule Inhibitor of AICAR Transformylase Homodimerization

S. Benkovic, J. Blaydes, A. Tavassoli, 2012, Chembiochem : a European journal of chemical biology.

Genetically selected cyclic-peptide inhibitors of AICAR transformylase homodimerization.

S. Benkovic, A. Tavassoli, 2005, Angewandte Chemie.

Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site.

I. Wilson, S. Benkovic, D. Wolan, 2003, Biochemistry.

Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis

I. Wilson, S. Benkovic, S. Greasley, 2001, Nature Structural Biology.

On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver.

S. Benkovic, W. T. Mueller, 1981, Biochemistry.

A New View into the Regulation of Purine Metabolism: The Purinosome.

S. Benkovic, Anthony M. Pedley, 2017, Trends in biochemical sciences.

Catalytic mechanism of Escherichia coli glycinamide ribonucleotide transformylase probed by site-directed mutagenesis and pH-dependent studies.

J. H. Shim, S. Benkovic, 1999, Biochemistry.

The transformylase enzymes of de novo purine biosynthesis

S. Benkovic, J. Shim, L. T. Gooljarsingh, 1984 .

Direct transfer of one-carbon units in the transformylations of de novo purine biosynthesis.

S. Benkovic, L. Slieker, W. T. Mueller, 1982, Biochemistry.

Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle.

S. Benkovic, Mark Hedglin, 2017, Chemical reviews.

Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA

S. Benkovic, Mark Hedglin, 2017, Biochemistry.

10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.

D. Boger, I. Wilson, S. Benkovic, 2003, Bioorganic & medicinal chemistry.

Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.

Stephen J Benkovic, Yan Zhang, Ali Tavassoli, 2003, Biochemistry.

Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.

J. H. Shim, D. Boger, S. Benkovic, 2000, Bioorganic & medicinal chemistry letters.

New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.

D. Boger, I. Wilson, S. Benkovic, 1999, Biochemistry.

Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase.

D. Boger, S. Benkovic, M. S. Warren, 1997, Bioorganic & medicinal chemistry.

Multisubstrate analogue based on 5,8,10-trideazafolate.

D. Boger, S. Benkovic, M. S. Warren, 1997, Bioorganic & medicinal chemistry.

Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution.

I. Wilson, S. Benkovic, C. Klein, 1995, Journal of molecular biology.

Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy.

I. Wilson, S. Benkovic, James Inglese, 1992, Journal of molecular biology.

Preliminary crystallographic investigations of glycinamide ribonucleotide transformylase.

I. Wilson, S. Benkovic, James Inglese, 1989, The Journal of biological chemistry.

Structural and mechanistic studies on the HeLa and chicken liver proteins that catalyze glycinamide ribonucleotide synthesis and formylation and aminoimidazole ribonucleotide synthesis.

S. Benkovic, R. Sammons, S. Daubner, 1986, Biochemistry.

A multisubstrate adduct inhibitor of AICAR transformylase.

S. Benkovic, J. Shim, M. Wall, 1999, Journal of medicinal chemistry.

Inhibition of HKSV28 cell growth by 5,11-methenyl-tetrahydrohomofolate.

S. Benkovic, L. Slieker, 1984, Molecular pharmacology.

L(-)-10-Formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver.

S. Benkovic, P. Benkovic, G. K. Smith, 1981, Biochemistry.

Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF.

D. Boger, I. Wilson, S. Benkovic, 2005, Bioorganic & medicinal chemistry.

Preparation of 2-amino-4(3H)-oxopyrimido[5,4-b] [1,4]thiazines (5-thiapterins) and their evaluation as cofactors for phenylalanine hydroxylase.

S. Benkovic, R. Lazarus, R. Henrie, 1983, Journal of medicinal chemistry.

Biochemical Characterization of Bacteriophage T4 Mre11-Rad50 Complex*

S. Benkovic, S. Nelson, T. Herdendorf, 2010, The Journal of Biological Chemistry.

6 Chemical Basis of Biological Phosphoryl Transfer

S. Benkovic, K. Schray, 1973 .

Unambiguous stereochemical course of rabbit liver fructose bisphosphatase hydrolysis.

S. Benkovic, J. Rahil, P. Domanico, 1985, Biochemistry.

Investigation of the pre-steady-state kinetics of fructose bisphosphatase by employment of an indicator method.

S. Benkovic, P. Benkovic, B. Cunningham, 1979, Biochemistry.

The binding of products, metal ion, and a substrate analog to rabbit liver fructose bisphosphatase.

S. Benkovic, P. Benkovic, W. A. Frey, 1978, Archives of biochemistry and biophysics.

Isotope-tapping experiments with rabbit liver fructose bisphosphatase.

S. Benkovic, W. A. Frey, C. Caperelli, 1978, Biochemistry.

[60] Fructose-1,6-diphosphatase from rabbit liver

S. Benkovic, E. Ulm, B. Pogell, 1975 .

Bait and switch strategy for obtaining catalytic antibodies with acyl-transfer capabilities

R. Lerner, S. Benkovic, K. Janda, 1990 .

A novel combined chemical-enzymatic synthesis of cross-linked DNA using a nucleoside triphosphate analogue.

S. Benkovic, M. Cowart, 1991, Biochemistry.

Inactivation of DNA polymerase I (Klenow fragment) by adenosine 2',3'-epoxide 5'-triphosphate: evidence for the formation of a tight-binding inhibitor.

S. Benkovic, C. Catalano, Stephen J. Benkovic, 1989, Biochemistry.

[13] Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase

C. Cameron, S. Benkovic, S. F. Grice, 1995 .

On the mechanism of T4 RNA ligase

S. Benkovic, F. R. Bryant, 1981 .

DNA substrate structural requirements for the exonuclease and polymerase activities of procaryotic and phage DNA polymerases.

S. Benkovic, K. Gibson, D. Allen, 1989, Biochemistry.

Recombinant HIV-1 nucleocapsid protein accelerates HIV-1 reverse transcriptase catalyzed DNA strand transfer reactions and modulates RNase H activity.

S. Balasubramanian, D. Giedroc, S. Benkovic, 1994, Biochemistry.

The synthesis and properties in enzymic reactions of substrate analogs containing the methylphosphonyl group.

S. Benkovic, R. Lazarus, P. Benkovic, 1979, Archives of biochemistry and biophysics.

Metal ion catalysis of phosphoryl transfer from phosphoenolpyruvate.

S. Benkovic, K. Schray, 1968, Biochemistry.

The kinetics and mechanisms of phosphoenolpyruvate hydrolysis.

S. Benkovic, K. Schray, 1968, Biochemistry.

Effect of accessory proteins on T4 DNA polymerase replication fidelity.

T. Kunkel, S. Benkovic, M. W. Frey, 1998, Journal of molecular biology.

Mechanism of DNA Polymerase I

S. Benkovic, S. Carroll, 1991 .

Interaction of Escherichia coli DNA polymerase I with azidoDNA and fluorescent DNA probes: identification of protein-DNA contacts.

S. Benkovic, C. Catalano, D. Allen, 1990, Biochemistry.

Resonance energy transfer measurements between substrate binding sites within the large (Klenow) fragment of Escherichia coli DNA polymerase I.

S. Benkovic, D. Allen, 1989, Biochemistry.

Mechanism of the idling-turnover reaction of the large (Klenow) fragment of Escherichia coli DNA polymerase I.

S. Benkovic, V. Mizrahi, P. Benkovic, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Elementary steps in the DNA polymerase I reaction pathway.

S. Benkovic, K. Johnson, F. R. Bryant, 1983, Biochemistry.

4 Analysis of Protein Function by Mutagenesis

S. Benkovic, K. Johnson, 1990 .

The dynamics of DNA polymerase-catalyzed reactions.

S. Benkovic, V. Mizrahi, 1988, Advances in enzymology and related areas of molecular biology.

Truncating α-Helix E′ of p66 Human Immunodeficiency Virus Reverse Transcriptase Modulates RNase H Function and Impairs DNA Strand Transfer (*)

C. Cameron, S. Benkovic, S. Hughes, 1995, The Journal of Biological Chemistry.

Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities.

S. Benkovic, J. Peliska, V. Gopalakrishnan, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The stereochemical course of thiophosphoryl group transfer catalyzed by T4 polynucleotide kinase.

P. Frey, S. Benkovic, F. R. Bryant, 1981, The Journal of biological chemistry.

A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity.

S. Benkovic, S. Carroll, M. Cowart, 1991, Biochemistry.

On the mechanism of de novo polymerization by form I polynucleotide phosphorylase of Micrococcus luteus.

S. Benkovic, J. Marlier, 1982, Biochemistry.

THE STEREOCHEMICAL COURSE OF SEVERAL ENZYME CATALYZED REACTIONS AT THE PHOSPHODIESTER LEVEL

S. Benkovic, F. R. Bryant, J. Marlier, 1980 .

Synthesis and separation of diastereomers of deoxynucleoside 5'-O-(1-thio)triphosphates.

S. Benkovic, J. T. Chen, 1983, Nucleic acids research.

The nucleotide analog 2-aminopurine as a spectroscopic probe of nucleotide incorporation by the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase.

S. Benkovic, D. Millar, L. Sowers, 1995, Biochemistry.

Binding and kinetic data for rabbit liver fructose-1,6-bisphosphatase with Zn2+ as cofactor.

S. Benkovic, P. Benkovic, M. D. de Maine, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Kinetic and binding studies of Mn (II) and fructose 1,6-bisphosphate with rabbit liver hexosebisphosphatase.

S. Benkovic, J. Villafranca, W. A. Frey, 1975, The Journal of biological chemistry.

Production of Cyclic Proteins and Peptides

S. Benkovic, A. Tavassoli, T. Naumann, 2005 .

Combinatorial protein engineering by incremental truncation.

J. H. Shim, S. Benkovic, M. Ostermeier, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Selection of catalytic antibodies for a biosynthetic reaction from a combinatorial cDNA library by complementation of an auxotrophic Escherichia coli: antibodies for orotate decarboxylation.

S. Benkovic, J. Smiley, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance.

S. Benkovic, Mark Hedglin, 2015, Annual review of biophysics.

Purinosome formation as a function of the cell cycle

X. Zhuang, T. Huang, S. Benkovic, 2015, Proceedings of the National Academy of Sciences.

Evidence that the folate-requiring enzymes of de novo purine biosynthesis are encoded by individual mRNAs.

J. Taylor, W. Liao, S. Benkovic, 1984, Biochemistry.

Abstracts, Division of Biological Chemistry, 194th National Meeting of the American Chemical Society, August 30 - September 4, 1987

D. Gorenstein, S. Benkovic, C. Poulter, 1987 .

Interaction of T4 UvsW helicase and single-stranded DNA binding protein gp32 through its carboxy-terminal acidic tail.

S. Benkovic, Senthil K. Perumal, S. Nelson, 2013, Journal of molecular biology.

Supplementary Materials for Direct Observation of Stalled Fork Restart via Fork Regression in the T4 Replication System

Stephen J. Benkovic, Vincent Croquette, S. Benkovic, 2012 .

Mechanism of strand displacement synthesis by DNA replicative polymerases

S. Benkovic, J. Allemand, V. Croquette, 2012, Nucleic acids research.

Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism

S. Benkovic, T. Lionnet, V. Croquette, 2007, Proceedings of the National Academy of Sciences.

Intramolecular catalysis of sulfate ester hydrolysis. A model for aryl sulfate sulfohydrolase.

S. Benkovic, L. Dunikoski, 1970, Biochemistry.

Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interaction.

Stanley N Cohen, S. Benkovic, Q. Lu, 2008, ACS chemical biology.

Replication clamps and clamp loaders.

S. Benkovic, Ravindra Kumar, Mark Hedglin, 2013, Cold Spring Harbor perspectives in biology.

The control mechanism for lagging strand polymerase recycling during bacteriophage T4 DNA replication.

S. Benkovic, S. Nelson, Jingsong Yang, 2006, Molecular cell.

A fluorescence-based assay for monitoring helicase activity.

S. Benkovic, D. Millar, K. Raney, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Cyclic Peptides, A Chemical Genetics Tool for Biologists

S. Benkovic, A. Horswill, 2005, Cell cycle.

Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate.

S. Benkovic, C. Wagner, R. McIvor, 2003, Journal of medicinal chemistry.

Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: construction of a heavy chain variable region-specific cDNA library.

R. Lerner, S. Benkovic, W. Huse, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Expression of properly folded catalytic antibodies in Escherichia coli.

S. Benkovic, B. Posner, I. Lee, 1995, Methods in enzymology.

Purine biosynthetic enzymes assemble into liquid-like condensates dependent on the activity of chaperone protein HSP90

S. Benkovic, Anthony M. Pedley, C. Chan, 2022, The Journal of biological chemistry.

Single-molecule studies of DNA replisome function.

S. Benkovic, M. M. Spiering, Hongjun Yue, 2010, Biochimica et biophysica acta.

Synthesis and biological evaluation of 9‐thia‐5,10‐dideazafolic acid

S. Benkovic, M. Wall, 2002 .

Fidelity of in vitro DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.

S. Benkovic, J. Peliska, J. A. Peliska, 1994, Biochemistry.

Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.

S. Benkovic, J. Peliska, S J Benkovic, 1992, Science.

Corrigendum: RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue

Stephen J. Benkovic, Felix Ritort, Vincent Croquette, 2014, Nature Communications.

Lab-on-a-chip technologies for single-molecule studies.

Tony Jun Huang, Joseph Rufo, Yanhui Zhao, 2013, Lab on a chip.

Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases.

S. Benkovic, K. R. Maples, Rajeshwar Singh, 2006, Bioorganic & medicinal chemistry letters.

Site-directed Mutations of T4 Helicase Loading Protein (gp59) Reveal Multiple Modes of DNA Polymerase Inhibition and the Mechanism of Unlocking by gp41 Helicase*

Stephen J Benkovic, S. Benkovic, S. Nelson, 2006, Journal of Biological Chemistry.

On the mechanism of the metallo-beta-lactamase from Bacteroides fragilis.

Z Wang, S. Benkovic, W. Fast, 1999, Biochemistry.

Threading your way to protein function.

S. Benkovic, A. Nixon, S. Firestine, 1996, Chemistry & biology.

Consideration of the pH-dependent inhibition of dihydrofolate reductase by methotrexate.

S. Benkovic, B. Garrison, W. R. Cannon, 1997, Journal of molecular biology.

A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A.

J. H. Shim, I. Wilson, S. Benkovic, 1998, Journal of molecular biology.

A rapid screen of active site mutants in glycinamide ribonucleotide transformylase.

S. Benkovic, M. S. Warren, A. Marolewski, 1996, Biochemistry.

Formyltetrahydrofolate hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli

S. Benkovic, H. Zalkin, A. Marolewski, 1995, Journal of bacteriology.

Gap misrepair mutagenesis: efficient site-directed induction of transition, transversion, and frameshift mutations in vitro.

D. Botstein, D. Shortle, S. Benkovic, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria

X. Zhuang, S. Benkovic, Anthony M. Pedley, 2018, Proceedings of the National Academy of Sciences.

Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase.

S. Benkovic, K. Taira, 1988, Journal of medicinal chemistry.

Hybrid enzymes: manipulating enzyme design.

S. Benkovic, M. Ostermeier, A. Nixon, 1998, Trends in biotechnology.

The Purinosome: A Case Study for a Mammalian Metabolon.

S. Benkovic, Anthony M. Pedley, V. Pareek, 2022, Annual review of biochemistry.

For the manuscript: RecG and UvsW catalyze robust DNA rewinding critical for stalled DNA replication fork rescue

F. Ritort, S. Benkovic, V. Croquette, 2013 .

Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis

S. Benkovic, B. Pandey, Mark Hedglin, 2016, Proceedings of the National Academy of Sciences.

Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket.

R. Lerner, J. Tainer, E. Getzoff, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism of polynucleotide phosphorylase.

S. Benkovic, K. Johnson, S. Marchese-Ragona, 1989, Biochemistry.

Molecular structure of Escherichia coli PurT-encoded glycinamide ribonucleotide transformylase.

S. Benkovic, J. Thoden, H. Holden, 2000, Biochemistry.

Dynamics of the dihydrofolate reductase-folate complex: catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features.

P. Wright, S. Benkovic, D. Epstein, 1995, Biochemistry.

Perspectives on Electrostatics and Conformational Motions in Enzyme Catalysis

S. Benkovic, C. Liu, Philip Hanoian, 2015, Accounts of chemical research.

Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans

Tom H. Pringle, S. Benkovic, J. French, 2013, Proceedings of the National Academy of Sciences.

Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction.

S. Benkovic, A. Kohen, Laura L. Perissinotti, 2012, Journal of the American Chemical Society.

Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase

N. Goodey, S. Benkovic, A. Kohen, 2006, Proceedings of the National Academy of Sciences.

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli.

S. Benkovic, C. Fierke, K. Johnson, 1987, Biochemistry.

An antibody probe to determine the native species of glycinamide ribonucleotide transformylase in chicken liver.

S. Benkovic, W. T. Mueller, R. Sammons, 1984, Biochemistry.

Effects of a distal mutation on active site chemistry.

S. Benkovic, T. Selzer, A. Kohen, 2006, Biochemistry.

Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase.

S. Benkovic, G. Hammes, R. Smiley, 2005, Biochemistry.

Protein engineering of dihydrofolate reductase. pH dependency of Phe-31 mutants

S. Benkovic, C. Fierke, K. Taira, 1987 .

Synthesis of (6R,11S)- and (6R,11R)-5,10-methylene[11-1H,2H]tetrahydrofolate. Stereochemical paths of serine hydroxymethyltransferase, 5,10-methylenetetrahydrofolate dehydrogenase, and thymidylate synthetase catalysis

S. Benkovic, L. Slieker, 1984 .

Impact on catalysis of secondary structural manipulation of the alpha C-helix of Escherichia coli dihydrofolate reductase.

S. Benkovic, L. Li, 1991, Biochemistry.

Identification of the Active Oligomeric State of an Essential Adenine DNA Methyltransferase from Caulobacter crescentus *

S. Benkovic, S J Benkovic, V K Shier, 2001, The Journal of Biological Chemistry.

Principles of antibody catalysis

R. Lerner, S. Benkovic, 1988, BioEssays : news and reviews in molecular, cellular and developmental biology.

Catalysis of a stereospecific bimolecular amide synthesis by an antibody.

R. Lerner, S. Benkovic, A. Napper, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Metabolic channeling: predictions, deductions, and evidence.

N. Wingreen, S. Benkovic, Z. Sha, 2021, Molecular cell.

On the mechanism of alkaline and neutral fructose 1, 6-diphosphatase: inhibition by substrate analogs at neutral pH.

S. Benkovic, M. D. de Maine, 1972, Archives of biochemistry and biophysics.

Selective modification of rabbit liver fructose bisphosphatase.

S. Benkovic, M. Demaine, M. deMaine, 1980, Archives of biochemistry and biophysics.

Rapid-quench and isotope-trapping studies on fructose-1,6-bisphosphatase.

S. Benkovic, J. Rahil, M. D. de Maine, 1982, Biochemistry.

On the structural and functional modularity of glycinamide ribonucleotide formyltransferases

S. Benkovic, S. Lutz, Seung‐Goo Lee, 2003, Protein science : a publication of the Protein Society.

Localization of GAR transformylase in Escherichia coli and mammalian cells

S. Benkovic, S. Gilroy, L. T. Gooljarsingh, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase.

S. Benkovic, C. Wagner, Z. Huang, 1994, Biochemistry.

Functional role of a mobile loop of Escherichia coli dihydrofolate reductase in transition-state stabilization.

P. Wright, S. Benkovic, L. Li, 1992, Biochemistry.

Complementary perturbation of the kinetic mechanism and catalytic effectiveness of dihydrofolate reductase by side-chain interchange.

S. Benkovic, C. Wagner, J. Thillet, 1992, Biochemistry.

The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli.

S. Benkovic, C. Fierke, J. Adams, 1991, Biochemistry.

Effects of distal point-site mutations on the binding and catalysis of dihydrofolate reductase from Escherichia coli.

R. Matthews, S. Benkovic, J. Adams, 1989, Biochemistry.

Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding.

S. Benkovic, C. Fierke, 1989, Biochemistry.

On interpreting the inhibition of and catalysis by dihydrofolate reductase

S. Benkovic, C. Fierke, K. Taira, 1987 .

Hydrophobic interactions via mutants of Escherichia coli dihydrofolate reductase: separation of binding and catalysis.

S. Benkovic, D. Murphy, 1989, Biochemistry.

Insights into enzyme function from studies on mutants of dihydrofolate reductase.

S. Benkovic, C. Fierke, S J Benkovic, 1988, Science.

Computational studies on pterins and speculations on the mechanism of action of dihydrofolate reductase.

S. Benkovic, K. Taira, K. Furukawa, 1989, Biochemical and biophysical research communications.

Protein Engineering of Dihydrofolate Reductase. Improved Catalytic Step of Mutant-Enzymes

S. Benkovic, R. Mayer, K. Taira, 1987 .

Probing the functional role of phenylalanine-31 of Escherichia coli dihydrofolate reductase by site-directed mutagenesis.

S. Benkovic, K. Taira, C. Tu, 1987, Biochemistry.

Site-Specific Mutations in Dihydrofolate Reductase at the Dihydrofolate Binding Site

S. Benkovic, R. Mayer, K. Taira, 1987 .

Role of a solvent‐exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo‐β‐lactamase

H. Dyson, P. Wright, S. Benkovic, 2003, Protein science : a publication of the Protein Society.

Mechanism of "uncoupled" tetrahydropterin oxidation by phenylalanine hydroxylase.

S. Benkovic, T. Dix, 1985, Biochemistry.

G-protein-coupled receptor regulation of de novo purine biosynthesis: a novel druggable mechanism

Ye Fang, S. Benkovic, Hong Zhao, 2013, Biotechnology & genetic engineering reviews.

Site directed mutagenesis: a tool for enzyme mechanism dissection.

S. Benkovic, C. R. Wagner, 1990, Trends in biotechnology.

Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.

Stephen J Benkovic, Peter E Wright, H Jane Dyson, 2004, Biochemistry.

PCNA monoubiquitination is regulated by diffusion of Rad6/Rad18 complexes along RPA filaments

S. Benkovic, Tae-Hee Lee, Mingjie Li, 2020, bioRxiv.

Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen

S. Benkovic, Anthony M. Pedley, M. Aitha, 2019, The Journal of Biological Chemistry.

Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

S. Benkovic, B. Pandey, Mark Hedglin, 2016, eLife.

Single-molecule investigation of the T4 bacteriophage DNA polymerase holoenzyme: multiple pathways of holoenzyme formation.

Stephen J Benkovic, S. Benkovic, Zhihao Zhuang, 2006, Biochemistry.

An alternative clamp loading pathway via the T4 clamp loader gp44/62-DNA complex.

S. Benkovic, Zhihao Zhuang, A. Berdis, 2006, Biochemistry.

How a holoenzyme for DNA replication is formed

S. Benkovic, S. Perumal, Tae-Hee Lee, 2012, Proceedings of the National Academy of Sciences.

Interaction between the T4 helicase-loading protein (gp59) and the DNA polymerase (gp43): a locking mechanism to delay replication during replisome assembly.

Stephen J Benkovic, Zhiquan Zhang, S. Benkovic, 2005, Biochemistry.

No Job Name

S. Benkovic, C. M. Joyce, 2005 .

Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4.

S. Benkovic, J. Peliska, T. Capson, 1992, Biochemistry.

No Job Name

S. Benkovic, C. M. Joyce, 2022 .

An examination of the copper requirement of phenylalanine hydroxylase from Chromobacterium violaceum.

S. Benkovic, R. Carr, 1993, Biochemistry.

Mapping Protein-Protein Proximity in the Purinosome*

S. Benkovic, Hong Zhao, J. French, 2012, The Journal of Biological Chemistry.

Kinetic and structural characterization of dihydrofolate reductase from Streptococcus pneumoniae.

Stephen J Benkovic, S. Benkovic, Jeeyeon Lee, 2010, Biochemistry.

Insights into Enzymic Catalysis from Studies on Dihydrofolate Reductases

S. Benkovic, C. Fierke, J. Adams, 1989 .

Importance of a hydrophobic residue in binding and catalysis by dihydrofolate reductase.

S. Benkovic, R. Mayer, C. Fierke, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Hypoxia drives the assembly of the multienzyme purinosome complex

S. Benkovic, Anthony M. Pedley, A. Tavassoli, 2020, The Journal of Biological Chemistry.

Site-directed mutagenesis of a catalytic antibody: an arginine and a histidine residue play key roles.

E. Getzoff, V. Roberts, S. Benkovic, 1994, Biochemistry.

Catalytic antibody for imide hydrolysis featuring a bifunctional transition-state mimic

G. Miller, S. Benkovic, L. Liotta, 1993 .

Substituent effects of an antibody-catalyzed hydrolysis of phenyl esters: further evidence for an acyl-antibody intermediate

R. Gibbs, R. Lerner, S. Benkovic, 1992 .

Dissecting the order of bacteriophage T4 DNA polymerase holoenzyme assembly.

S. Benkovic, T. Carver, D J Sexton, 1998, Biochemistry.

Protein-Protein and Protein-DNA Interactions at the Bacteriophage T4 DNA Replication Fork

S. Benkovic, T. Carver, A. Berdis, 1996, The Journal of Biological Chemistry.

Minimal kinetic mechanism for misincorporation by DNA polymerase I (Klenow fragment).

S. Benkovic, B. Eger, 1992, Biochemistry.

Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-).

S. Benkovic, C. M. Joyce, B. Eger, 1991, Biochemistry.

Kinetic analysis of nucleotide incorporation and misincorporation by Klenow fragment of Escherichia coli DNA polymerase I.

C. Cameron, S. Benkovic, 1995, Methods in enzymology.

Kinetic and structural investigations of the replicative fidelity of the Klenow fragment.

S. Benkovic, R. Kuchta, D. Allen, 1988, Biochemical Society Transactions.

Mechanism of DNA polymerase I: exonuclease/polymerase activity switch and DNA sequence dependence of pyrophosphorolysis and misincorporation reactions.

S. Benkovic, V. Mizrahi, P. Benkovic, 1986, Proceedings of the National Academy of Sciences of the United States of America.

1H, 15N and 13C resonance assignments, secondary structure, and the conformation of substrate in the binary folate complex of Escherichia coli dihydrofolate reductase

P. Wright, S. Benkovic, A. Palmer, 1994, Journal of biomolecular NMR.

Partial 1H NMR assignments of the Escherichia coli dihydrofolate reductase complex with folate: evidence for a unique conformation of bound folate.

P. Wright, S. Benkovic, C. J. Falzone, 1990, Biochemistry.

Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein.

C. Cameron, S. Benkovic, S. L. Le Grice, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Catalytic antibody model and mutagenesis implicate arginine in transition-state stabilization.

E. Getzoff, V. Roberts, S. Benkovic, 1994, Journal of molecular biology.

Elucidation of the metal-binding properties of the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase by lanthanide(III) luminescence spectroscopy.

S. Benkovic, S. Frey, M. W. Frey, 1996, Chemistry & biology.

Mechanistic Studies on DNA Polymerase I

S. Benkovic, V. Mizrahi, R. Kuchta, 1988 .

The effect of the 3',5' thiophosphoryl linkage on the exonuclease activities of T4 polymerase and the Klenow fragment.

S. Benkovic, P. Benkovic, A. Gupta, 1984, Nucleic acids research.

Template-prime-dependent turnover of (Sp)-dATP alpha S by T4 DNA polymerase. The stereochemistry of the associated 3' goes to 5'-exonuclease.

S. Benkovic, C. Debrosse, A. Gupta, 1982, The Journal of biological chemistry.

Transition-state stabilization as a measure of the efficiency of antibody catalysis

S. Benkovic, J. Stewart, 1995, Nature.

Interaction between the T4 helicase loading protein (gp59) and the DNA polymerase (gp43): unlocking of the gp59-gp43-DNA complex to initiate assembly of a fully functional replisome.

S. Benkovic, Zhihao Zhuang, G. Hammes, 2005, Biochemistry.

Architecture of the bacteriophage T4 primosome: electron microscopy studies of helicase (gp41) and primase (gp61).

J. Warrington, S. Benkovic, M. Trakselis, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Stoichiometry and DNA Unwinding by the Bacteriophage T4 41:59 Helicase*

S. Benkovic, T. Carver, K. Raney, 1996, The Journal of Biological Chemistry.

Dual role of the 44/62 protein as a matchmaker protein and DNA polymerase chaperone during assembly of the bacteriophage T4 holoenzyme complex.

S. Benkovic, B. F. Kaboord, 1996, Biochemistry.

Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase.

Sharon Hammes-Schiffer, Stephen J Benkovic, S. Benkovic, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate.

S. Benkovic, G. Hammes, P. Rajagopalan, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates.

S. Benkovic, P. Rajagopalan, S. Lutz, 2002, Biochemistry.

Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism.

P E Wright, H. Dyson, P. Wright, 2001, Biochemistry.

Magnetic tweezers for the study of DNA tracking motors.

Stephen J Benkovic, Fangyuan Ding, David Bensimon, 2010, Methods in enzymology.

Examination of the role of the clamp-loader and ATP hydrolysis in the formation of the bacteriophage T4 polymerase holoenzyme.

S. Benkovic, M. Trakselis, A. Berdis, 2003, Journal of molecular biology.

Clamp subunit dissociation dictates bacteriophage T4 DNA polymerase holoenzyme disassembly.

S. Benkovic, D. Sexton, P. Soumillion, 1998, Biochemistry.

Dissociation of bacteriophage T4 DNA polymerase and its processivity clamp after completion of Okazaki fragment synthesis.

S. Benkovic, T. Carver, D. Sexton, 1997, Biochemistry.

Genetic Selection of Cyclic Peptide Dam Methyltransferase Inhibitors

Stephen J Benkovic, Ali Tavassoli, S. Benkovic, 2008, Chembiochem : a European journal of chemical biology.

A systematic method for identifying small-molecule modulators of protein-protein interactions.

S. Benkovic, S. Savinov, A. Horswill, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Detection of a catalytic antibody species acylated at the active site by electrospray mass spectrometry.

G. Siuzdak, H. Dyson, S. Benkovic, 1995, Biochemistry.

On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liver.

S. Benkovic, W. T. Mueller, P. Benkovic, 1981, Biochemistry.

A catalytic antibody uses a multistep kinetic sequence.

R. Lerner, S. Benkovic, K. Janda, 1991, Ciba Foundation symposium.

Continuous assay for DNA polymerization by light scattering.

S. Benkovic, K. Johnson, F. R. Bryant, 1984, Analytical biochemistry.

L-[2,5-H2]phenylalanine, an alternate substrate for rat liver phenylalanine hydroxylase.

S. Benkovic, R. Miller, 1988, Biochemistry.

The Mechanism of Action of Phenylalanine Hydroxylase

S. Benkovic, G. Bollag, L. Bloom, 1986, Annals of the New York Academy of Sciences.

Design and Evolution of New Catalytic Activity with an Existing Protein Scaffold

Sung-Hun Nam, Stephen J Benkovic, Hee-Sung Park, 2006, Science.

FamClash: A method for ranking the activity of engineered enzymes

Stephen J Benkovic, Costas D Maranas, C. Maranas, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Construction of hybrid gene libraries involving the circular permutation of DNA

S. Benkovic, M. Ostermeier, 2001, Biotechnology Letters.

Using incremental truncation to create libraries of hybrid enzymes.

S. Benkovic, A. Horswill, T. Naumann, 2004, Methods in enzymology.

Retracing Enzyme Evolution in the (βα)8‐Barrel Scaffold

S. Benkovic, S. Lutz, J. D. Stevenson, 2001 .

Homology-independent protein engineering.

S. Benkovic, S. Lutz, S J Benkovic, 2000, Current opinion in biotechnology.

Incremental truncation as a strategy in the engineering of novel biocatalysts.

S. Benkovic, M. Ostermeier, A. Nixon, 1999, Bioorganic & medicinal chemistry.

Catecholate LMCT Bands as Probes for the Active Sites of Nonheme Iron Oxygenases.

S. Benkovic, L. Que, L. Bloom, 1988 .

Improvement in the efficiency of formyl transfer of a GAR transformylase hybrid enzyme.

S. Benkovic, A. Nixon, A E Nixon, 2000, Protein engineering.

Temporally overlapped but uncoupled motions in dihydrofolate reductase catalysis.

N. Goodey, S. Benkovic, Lin Wang, 2013, Biochemistry.

The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase

N. Goodey, S. Benkovic, A. Kohen, 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

Dynamics of a flexible loop in dihydrofolate reductase from Escherichia coli and its implication for catalysis.

P E Wright, P. Wright, S. Benkovic, 1994, Biochemistry.

Kinetic hysteresis for fructose bisphosphatase: a change in substrate configuration specificity.

S. Benkovic, M. Demaine, 1979, Biochemical and biophysical research communications.

ELECTROSTATIC CHARACTERIZATION OF ENZYME COMPLEXES : EVALUATION OF THE MECHANISM OF CATALYSIS OF DIHYDROFOLATE REDUCTASE

Barbara J. Garrison, Stephen J. Benkovic, William R. Cannon, 1997 .

A perspective on biological catalysis

S. Benkovic, S. Singleton, W. R. Cannon, 1996, Nature Structural Biology.

On the solution structure of the T4 sliding clamp (gp45).

S. Benkovic, M. Trakselis, David Millar, 2004, Biochemistry.

Substrate-driven chemotactic assembly in an enzyme cascade.

M. Gilson, S. Benkovic, Ayusman Sen, 2018, Nature chemistry.

Mechanism of bacteriophage T4 DNA holoenzyme assembly: the 44/62 protein acts as a molecular motor.

S. Benkovic, A. Berdis, 1997, Biochemistry.

Mechanism-based inhibition of an essential bacterial adenine DNA methyltransferase: rationally designed antibiotics.

S. Benkovic, D. Wahnon, S J Benkovic, 2001, Journal of the American Chemical Society.

Stopped-Flow Apparatus for a Zeiss PMQ II Spectrophotometer

S. Benkovic, T. C. Bruice, T. French, 1965 .

Studies on sulfate esters. III. A comparison of the solvolyses of salicyl sulfate and sulfur trioxide

S. Benkovic, P. Benkovic, 1968 .

Spatial relationship between polymerase and exonuclease active sites of phage T4 DNA polymerase enzyme.

S. Benkovic, V. Gopalakrishnan, 1994, The Journal of biological chemistry.

The Purinosome, a Multi-Protein Complex Involved in the de novo Biosynthesis of Purines in Humans

Ye Fang, Stephen J. Benkovic, S. Benkovic, 2013 .

DNA Replication Fork, Bacterial

S. Benkovic, M. M. Spiering, 2013 .

Using an AraC-based three-hybrid system to detect biocatalysts in vivo

Stephen J Benkovic, S. Benkovic, F. Salinas, 2000, Nature Biotechnology.

Screening combinatorial antibody libraries for catalytic acyl transfer reactions.

R. Lerner, S. Benkovic, L. Sastry, 1991, Ciba Foundation symposium.

Protein Conformational Changes Are Detected and Resolved Site Specifically by Second-Harmonic Generation

S. Benkovic, J. Salafsky, Ben Moree, 2015, Biophysical journal.

Preorganization and protein dynamics in enzyme catalysis.

S. Benkovic, P. Rajagopalan, 2002, Chemical record.

Predicting crossover generation in DNA shuffling

C D Maranas, C. Maranas, S. Benkovic, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Too fast for catalysis

S. Benkovic, R. Stewart, C. Liu, 2013 .

Rational design of a scytalone dehydratase-like enzyme using a structurally homologous protein scaffold.

S. Benkovic, F. Salinas, A. Nixon, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Investigation of an antibody-ligase. Evidence for strain-induced catalysis.

S. Benkovic, S. Savinov, R. Hirschmann, 2003, Bioorganic & medicinal chemistry letters.

Stretching exercises--flexibility in dihydrofolate reductase catalysis.

G. Miller, S. Benkovic, 1998, Chemistry & biology.

Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models.

Yunchao Su, S. Benkovic, S. Barman, 2023, European heart journal.

On the mechanism of decomposition of geminal diamines

S. Benkovic, G. Moad, 1978 .

Stereospecificity of thymidylate synthetase

J. Vederas, E. Schleicher, S. Benkovic, 1977 .

Intramolecular and divalent metal ion catalysis. The hydrolytic mechanism of O-phenyl N-(glycyl)phosphoramidate.

S. Benkovic, E. Sampson, J. Fedor, 1973, The Journal of organic chemistry.

Structural determination of quinonoid dihydropterins

S. Benkovic, R. Lazarus, C. Debrosse, 1982 .

Novel phosphonothioate substrates for phosphodiesterases.

S. Benkovic, N. Dudman, 1977, Journal of the American Chemical Society.

The state of antibody catalysis.

S. Benkovic, D. Smithrud, 1997, Current opinion in biotechnology.

Catalytic Antibodies: Mechanistic and Practical Considerations.

S. Benkovic, J. Stewart, 1993 .

Spectroscopic Studies on the Designed Metal-Binding Sites of the 43C9 Single Chain Antibody?

E. Getzoff, V. Roberts, S. Benkovic, 1995 .

Dissection of an antibody-catalyzed reaction.

G. Siuzdak, S. Benkovic, J. Krebs, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Unnatural translation initiation.

S. Benkovic, J. Tomsho, 2008, ACS chemical biology.

Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease

Bryan J. Venters, S. Benkovic, A. Horswill, 2007, Protein science : a publication of the Protein Society.

Engineering an affinity tag for genetically encoded cyclic peptides.

S. Benkovic, S. Savinov, T. Naumann, 2005, Biotechnology and bioengineering.

Boron-Containing Inhibitors of Synthetases

S. Benkovic, S. Baker, J. Tomsho, 2011 .

Purification and properties of an arylsulfatase from Aspergillus oryzae.

S. Benkovic, R. Hevey, E. Vergara, 1971, The Journal of biological chemistry.

Mechanisms of folate cofactors

S. Benkovic, C. Tatum, 1977 .

Evidence for two interconverting protein isomers in the methotrexate complex of dihydrofolate reductase from Escherichia coli.

P. Wright, S. Benkovic, C. J. Falzone, 1991, Biochemistry.

Enzyme Motions Inside and Out

S. Benkovic, S. Hammes‐Schiffer, 2006, Science.

[53] Fructose-bisphosphatase, zinc-free, from rabbit liver

S. Benkovic, C. Caperelli, M. Demaine, 1982 .

Inhibition of chicken liver 5-aminoimidazole-4-carboxamide ribonucleotide transformylase by 5,8-dideaza analogues of folic acid.

S. Benkovic, W. T. Mueller, J. Hynes, 1988, Biochemical pharmacology.

The use of modified and non-natural nucleotides provide unique insights into pro-mutagenic replication catalyzed by polymerase eta

S. Benkovic, A. Berdis, Anvesh K. R. Dasari, 2015, Nucleic acids research.

Direct demonstration of the active salvage of preformed purines by murine tumors.

S. Benkovic, D. Johnson, R. Mullin, 1990, Biochemical and biophysical research communications.

Tunable, pulsatile chemical gradient generation via acoustically driven oscillating bubbles.

Daniel Ahmed, Nitesh Nama, Chung Yu Chan, 2013, Lab on a chip.

Generation and thiol reduction of a "quinonoid" dihydropterin and an oxidized pyrimidine analog

S. Benkovic, R. Dietrich, 1979 .

ADP-mediated dissociation of stable complexes of recA protein and single-stranded DNA.

I. Lehman, S. Benkovic, M. Cox, 1983, The Journal of biological chemistry.

Glu-111 is required for activation of the DNA cleavage center of EcoRI endonuclease.

S. Benkovic, P. Modrich, P Modrich, 1989, The Journal of biological chemistry.

SIMS (Imaging Secondary Ion Mass Spectrometry) Analysis of a Cross-section Sample From Leonardo Da Vinci’s Adoration of the Magi

S. Benkovic, Hua Tian, N. Winograd, 2020 .

31 P and 13 C nmr measurements of a fructose-1-phosphate, Mn (II) and fructose 1,6-diphosphatase complex.

S. Benkovic, J. Villafranca, J. J. Kleinschuster, 1973, Archives of biochemistry and biophysics.

A DNA fragment with an alpha-phosphorothioate nucleotide at one end is asymmetrically blocked from digestion by exonuclease III and can be replicated in vivo.

S. Benkovic, P. Schimmel, S J Benkovic, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Structural basis of the T4 bacteriophage primosome assembly and primer synthesis

S. Benkovic, Huilin Li, M. M. Spiering, 2023, bioRxiv.

Metallo-beta-lactamase: structure and mechanism.

Z Wang, S. Benkovic, W. Fast, 1999, Current opinion in chemical biology.

Combinatorial manipulation of three key active site residues in glycinamide ribonucleotide transformylase.

S. Benkovic, M. S. Warren, 1997, Protein engineering.

A mass spectrometric solution to the address problem of combinatorial libraries.

S. Benkovic, N. Winograd, C L Brummel, 1994, Science.

THE INTERCONVERSION OF THE 5,6,7,8-TETRAHYDRO-, 6,7,8-DIHYDRO-, AND RADICAL FORMS OF 6,6,7,7-TETRAMETHYLDIHYDROPTERIN. A MODEL FOR THE BIOPTERIN CENTER OF AROMATIC AMINO ACID MIXED FUNCTION OXIDASES

S. Benkovic, T. C. Bruice, R. Lazarus, 1985 .

Identifying Small‐Molecule Modulators of Protein‐Protein Interactions

S. Benkovic, A. Horswill, Stephen J. Benkovic, 2006, Current protocols in protein science.

Model reactions for catalysis of phosphate and sulfate transfer.

S. Benkovic, 1970, Annals of the New York Academy of Sciences.

Stereochemistry of acetic acid formation from 5-methyltetrahydrofolate by Clostridium thermoaceticum

S. Benkovic, H. Simon, H. Lebertz, 1987 .

Stereochemical analysis of the methyl transfer catalyzed by cobalamin-dependent methionine synthase from Escherichia coli B

R. Matthews, S. Benkovic, V. Frasca, 1986 .

NMR characterization of the metallo-beta-lactamase from Bacteroides fragilis and its interaction with a tight-binding inhibitor: role of an active-site loop.

H. Dyson, P. Wright, S. Benkovic, 1999, Biochemistry.

Antibody-Catalyzed Rearrangement of a Peptide Bond: Mechanistic and Kinetic Investigations

Scott D. Taylor, R. Gibbs, S. Benkovic, 1995 .

A free-energy perturbation study of the binding of methotrexate to mutants of dihydrofolate reductase.

U. Singh, S. Benkovic, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Using transcriptional-based systems for in vivo enzyme screening.

S. Benkovic, F. Salinas, S. Firestine, 2003, Methods in molecular biology.

Structural and functional modularity of proteins in the de novo purine biosynthetic pathway

S. Benkovic, W. Fast, Hui Li, 2009, Protein science : a publication of the Protein Society.

Supporting Online Material Materials and Methods Figs. S1 to S8 Tables S1 to S4 References a Stochastic Single-molecule Event Triggers Phenotype Switching of a Bacterial Cell

Kirsten L. Frieda, Paul J. Choi, X. Xie, 2022 .

Site‐specific mutagenesis of dihydrofolate reductase from Escherichia coli

S. Benkovic, R. Mayer, C. Fierke, 1985, Journal of cellular biochemistry.

A handy enzyme for transcription

S. Benkovic, J. A. Peliska, 1992, Current Biology.

Mechanism of hydrolysis of phosphorylethanolamine diesters. Intramolecular nucleophilic amine participation

S. Benkovic, R. Lazarus, P. Benkovic, 1980 .

Mechanism of hydrolysis of phosphorylethanolamine triesters. Multiple catalytic effects of an intramolecular amino group

S. Benkovic, R. Lazarus, 1979 .

Kinetic characterization of a bacteriophage T4 antimutator DNA polymerase.

S. Benkovic, P. Wu, N. G. Nossal, 1998, Biochemistry.

Magnetic tweezers for the study of DNA tracking motors.

S. Benkovic, O. Saleh, J. Allemand, 2010, Methods in enzymology.

Active site topology of artificial peroxidase-like hemoproteins based on antibodies constructed from a specifically designed ortho-carboxy-substituted tetraarylporphyrin.

S. Benkovic, D. Mansuy, M. Sari, 1998, European journal of biochemistry.

A New View into the Regulation of Purine Metabolism: The Purinosome.

S. Benkovic, Anthony M. Pedley, 2017, Trends in biochemical sciences.

Metal Ion-Activated Enzymes

S. Benkovic, 1973 .

Biochemical Characterization of Bacteriophage T4 Mre11-Rad50 Complex*

S. Benkovic, S. Nelson, T. Herdendorf, 2010, The Journal of Biological Chemistry.

Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle.

S. Benkovic, Mark Hedglin, 2017, Chemical reviews.

Supplementary Materials for Direct Observation of Stalled Fork Restart via Fork Regression in the T4 Replication System

S. Benkovic, V. Croquette, Senthil K. Perumal, 2012 .

Pentacovalent phosphorus in the hydrolysis of dibenzylphosphoenolpyruvate

S. Benkovic, K. Schray, 1969 .

A bio-hybrid rotaxane catalyst

S. Benkovic, R. Nolte, A. Rowan, 2018 .