D. Rajpal

发表

Computational biology approaches for selecting host-pathogen drug targets.

James R. Brown, P. Sanseau, M. Magid-Slav, 2011, Drug discovery today.

Computational Drug Repositioning: From Data to Therapeutics

P. Sanseau, Pankaj Agarwal, Lun Yang, 2013, Clinical pharmacology and therapeutics.

Phenome-wide association study using research participants’ self-reported data provides insight into the Th17 and IL-17 pathway

Li Li, Deepak K Rajpal, M. Nelson, 2017, PloS one.

The role of translational bioinformatics in drug discovery.

Philippe Sanseau, Ranga Chandra Gudivada, Deepak K Rajpal, 2011, Drug discovery today.

Novel Gut-Based Pharmacology of Metformin in Patients with Type 2 Diabetes Mellitus

James R. Brown, Sam R. Miller, D. Rajpal, 2014, PloS one.

Applications of Connectivity Map in drug discovery and development.

Deepak K Rajpal, Xiaoyan A Qu, D. Rajpal, 2012, Drug discovery today.

Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility

D. Rajpal, J. Chen, A. Billin, 2015, PloS one.

The Microbiome as a Therapeutic Target for Metabolic Diseases

James R. Brown, D. Rajpal, James R. Brown, 2013 .

Gastrointestinal weight-loss surgery: glimpses at the molecular level.

Michal Magid-Slav, Johannes M Freudenberg, Deepak K Rajpal, 2013, Drug discovery today.

Integrative clinical transcriptomics analyses for new therapeutic intervention strategies: a psoriasis case study.

P. Sanseau, D. Rajpal, J. Freudenberg, 2014, Drug discovery today.

ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.

D. Rajpal, R. McPherson, R. Evans, 2010, Molecular endocrinology.

Effect of Roux-en-Y Gastric Bypass Surgery on Bile Acid Metabolism in Normal and Obese Diabetic Rats

D. Rajpal, J. Freudenberg, A. Tavakkoli, 2015, PloS one.

The Comparison of Skin Transcriptomes Confirms Canine Atopic Dermatitis Is a Natural Homologue to the Human Disease.

D. Rajpal, J. Freudenberg, T. Olivry, 2019, The Journal of investigative dermatology.

Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci

D. Rajpal, Xia Yang, Qingying Meng, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Kyle J. Gaulton, Sara M. Willems, D. Kiel, 2017, Nature Communications.

Effect of topical soluble epoxide hydrolase inhibition in a preclinical diabetic wound healing model

D. Rajpal, P. Agarwal, P. Jain, 2019, bioRxiv.

Significant obesity‐associated gene expression changes occur in the stomach but not intestines in obese mice

P. Sanseau, J. Chen, D. Rajpal, 2016, Physiological reports.

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

D. Rajpal, J. Freudenberg, K. Nosaka, 2018, Skeletal Muscle.

Early Activation of Th2/Th22 Inflammatory and Pruritogenic Pathways in Acute Canine Atopic Dermatitis Skin Lesions.

D. Rajpal, H. Hofland, T. Olivry, 2016, The Journal of investigative dermatology.

A tissue- and organ-based cell biological atlas of obesity-related human genes and cellular pathways

R. Iyengar, P. Sanseau, J. Goldfarb, 2020, bioRxiv.

Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans.

T. Willson, Dalei Wu, D. Rajpal, 2017, The Journal of investigative dermatology.

Gut microbiome differences between metformin‐ and liraglutide‐treated T2DM subjects

James R. Brown, D. Rajpal, S. Van Horn, 2017, Endocrinology, diabetes & metabolism.

Title : Effect of topical soluble epoxide hydrolase inhibition in a preclinical diabetic 2 wound healing model . 3 Short title : EPHX 2 inhibition and wound healing 4

D. Rajpal, P. Agarwal, P. Jain, 2022 .

Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research Repository

D. Rajpal, C. Loh, S. Lessard, 2022, Frontiers in Medicine.

Empowering the discovery of novel target-disease associations via machine learning approaches in the open targets platform

Cheng Zhu, D. Rajpal, Yingnan Han, 2022, BMC Bioinformatics.

Multi-omics integration reveals molecular networks and regulators of psoriasis

Deepali Jhamb, Xia Yang, Le Shu, 2019, BMC Systems Biology.

Human microbial metabolites as a source of new drugs.

James R. Brown, D. Rajpal, Somdutta Saha, 2016, Drug discovery today.

Uncovering novel repositioning opportunities using the Open Targets platform.

Gautier Koscielny, Pankaj Agarwal, Philippe Sanseau, 2017, Drug discovery today.

098 Comparative RNA-Seq profiling of oral lichen planus and mucous membrane pemphigoid patient samples reveal distinct and shared molecular pathways

D. Rajpal, J. Freudenberg, P. Googe, 2020 .

Atlas of epistasis

D. Rajpal, S. Lessard, V. Thuillier, 2021, medRxiv.

Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress

M. Bantscheff, D. Rajpal, G. Bergamini, 2017, Journal of the American Heart Association.

Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease

Pankaj Agarwal, D. Rajpal, Vinod Kumar, 2019, PloS one.

BET Inhibition Improves NASH and Liver Fibrosis

Sarah A. Middleton, Pankaj Agarwal, D. Rajpal, 2018, Scientific Reports.

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models

James R. Brown, D. Rajpal, G. P. Livi, 2015, PloS one.

Lysosomal-Immune Axis Is Associated with COVID 19 Disease Severity: Insights from Patient Single Cell Data

K. Klinger, D. Rajpal, E. Teeple, 2021, bioRxiv.

Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration

D. Rajpal, Virginia Savova, Yingnan Han, 2022, Nature Neuroscience.

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Matthew S. Lebo, Beryl B. Cummings, John D. Eicher, 2021, Nature Network Boston.

Single Cell Atlas of Human Putamen Reveals Disease Specific Changes in Synucleinopathies: Parkinson’s Disease and Multiple System Atrophy

K. Klinger, D. Rajpal, S. Madden, 2021, bioRxiv.

An integrative network-based approach for drug target indication expansion

Cheng Zhu, D. Rajpal, Yingnan Han, 2021, PloS one.

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Beryl B. Cummings, John D. Eicher, M. Pirinen, 2020, Nature Communications.

Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes.

D. Rajpal, Chari D Smith, B. Gedulin, 2012, American journal of physiology. Endocrinology and metabolism.

Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands

P. Sanseau, I. Dunham, D. Rajpal, 2018, BMC Bioinformatics.

FinnGen provides genetic insights from a well-phenotyped isolated population

Jacob C. Ulirsch, Benjamin B. Sun, Christopher N. Foley, 2023, Nature.

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

Beryl B. Cummings, John D. Eicher, Jonathan H. Chung, 2022, Communications Biology.

Gastrointestinal weight-loss surgery : an effective treatment option for obesity

M. Magid-Slav, D. Rajpal, J. Freudenberg, 2013 .

Assessment of rosacea symptom severity by genome-wide association study and expression analysis highlights immuno-inflammatory and skin pigmentation genes

M. Ehm, D. Hinds, D. Rajpal, 2018, Human molecular genetics.

The epigenetic signature of systemic insulin resistance in obese women

D. Rajpal, T. Johnson, P. Arner, 2016, Diabetologia.

Modulating the Human Gut Microbiome as an Emerging Therapeutic Paradigm

James R. Brown, D. Rajpal, 2013, Science progress.

Single Nuclei Sequencing of Human Putamen Oligodendrocytes Reveals Altered Heterogeneity and Disease-Associated Changes in Parkinson’s Disease and Multiple System Atrophy

K. Klinger, D. Rajpal, S. Madden, 2021, bioRxiv.

Mining emerging biomedical literature for understanding disease associations in drug discovery.

Johannes M Freudenberg, Deepak K Rajpal, Xiaoyan A Qu, 2014, Methods in molecular biology.

Could advances in representation learning in Artificial Intelligence provide the new paradigm for data integration in drug discovery?

Pankaj Agarwal, Andrew D Rouillard, Deepak K Rajpal, 2019, Expert opinion on drug discovery.

Microglia ferroptosis is prevalent in neurodegenerative disease and regulated by SEC24B

D. Rajpal, Bailin Zhang, D. Ofengeim, 2021 .

Integrated Label Transfer for Oligodendrocyte Subpopulation Profiling in Parkinson's Disease and Multiple System Atrophy

D. Rajpal, S. Madden, A. Cedazo-Mínguez, 2022, HEALTHINF.

A Hidradenitis Suppurativa molecular disease signature derived from patient samples by high-throughput RNA sequencing and re-analysis of previously reported transcriptomic data sets

D. Rajpal, J. Freudenberg, Elizabeth Thomas, 2023, PloS one.

Erratum to: The epigenetic signature of systemic insulin resistance in obese women

D. Rajpal, T. Johnson, P. Arner, 2016, Diabetologia.

ERRγ Regulates Cardiac, Gastric, and Renal Potassium Homeostasis.

D. Rajpal, R. McPherson, R. Evans, 2009, Endocrine reviews.

Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands

Philippe Sanseau, Ian Dunham, Deepak K Rajpal, 2018, BMC Bioinformatics.

Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population

Christopher N. Foley, R. Mägi, K. Kristiansson, 2023, Nature.

The essentiality of drug targets: an analysis of current literature and genomic databases.

D. Rajpal, J. Freudenberg, Xiao Ji, 2019, Drug discovery today.