J. Hamon

发表

Large Scale Prediction and Testing of Drug Activity on Side-Effect Targets

Michael J. Keiser, B. Shoichet, J. Jenkins, 2012, Nature.

Mapping adverse drug reactions in chemical space.

M. Milik, A. Bender, J. Jenkins, 2009, Journal of medicinal chemistry.

Analysis of Pharmacology Data and the Prediction of Adverse Drug Reactions and Off‐Target Effects from Chemical Structure

A. Bender, J. Jenkins, J. Scheiber, 2007, ChemMedChem.

Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development.

D. Bojanic, S. Whitebread, J. Hamon, 2005, Drug discovery today.

Modeling Promiscuity Based on in vitro Safety Pharmacology Profiling Data

A. Bender, J. Jenkins, E. Jacoby, 2007, ChemMedChem.

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

Gareth J Waldron, S. Whitebread, J. Hamon, 2012, Nature Reviews Drug Discovery.

In vitro safety pharmacology profiling: what else beyond hERG?

K. Azzaoui, S. Whitebread, J. Hamon, 2009, Future medicinal chemistry.

Multidimensional de novo design reveals 5-HT2B receptor-selective ligands.

Gisbert Schneider, Daniel Reker, Guido Koch, 2015, Angewandte Chemie.

Clustering and Rule‐Based Classifications of Chemical Structures Evaluated in the Biological Activity Space.

Paul M. Selzer, Jeremy L. Jenkins, Peter Ertl, 2007 .

High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis

D. Bojanic, K. Azzaoui, S. Whitebread, 2006, Expert opinion on drug metabolism & toxicology.

Screening for Safety‐Relevant Off‐Target Activities

D. Mikhailov, K. Azzaoui, S. Whitebread, 2012 .

Translation of off-target effects: prediction of ADRs by integrated experimental and computational approach

J. Jenkins, Eugen Lounkine, S. Whitebread, 2014 .

Cover Picture: Analysis of Pharmacology Data and the Prediction of Adverse Drug Reactions and Off-Target Effects from Chemical Structure (ChemMedChem 6/2007)

A. Bender, J. Jenkins, J. Scheiber, 2007 .

Pharmacological properties of trimebutine and N-monodesmethyltrimebutine.

J. Hamon, P. Champéroux, S. Richard, 1999, The Journal of pharmacology and experimental therapeutics.

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.

Doriano Fabbro, Pascal Furet, Giorgio Caravatti, 2013, Bioorganic & medicinal chemistry letters.

Alkylamides from Echinacea Are a New Class of Cannabinomimetics

Xiang-Qun Xie, Bernard Faller, Karl-Heinz Altmann, 2006, Journal of Biological Chemistry.

The low affinity PCP sites in the rat cerebellum not only bind TCP-like but also BTCP-like structures.

J. Hamon, H. Hirbec, J. Vignon, 2000, European journal of medicinal chemistry.

PAX8 and MECOM are interaction partners driving ovarian cancer

G. G. Galli, D. Erdmann, D. Schübeler, 2021, Nature Communications.

Identification of the C3a Receptor (C3AR1) as the Target of the VGF-derived Peptide TLQP-21 in Rodent Cells

E. Oakeley, J. Hamon, M. Beibel, 2013, The Journal of Biological Chemistry.

Effect of lowered lipophilicity on the affinity of PCP analogues for the PCP receptor and the dopamine transporter

J. Hamon, J. Vignon, J. Kamenka, 1996 .

Clustering and Rule-Based Classifications of Chemical Structures Evaluated in the Biological Activity Space

Jeremy L. Jenkins, Peter Ertl, Nathan Brown, 2007, J. Chem. Inf. Model..

Gaining Insight into Off-Target Mediated Effects of Drug Candidates with a Comprehensive Systems Chemical Biology Analysis

Bin Chen, Andreas Bender, Meir Glick, 2009, J. Chem. Inf. Model..

Targets Associated with Drug‐Related Suicidal Ideation and Behavior

S. Whitebread, J. Hamon, L. Urban, 2015 .

Corrigendum to “Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation” [Bioorg. Med. Chem. Lett. 23 (2013) 3741–3748]

D. Fabbro, J. Hamon, P. Furet, 2013 .

In Vitro Safety Pharmacology Profiling: An Important Tool to Decrease Attrition

S. Whitebread, J. Hamon, 2009 .

Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors.

J. Hamon, P. Ducrot, P. Cluzeau, 2005, Bioorganic & medicinal chemistry letters.

Efficient search of chemical space: navigating from fragments to structurally diverse chemotypes.

Anne Mai Wassermann, Eugen Lounkine, Meir Glick, 2013, Journal of medicinal chemistry.

The search for TCP analogues binding to the low affinity PCP receptor sites in the rat cerebellum

J. Hamon, J. Vignon, J. Kamenka, 1999 .

Efficient search of chemical space: navigating from fragments to structurally diverse chemotypes.

Peter S. Kutchukian, M. Glick, Eugen Lounkine, 2013, Journal of medicinal chemistry.