S. Kane

发表

Temporal Dynamics of Tyrosine Phosphorylation in Insulin Signaling

F. White, Katrin Schmelzle, S. Kane, 2006, Diabetes.

Hormonal regulation of the insulin-responsive glucose transporter, GLUT4: some recent advances

S. Kane, I. Campbell, C. Livingstone, 1996, Proceedings of the Nutrition Society.

Darpp-32 and t-Darpp are differentially expressed in normal and malignant mouse mammary tissue

S. Kane, Jessica L. Christenson, 2014, Molecular Cancer.

Construction and characterization of single-transcript tricistronic retroviral vectors using two internal ribosome entry sites

K. Kuchler, S. Kane, A. Pichler, 1998, Somatic cell and molecular genetics.

Nucleoprotein-based nanoscale assembly.

D. S. Joy, S. S. Smith, S. Kane, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of methylation at two internal N6-methyladenosine sites caused by GAC to GAU mutations.

S. Kane, K. Beemon, 1987, The Journal of biological chemistry.

Precise localization of m6A in Rous sarcoma virus RNA reveals clustering of methylation sites: implications for RNA processing

S. Kane, K. Beemon, 1985, Molecular and cellular biology.

Calmodulin binds to the Rab GTPase activating protein required for insulin-stimulated GLUT4 translocation.

S. Kane, G. Lienhard, 2005, Biochemical and biophysical research communications.

Exosomal pMHC-I complex targets T cell-based vaccine to directly stimulate CTL responses leading to antitumor immunity in transgenic FVBneuN and HLA-A2/HER2 mice and eradicating trastuzumab-resistant tumor in athymic nude mice

J. Xiang, R. Chibbar, S. Kane, 2013, Breast Cancer Research and Treatment.

Cancer therapies targeted to the epidermal growth factor receptor and its family members

S. Kane, 2006 .

Synip phosphorylation does not regulate insulin-stimulated GLUT4 translocation.

S. Kane, G. Lienhard, H. Sano, 2005, Biochemical and biophysical research communications.

Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects.

S. Kane, G. Lienhard, J. Zierath, 2005, Diabetes.

LIPOSOMAL DAUNORUBICIN OVERCOMES DRUG RESISTANCE IN HUMAN BREAST, OVARIAN AND LUNG CARCINOMA CELLS

S. Kane, D. Sadava, A. Coleman, 2002, Journal of liposome research.

Transferrin overcomes drug resistance to artemisinin in human small-cell lung carcinoma cells.

S. Kane, D. Sadava, T. Phillips, 2002, Cancer letters.

Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein.

S. Kane, G. Lienhard, T. McGraw, 2005, Cell metabolism.

Pancreatic cancer in vitro toxicity mediated by Chinese herbs SPES and PC-SPES: implications for monotherapy and combination treatment.

S. Kane, D. Sadava, R. Schwarz, 2003, Cancer letters.

The role of cathepsin L in malignant transformation.

M. Gottesman, S. Kane, 1990, Seminars in cancer biology.

Desensitization and sensitization of cells to fluoropyrimidines with different antisenses directed against thymidylate synthase messenger RNA.

S. Kane, H. Lenz, K. Danenberg, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression.

I. Pastan, M. Gottesman, S. Kane, 1993, The Journal of biological chemistry.

Mouse procathepsin L lacking a functional glycosylation site is properly folded, stable, and secreted by NIH 3T3 cells.

S. Kane, 1993, The Journal of biological chemistry.

Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation*

S. Kane, W. Gu, Jianyuan Luo, 2008, Journal of Biological Chemistry.

The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells.

S. Kane, D. Sadava, E. Whitlock, 2007, Biochemical and biophysical research communications.

Alteration of substrate specificity by mutations at the His61 position in predicted transmembrane domain 1 of human MDR1/P-glycoprotein.

S. Kane, K. Ueda, T. Komano, 1997, Biochemistry.

High Level Gene Expression in Fibrosarcoma Use of the Stress-inducible grp 78 / BiP Promoter in Targeting

S. Kane, P. Nichols, Amy S. Lee, 2006 .

Use of the stress-inducible grp78/BiP promoter in targeting high level gene expression in fibrosarcoma in vivo.

S. Kane, P. Nichols, A. S. Lee, 1995, Cancer research.

A new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells.

I. Pastan, M. Gottesman, S. Kane, 1989, Gene.

Harvey murine sarcoma virus/MDR1 retroviral vectors: efficient virus production and foreign gene transduction using MDR1 as a selectable marker.

S. Kane, M. Metz, D. Best, 1995, Virology.

t-Darpp overexpression in HER2-positive breast cancer confers a survival advantage in lapatinib

S. Kane, Jessica L. Christenson, Erin C Denny, 2015, Oncotarget.

CD30 Downregulation, MMAE Resistance, and MDR1 Upregulation Are All Associated with Resistance to Brentuximab Vedotin

S. Kane, S. Forman, E. Newman, 2015, Molecular Cancer Therapeutics.

Transduction of NIH 3T3 cells with a retrovirus carrying both human MDR1 and glutathione S-transferase pi produces broad-range multidrug resistance.

S. Kane, M. Muramatsu, M. Metz, 1995, Cancer research.

Effects of four Chinese herbal extracts on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells

S. Kane, D. Sadava, Mei-Lin Pang, 2002, Cancer Chemotherapy and Pharmacology.

High-level expression of foreign genes in mammalian cells.

S. Kane, Susan E. Kane, 1991, Genetic engineering.

Improvement of sensitivity to t amoxifen in estrogen receptor-positive and Herceptin-resistant breast cancer cells

S. Kane, Shiuan Chen, Yuan-Zhong Wang, 2008 .

Glycosylation of procathepsin L does not account for species molecular-mass differences and is not required for proteolytic activity.

M. Gottesman, S. Kane, S. Smith, 1989, The Biochemical journal.

Structure-function analysis of liver-type (GLUT2) and brain-type (GLUT3) glucose transporters: expression of chimeric transporters in Xenopus oocytes suggests an important role for putative transmembrane helix 7 in determining substrate selectivity.

S. Kane, M. Arbuckle, L. Porter, 1996, Biochemistry.

Magnetic-affinity cell sorting of human multidrug-resistant cells.

I. Pastan, M. Willingham, M. Gottesman, 1991, Journal of the National Cancer Institute.

Comparison of the breadth and complexity of bovine viral diarrhea (BVDV) populations circulating in 34 persistently infected cattle generated in one outbreak.

S. Kane, D. Bayles, D. Young, 2015, Virology.

Multidrug resistance in the laboratory and clinic.

M. Gottesman, S. Kane, 1989, Cancer cells.

Effect of Ganoderma on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells.

S. Kane, D. Sadava, D. Still, 2009, Cancer letters.

t-Darpp stimulates protein kinase A activity by forming a complex with its RI regulatory subunit.

S. Kane, J. Momand, Dirk Theile, 2017, Cellular signalling.

Resistance to HER2-Targeted Therapy

S. Kane, J. Momand, Dirk Theile, 2017 .

t-Darpp Promotes Enhanced EGFR Activation and New Drug Synergies in Her2-Positive Breast Cancer Cells

S. Kane, Erin C Denny, 2015, PloS one.

Protein Kinase A Activation Confers Resistance to Trastuzumab in Human Breast Cancer Cell Lines

S. Kane, G. Somlo, S. Lau, 2009, Clinical Cancer Research.

Darpp-32 and Its Truncated Variant t-Darpp Have Antagonistic Effects on Breast Cancer Cell Growth and Herceptin Resistance

S. Kane, S. Waliany, Long Gu, 2009, PloS one.

Cancer Therapy : Preclinical Protein Kinase A Activation Confers Resistance to Trastuzumab in Human Breast Cancer Cell Lines

S. Kane, G. Somlo, S. Lau, 2009 .

Differential sensitivities of trastuzumab (Herceptin®)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors

S. Kane, M. Metz, Carmel T. Chan, 2005, Breast Cancer Research and Treatment.

LIN28 phosphorylation by MAPK/ERK couples signaling to the post-transcriptional control of pluripotency

John T. Powers, G. Daley, S. Gygi, 2016, Nature Cell Biology.

AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.

S. Kane, G. Lienhard, William Arbuthnot Sir Lane, 2005, The Biochemical journal.

A Method to Identify Serine Kinase Substrates

S. Kane, G. Lienhard, William Arbuthnot Sir Lane, 2002, The Journal of Biological Chemistry.

Use of multidrug resistance gene in mammalian expression vectors.

M. Gottesman, S. Kane, 1993, Methods in enzymology.

MDR1 bicistronic vectors: analysis of selection stringency, amplified gene expression, and vector stability in cell lines.

S. Kane, S. W. Lin, M. Metz, 2001, Biochemical pharmacology.

Selection of transfected cells and coamplification of transfected genes.

S. Kane, 1997, Methods in molecular biology.

Multidrug Resistance of Cancer Cells

S. Kane, 1996 .

Chemosensitization by fibroblast growth factor-2 is not dependent upon proliferation, S-phase accumulation, or p53 status.

S. Kane, M. Metz, R. Schwarz, 2002, Biochemical pharmacology.

Genetic basis of multidrug resistance of tumor cells

I. Pastan, M. Gottesman, S. Kane, 1990, Journal of bioenergetics and biomembranes.

Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease

I. Pastan, M. Gottesman, S. Kane, 1988, Molecular and cellular biology.

Bicistronic and two-gene retroviral vectors for using MDR1 as a selectable marker and a therapeutic gene.

S. Kane, M. Metz, K. Winters, 1996, Virology.

Bioimaging Real-Time PXR-Dependent mdr1a Gene Regulation in mdr1a.fLUC Reporter Mice

Jasmine Chen, S. Kane, B. M. Forman, 2013, The Journal of Pharmacology and Experimental Therapeutics.

A new model for studying tissue-specific mdr1a gene expression in vivo by live imaging

S. Kane, S. Blanchard, T. Synold, 2009, Proceedings of the National Academy of Sciences.

t-Darpp Activates IGF-1R Signaling to Regulate Glucose Metabolism in Trastuzumab-Resistant Breast Cancer Cells

S. Kane, J. Momand, J. Huss, 2017, Clinical Cancer Research.

A phase I/II prospective, single arm trial of gefitinib, trastuzumab, and docetaxel in patients with stage IV HER-2 positive metastatic breast cancer

S. Kane, L. Leong, C. Russell, 2012, Breast Cancer Research and Treatment.

Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation*

John M Asara, S. Kane, G. Lienhard, 2003, The Journal of Biological Chemistry.

Bovine viral diarrhea virus outbreak in a beef cow herd in South Dakota.

S. Kane, D. Young, J. Neill, 2015, Journal of the American Veterinary Medical Association.

The synaptic vesicle protein, cysteine-string protein, is associated with the plasma membrane in 3T3-L1 adipocytes and interacts with syntaxin 4.

S. Kane, V. H. Maier, G. Gould, 2001, Journal of cell science.

INSTITUTION:City of Hope GRANT TITLE: Nucleoprotein-Based Nanoscale Fabrication AWARD PERIOD:15/August/1994 - l/April/1998 OBJECTIVE: To develop a series of nanoscale structures and devices based on addressable molecular components. ACCOMPLISHMENTS: We have provided a clear demonstration of each of

D. S. Joy, S. Kane, Steven S. Smith, 1999 .

The effect of brassinolide, a plant steroid hormone, on drug resistant small-cell lung carcinoma cells.

S. Kane, D. Sadava, David Sadava, 2017, Biochemical and biophysical research communications.

Silibinin reverses drug resistance in human small-cell lung carcinoma cells.

S. Kane, D. Sadava, 2013, Cancer letters.

t‐Darpp is an elongated monomer that binds calcium and is phosphorylated by cyclin‐dependent kinases 1 and 5

Dianlu Jiang, Feimeng Zhou, S. Kane, 2017, FEBS open bio.

t-Darpp is an elongated monomer that binds to calcium and is phosphorylated by cyclin-dependent kinases 1 and 5

S. Kane, Xiaoying Wang, J. Momand, 2017, bioRxiv.

Overexpression of t-Darpp in cultured cells leads to increased protein kinase A activity and increased phosphorylation of AKT (protein kinase B). In HER2+ breast cancer cells t-Darpp

S. Kane, Xiaoying Wang, J. Momand, 2017 .

Effect of carbohydrate position on lysosomal transport of procathepsin L.

D. S. Joy, S. Kane, M. Sherman, 1998, Molecular biology of the cell.

Improvement of sensitivity to tamoxifen in estrogen receptor-positive and Herceptin-resistant breast cancer cells.

S. Kane, Shiuan Chen, Bin Chen, 2008, Journal of molecular endocrinology.

Abnormal Glycosylation of Procathepsin L Due to N-terminal Point Mutations Correlates with Failure to Sort to Lysosomes*

S. Kane, A. Erickson, Richard L. Chapman, 1997, The Journal of Biological Chemistry.

Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate.

S. Kane, G. Sonenshein, S. Eddy, 2007, Cancer research.

Trastuzumab-Resistant HER 2-Driven Breast Cancer Cells Are Sensitive to Epigallocatechin-3 Gallate

S. Kane, G. Sonenshein, S. Eddy, 2007 .

Evidence for a Role of the Exocyst in Insulin-stimulated Glut4 Trafficking in 3T3-L1 Adipocytes*

S. Kane, G. Gould, M. Clarke, 2005, Journal of Biological Chemistry.

Involvement of carboxy-terminal amino acids in secretion of human lysosomal protease cathepsin L.

M. Willingham, M. Gottesman, S. Kane, 1998, Biochemistry.

Construction and expression of retroviruses encoding dual drug resistance genes in human umbilical cord blood CD34+ cells

S. Kane, Jun Yang, Y. You, 2000 .

Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.

I. Pastan, M. Willingham, M. Gottesman, 1992, The Journal of biological chemistry.

Structure-function studies of the brain-type glucose transporter, GLUT3: alanine-scanning mutagenesis of putative transmembrane helix VIII and an investigation of the role of proline residues in transport catalysis.

S. Kane, M. Arbuckle, L. Porter, 1997, Biochemistry.

The effect of brassinolide, a plant steroid hormone, on drug resistant small-cell lung carcinoma cells.

S. Kane, D. Sadava, 2017, Biochemical and biophysical research communications.