D. Livingston

发表

Network modeling links breast cancer susceptibility and centrosome dysfunction.

K. Gunsalus, M. Vidal, K. Venkatesan, 2007, Nature genetics.

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

D. Sgroi, D. Haber, D. Livingston, 2001, Cell.

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

Ben S. Wittner, B. Wittner, J. Mesirov, 2009, Nature.

Lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells

Myles A Brown, D. Livingston, K. Jeang, 1987, Cell.

Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells

C. J. Collins, D. Livingston, J. Figge, 1988, Cell.

p300/MDM2 complexes participate in MDM2-mediated p53 degradation.

D. Livingston, S. Grossman, P. Howley, 1998, Molecular cell.

E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control.

J. Nevins, D. Livingston, S. Gaubatz, 2000, Molecular cell.

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

David M. Livingston, Charles J. Sherr, M. Ewen, 1993, Cell.

Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases.

M. Ewen, D. Livingston, Z. Xiao, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300

David Newsome, Miriam Fuchs, En Li, 1998, Cell.

Interaction between the retinoblastoma protein and the oncoprotein MDM2

W. Sellers, A. Levine, D. Livingston, 1995, Nature.

Anergy and tryptophan metabolism in Hodgkin's disease.

V. Devita, D. Livingston, V. Oliverio, 1971, The American journal of clinical nutrition.

Abnormalities of tryptophan metabolism and plasma pyridoxal phosphate in Hodgkin's disease.

V. Devita, D. Livingston, V. Oliverio, 1970, The New England journal of medicine.

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

Peggy J. Farnham, Wilhelm Krek, David M. Livingston, 1992, Cell.

The subcellular localization of E2F-4 is cell-cycle dependent.

D. Livingston, D. Ginsberg, S. Gaubatz, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing.

Shridar Ganesan, Klaus Rajewsky, Andrew L Kung, 2005, Genes & development.

X chromosomal abnormalities in basal-like human breast cancer.

Shridar Ganesan, Xin Lu, Myles Brown, 2006, Cancer cell.

An essential role for p300/CBP in the cellular response to hypoxia.

S. Bhattacharya, D. Livingston, L. Huang, 1996, Proceedings of the National Academy of Sciences of the United States of America.

A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting.

D. Livingston, R. Bronson, S. Gaubatz, 1998, Genes & development.

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

Ralph Scully, D. Livingston, Junjie Chen, 1997, Cell.

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Yonghong Xiao, Ralph Scully, Yonghong Xiao, 1997, Cell.

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit*

D. Livingston, L. Huang, H. Bunn, 1996, The Journal of Biological Chemistry.

Suppression of tumor growth through disruption of hypoxia-inducible transcription

Andrew L. Kung, David M. Livingston, J. Klco, 2000, Nature Medicine.

RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

Aedín C Culhane, Bing Xia, R. Greenberg, 2007, Science.

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

Wilhelm Krek, David M. Livingston, M. Ewen, 1994, Cell.

An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells.

Birgit Schoeberl, Andrew L. Kung, David M. Livingston, 2010, Cancer cell.

A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G0 Cells

David M. Livingston, D. Livingston, Y. Nakatani, 2002, Science.

Role of small t antigen in the acute transforming activity of SV40

D. Livingston, J. Figge, H. Rubin, 1982, Cell.

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage

D. Neuberg, K. Eggan, D. Livingston, 2016, Proceedings of the National Academy of Sciences.

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

M. Ewen, D. Livingston, S. van den Heuvel, 1993, Genes & development.

Association of p300 and CBP with simian virus 40 large T antigen

D. Livingston, J. Decaprio, J. Morgan, 1996, Molecular and cellular biology.

The disappearing Barr body in breast and ovarian cancers

J. Lawrence, D. Livingston, S. Ganesan, 2007, Nature Reviews Cancer.

Radioimmunoassay of mammalian type C viral proteins. I. Species specific reactions of murine and feline viruses.

E. Scolnick, D. Livingston, W. Parks, 1972, Journal of immunology.

Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members.

D. Livingston, W. Krek, S. Shirodkar, 1993, Science.

The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.

D. Livingston, J. Decaprio, J. Griffin, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

D. Livingston, D. Ginsberg, G. Vairo, 1995, Genes & development.

A recombinant murine retrovirus for simian virus 40 large T cDNA transforms mouse fibroblasts to anchorage-independent growth

Myles A Brown, D. Livingston, M. Farrell, 1986, Journal of virology.

The simian virus 40 large T antigen. A lot packed into a little.

D. Livingston, M. Bradley, 1987, Molecular biology & medicine.

Tumor Suppression by a Severely Truncated Species of Retinoblastoma Protein

T. Jacks, D. Livingston, R. Bronson, 2002, Molecular and Cellular Biology.

Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events

J. Massagué, D. Livingston, J. Decaprio, 1991, Molecular and cellular biology.

DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.

W. Foulkes, P. Broderick, R. Houlston, 2011, JAMA.

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

M. Ewen, D. Livingston, J. Decaprio, 1992, Cell.

BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation

A. Giobbie-Hurder, W. Kaelin, R. Gelman, 2018, Proceedings of the National Academy of Sciences.

p400 Is Required for E1A to Promote Apoptosis*

S. Lowe, D. Livingston, M. Narita, 2005, Journal of Biological Chemistry.

Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors.

D. Livingston, D. Krainc, L. Huang, 1997, Kidney international.

Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.

D. Livingston, J. Decaprio, A. Freedman, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

M. Ewen, J. Lawrence, D. Livingston, 1991, Cell.

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product

M. Ewen, W. Kaelin, D. Livingston, 1990, Molecular and cellular biology.

An N-Terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110 Rb and a second cellular protein, p120

M. Ewen, R. Millikan, E. Marsilio, 1989, Cell.

SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.

H. Heng, D. Livingston, T. Chiba, 2004, Genes & development.

Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation

D. Livingston, T. Yao, K. Taira, 1998, Nature.

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

S. Elledge, D. Livingston, R. Tibbetts, 2000, Genes & development.

Polyoma small T antigen triggers cell death via mitotic catastrophe

D. Livingston, T. Roberts, B. Schaffhausen, 2014, Oncogene.

The effect of DNA replication mutations on CAG tract stability in yeast.

D. Livingston, J. K. Schweitzer, 1999, Genetics.

Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit

R. DePinho, D. Livingston, K. Rudolph, 2001, Current Biology.

p300 Interacts with the Nuclear Proto-Oncoprotein SYT as Part of the Active Control of Cell Adhesion

D. Livingston, A. Kung, R. Scully, 2000, Cell.

Interactions of the Nijmegen breakage syndrome protein with ATM and BRCA1.

D. Livingston, William Arbuthnot Sir Lane, D. Weaver, 2000, Cold Spring Harbor symposia on quantitative biology.

Identification of BRCA1-IRIS, a BRCA1 locus product

W. ElShamy, D. Livingston, 2004, Nature Cell Biology.

E2F4 Is Exported from the Nucleus in a CRM1-Dependent Manner

D. Livingston, J. Lees, S. Gaubatz, 2001, Molecular and Cellular Biology.

Number : DAMD 17-021-0360 TITLE : Functional Study of the Human BRCA 2 Tumor Suppressor

D. Livingston, Ph. D. Bing Xia, 2022 .

Intracellular neutralization of SV40 tumor antigens following microinjection of specific antibody

D. Livingston, K. Antman, 1980, Cell.

Regulation of endogenous E2F1 stability by the retinoblastoma family proteins.

D. Livingston, F. Martelli, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Opening a Door to PARP Inhibitor-Induced Lethality in HR-Proficient Human Tumor Cells.

D. Livingston, Elodie Hatchi, 2020, Cancer cell.

Control of JunB and Extracellular Matrix Protein Expression by Transforming Growth Factor-1l Is Independent of Simian Virus 40 T Antigen-Sensitive Growth-Inhibitory Events

D. Livingston, J. Decaprio, M. Laiho, 2022 .

Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.

D. Livingston, S. Cantor, P. Jeffrey, 2002, Genes & development.

Phenotypic complementation of the SV40 tsA mutant defect in viral DNA synthesis following microinjection of SV40 T antigen

D. Livingston, J. Griffin, M. Kriegler, 1978, Cell.

Identification de composes qui modifient les reponses transcriptionnelles a l'hypoxie

S. Bhattacharya, D. Livingston, A. Kung, 2000 .

BRCA1 and RNAi factors promote small RNA- and PalB2/Rad52-mediated repair

John Quackenbush, Yaoyu E. Wang, D. Livingston, 2021 .

Molecular cloning of cDNA for human von willebrand factor: Authentication by a new method

C. J. Collins, Myles A Brown, D. Livingston, 1985, Cell.

Measurements of the molecular size of the simian virus 40 large T antigen

D. Livingston, J. Griffin, S. Light, 1978, Journal of virology.

Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation

D. Livingston, J. Walter, A. De Nicolo, 2010, Proceedings of the National Academy of Sciences.

The impact of lagging strand replication mutations on the stability of CAG repeat tracts in yeast.

D. Livingston, M. J. Ireland, S. S. Reinke, 2000, Genetics.

Deoxyribonucleic acid sequence organization of a yeast plasmid

D. Livingston, H. Klein, D. M. Livingston, 1977, Journal of bacteriology.

Relationship between RNA-directed DNA polymerase (reverse transcriptase) from human acute leukemic blood cells and primate type-C viruses.

D. Livingston, R. Gallo, G. Todaro, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Simian virus 40 small tumor antigen and an amino-terminal domain of large tumor antigen share a common transforming function.

R. Millikan, D. Livingston, X. Montano, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal

Andrew L. Kung, David M. Livingston, Elizabeth A. Tanner, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Relationship of oligomerization to enzymatic and DNA-binding properties of the SV40 large T antigen

D. Livingston, J. Griffin, M. Bradley, 1982, Cell.

Rapid and sensitive quantitative immunoassay for the large simian virus 40 T antigen

D. Livingston, M. Bradley, C. Mehta, 1981, Journal of virology.

Identification and initial characterization of a new low-molecular-weight virus-encoded T antigen in a line of simian virus 40-transformed cells

D. Livingston, J. Griffin, H. Rubin, 1980, Journal of virology.

Subunit composition of oligomeric human von Willebrand factor.

D. Livingston, D. Lynch, E. Kirby, 1983, The Journal of biological chemistry.

Trans-activation of RNA polymerase II and III promoters by SV40 small t antigen

M. Loeken, D. Livingston, J. Brady, 1988, Cell.

Immunoaffinity chromatography of proteins.

D. Livingston, 1974, Methods in enzymology.

Transrepression of RNA polymerase II promoters by the simian virus 40 small t antigen

E. Marsilio, D. Livingston, W. Wang, 1994, Journal of virology.

Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6

D. Livingston, S. Gaubatz, H. Elsässer, 2002, EMBO reports.

Identification of regions of the SV40 genome which contain preferred SV40 T antigen-binding sites

D. Tenen, D. Livingston, J. Hudson, 1976, Cell.

Twenty-fifth annual Pezcoller Symposium: Metabolism and tumorigenesis.

M. Loda, W. Kaelin, D. Livingston, 2013, Cancer research.

E2F-1 Degradation by the Ubiquitin-Proteasome Pathway

D. Livingston, F. Hofmann, 1997 .

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

J. Massagué, D. Livingston, J. Decaprio, 1990, Cell.

SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen

Myles A Brown, D. Livingston, X. Montano, 1987, Cell.

The t-unique coding domain is important to the transformation maintenance function of the simian virus 40 small t antigen

D. Livingston, E. Brown, H. Mamon, 1986, Molecular and cellular biology.

Protein kinase activity associated with simian virus 40 T antigen.

D. Livingston, J. Griffin, G. Spangler, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Microenvironment and Immunology Transcription Factor NFATc 2 Controls the Emergence of Colon Cancer Associated with IL-6 – Dependent Colitis

Anna L. Brown, M. You, B. Tromberg, 2012 .

Purification and functional properties of simian virus 40 large and small T antigens overproduced in insect cells

D. Livingston, H. Piwnica-Worms, M. Bradley, 1988, Journal of virology.

Purification and subunit structure of mouse liver cystathionase.

D. Livingston, I. Bikel, T. N. Pavlatos, 1978, Archives of biochemistry and biophysics.

Endogenous E2F-1 promotes timely G0 exit of resting mouse embryo fibroblasts.

D. Livingston, H. Yang, Z. Wang, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F

D. Livingston, J. Decaprio, T. Chittenden, 1993, Molecular and cellular biology.

Cystine requirement of continuous human lymphoid cell lines of normal and leukemic origin.

H. Lazarus, J. Iglehart, D. Livingston, 1977, The Journal of biological chemistry.

Endogenous type C virus from a cat cell clone with properties distinct from previously described feline type C virus.

D. Livingston, G. Todaro, 1973, Virology.

RADIOIMMUNOASSAY OF MAMMALIAN TYPE C VIRAL PROTEINS

E. Scolnick, D. Livingston, G. Todaro, 1973, The Journal of experimental medicine.

Interaction of partially purified simian virus 40 T antigen with circular viral DNA molecules.

D. Tenen, D. Livingston, J. Hudson, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).

W. Kaelin, D. Livingston, T. Chittenden, 1993, British Journal of Cancer.

Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.

S. Elledge, D. Livingston, Britt Adamson, 2012, Molecular cell.

Interaction of Simian Virus 40 chromatin with Simian Virus 40 T-antigen

D. Livingston, R. Martin, M. Persico-Dilauro, 1977, Journal of virology.

Biological and biochemical studies of cells transformed by simian virus 40 temperature-sensitive gene A mutants and A mutant revertants

D. Tenen, D. Livingston, R. Martin, 1977, Journal of virology.

Synthesis of simian virus 40 t antigen in Escherichia coli.

D. Livingston, M. Ptashne, T. Roberts, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Mapping of SV40 DNA replication origin region binding sites for the SV40 T antigen by protection against exonuclease III digestion

D. Livingston, D. Shalloway, T. Kleinberger, 1980, Cell.

Purification of biologically active simian virus 40 small tumor antigen.

D. Livingston, T. Roberts, M. T. Bladon, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Expression of abnormal von Willebrand factor by endothelial cells from a patient with type IIA von Willebrand disease.

D. Livingston, D. Lynch, J. Chediak, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Spectro-chemical probes for protein conformation and function.

D. Livingston, B. Vallee, J. Riordan, 1972, Cold Spring Harbor symposia on quantitative biology.

RNA-dependent DNA polymerase (reverse transcriptase) from avian myeloblastosis virus: a zinc metalloenzyme.

D. Livingston, B. Vallee, D. Auld, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

F. Kaye, W. Kaelin, D. Livingston, 1991, Cell.

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α

D. Livingston, G. Wagner, A. Kung, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Specific enzymatic dephosphorylation of the retinoblastoma protein

D. Livingston, J. Decaprio, J. Ludlow, 1993, Molecular and cellular biology.

Identification of infectious virions which are vesicular stomatitis virus pseudotypes of murine type C virus.

D. Livingston, C. Spence, T. Howard, 1976, Virology.

Studies on the type C viral replication defect in MSV-transformed rat nonproducer variant clones.

D. Livingston, L. Desai, 1974, Virology.

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

Wen-Hwa Lee, David M. Livingston, Chun-Ming Huang, 1988, Cell.

SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter.

Jennifer A. Smith, D. Livingston, J. Decaprio, 2014, Virology.

Relationship between T-antigen and tumor-specific transplantation antigen in simian virus 40-transformed cells

D. Livingston, P. Mora, C. Chang, 1979, Journal of virology.

Nuclear preparations of SV40-transformed cells contain tumor-specific transplantation antigen activity.

D. Livingston, P. Mora, R. Martin, 1977, Virology.

Partial purification and characterization of the SV40 T antigen.

D. Livingston, I. Henderson, 1974, Cell.

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

M. Greenberg, S. Orkin, W. Kaelin, 1996, Cell.

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

M. Ewen, D. Livingston, H. K. Sluss, 1993, Cell.

PROTEINS III. DETECTION OF VIRAL ANTIGEN IN NORMAL MURINE CELLS AND TISSUES

E. Scolnick, D. Livingston, G. Todaro, 1973 .

Characterization of a new murine cellular DNA polymerase.

D. Livingston, J. Hudson, G. Todaro, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Infectious C-type virus isolated from a baboon placenta

D. Livingston, C. Sherr, G. Todaro, 1974, Nature.

Characterization of a unique cell line (LAZ 221) from human acute lymphocytic ("null" cell) leukemia.

H. Lazarus, D. Livingston, L. Chess, 1978, Cancer research.

Mechanisms of BRCA1 tumor suppression.

D. Livingston, D. Silver, 2012, Cancer discovery.

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

J B Lawrence, M. Ewen, J. Lawrence, 1994, Genes & development.

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

D. Livingston, D. Newsome, R. Eckner, 1995, Nature.

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

David M. Livingston, Chun-Ming Huang, John W. Ludlow, 1989, Cell.

T antigen repression of SV40 early transcription from two promoters

P. Sharp, D. Tenen, D. Livingston, 1981, Cell.

Localization of the simian virus 40 small t antigen in the nucleus and cytoplasm of monkey and mouse cells

D. Livingston, J. Figge, T. Roberts, 1984, Journal of virology.

p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen

D. Livingston, M. J. Tevethia, R. Eckner, 1997, Journal of virology.

Identification of a growth suppression domain within the retinoblastoma gene product.

W. Kaelin, D. Livingston, T. Chittenden, 1992, Genes & development.

The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence

E. Marsilio, D. Livingston, B. Schaffhausen, 1991, Journal of virology.

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

S. Ficarro, D. Livingston, Fieda Abderazzaq, 2021, Nature Communications.

X chromosome inactivation in the absence of Dicer

K. Plath, D. Livingston, S. Muljo, 2009, Proceedings of the National Academy of Sciences.

Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300

D. Livingston, S. Grossman, A. Kung, 2003, Science.

Complicated Supercomplexes

D. Livingston, 2009, Science.

Analysis of PALB2/FANCN-associated breast cancer families

Petra M. Nederlof, Jorge S. Reis-Filho, David M. Livingston, 2007, Proceedings of the National Academy of Sciences.

A recurrent mutation in PALB2 in Finnish cancer families

Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, 2007, Nature.

Fanconi anemia is associated with a defect in the BRCA2 partner PALB2

Hans Joenje, Bing Xia, Weidong Wang, 2007, Nature Genetics.

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

F. Couch, D. Livingston, Qing Sheng, 2006, Molecular cell.

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.

R. Greenberg, B. Sobhian, D. Livingston, 2006, Genes & development.

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.

F. Couch, B. Weber, A. Gazdar, 1998, Molecular cell.

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

D. Livingston, R. Bronson, A. Culhane, 2013, Proceedings of the National Academy of Sciences.

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci.

B. Sobhian, D. Livingston, R. Scully, 2011, Genes & development.

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.

D. Livingston, S. Cantor, R. Drapkin, 2004, Proceedings of the National Academy of Sciences of the United States of America.

BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model

Z. Szallasi, A. Giobbie-Hurder, A. Bass, 2021, Proceedings of the National Academy of Sciences.

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP.

D. Livingston, R. Bronson, A. Kung, 2000, Genes & development.

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

D. Livingston, R. Scully, T. Yao, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Phosphorylation of the adenovirus E1A‐associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells.

D. Livingston, R. Eckner, I. Kitabayashi, 1995, The EMBO journal.

BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair.

D. Livingston, David M Livingston, Peter J O'Donovan, 2010, Carcinogenesis.

In search of the tumour-suppressor functions of BRCA1 and BRCA2

D. Livingston, R. Scully, 2000, Nature.

BRCA1 haploinsufficiency for replication stress suppression in primary cells

A. Richardson, K. Polyak, D. Livingston, 2014, Nature Communications.

PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.

Elgene Lim, Scott B Ficarro, Jarrod A Marto, 2014, Cancer discovery.

BRCA 1 / BARD 1-containing complexes Multifactorial contributions to an acute DNA damage response

R. Greenberg, B. Sobhian, D. Livingston, 2005 .

Association of BRCA1 with the inactive X chromosome and XIST RNA.

R. Greenberg, D. Livingston, S. Ganesan, 2004, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Novel consensus DNA‐binding sequence for BRCA1 protein complexes

P. Futreal, D. Livingston, Leping Li, 2003, Molecular carcinogenesis.

BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome

C. Deng, R. Greenberg, D. Livingston, 2002, Cell.

Genetic analysis of BRCA1 function in a defined tumor cell line.

D. Livingston, S. Ganesan, M. Socolovsky, 1999, Molecular cell.

p19ARF targets certain E2F species for degradation

David M. Livingston, Fabio Martelli, Ronald A. DePinho, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Binding and modulation of p53 by p300/CBP coactivators

D. Livingston, J. Decaprio, S. Grossman, 1997, Nature.

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

W. Kaelin, D. Livingston, P. Adams, 1994, Proceedings of the National Academy of Sciences of the United States of America.

BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.

A. Giobbie-Hurder, K. Polyak, R. Gelman, 2016, Molecular cell.

BRCA1 is required for postreplication repair after UV-induced DNA damage.

D. Livingston, G. Adelmant, J. Marto, 2011, Molecular cell.

The BRCA1/BARD1 Heterodimer Modulates Ran-Dependent Mitotic Spindle Assembly

David M. Livingston, Johannes C. Walter, D. Livingston, 2006, Cell.

The BRCA1 isoform, BRCA1-IRIS, operates independently of the full-length BRCA1 in the Fanconi anemia pathway

D. Livingston, S. Cantor, J. Brugge, 2022, bioRxiv.

Small DNA tumor viruses: large contributors to biomedical sciences.

D. Livingston, P. Howley, 2009, Virology.

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.

D. Livingston, H. Naegeli, A. Kung, 2004, Cancer cell.

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

Joshua E. Elias, John Quackenbush, S. Gygi, 2011, Nature.

TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest.

M. Ewen, D. Livingston, H. K. Sluss, 1993, Cell.

p21 transcription is regulated by differential localization of histone H2A.Z.

D. Livingston, N. Gevry, H. Chan, 2007, Genes & development.

The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway.

S. Lowe, D. Livingston, M. Narita, 2005, Genes & development.

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

B. Karlan, D. Livingston, Junjie Chen, 1999, Nature Genetics.

Aberrant T cell differentiation in the absence of Dicer

K. Rajewsky, D. Livingston, A. Rao, 2005, The Journal of experimental medicine.

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

F. Alt, Heikyung Suh, D. Livingston, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Toward mechanism-based cancer care.

D. Livingston, R. Shivdasani, 2001, Journal of the American Medical Association (JAMA).

Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

D. Livingston, E. Fox, Jing Chen, 2001, Proceedings of the National Academy of Sciences of the United States of America.

BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway.

D. Livingston, S. Cantor, Jing Chen, 1999, Cancer research.

Location of BRCA1 in Human Breast and Ovarian Cancer Cells

C. Osborne, S. Schnitt, D. Livingston, 1996, Science.

E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators

W. Sellers, D. Livingston, R. Eckner, 1994, Cell.

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1.

S. Bhattacharya, D. Livingston, A. Kung, 1999, Genes & development.

BRCA1 Pathway Function in Basal-Like Breast Cancer Cells

D. Livingston, D. Silver, S. Hill, 2014, Molecular and Cellular Biology.

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

Manolis Kellis, G. Parmigiani, D. Livingston, 2015, Molecular cell.

Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1.

S. Bhattacharya, D. Livingston, T. Jones, 1999, Genomics.

Interaction between human cyclin A and adenovirus E1A-associated p107 protein.

M. Ewen, L. Tsai, D. Livingston, 1992, Science.

Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins.

M. Ewen, D. Livingston, B. Faha, 1992, Science.

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

W. Kaelin, D. Livingston, T. Chittenden, 1991, Cell.

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

D. Livingston, William Arbuthnot Sir Lane, D. Weaver, 2000, Nature.

p 21 senescence pathway → The p 400 E 1 A-associated protein is a novel component of the p 53 Material Supplemental

S. Lowe, D. Livingston, M. Narita, 2004 .

The p400 Complex Is an Essential E1A Transformation Target

Jill D. Gerber, D. Livingston, William Arbuthnot Sir Lane, 2001, Cell.

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

D. Livingston, W. Krek, Gangfeng Xu, 1995, Cell.

Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6.

D. Livingston, S. Gaubatz, Jason G. Wood, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Multiple members of the E2F transcription factor family are the products of oncogenes.

D. Livingston, W. Krek, Gangfeng Xu, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity.

D. Livingston, D. Silver, 2001, Molecular cell.

PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length.

W. Hahn, D. Livingston, L. Litovchick, 2014, Molecular cell.

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

Chun-Ming Huang, D. Livingston, J. Decaprio, 1989, Cell.

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

D. Livingston, J. Decaprio, J. Pipas, 1990, Cell.

Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturation.

D. Livingston, J. K. Schweitzer, D. M. Livingston, 1998, Human molecular genetics.

Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection

Andrew L. Kung, David M. Livingston, Nezih Cereb, 2001, Science.

Cellular proteins which can specifically associate with simian virus 40 small t antigen

D. Livingston, I. Bikel, C. I. Murphy, 1986, Journal of virology.

Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation.

D. Livingston, T. Yao, R. Eckner, 1996, Genes & development.

Two different E2F6 proteins generated by alternative splicing and internal translation initiation.

Tillman Dahme, D. Livingston, S. Gaubatz, 2002, European journal of biochemistry.

Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics

G. Mills, C. Paweletz, V. Velculescu, 2016, Clinical Cancer Research.

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α

S. Bhattacharya, D. Livingston, S. Grossman, 1996, Nature.

Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.

L. Tsai, D. Livingston, C. Missero, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Mammalian Cells in Culture Frequently Release Type C Viruses

D. Livingston, G. Todaro, M. Lieber, 1973, Science.

Infectious type C viruses released by normal cat embryo cells.

D. Livingston, G. Todaro, M. Lieber, 1973, Virology.

The adenovirus E1A-associated 300-kD protein exhibits properties of a transcriptional coactivator and belongs to an evolutionarily conserved family.

M. Ewen, W. Sellers, D. Livingston, 1994, Cold Spring Harbor symposia on quantitative biology.

BRCA1 is a component of the RNA polymerase II holoenzyme.

R. Young, D. Livingston, J. Parvin, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage.

W. ElShamy, D. Livingston, S. Ganesan, 2003, Molecular cell.

RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci

D. Livingston, Zhe Li, G. Micevic, 2020, Proceedings of the National Academy of Sciences.

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.

D. Livingston, F. Hofmann, F. Martelli, 1996, Genes & development.

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

J. Lawrence, D. Livingston, J. Decaprio, 1994, Genes & development.

Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle

D. Livingston, C. Kanellopoulou, S. Pathania, 2013, Genes & development.

MYC recruits the TIP60 histone acetyltransferase complex to chromatin

D. Livingston, B. Amati, T. Parisi, 2003, EMBO reports.

Further Evidence for BRCA1 Communication with the Inactive X Chromosome

R. Gelman, D. Livingston, J. Mar, 2007, Cell.

Abnormalities of the inactive X chromosome are a common feature of BRCA1 mutant and sporadic basal-like breast cancer.

A. Richardson, D. Livingston, S. Ganesan, 2005, Cold Spring Harbor symposia on quantitative biology.

Mechanisms of BRCA 1 Tumor Suppression

D. Livingston, D. Silver, 2012 .

Affinity chromatography of avian type C viral reverse transcriptase: studies with Rous sarcoma virus transformed rat cells.

E. Scolnick, D. Livingston, W. Parks, 1972, Virology.

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

J. Joung, M. Vidal, S. Gaudet, 2014, Genes & development.

Meiotic alterations in CAG repeat tracts.

D. Livingston, J. K. Schweitzer, S. S. Reinke, 2001, Genetics.

Destabilization of CAG trinucleotide repeat tracts by mismatch repair mutations in yeast.

D. Livingston, J. K. Schweitzer, 1997, Human molecular genetics.

Orientation dependence of trinucleotide CAG repeat instability in Saccharomyces cerevisiae

D. Livingston, B. O'Callaghan, D. J. Maurer, 1996, Molecular and cellular biology.

Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.

D. Livingston, F. Hofmann, 1996, Genes & development.

BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2–RAD52

John Quackenbush, Yaoyu E. Wang, D. Livingston, 2021, Nature.

BRCA 1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

Manolis Kellis, G. Parmigiani, D. Livingston, 2022 .

Sound credit scores and financial decisions despite cognitive aging

Rameen Beroukhim, William C Hahn, Pratiti Bandopadhayay, 2014, Proceedings of the National Academy of Sciences.

Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300.

E. Moran, D. Livingston, Y. Shi, 1995, Genes & development.

Cysteine auxotrophy of human leukemic lymphoblasts is associated with decreased amounts of intracellular cystathionase messenger ribonucleic acid.

D. Livingston, M. Kriegler, A. Pawlowski, 1981, Biochemistry.

E2F-Dependent Histone Acetylation and Recruitment of the Tip60 Acetyltransferase Complex to Chromatin in Late G1

David M. Livingston, Bruno Amati, Miriam Fuchs, 2004, Molecular and Cellular Biology.

Independence of R/M/N Focus Formation and the Presence of Intact BRCA1

D. Livingston, Junjie Chen, D. Weaver, 2000, Science.

Chemically facilitated microinjection of proteins into intact monolayers of tissue culture cells

D. Livingston, M. Kriegler, 1977, Somatic cell genetics.

EMSY, a BRCA-2 partner in crime

D. Livingston, 2004, Nature Medicine.

Deoxyribonucleic acid polymerase III of Escherichia coli. Characterization of associated exonuclease activities.

D. Livingston, C. Richardson, 1975, The Journal of biological chemistry.

Proteomic identification of a direct role for cyclin d1 in DNA damage repair.

D. Livingston, P. Sicinski, S. Jirawatnotai, 2012, Cancer research.

Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.

S. Armstrong, D. Livingston, M. Lecocke, 2011, Blood.

Proteomic Identi fi cation of a Direct Role for Cyclin D 1 in DNA Damage Repair

D. Livingston, P. Sicinski, S. Jirawatnotai, 2012 .

Papillomavirus E7 Oncoproteins Share Functions with Polyomavirus Small T Antigens

W. Hahn, D. Livingston, T. Roberts, 2014, Journal of Virology.

Consensus topography in the ATP binding site of the simian virus 40 and polyomavirus large tumor antigens.

R H Lathrop, R. Lathrop, T. Smith, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Purification of simian virus 40 tumor antigen from a line of simian virus 40-transformed human cells.

D. Tenen, D. Livingston, J. Hudson, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Penetrance Analysis of the PALB2 c.1592delT Founder Mutation

J. Hopper, M. Southey, A. Mannermaa, 2008, Clinical Cancer Research.

PenetranceAnalysis of the PALB 2 c . 1592 delT Founder Mutation

M. Southey, V. Kosma, V. Kataja, 2008 .

Chemical modification of carboxypeptidase A crystals. Azo coupling with tyrosine-248.

D. Livingston, B. Vallee, J. T. Johansen, 1972, Biochemistry.

Conformational and activity changes on subtilisin cleavage of carboxypeptidase A.

D. Livingston, J. Riordan, 1971, Biochemical and biophysical research communications.

Book ReviewCancer: A comprehensive treatise. Vol. 2. Etiology: Viral carcinogenesis:

D. Livingston, 1976 .

Independence of R/M/N focus formation and the presence of intact BRCA1.

D. Livingston, D. Weaver, J. Petrini, 2000, Science.

The transcription factor E2F-1 is a downstream target of RB action

M. Ewen, W. Sellers, W. Kaelin, 1995, Molecular and cellular biology.

Cloning, sequencing, and expression of the Pseudomonas putida protocatechuate 3,4-dioxygenase genes

D. Livingston, J. Lipscomb, D. Laporte, 1993, Journal of bacteriology.

DNA Polymerases of Escherichia coli

J. W. Chase, H. Shizuya, D. Livingston, 1973 .

Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer

H. Clevers, D. Livingston, Norman Sachs, 2019, Cell.

RB associates with an E2F-like, sequence-specific DNA-binding protein.

W. Kaelin, D. Livingston, T. Chittenden, 1991, Cold Spring Harbor symposia on quantitative biology.

Specific in vitro adenylylation of the simian virus 40 large tumor antigen.

D. Livingston, J. Hudson, M. Bradley, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Zinc reverse transcriptases from mammalian RNA type C viruses.

D. Livingston, B. Vallee, D. Auld, 1975, Biochemical and biophysical research communications.

Reverse transcriptase from avian myeloblastosis virus: a zinc metalloenzyme.

D. Livingston, B. Vallee, D. Auld, 1974, Biochemical and biophysical research communications.

Twenty-fourth annual Pezcoller symposium: Molecular basis for resistance to targeted agents.

W. Sellers, D. Livingston, R. Marais, 2013, Cancer research.

A Family of High Molecular Weight Proteins Active in Differentiation and Growth Control

D. Livingston, R. Eckner, Z. Arany, 1995 .

Deoxyribonucleic acid polymerase III of Escherichia coli. Purification and properties.

D. Livingston, C. Richardson, D. Hinkle, 1975, The Journal of biological chemistry.

An Activated ErbB 3 / NRG 1 Autocrine Loop Supports In Vivo Proliferation in Ovarian Cancer Cells

W. Hahn, M. Meyerson, H. Greulich, 2022 .

Localization of human CREB-binding protein gene (CREBBP) to 16p13.2-p13.3 by fluorescence in situ hybridization.

J. Lawrence, S. Bhattacharya, D. Livingston, 1995, Genomics.

MOLECULAR CLONING OF THE HUMAN GENE FOR VON WILLEBRAND FACTOR AND IDENTIFICATION OF THE TRANSCRIPTION INITIATION SITE

D. Livingston, D. Lynch, C. Ravera, 1987, Thrombosis and Haemostasis.

Cysteine auxotrophy of human leukemic lymphoblasts is associated with decreased amounts of intracellular cystathionase protein.

D. Livingston, M. Kriegler, L. Glodé, 1981, Biochemistry.

Binding of simian virus 40 large T antigen from virus-infected monkey cells to wild-type and mutant viral replication origins.

D. Tenen, D. Livingston, M. Bradley, 1983, Journal of molecular biology.

Binding of an analog of the simian virus 40 T antigen to wild-type and mutant viral replication origins.

D. Tenen, D. Livingston, L. Haines, 1982, Journal of molecular biology.

Superinduction of Endogenous Type C Virus by 5-Bromodeoxyuridine from Transformed Mouse Clones

D. Livingston, G. Todaro, M. Lieber, 1973, Science.

Effect of a stem-loop structure within the SV40 replication origin upon SV40 T antigen binding to origin region sequences

D. Tenen, D. Livingston, Shaw-Shyan Wang, 1983, Cell.

Isolation of a specialized transducing bacteriophage lambda carrying the polC locus of Escherichia coli.

H. Shizuya, D. Livingston, C. Richardson, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Biosynthesis of the subunits of factor VIIIR by bovine aortic endothelial cells.

D. Livingston, D. Lynch, E. Kirby, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Cyclin A-Kinase Binding to and Regulation of the Function of a Growth-Promoting Transcription Factor

D. Livingston, W. Krek, Gangfeng Xu, 1996 .

Thermolabile T (tumor) antigen from cells transformed by a temperature-sensitive mutant of simian virus 40.

D. Tenen, D. Livingston, P. Baygell, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Accumulation of cystine auxotrophic thymocytes accompanying type C viral leukemogenesis in the mouse

H. Lazarus, D. Livingston, C. Ferguson, 1976, Cell.

Cancer: Crossing over to drug resistance

David M. Livingston, D. Livingston, D. Silver, 2008, Nature.

Cancer: Chromosome defects in the colon

D. Livingston, 2001, Nature.

A simple enzymic assay for pyridoxal phosphate.

D. Livingston, B. Chabner, B. Chabner, 1970, Analytical biochemistry.

Acute Lymphocytic ( ' ' Null ' ' Cell ) Leukemia Characterization of a Unique Cell Line ( LAZ 221 ) from Human Updated

H. Lazarus, D. Livingston, L. Chess, 2006 .

Septic complications in the trauma patient

D. Livingston, E. Deitch, C. Hauser, 1999 .

Enzymatic activities associated with the SV40 large T antigen.

D. Livingston, J. Griffin, G. Spangler, 1980, Cold Spring Harbor symposia on quantitative biology.

Immunologic analyses of mouse cystathionase in normal and leukemic cells.

D. Livingston, I. Bikel, J. Uren, 1978, Biochemistry.

Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics

G. Mills, C. Paweletz, V. Velculescu, 2016, Clinical Cancer Research.

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

D. Livingston, R. Bronson, A. Culhane, 2013, Proceedings of the National Academy of Sciences.

Aberrant T cell differentiation in the absence of Dicer

K. Rajewsky, D. Livingston, A. Rao, 2005, The Journal of experimental medicine.

Affinity chromatography of RNA-dependent DNA polymerase from RNA tumor viruses on a solid phase immunoadsorbent.

E. Scolnick, D. Livingston, W. Parks, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Mechanisms that could increase cancer vulnerability in COVID-19 mRNA vaccine recipients

D. Livingston, 2022 .