V. Hilser

发表

Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensemble.

J. Lee, H. Pan, V. Hilser, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Ensemble allosteric model: energetic frustration within the intrinsically disordered glucocorticoid receptor

V. Hilser, J. Wrabl, Jordan T White, 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

The ensemble nature of allostery

V. Hilser, J. Wrabl, Jing Li, 2014, Nature.

Structural and energetic basis of allostery.

James O. Wrabl, V. Hilser, J. Wrabl, 2012, Annual review of biophysics.

The role of protein conformational fluctuations in allostery, function, and evolution.

James O. Wrabl, V. Hilser, J. Wrabl, 2011, Biophysical chemistry.

Local conformational fluctuations can modulate the coupling between proton binding and global structural transitions in proteins.

Vincent J Hilser, V. Hilser, S. Whitten, 2005, Proceedings of the National Academy of Sciences of the United States of America.

An Ensemble View of Allostery

Vincent J Hilser, V. Hilser, 2010, Science.

Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors.

V. Hilser, E. Freire, E. Freire, 1996, Journal of molecular biology.

The magnitude of the backbone conformational entropy change in protein folding

V. Hilser, L. Amzel, E. Freire, 1996, Proteins.

Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins

V. Hilser, E. Thompson, E. Thompson, 2007, Proceedings of the National Academy of Sciences.

A statistical thermodynamic model of the protein ensemble.

T. Oas, V. Hilser, S. Whitten, 2006, Chemical reviews.

Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins

V. Hilser, T. Schrank, D. W. Bolen, 2009, Proceedings of the National Academy of Sciences.

Functional residues serve a dominant role in mediating the cooperativity of the protein ensemble

V. Hilser, Tong Liu, S. Whitten, 2007, Proceedings of the National Academy of Sciences.

Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

Jing Li, Kaixian Liu, Vincent J Hilser, 2017, eLife.

The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble.

T. Oas, V. Hilser, E. Freire, 1998, Proceedings of the National Academy of Sciences of the United States of America.

A General Horizontal Alignment Tool for Shape Comparison of Diverse One-Dimensional Protein Data

James O. Wrabl, V. Hilser, J. Wrabl, 2013 .

Characterizing the role of ensemble modulation in mutation-induced changes in binding affinity.

J. Ferreon, V. Hilser, S. Whitten, 2009, Journal of the American Chemical Society.

Predicting the energetics of conformational fluctuations in proteins from sequence: a strategy for profiling the proteome.

V. Hilser, Jenny Gu, J. Gu, 2008, Structure.

Sequence-based analysis of protein energy landscapes reveals nonuniform thermal adaptation within the proteome.

V. Hilser, Jenny Gu, J. Gu, 2009, Molecular biology and evolution.

Hidden dynamic signatures drive substrate selectivity in the disordered phosphoproteome

V. Hilser, J. Wrabl, Min-Hyung Cho, 2020, Proceedings of the National Academy of Sciences.

Hidden dynamic signatures drive substrate selectivity in the disordered phosphoproteome

V. Hilser, J. Wrabl, Min-Hyung Cho, 2019, Proceedings of the National Academy of Sciences.

Thermodynamic Dissection of the Intrinsically Disordered N-terminal Domain of Human Glucocorticoid Receptor*

V. Hilser, Jing Li, H. Motlagh, 2012, The Journal of Biological Chemistry.

Intrinsically Disordered Protein: A Thermodynamic Perspective

V. Hilser, J. Wrabl, Jing Li, 2015 .

Energetic profiling of protein folds.

James O. Wrabl, V. Hilser, J. Wrabl, 2009, Methods in enzymology.

Evolutionary conservation of the polyproline II conformation surrounding intrinsically disordered phosphorylation sites

V. Hilser, T. Schrank, W. Austin Elam, 2013, Protein science : a publication of the Protein Society.

Structural biology: Finding the wet spots

V. Hilser, 2011, Nature.

A Statistical Thermodynamic Model of the Protein Ensemble

T. Oas, V. Hilser, S. Whitten, 2006 .

Quantitative analysis of conformational equilibrium using capillary electrophoresis: applications to protein folding.

V. Hilser, E. Freire, 1995, Analytical biochemistry.

A Thermodynamic Atlas of Proteomes Reveals Energetic Innovation across the Tree of Life

James O. Wrabl, V. Hilser, J. Wrabl, 2022, Molecular biology and evolution.

THE SIGNIFICANCE AND IMPACTS OF PROTEIN DISORDER AND CONFORMATIONAL VARIANTS

V. Hilser, Jenny Gu, J. Gu, 2008 .

Correction: Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

V. Hilser, J. Wrabl, T. Schroer, 2018, eLife.

Simplified Novel Protein Design Using Thermodynamic Environments

James O. Wrabl, V. Hilser, J. Wrabl, 2016 .

Allosteric Regulation and Intrinsic Disorder in Nuclear Hormone Receptors

V. Hilser, Jordan T White, Jing Li, 2015 .

Using biochemistry and biophysics to extinguish androgen receptor signaling in prostate cancer

I. Asangani, V. Hilser, S. Plymate, 2020, The Journal of biological chemistry.

Conformational heterogeneity within the LID domain mediates substrate binding to Escherichia coli adenylate kinase: function follows fluctuations.

James O. Wrabl, V. Hilser, J. Wrabl, 2013, Topics in current chemistry.

Experimental and Computational Studies of Polyproline II Propensity

V. Hilser, T. Schrank, W. A. Elam, 2012 .

Strategies for the thermodynamic characterization of linked binding/local folding reactions within the native state application to the LID domain of adenylate kinase from Escherichia coli.

V. Hilser, Jing Li, T. Schrank, 2011, Methods in enzymology.

Disordered allostery: lessons from glucocorticoid receptor

V. Hilser, Jing Li, H. Motlagh, 2015, Biophysical Reviews.

Exploring the impact of polyproline II (PII) conformational bias on the binding of peptides to the SEM‐5 SH3 domain

V. Hilser, S. Whitten, R. Fox, 2008, Protein science : a publication of the Protein Society.

Effect of Diffusion on Resonance Energy Transfer Rate Distributions: Implications for Distance Measurements.

V. Hilser, D. Toptygin, Alexander F. Chin, 2015, The journal of physical chemistry. B.

The origin of pH-dependent changes in m-values for the denaturant-induced unfolding of proteins.

V. Hilser, S. Whitten, B. García-Moreno E., 2001, Journal of molecular biology.

The heat capacity of proteins

V. Hilser, D. Xie, E. Freire, 1995, Proteins.

Allostery in Its Many Disguises: From Theory to Applications.

Ruth Nussinov, Ivet Bahar, Dima Kozakov, 2019, Structure.

A Horizontal Alignment Tool for Numerical Trend Discovery in Sequence Data: Application to Protein Hydropathy

James O. Wrabl, Vincent J. Hilser, Omar Hadzipasic, 2013, PLoS Comput. Biol..

Molecular mechanisms of pH‐driven conformational transitions of proteins: Insights from continuum electrostatics calculations of acid unfolding

V. Hilser, S. Whitten, B. García-Moreno E., 2006, Proteins.

Ribosome A and P sites revealed by length analysis of ribosome profiling data

James Taylor, Vincent J. Hilser, James Taylor, 2015, Nucleic acids research.

Denatured-state energy landscapes of a protein structural database reveal the energetic determinants of a framework model for folding.

V. Hilser, Jenny Gu, S. Whitten, 2008, Journal of molecular biology.

Coupled motion in proteins revealed by pressure perturbation.

Vincent J Hilser, Yinan Fu, A Joshua Wand, 2012, Journal of the American Chemical Society.

The COREX/BEST Algorithm

V. Hilser, 2005 .

Ligand‐induced changes in dynamics in the RT loop of the C‐terminal SH3 domain of Sem‐5 indicate cooperative conformational coupling

J. Ferreon, V. Hilser, 2003, Protein science : a publication of the Protein Society.

conformational coupling C-terminal SH 3 domain of Sem-5 indicate cooperative Ligand-induced changes in dynamics in the RT loop of the

J. Ferreon, V. Hilser, 2002 .

The equilibrium ensemble of conformational states in staphylococcal nuclease

V. Hilser, E. Freire, 1997 .

Single-Molecule Chemo-Mechanical Spectroscopy Provides Structural Identity of Folding Intermediates.

V. Hilser, H. Motlagh, D. Toptygin, 2016, Biophysical journal.

Dynamic allostery can drive cold adaptation in enzymes

V. Hilser, J. Wrabl, Jing Li, 2018, Nature.

Investigating Homology between Proteins using Energetic Profiles

James O. Wrabl, Vincent J. Hilser, V. Hilser, 2010, PLoS Comput. Biol..

Using the COREX/BEST server to model the native-state ensemble.

V. Hilser, S. Whitten, 2014, Methods in molecular biology.

An energetic representation of protein architecture that is independent of primary and secondary structure.

James O. Wrabl, V. Hilser, J. Wrabl, 2009, Biophysical journal.

Ensemble‐based signatures of energy propagation in proteins: A new view of an old phenomenon

V. Hilser, Tong Liu, S. Whitten, 2005, Proteins.

Structural Dynamics, Intrinsic Disorder, and Allostery in Nuclear Receptors as Transcription Factors*

V. Hilser, E. Thompson, E. Thompson, 2011, The Journal of Biological Chemistry.

The role of negative selection in protein evolution revealed through the energetics of the native state ensemble

James O. Wrabl, Jordan Hoffmann, V. Hilser, 2016, Proteins.

The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions.

N. Oezguen, J. Tainer, V. Hilser, 2013, Journal of molecular biology.

Solution structure, dynamics, and thermodynamics of the native state ensemble of the Sem-5 C-terminal SH3 domain.

D. Volk, D. Gorenstein, J. Ferreon, 2003, Biochemistry.

Exploring allosteric coupling in the α-subunit of Heterotrimeric G proteins using evolutionary and ensemble-based approaches

Vincent J Hilser, V. Hilser, Tong Liu, 2008, BMC Structural Biology.

Conserved allosteric ensembles in a disordered protein using TROSY/Anti-TROSY R2-filtered spectroscopy.

James O. Wrabl, V. Hilser, J. Wrabl, 2021, Biophysical journal.

Design of protein switches based on an ensemble model of allostery

V. Hilser, M. Ostermeier, Jay H. Choi, 2015, Nature Communications.

Temperature and urea have opposing impacts on polyproline II conformational bias.

V. Hilser, T. Schrank, W. A. Elam, 2013, Biochemistry.

Direct access to the cooperative substructure of proteins and the protein ensemble via cold denaturation

A. Wand, V. Hilser, C. R. Babu, 2004, Nature Structural &Molecular Biology.

Phylogenetic convergence of phase separation and mitotic function in the disordered protein BuGZ

V. Hilser, Yixian Zheng, Alexander F. Chin, 2022, Protein science : a publication of the Protein Society.

The variable domain from the mitochondrial fission mechanoenzyme Drp1 promotes liquid-liquid phase separation

Nolan W. Kennedy, V. Hilser, J. Harden, 2020, bioRxiv.

Interplay between allostery and intrinsic disorder in an ensemble.

V. Hilser, Jing Li, H. Motlagh, 2012, Biochemical Society transactions.

The enthalpy change in protein folding and binding: Refinement of parameters for structure‐based calculations

V. Hilser, E. Freire, J. Gómez, 1996, Proteins.

What's in an Average? An Ensemble View of Phosphorylation Effects.

V. Hilser, Alexander F. Chin, 2017, Structure.

Ligand effects on the protein ensemble: unifying the descriptions of ligand binding, local conformational fluctuations, and protein stability.

V. Hilser, S. Whitten, B. García-Moreno, 2008, Methods in cell biology.

Structure-based statistical thermodynamic analysis of T4 lysozyme mutants: structural mapping of cooperative interactions.

V. Hilser, E. Freire, E. Freire, 1997, Biophysical chemistry.

Modeling the native state ensemble.

V. Hilser, 2001, Methods in molecular biology.

Agonism/antagonism switching in allosteric ensembles

V. Hilser, H. Motlagh, 2012, Proceedings of the National Academy of Sciences.

Assessing Allostery in Intrinsically Disordered Proteins With Ensemble Allosteric Model.

V. Hilser, Jing Li, 2018, Methods in enzymology.

Tumor susceptibility gene-101 regulates glucocorticoid receptor through disorder-mediated allostery

James O. Wrabl, V. Hilser, J. Wrabl, 2020, bioRxiv.

Structural Stability of the Coiled-Coil Domain of Tumor Susceptibility Gene (TSG)-101

V. Hilser, Jordan T White, D. Toptygin, 2017, Biochemistry.

Quantitative Assessment of Protein Structural Models by Comparison of H/D Exchange MS Data with Exchange Behavior Accurately Predicted by DXCOREX

Virgil L. Woods, V. Hilser, Sheng Li, 2011, Journal of The American Society for Mass Spectrometry.

Revealing the nature of the native state ensemble through cold denaturation.

A. Wand, V. Hilser, S. Whitten, 2006, Biochemistry.

Dynamic allostery can drive cold adaptation in enzymes

V. Hilser, J. Wrabl, Jing Li, 2018, Nature.

Phosphorylation Increases Persistence Length and End-to-End Distance of a Segment of Tau Protein.

V. Hilser, T. Schrank, W. A. Elam, 2016, Biophysical journal.

Protein and peptide mobility in capillary zone electrophoresis. A comparison of existing models and further analysis.

V. Hilser, G. Worosila, S. E. Rudnick, 1993, Journal of chromatography.

Thermodynamic propensities of amino acids in the native state ensemble: Implications for fold recognition

James O. Wrabl, V. Hilser, J. Wrabl, 2001, Protein science : a publication of the Protein Society.

Directed discovery of bivalent peptide ligands to an SH3 domain

J. Ferreon, V. Hilser, M. Ferguson, 2004, Protein science : a publication of the Protein Society.

The effect of the polyproline II (PPII) conformation on the denatured state entropy

J. Ferreon, V. Hilser, Josephine C. Ferreon, 2003, Protein science : a publication of the Protein Society.

Allostery vs. “allokairy”

V. Hilser, H. Motlagh, Jeremy Anderson, 2015, Proceedings of the National Academy of Sciences.

Predicting the equilibrium protein folding pathway: Structure‐based analysis of staphylococcal nuclease

V. Hilser, E. Freire, 1997, Proteins.

A Predictive Energy Landscape Model of Metamorphic Protein Conformational Specificity

James O. Wrabl, V. Hilser, J. Wrabl, 2021, bioRxiv.

Ensemble modulation as an origin of denaturant-independent hydrogen exchange in proteins.

V. Hilser, J. Wrabl, J. Wooll, 2000, Journal of molecular biology.

Thermodynamic Dissection of the Intrinsically Disordered N-terminal Domain of Human Glucocorticoid Receptor*

V. Hilser, Jing Li, H. Motlagh, 2012, The Journal of Biological Chemistry.

The ensemble nature of allostery

James O. Wrabl, V. Hilser, J. Wrabl, 2014, Nature.

Thermodynamic environments in proteins: Fundamental determinants of fold specificity

James O. Wrabl, V. Hilser, James O. Wrabl, 2002, Protein science : a publication of the Protein Society.

The variable domain from dynamin‐related protein 1 promotes liquid–liquid phase separation that enhances its interaction with cardiolipin‐containing membranes

Nolan W. Kennedy, V. Hilser, Ammon E. Posey, 2023, Protein science : a publication of the Protein Society.

Exploring the impact of polyproline II (PII) conformational bias on the binding of peptides to the SEM‐5 SH3 domain

V. Hilser, S. Whitten, R. Fox, 2008, Protein science : a publication of the Protein Society.

Analysis of the “thermodynamic information content” of a Homo sapiens structural database reveals hierarchical thermodynamic organization

V. Hilser, Scott A Larson, 2004, Protein science : a publication of the Protein Society.

COREX/BEST server: a web browser-based program that calculates regional stability variations within protein structures

Vincent J. Hilser, Jason Vertrees, Phillip Barritt, 2005, Bioinform..

Temperature and urea have opposing impacts on polyproline II conformational bias.

V. Hilser, T. Schrank, W. A. Elam, 2013, Biochemistry.

Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

James O. Wrabl, V. Hilser, T. Schroer, 2017, eLife.

Thermodynamics of binding to SH3 domains: the energetic impact of polyproline II (PII) helix formation.

Vincent J Hilser, J. Ferreon, V. Hilser, 2004, Biochemistry.

UvA-DARE (Digital Academic Repository) Allostery in Its Many Disguises: From Theory to Applications

S. Wodak, M. Wyart, Chung-Jung Tsai, 2022 .

Single-Molecule Chemo-Mechanical Spectroscopy Provides Structural Identity of Folding Intermediates.

V. Hilser, H. Motlagh, D. Toptygin, 2016, Biophysical journal.