J. Perfect

发表

Antifungal Activities of Antineoplastic Agents:Saccharomyces cerevisiae as a Model System To Study Drug Action

J. Heitman, M. Cárdenas, M. C. Cruz, 1999, Clinical Microbiology Reviews.

Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood

A. E. Eckhardt, T. G. Mitchell, J. Perfect, 2012, European Journal of Clinical Microbiology & Infectious Diseases.

Microfluidic platform versus conventional real-time polymerase chain reaction for the detection of Mycoplasma pneumoniae in respiratory specimens.

Zhishan Hua, Vijay Srinivasan, Charles B Cairns, 2010, Diagnostic microbiology and infectious disease.

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

Alexander Hoischen, Cisca Wijmenga, Ramnik J. Xavier, 2013, Nature Communications.

Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii

Christina A. Cuomo, T. G. Mitchell, Rhys A. Farrer, 2017, mBio.

Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals.

J. Heitman, J. Perfect, K. Bartlett, 2011, Microbes and infection.

Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak

J. Heitman, F. Dietrich, J. Perfect, 2005, Nature.

Aspergillus fumigatus Calcipressin CbpA Is Involved in Hyphal Growth and Calcium Homeostasis

J. Heitman, J. Perfect, R. A. Cramer, 2009, Eukaryotic Cell.

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

A. Zaas, S. Lindquist, J. Perfect, 2009, Proceedings of the National Academy of Sciences.

Calcineurin Target CrzA Regulates Conidial Germination, Hyphal Growth, and Pathogenesis of Aspergillus fumigatus

J. Heitman, J. Perfect, R. A. Cramer, 2008, Eukaryotic Cell.

Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study.

M. Oosting, L. Joosten, M. Netea, 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Interlaboratory Comparison of Results of Susceptibility Testing with Caspofungin against Candida and Aspergillus Species

J. Perfect, M. Ghannoum, W. Schell, 2004, Journal of Clinical Microbiology.

Resistance to Antifungal Agents : Mechanisms and Clinical Impact

J. Perfect, Z. Kanafani, 2007 .

Carbonic Anhydrase and CO2 Sensing during Cryptococcus neoformans Growth, Differentiation, and Virulence

J. Heitman, J. Perfect, Y. Bahn, 2005, Current Biology.

Status of medical mycology education.

T. G. Mitchell, J. Perfect, W. Schell, 2003, Medical mycology.

Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group.

Patricia Muñoz, Angela Restrepo, Raoul Herbrecht, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Blood Gene Expression Signatures Predict Invasive Candidiasis

A. Zaas, G. Ginsburg, J. Lucas, 2010, Science Translational Medicine.

Repeated therapeutic lumbar punctures in cryptococcal meningitis – necessity and/or opportunity?

Christina C. Chang, J. Perfect, C. Chang, 2016, Current opinion in infectious diseases.

The Cryptococcus neoformans Transcriptome at the Site of Human Meningitis

Thomas G. Mitchell, Kirsten Nielsen, T. G. Mitchell, 2014, mBio.

Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design

J. Perfect, R. Brennan, J. Tenor, 2017, mBio.

“Is there an emerging need for new antifungals?”

J. Perfect, 2016, Expert opinion on emerging drugs.

The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections

C. Wijmenga, B. J. Kullberg, M. Huynen, 2014, European Journal of Clinical Microbiology & Infectious Diseases.

Review Fungal diagnosis: how do we do it and can we do better?

J. Perfect, 2013 .

Fungal diagnosis: how do we do it and can we do better?

J. Perfect, 2013, Current medical research and opinion.

Antifungal therapy: current concepts and evidence-based management

J. Perfect, D. Andes, 2013 .

β-D-glucan Surveillance with Preemptive Anidulafungin for Invasive Candidiasis in Intensive Care Unit Patients: A Randomized Pilot Study

A. Zaas, J. Perfect, B. Alexander, 2012, PloS one.

Mortality, length of hospitalization, and costs associated with invasive fungal infections in high-risk patients.

J. Perfect, J. Menzin, M. Friedman, 2009, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

Aimee K. Zaas, Wiley A. Schell, A. Zaas, 2009, PLoS pathogens.

Comparison of caspofungin and amphotericin B for invasive candidiasis.

J. Perfect, R. Betts, J. Smietana, 2002, The New England journal of medicine.

Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans

Christina A Cuomo, Joseph Heitman, Christina A. Cuomo, 2017, bioRxiv.

The robust and rapid role of molecular testing in precision fungal diagnostics: A case report

J. Perfect, David K. Hong, J. Steinbrink, 2020, Medical mycology case reports.

A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy

J. Perfect, D. Brander, J. Messina, 2019, Medical mycology case reports.

Human dectin-1 deficiency and mucocutaneous fungal infections.

Trees Jansen, L. Jacobs, L. Joosten, 2009, The New England journal of medicine.

Phase I Evaluation of the Safety and Pharmacokinetics of Murine-Derived Anticryptococcal Antibody 18B7 in Subjects with Treated Cryptococcal Meningitis

A. Casadevall, J. Perfect, J. Aberg, 2005, Antimicrobial Agents and Chemotherapy.

Risk of Fungemia Due to Rhodotorula and Antifungal Susceptibility Testing of Rhodotorula Isolates

A. Zaas, J. Perfect, W. Schell, 2003, Journal of Clinical Microbiology.

Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans

A. Casadevall, J. Perfect, M. Ghannoum, 2001, Molecular microbiology.

Surfactant Protein D Increases Phagocytosis of Hypocapsular Cryptococcus neoformans by Murine Macrophages and Enhances Fungal Survival

J. Heitman, J. Lodge, J. Perfect, 2009, Infection and Immunity.

Scedosporium Species Infections and Treatments

J. Perfect, W. Steinbach, 2003, Journal of chemotherapy.

Adaptive Immunity to Fungi

J. Perfect, S. Brunke, S. Gaffen, 2014 .

Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion

J. Perfect, D. Tobin, J. Tenor, 2015, mBio.

Cryptococcus neoformans : a Sugar-Coated Killer

J. Perfect, 2006 .

Cryptococcus neoformans: a sugar-coated killer with designer genes.

J. Perfect, 2005, FEMS immunology and medical microbiology.

Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA

J. Perfect, D. Durack, S. Johnston, 1993, Journal of bacteriology.

Cryptococcus neoformans: virulence and host defences.

J. Perfect, P. Williamson, B. Wong, 1998, Medical mycology.

Chapter 46 – Fungal Infections of the Central Nervous System

J. Perfect, 2014 .

Isavuconazole treatment for rare fungal diseases and for invasive aspergillosis in patients with renal impairment: Challenges and lessons of the VITAL trial

J. Perfect, F. Marty, L. Ostrosky-Zeichner, 2018, Mycoses.

Molds: hyalohyphomycosis, phaeohyphomycosis, and zygomycosis.

J. Perfect, S. Naggie, 2009, Clinics in chest medicine.

Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide.

J. Perfect, D. Durack, D. Granger, 1985, The Journal of clinical investigation.

Karyotyping of Cryptococcus neoformans as an epidemiological tool

J. Perfect, G. Cox, N. Ketabchi, 1993, Journal of clinical microbiology.

Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase‐encoding gene, MAN1, and its impact on pathogenicity

A. Casadevall, M. Del Poeta, J. Perfect, 2001, Molecular microbiology.

Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia.

J. Perfect, R. Suresh, T. Walsh, 2007, The New England journal of medicine.

Nuances of new anti-Aspergillus antifungals.

J. Perfect, 2005, Medical mycology.

OUR CURRENT UNDERSTANDING OF THERAPIES FOR INVASIVE FUNGAL INFECTIONS

J. Perfect, 2004 .

Infections due to Aspergillus terreus: a multicenter retrospective analysis of 83 cases.

J. Perfect, H. Jafri, D. Benjamin, 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis.

J. Perfect, V. Morrison, D. Stevens, 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Value of an inhalational model of invasive aspergillosis.

W. M. Foster, A. Zaas, J. Perfect, 2004, Medical mycology.

Rare and Emerging Fungal Pulmonary Infections

Jay B. Varkey, J. Perfect, Jay Varkey1, 2008, Seminars in respiratory and critical care medicine.

Differential Effects of Inhibiting Chitin and 1,3-β-d-Glucan Synthesis in Ras and Calcineurin Mutants of Aspergillus fumigatus

J. Perfect, P. Juvvadi, Jarrod R. Fortwendel, 2008, Antimicrobial Agents and Chemotherapy.

Urease as a Virulence Factor in Experimental Cryptococcosis

A. Casadevall, J. Perfect, G. Cox, 2000, Infection and Immunity.

Role of Alternative Oxidase Gene in Pathogenesis of Cryptococcus neoformans

J. Perfect, G. Cox, G. Heinrich, 2003, Infection and Immunity.

Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses

Christina A. Cuomo, J. Perfect, C. Cuomo, 2019, Microbial genomics.

Knockout mice as experimental models of virulence.

J. Perfect, G. Huffnagle, L. Romani, 2000, Medical mycology.

Virulence mechanisms for fungi, Part II.

J. Perfect, G. Cox, 2000 .

Calcineurin Controls Growth, Morphology, and Pathogenicity in Aspergillus fumigatus

J. Heitman, J. Perfect, R. A. Cramer, 2006 .

Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents.

J. Perfect, W. Wilson, D. Boykin, 2001, Journal of medicinal chemistry.

Transcriptional Regulation of Chitin Synthases by Calcineurin Controls Paradoxical Growth of Aspergillus fumigatus in Response to Caspofungin

J. Perfect, P. Juvvadi, Jarrod R. Fortwendel, 2010, Antimicrobial Agents and Chemotherapy.

Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients

T. G. Mitchell, J. Perfect, R. Aurora, 2011, BMC Genomics.

Cost-effectiveness of posaconazole versus fluconazole or itraconazole in the prevention of invasive fungal infections among neutropenic patients in the United States.

M. Weinstein, J. Perfect, D. Thompson, 2009, Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.

Antifungal pharmacotherapy for invasive mould infections

Jason C. Gallagher, J. Perfect, R. Drew, 2003, Expert opinion on pharmacotherapy.

Trehalose 6‐phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus

J. Perfect, B. Bothner, D. Perlin, 2010, Molecular microbiology.

Gpr1, a Putative G-Protein-Coupled Receptor, Regulates Morphogenesis and Hypha Formation in the Pathogenic Fungus Candida albicans

J. Perfect, W. Schell, H. Kumagai, 2004, Eukaryotic Cell.

Cryptococcal antigen in serum and cerebrospinal fluid for detecting cryptococcal meningitis in adults living with HIV: systematic review and meta-analysis of diagnostic test accuracy studies.

Jérémie F. Cohen, J. Perfect, T. Harrison, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.

N. Ampel, G. Sarosi, J. Perfect, 2011, American journal of respiratory and critical care medicine.

Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States

Lefko T. Charalambous, J. Perfect, S. Lad, 2018, Journal of medical microbiology.

Role of autophagy genetic variants for the risk of Candida infections.

M. Oosting, L. Joosten, M. Netea, 2014, Medical mycology.

Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium

J. Perfect, H. Masur, A. Caliendo, 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The Trehalose Synthesis Pathway Is an Integral Part of the Virulence Composite for Cryptococcus gattii

J. Perfect, U. Himmelreich, H. Daniel, 2009, Infection and Immunity.

Transcriptional Profiles Elucidate Differential Host Responses to Infection with Cryptococcus neoformans and Cryptococcus gattii

A. Zaas, J. Perfect, M. McClain, 2022, Journal of fungi.

Intracellular Action of a Secreted Peptide Required for Fungal Virulence.

Christina A. Cuomo, J. Diedrich, J. Yates, 2016, Cell host & microbe.

Recent advances in the epidemiology, prevention, diagnosis, and treatment of fungal pneumonia

J. Perfect, R. Drew, M. Pound, 2002, Current opinion in infectious diseases.

Ecology of Cryptococcus neoformans

A. Casadevall, J. Perfect, 1998 .

Invasive Fungal Infection after Lung Transplantation: Epidemiology in the Setting of Antifungal Prophylaxis.

J. Perfect, B. Alexander, Melissa D. Johnson, 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Comparative Evaluation of Etest and Sensititre YeastOne Panels against the Clinical and Laboratory Standards Institute M27-A2 Reference Broth Microdilution Method for Testing Candida Susceptibility to Seven Antifungal Agents

K. Anstrom, J. Perfect, B. Alexander, 2007, Journal of Clinical Microbiology.

Caspofungin for invasive candidiasis at a tertiary care medical center.

A. Zaas, J. Perfect, B. Alexander, 2006, The American journal of medicine.

Safety and efficacy of quinupristin/dalfopristin for treatment of invasive Gram-positive infections in pediatric patients

J. Perfect, G. Talbot, R. Drew, 2002, The Pediatric infectious disease journal.

Candida pneumonia: What we know and what we don’t

J. Perfect, C. Barkauskas, 2009 .

The impact of the host on fungal infections.

J. Perfect, 2012, The American journal of medicine.

Invasive Fungal Disease in the Transplant Population: An Overview

J. Perfect, B. Alexander, Jennifer L. Saullo, 2019, Principles and Practice of Transplant Infectious Diseases.

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

J. Perfect, D. Durack, J. Hibbs, 1988, The Journal of clinical investigation.

Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier

J. Perfect, E. Eugenin, C. Xue, 2013, PLoS pathogens.

Prospective Aspergillus Galactomannan Antigen Testing in Pediatric Hematopoietic Stem Cell Transplant Recipients

J. Perfect, B. Alexander, W. Steinbach, 2007, The Pediatric infectious disease journal.

Invasive mould infections: a multi-disciplinary update.

J. Perfect, Nina Singh, T. Calandra, 2009, Medical mycology.

Fungal Molecular Pathogenesis: What Can It Do and Why Do We Need It?

A. Casadevall, J. Perfect, 2006 .

Cryptococcus neoformans Mitochondrial Superoxide Dismutase: an Essential Link between Antioxidant Function and High-Temperature Growth

J. Perfect, I. Batinic-Haberle, G. Cox, 2005, Eukaryotic Cell.

Posaconazole as salvage treatment of invasive fungal infections in patients with underlying renal impairment.

J. Perfect, J. Graybill, A. Langston, 2008, The Journal of antimicrobial chemotherapy.

Core Recommendations for Antifungal Stewardship: A Statement of the Mycoses Study Group Education and Research Consortium.

J. Perfect, Melissa D. Johnson, D. Kontoyiannis, 2020, The Journal of infectious diseases.

Identification and Characterization of an SKN7 Homologue in Cryptococcus neoformans

J. Perfect, J. Miller, G. Cox, 2005, Infection and Immunity.

A meta-analysis of medical versus surgical therapy for Candida endocarditis.

A. Zaas, J. Perfect, V. Fowler, 2005, The Journal of infection.

Population Pharmacodynamics of Amphotericin B Deoxycholate for Disseminated Infection Caused by Talaromyces marneffei

R. Kolamunnage-Dona, J. Perfect, N. Thu, 2018, Antimicrobial Agents and Chemotherapy.

What Can the Clinical Mycology Laboratory Do for Clinicians Today and Tomorrow?

J. Perfect, A. Mourad, 2017, Current Clinical Microbiology Reports.

Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts.

J. Perfect, J. Wingard, T. Walsh, 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Occult Talaromyces marneffei Infection Unveiled by the Novel Mp1p Antigen Detection Assay

J. Chan, J. Perfect, N. Thu, 2020, Open forum infectious diseases.

Superiority of a Novel Mp1p Antigen Detection Enzyme Immunoassay Compared to Standard BACTEC Blood Culture in the Diagnosis of Talaromycosis

N. P. H. Lan, Jian-Piao Cai, J. Chan, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

How Clean Is the Linen at My Hospital? The Mucorales on Unclean Linen Discovery Study of Large United States Transplant and Cancer Centers

J. Perfect, J. Wingard, K. Hanson, 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Immune reconstitution syndrome and exacerbation of infections after pregnancy.

J. Perfect, Nina Singh, N. Singh, 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans

J. Perfect, J. Kronstad, G. Hu, 2016, mSphere.

Macrophage-mediated fungistasis: requirement for a macromolecular component in serum.

J. Perfect, D. Durack, D. Granger, 1986, Journal of immunology.

Breakthrough Invasive Candidiasis in Patients on Micafungin

A. Zaas, J. Perfect, B. Alexander, 2010, Journal of Clinical Microbiology.

The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid

J. Perfect, T. Rude, D. Toffaletti, 1993, Infection and immunity.

Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans

J. Perfect, P. Williamson, K. Kwon-Chung, 1996, The Journal of experimental medicine.

Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans.

A. Casadevall, Y. Hannun, M. Del Poeta, 2001, Genes & development.

Impact of Surfactant Protein D, Interleukin-5, and Eosinophilia on Cryptococcosis

J. Perfect, R. Frothingham, J. Ledford, 2013, Infection and Immunity.

Surfactant Protein D Facilitates Cryptococcus neoformans Infection

J. Heitman, J. Perfect, S. Geunes-Boyer, 2012, Infection and Immunity.

Host Defenses Against Cryptococcosis

J. Perfect, M. Price, 2011, Immunological investigations.

Cryptococcus neoformans Is Resistant to Surfactant Protein A Mediated Host Defense Mechanisms

A. Zaas, J. Perfect, S. Giles, 2007, PloS one.

Calcineurin Inhibition or Mutation Enhances Cell Wall Inhibitors against Aspergillus fumigatus

J. Heitman, J. Perfect, R. A. Cramer, 2007, Antimicrobial Agents and Chemotherapy.

The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of Candida albicans

J. Heitman, J. Perfect, F. Wormley, 2004, Infection and Immunity.

The war on cryptococcosis: A Review of the antifungal arsenal

J. Perfect, A. Mourad, 2018, Memorias do Instituto Oswaldo Cruz.

Drug resistance in Cryptococcus neoformans.

J. Perfect, G. Cox, 1999, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

The History of Cryptococcus and Cryptococcosis

A. Casadevall, J. Perfect, 2011 .

J. Perfect, S. Brunke, S. Gaffen, 2014 .

Differential Effects of Inhibiting Chitin and 1,3- (cid:2) - D -Glucan Synthesis in Ras and Calcineurin Mutants of Aspergillus fumigatus (cid:1)

J. Perfect, P. Juvvadi, Jarrod R. Fortwendel, 2009 .

Targeting the Calcineurin Pathway Enhances Ergosterol Biosynthesis Inhibitors against Trichophyton mentagrophytes In Vitro and in a Human Skin Infection Model

J. Heitman, J. Perfect, W. Schell, 2007, Antimicrobial Agents and Chemotherapy.

Copy number variation contributes to cryptic genetic variation in outbreak lineages of Cryptococcus gattii from the North American Pacific Northwest

J. Perfect, J. Steenwyk, J. Soghigian, 2016, BMC Genomics.

Cryptococcal Antigen in Serum and Cerebrospinal Fluid for Detecting Cryptococcal Meningitis in Adults Living With Human Immunodeficiency Virus: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies

J. Perfect, T. Chiller, O. Lortholary, 2021 .

When primary antifungal therapy fails.

J. Perfect, M. Nucci, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance

J. Perfect, M. Hughes, T. Harrison, 2019, mBio.

Pharmacodynamics of Isavuconazole in a Rabbit Model of Cryptococcal Meningoencephalitis

J. Perfect, Katelyn Ripple, C. Giamberardino, 2019, Antimicrobial Agents and Chemotherapy.

Population Pharmacodynamics of Amphotericin B Deoxycholate for Disseminated Infection Caused by Talaromyces marneffei

R. Kolamunnage-Dona, J. Perfect, N. Thu, 2019 .

Experimental Models of Short Courses of Liposomal Amphotericin B for Induction Therapy for Cryptococcal Meningitis

J. Perfect, T. Harrison, W. Hope, 2017, Antimicrobial Agents and Chemotherapy.

Identification of Genes from the Fungal Pathogen Cryptococcus neoformans Related to Transmigration into the Central Nervous System

J. Perfect, A. Jong, W. Cho, 2012, PloS one.

Addressing current medical needs in invasive fungal infection prevention and treatment with new antifungal agents, strategies and formulations

J. Perfect, R. Drew, Stuart K Pitman, 2011, Expert opinion on emerging drugs.

Caspofungin: first approved agent in a new class of antifungals

J. Perfect, Melissa D. Johnson, 2003, Expert opinion on pharmacotherapy.

Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits

J. Perfect, D. Durack, D. Savani, 1986, Antimicrobial Agents and Chemotherapy.

Penetration of imidazoles and triazoles into cerebrospinal fluid of rabbits.

J. Perfect, D. Durack, 1985, The Journal of antimicrobial chemotherapy.

Failure of ketoconazole in cryptococcal meningitis.

J. Perfect, D. Durack, J. Hamilton, 1982, JAMA.

Fungal Infections in Lung and Heart‐Lung Transplant Recipients: Report of 9 Cases and Review of the Literature

J. Perfect, V. Tapson, M. Baz, 1996, Medicine.

Quantitation of Candida CFU in Initial Positive Blood Cultures

J. Perfect, G. Samsa, B. Alexander, 2011, Journal of Clinical Microbiology.

T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation

J. Perfect, M. Shinohara, Michael E Brown, 2014, Proceedings of the National Academy of Sciences.

Introduction to the Pathogen

A. Casadevall, J. Perfect, 1998 .

Production of the hexitol D-mannitol by Cryptococcus neoformans in vitro and in rabbits with experimental meningitis

J. Perfect, B. Wong, S. Beggs, 1990, Infection and immunity.

Separation of chromosomes of Cryptococcus neoformans by pulsed field gel electrophoresis

P. T. Magee, J. Perfect, B. Magee, 1989, Infection and immunity.

Chronic cryptococcal meningitis: a new experimental model in rabbits.

J. Perfect, D. Durack, S. Lang, 1980, The American journal of pathology.

Use of fluconazole in a patient with documented malabsorption of ketoconazole.

J. Perfect, H. Gallis, R. Drew, 1988, Clinical pharmacy.

ECMM/ISHAM recommendations for clinical management of COVID‐19 associated mucormycosis in low‐ and middle‐income countries

J. Perfect, J. Meis, S. Rudramurthy, 2021, Mycoses.

Fatty Acid Synthesis Is Essential for Survival of Cryptococcus neoformans and a Potential Fungicidal Target

J. Perfect, M. Chayakulkeeree, T. Rude, 2007, Antimicrobial Agents and Chemotherapy.

Cryptococcus: from human pathogen to model yeast.

J. Heitman, A. Casadevall, J. Perfect, 2010 .

Cryptococcus gattii Species Complex as an Opportunistic Pathogen: Underlying Medical Conditions Associated with the Infection

K. Wollenberg, J. Perfect, S. Holland, 2021, mBio.

A Case of Cryptococcus gattii in Western Florida: An Aggressive Pathogen in an Immunocompetent Host

J. Heitman, J. Perfect, A. Ottaviani, 2015 .

Future strategies for the treatment of cryptococcal meningoencephalitis in pediatric patients

J. Perfect, R. Drew, Justin Spivey, 2014 .

Erratum: NIAID mycoses study group multicenter trial of oral itraconazole therapy for invasive aspergillosis (American Journal of Medicine (August 1994) 97 (135-144))

J. Perfect, D. Denning, J. Galgiani, 1994 .

Drug Resistance in Cryptococcosis

J. Perfect, B. Alexander, K. Hanson, 2017 .

Cryptococcus neoformans: Latency and Disease

A. Casadevall, J. Perfect, T. Sorrell, 2011 .

Management of Cryptococcosis: How Are We Doing?

J. Perfect, 2007, PLoS medicine.

The Case for Adopting the “Species Complex” Nomenclature for the Etiologic Agents of Cryptococcosis

Christina A. Cuomo, A. Casadevall, J. Perfect, 2017, mSphere.

Cryptococcosis in solid organ transplant recipients: current state of the science.

J. Perfect, Nina Singh, F. Dromer, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Polyhexamethylene biguanide and calcineurin inhibitors as novel antifungal treatments for Aspergillus keratitis.

J. Perfect, Ricardo M. Santaella, N. Afshari, 2011, Investigative ophthalmology & visual science.

Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance

J. Perfect, J. Meis, D. Vinh, 2020, The Lancet Infectious Diseases.

Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases.

E. Anaissie, J. Perfect, A. Reboli, 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Associations between Cryptococcus Genotypes, Phenotypes, and Clinical Parameters of Human Disease: A Review

Paul M. Magwene, J. Perfect, P. Magwene, 2021, Journal of fungi.

Cryptococcus neoformans: the yeast that likes it hot.

J. Perfect, 2006, FEMS yeast research.

Cryptococcus neoformans Inhibitors FK 506 and L-685 , 818 against Acetate ( L-743 , 873 ) with Calcineurin Pneumocandin MK-0991 / Caspofungin , Fluconazole , and the 1 Bafilomycin A Synergistic Antifungal Activities of

J. Heitman, M. Cárdenas, J. Perfect, 1999 .

Fungal Infections of the Eye

J. Perfect, W. Schell, G. Foulks, 2008 .

Emergence of the Molds Other than Aspergillus in Immunocompromised Patients.

J. Perfect, S. Arif, 2017, Clinics in chest medicine.

Emergence of the Molds 3 Specific risk factors in solid organ transplantation

J. Perfect, S. Arif, 2017 .

Scedosporium apiosermum infection of the “Native” valve: Fungal endocarditis in an orthotopic heart transplant recipient

J. Perfect, C. Patel, M. Clement, 2015, Medical mycology case reports.

Genotypic diversity and clinical outcome of cryptococcosis in renal transplant recipients in Brazil

J. Perfect, J. Medina-Pestana, Yuan Chen, 2019, Emerging microbes & infections.

Oropharyngeal candidiasis in patients with HIV: suggested guidelines for therapy.

J. Perfect, M. Ghannoum, J. Gallant, 1999, AIDS research and human retroviruses.

Molecular methods for epidemiological and diagnostic studies of fungal infections

J. Perfect, G. Cox, M. Gottfredsson, 1998, Pathology.

The use of amphotericin B in nosocomial fungal infection.

J. Perfect, W. Schell, B. Palmer, 1991, Reviews of infectious diseases.

Uncommon Yeasts and Molds Causing Human Disease

J. Perfect, Christopher J. Shoff, 2020 .

The current treatment landscape: other fungal diseases (cryptococcosis, fusariosis and mucormycosis).

J. Perfect, O. Lortholary, M. Fernández-Ruiz, 2016, The Journal of antimicrobial chemotherapy.

Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy.

R. M. Warren, J. Perfect, D. Haas, 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Non‐comparative evaluation of the safety of aerosolized amphotericin B lipid complex in patients undergoing allogeneic hematopoietic stem cell transplantation

J. Perfect, B. Alexander, R. Addison, 2006, Transplant infectious disease : an official journal of the Transplantation Society.

Hospital-Acquired Infections

J. Perfect, M. Klotman, 1985 .

Cloning the Cryptococcus neoformans TRP1 gene by complementation in Saccharomyces cerevisiae.

J. Perfect, T. Rude, L. Penning, 1992, Gene.

Chemotactic activity of cerebrospinal fluid in experimental cryptococcal meningitis.

J. Perfect, D. Durack, 1985, Sabouraudia.

Cryptococcus gattii genotype VGI infection in New England.

J. Heitman, J. Perfect, E. Byrnes, 2011, The Pediatric infectious disease journal.

Treatment of lymphocutaneous and visceral sporotrichosis with fluconazole.

J. Perfect, G. Cloud, W. Dismukes, 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Azole antifungals: 35 years of invasive fungal infection management

J. Perfect, R. Drew, D. Allen, 2015, Expert review of anti-infective therapy.

Reply to Day et al.

J. Perfect, Melissa D. Johnson, D. Kontoyiannis, 2021, The Journal of infectious diseases.

Combined therapy with amphotericin B and 5-fluorocytosine for Candida meningitis.

J. Perfect, D. Durack, R. Smego, 1984, Reviews of infectious diseases.

Method for the purification of Filobasidiella neoformans basidiospores by flow cytometry.

J. Perfect, D. Durack, J. Cohen, 1982, Sabouraudia.

CRYPTOCOCCOSIS AND THE BASIDIOSPORE

J. Perfect, D. Durack, J. Cohen, 1982, The Lancet.

The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial.

J. Perfect, B. Spellberg, D. Kontoyiannis, 2011, The Journal of antimicrobial chemotherapy.

Successful use of amphotericin B lipid complex in the treatment of cryptococcosis.

J. Perfect, L. Baddour, L. Ostrosky-Zeichner, 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Chest Discomfort Associated with Liposomal Amphotericin B: Report of Three Cases and Review of the Literature

J. Perfect, M. D. Johnson, Melissa D. Johnson, 1998, Pharmacotherapy.

Outcomes and Health Care Resource Utilization of Adult Bacterial Meningitis in the United States.

Syed M. Adil, Lefko T. Charalambous, Beth A. Parente, 2020, Neurology. Clinical practice.

Invasive candidiasis: investigational drugs in the clinical development pipeline and mechanisms of action

J. Perfect, M. Arendrup, M. Hoenigl, 2022, Expert opinion on investigational drugs.

Familial Adenomatous Polyposis Manifesting as Lactococcus Endocarditis: A Case Report and Review of the Association of Lactococcus with Underlying Gastrointestinal Disease

J. Perfect, S. Maskarinec, Taylor C Bazemore, 2016, Case reports in infectious diseases.

Candida Endocarditis: Contemporary Cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-MD)

J. Perfect, S. Eykyn, B. Hoen, 2004, Scandinavian journal of infectious diseases.

In Vitro Analyses, Animal Models, and 60 Clinical Cases of Invasive Aspergillus terreus Infection

J. Perfect, W. Schell, D. Benjamin, 2004, Antimicrobial Agents and Chemotherapy.

Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.

J. Perfect, V. Davisson, T. Klem, 1998, Archives of biochemistry and biophysics.

Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children

J. Perfect, T. Walsh, I. Lutsar, 2002, The Pediatric infectious disease journal.

Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review.

J. Perfect, A. Kaplan, D. Weber, 1989, Reviews of infectious diseases.

Antifungal Pharmacodynamics: Review of the Literature and Clinical Applications

J. Perfect, R. Drew, E. Dodds, 2000, Pharmacotherapy.

Management of invasive mycoses in hematology patients: current approaches.

J. Perfect, 2004, Oncology.

Use of antifungal agents in the intensive care unit

J. Perfect, M. Gottfredsson, 1999 .

Predictors and outcomes of Candida bloodstream infection: eight-year surveillance, western Saudi Arabia.

J. Perfect, F. Farahat, A. Al Amri, 2014, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Recent advances in antifungal pharmacotherapy for invasive fungal infections

Jason C. Gallagher, J. Perfect, C. MacDougall, 2004, Expert review of anti-infective therapy.

The impact of caspase-12 on susceptibility to candidemia

M. Netea, W. Scott, J. Perfect, 2011, European Journal of Clinical Microbiology & Infectious Diseases.

Emerging echinocandins for treatment of invasive fungal infections

J. Perfect, R. Drew, M. S. Turner, 2006, Expert opinion on emerging drugs.

Zygomycosis: the re-emerging fungal infection

J. Perfect, M. Ghannoum, M. Chayakulkeeree, 2006, European Journal of Clinical Microbiology and Infectious Diseases.

Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis.

J. Perfect, G. Rahav, F. Marty, 2016, The Lancet. Infectious diseases.

Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome

Christina A. Cuomo, J. Perfect, C. Cuomo, 2021, bioRxiv.

Dominant selection system for use in Cryptococcus neoformans.

J. Perfect, G. Cox, D. Toffaletti, 1996, Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology.

Antifungal Therapy for Invasive Fungal Diseases in Allogeneic Stem Cell Transplant Recipients: An Update

J. Perfect, R. Drew, Dustin T Wilson, 2009, Mycopathologia.

MSG07: An International Cohort Study Comparing Epidemiology and Outcomes of Patients with Cryptococcus neoformans or Cryptococcus gattii infections.

B. Jackson, J. Perfect, T. Sorrell, 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The actin gene from Cryptococcus neoformans: structure and phylogenetic analysis.

J. Perfect, G. Cox, C. Dykstra, 1995, Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology.

Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain.

J. Perfect, G. Cox, F. Wormley, 2005, Microbial pathogenesis.

Role of PLB1 in Pulmonary Inflammation and Cryptococcal Eicosanoid Production

J. Perfect, G. Huffnagle, G. Cox, 2003, Infection and Immunity.

Agents for treatment of invasive fungal infections.

J. Perfect, R. Drew, B. Luna, 2000, Otolaryngologic clinics of North America.

Diagnosis of Cryptococcosis

J. Perfect, M. Chayakulkeeree, 2007 .

Cryptococcemia

J. Perfect, D. Durack, H. Gallis, 1983, Medicine.

To help the sick: an historical and ethical essay concerning the refusal to care for patients with AIDS.

J. Perfect, J. Kim, 1988, The American journal of medicine.

Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis

Laura G. Dubois, J. Perfect, J. Thompson, 2022, mBio.

Rapamycin Antifungal Action Is Mediated via Conserved Complexes with FKBP12 and TOR Kinase Homologs inCryptococcus neoformans

J. Heitman, M. Cárdenas, J. Perfect, 1999, Molecular and Cellular Biology.

The virulence factor urease and its unexplored role in the metabolism of Cryptococcus neoformans.

J. Perfect, T. Boekhout, A. Botha, 2020, FEMS yeast research.

Present and Future Therapy of Cryptococcus Infections

J. Perfect, A. Mourad, 2018, Journal of fungi.

Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion.

J. Perfect, M. Olszewski, Gwo-hsiao Chen, 2004, The American journal of pathology.

Candida glabrata fungemia in transplant patients receiving voriconazole after fluconazole.

J. Perfect, B. Alexander, W. Schell, 2005, Transplantation.

Global Distribution and Outcomes for Candida Species Causing Invasive Candidiasis: Results from an International Randomized Double-Blind Study of Caspofungin Versus Amphotericin B for the Treatment of Invasive Candidiasis

J. Perfect, M. Motyl, A. Colombo, 2003, European Journal of Clinical Microbiology and Infectious Diseases.

Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1

J. Perfect, J. Bartlett, H. Waskin, 1993, Antimicrobial Agents and Chemotherapy.

Antifungal prophylaxis: to prevent or not.

J. Perfect, 1993, The American journal of medicine.

Fluconazole and Candida krusei fungemia.

J. Perfect, D. Persons, J. Hathorn, 1991, The New England journal of medicine.

A MAP kinase cascade composed of cell type specific and non‐specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans

J. Heitman, J. Perfect, R. Davidson, 2003, Molecular microbiology.

Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans.

J. Perfect, G. Cox, S. Giles, 2005, Fungal genetics and biology : FG & B.

Native valve endocarditis due to Candida glabrata treated without valvular replacement: a potential role for caspofungin in the induction and maintenance treatment.

J. Perfect, J. Gatell, W. Schell, 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Very Low Levels of 25-Hydroxyvitamin D Are Not Associated With Immunologic Changes or Clinical Outcome in South African Patients With HIV-Associated Cryptococcal Meningitis

J. Perfect, J. Jarvis, G. Meintjes, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Ceftaroline fosamil in the treatment of experimental meningitis caused by methicillin-resistant Staphylococcus aureus

J. Perfect, V. Fowler, L. Park, 2020 .

An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow.

J. Perfect, P. Williamson, J. Alspaugh, 2002, Medical mycology.

Rabbit Model of Cryptococcal Meningitis

J. Perfect, 1999 .

Molecular targets for new antifungal drugs

J. Perfect, 1995 .

The pharmacokinetics of BAY R3783 and its efficacy in the treatment of experimental cryptococcal meningitis.

J. Perfect, W. Ritter, K. Wright, 1990, The Journal of antimicrobial chemotherapy.

Fluconazole therapy for experimental cryptococcosis and candidiasis in the rabbit.

J. Perfect, 1990, Reviews of infectious diseases.

Treatment of experimental cryptococcal meningitis and disseminated candidiasis with SCH39304

J. Perfect, D. Durack, K. Wright, 1989, Antimicrobial Agents and Chemotherapy.

Comparison of amphotericin B and N-D-ornithyl amphotericin B methyl ester in experimental cryptococcal meningitis and Candida albicans endocarditis with pyelonephritis

J. Perfect, D. Durack, 1985, Antimicrobial Agents and Chemotherapy.

Influence of agglutinating antibody in experimental cryptococcal meningitis.

J. Perfect, D. Durack, S. Lang, 1981, British journal of experimental pathology.

Current Controversies in the Treatment of Fungal Infections

J. Perfect, B. Alexander, C. Pfeiffer, 2011 .

Cryptococcus neoformans: the yeast that likes it hot.

J. Perfect, 2006, FEMS yeast research.

In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds

M. Del Poeta, J. Perfect, W. Schell, 1997, Antimicrobial agents and chemotherapy.

Breakthrough Invasive Candidiasis in Patients on Micafungin (cid:1) †

A. Zaas, J. Perfect, B. Alexander, 2010 .

Cryptococcosis: a model for the understanding of infectious diseases.

J. Perfect, 2014, The Journal of clinical investigation.

The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein

J. Heitman, M. Del Poeta, J. Perfect, 1997, Antimicrobial agents and chemotherapy.

Genetic Susceptibility to Fungal Infections: What is in the Genes?

J. Perfect, Melissa D. Johnson, S. Maskarinec, 2016, Current Clinical Microbiology Reports.

Relationship of the Glyoxylate Pathway to the Pathogenesis of Cryptococcus neoformans

J. Perfect, G. Cox, T. Rude, 2002, Infection and Immunity.

Cerebrospinal fluid macrophage response to experimental cryptococcal meningitis: relationship between in vivo and in vitro measurements of cytotoxicity

J. Perfect, D. Durack, D. Granger, 1988, Infection and immunity.

Efficiently killing a sugar-coated yeast.

J. Perfect, 2013, The New England journal of medicine.

Synergistic Antifungal Activities of Bafilomycin A1, Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against Cryptococcus neoformans

Joseph Heitman, J. Heitman, M. Cárdenas, 2000, Antimicrobial Agents and Chemotherapy.

Isavuconazole Treatment of Cryptococcosis and Dimorphic Mycoses

J. Perfect, J. Vazquez, F. Queiroz-Telles, 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections.

J. Perfect, P. Pitisuttithum, J. Graybill, 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Treatment of non-Aspergillus moulds in immunocompromised patients, with amphotericin B lipid complex.

J. Perfect, 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans.

J. Heitman, J. Perfect, J. Alspaugh, 1998, Fungal genetics and biology : FG & B.

A nationwide survey of clinical laboratory methodologies for fungal infections.

J. Perfect, W. Schell, T. Grasela, 1992, Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology.

Pulmonary cryptococcosis. Pathophysiological and clinical characteristics.

J. Perfect, M. Bendinelli, H. Friedman, 1994 .

Opsonic activity of cerebrospinal fluid in experimental cryptococcal meningitis

J. Perfect, D. Durack, D. Granger, 1990, Infection and immunity.

The new fungal opportunists are coming.

J. Perfect, W. Schell, 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Infection and cyclosporine.

J. Perfect, J. Kim, 1989, Reviews of infectious diseases.

PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

A. Zaas, J. Perfect, A. Mitchell, 2010, PLoS pathogens.

Fungal infections of the bones and joints

J. Perfect, Melissa D. Johnson, 2001, Current infectious disease reports.

Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells.

J. Perfect, D. Durack, D. Granger, 1987, The Journal of infectious diseases.

Taming Amphotericin B.

J. Perfect, W. Schell, S. Regen, 2015, Bioconjugate chemistry.

AIDS-related mycoses: the way forward.

Lisa M. Graham, M. Netea, A. Casadevall, 2014, Trends in microbiology.

Oropharyngeal yeast flora and fluconazole resistance in HIV‐infected patientsreceiving long‐term continuous versus intermitent fluconazole therapy

J. Perfect, J. Bartlett, W. Schell, 1996, AIDS.

Cryptococcal meningoencephalitis: time for action.

J. Perfect, D. Lalloo, J. Jarvis, 2021, The Lancet. Infectious diseases.

In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus

J. Perfect, M. Kapoor, W. Schell, 2018, Antimicrobial Agents and Chemotherapy.

Feasibility of Neurapheresis™ as a Therapy for Multidrug Resistant Gram-negative Bacterial Meningitis

Lefko T. Charalambous, J. Perfect, B. Sharma-Kuinkel, 2017, Open Forum Infectious Diseases.

Sexual Cycle of Cryptococcus neoformans var. grubii and Virulence of Congenic a and α Isolates

J. Heitman, J. Perfect, G. Cox, 2003, Infection and Immunity.

Disseminated zygomycosis: report of four cases and review.

J. Perfect, C. W. Ingram, J. N. Cooper, 1989, Reviews of infectious diseases.

The impact of caspase-12 on susceptibility to candidemia

M. Netea, W. Scott, J. Perfect, 2011, European Journal of Clinical Microbiology & Infectious Diseases.

In vitro and in vivo characterisation of isolates of cryptococcus neoformans causing meningitis in hiv infected and uninfected patients in vietnam

P. Ashton, S. Baker, J. Perfect, 2017, bioRxiv.

IN VITRO AND IN VIVO CHARACTERISATION OF ISOLATES OF CRYPTOCOCCUS 1 NEOFORMANS CAUSING MENINGITIS IN HIV INFECTED AND UNINFECTED PATIENTS

P. Ashton, J. Beardsley, J. Perfect, 2017 .

1 IN VITRO AND IN VIVO CHARACTERISATION OF ISOLATES OF CRYPTOCOCCUS 1 NEOFORMANS CAUSING MENINGITIS IN HIV INFECTED AND UNINFECTED PATIENTS 2 IN VIETNAM 3 4

P. Ashton, J. Beardsley, S. Baker, 2017 .

Combination antifungal therapy: what can and should we expect?

J. Perfect, M. D. Johnson, J. R. Perfect, 2007, Bone Marrow Transplantation.

Trimethoprim-sulfamethoxazole vs. ampicillin in the treatment of experimental meningitis due to Streptococcus pneumoniae.

J. Perfect, D. Durack, G. Corey, 1982, Reviews of infectious diseases.

Comparison of cotrimoxazole, ampicillin, and chloramphenicol in treatment of experimental Haemophilus influenzae type B meningitis

J. Perfect, D. Durack, S. Lang, 1980, Antimicrobial Agents and Chemotherapy.

Aerosolized antifungal prophylaxis: the winds of change?

J. Perfect, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Structure-In Vitro Activity Relationships of Pentamidine Analogues and Dication-Substituted Bis-Benzimidazoles as New Antifungal Agents

M. Del Poeta, J. Perfect, Arvind Kumar, 1998, Antimicrobial Agents and Chemotherapy.

Management of endemic mycoses

J. Perfect, A. Mourad, 2019, Antifungal Therapy.

Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis.

J. Perfect, J. Jorgensen, H. Gallis, 1983, Annals of internal medicine.

Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria.

J. Perfect, S. Holland, J. Sobel, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Voriconazole treatment for less-common, emerging, or refractory fungal infections.

J. Perfect, T. Walsh, K. Marr, 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Antifungal Pharmacokinetics and Pharmacodynamics Subject Collection Human Fungal Pathogens Pneumocystis

J. Perfect, S. Brunke, S. Gaffen, 2014 .

Treatment of Vancomycin‐Resistant Enterococci, with a Focus on Quinupristin‐Dalfopristin

J. Perfect, R. Drew, R. E. Fuller, 1996, Pharmacotherapy.

Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450

J. Perfect, John R. Perfect, Yuzo Yoshida, 1999, Antimicrobial Agents and Chemotherapy.

Evaluation and management of Fungal infections in Immunocompromised patients

J. Perfect, S. A. Myers, P. Venkatesan, 2005, Dermatologic therapy.

Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans

T. G. Mitchell, J. Perfect, T G Mitchell, 1995, Clinical microbiology reviews.

Assessing the antimicrobial activity of zinc oxide thin films using disk diffusion and biofilm reactor

J. Perfect, R. Narayan, N. Monteiro-Riviere, 2009 .

New potential targets for antifungal development

Matthew R. Redinbo, J. Perfect, M. Redinbo, 2000 .

Treatment of methicillin-resistant Staphylococcus aureus infections with quinupristin–dalfopristin in patients intolerant of or failing prior therapy

J. Perfect, G. Talbot, R. Drew, 2000 .

In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp.

M. Del Poeta, J. Perfect, D. Boykin, 1999, The Journal of antimicrobial chemotherapy.

Diagnosis and treatment of oropharyngeal candidiasis in patients infected with HIV: a critical reassessment.

J. Perfect, W. Powderly, K. Mayer, 1999, AIDS research and human retroviruses.

In Vitro Antifungal Activities of a Series of Dication-Substituted Carbazoles, Furans, and Benzimidazoles

M. Del Poeta, J. Perfect, Arvind Kumar, 1998, Antimicrobial Agents and Chemotherapy.

The Cryptococcus neoformans Catalase Gene Family and Its Role in Antioxidant Defense

F. Dietrich, J. Perfect, J. Stajich, 2006, Eukaryotic Cell.

The antifungal pipeline: a reality check

J. Perfect, 2017, Nature Reviews Drug Discovery.

Novel modes of antifungal drug administration

J. Perfect, R. Drew, R. R. Arthur, 2004, Expert opinion on investigational drugs.

The spectrum of fungi that infects humans.

A. Casadevall, J. Perfect, J. Köhler, 2014, Cold Spring Harbor perspectives in medicine.

Is it time to abandon the use of amphotericin B bladder irrigation?

J. Perfect, R. Drew, R. R. Arthur, 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Resistance to Antifungal Agents: Mechanisms and Clinical Impact

John R Perfect, Zeina A Kanafani, J. Perfect, 2008 .

Strategies to manage antifungal drug resistance

J. Perfect, H. Tseng, 2011, Expert opinion on pharmacotherapy.

Cryptococcus neoformans: A Molecular Model for the Study of Fungal Pathogenesis and Drug Discovery in the Genomic Era

J. Lodge, J. Perfect, 2002 .

Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target.

J. Heitman, M. Del Poeta, J. Perfect, 1999, Genetics.

Combination Antifungal Therapy

J. Perfect, Melissa D. Johnson, J. Rex, 2004, Antimicrobial Agents and Chemotherapy.

Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America.

J. Perfect, M. Saag, J. Sobel, 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Cerebral phaeohyphomycosis in an immunodeficient child treated medically with combination antifungal therapy.

J. Perfect, J. Kurtzberg, Jane V. Trinh, 2003, Medical mycology.

Successful treatment of cryptococcal ventriculoatrial shunt infection with systemic therapy alone.

A. Friedman, J. Perfect, S. S. Yadav, 1988, Neurosurgery.

Fatal, disseminated Acremonium strictum infection in a neutropenic host

J. Perfect, W. Schell, 1996, Journal of clinical microbiology.

Pneumonia due to Fonsecaea pedrosoi and cerebral abscesses due to Emericella nidulans in a bone marrow transplant recipient.

J. Perfect, W. Schell, A. Morris, 1995, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Cutaneous infection caused by Curvularia pallescens: a case report and review of the spectrum of disease.

J. Perfect, W. Schell, D. Berg, 1995, Journal of the American Academy of Dermatology.

First report of involvement of Nodulisporium species in human disease

J. Perfect, W. Schell, G. Cox, 1994, Journal of clinical microbiology.

Phaeohyphomycoses (Brown-Black Moulds)

J. Perfect, B. Alexander, W. Schell, 2011 .

Superoxide Dismutase Influences the Virulence of Cryptococcus neoformans by Affecting Growth within Macrophages

A. Casadevall, J. Perfect, C. Taborda, 2003, Infection and Immunity.

Tolerability profile of the current antifungal armoury

J. Perfect, A. Mourad, 2018, The Journal of antimicrobial chemotherapy.

Fungi that Infect Humans.

A. Casadevall, J. Perfect, J. Köhler, 2017, Microbiology spectrum.

Fatal Scopulariopsis brevicaulis infection in a paediatric stem-cell transplant patient treated with voriconazole and caspofungin and a review of Scopulariopsis infections in immunocompromised patients.

J. Perfect, J. Miller, W. Schell, 2004, The Journal of infection.

Cryptococcosis diagnosis and treatment: What do we know now.

J. Perfect, T. Bicanic, 2015, Fungal genetics and biology : FG & B.

Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.

J. Perfect, Nina Singh, J. Sobel, 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages.

J. Perfect, D. Durack, J. Hibbs, 1990, The Journal of clinical investigation.

Alopecia Associated with Fluconazole Therapy

J. Perfect, J. Sobel, D. Bamberger, 1995, Annals of Internal Medicine.

Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever.

E. Anaissie, J. Perfect, J. Wingard, 2002, The New England journal of medicine.

Caspofungin for the treatment of azole resistant candidemia in a premature infant

J. Perfect, P. Smith, W. Schell, 2007, Journal of Perinatology.

Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis

J. Perfect, D. Durack, L. Cobo, 1987, Antimicrobial Agents and Chemotherapy.

Antifungal Resistance Trends Towards the Year 2000

J. Perfect, B. Alexander, 1997, Drugs.

Dematiaceous fungi mimicking a conjunctival melanoma.

J. Perfect, W. Schell, W. Fowler, 2013, Ophthalmic plastic and reconstructive surgery.

Isavuconazole for treatment of rare invasive fungal diseases

J. Perfect, G. Rahav, F. Marty, 2018, Mycoses.

Adverse Drug Reactions to Systemic Antifungals

J. Perfect, R. Drew, Myra H. Lindsay, 1992, Drug safety.

Treatment of experimental cryptococcal meningitis with amphotericin B, 5-fluorocytosine, and ketoconazole.

J. Perfect, D. Durack, 1982, The Journal of infectious diseases.

Antifungal therapy 1989

J. Perfect, 1989 .

Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial.

J. Perfect, C. White, R. Greene, 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Uptake of itraconazole by alveolar macrophages

J. Perfect, D. Durack, D. Savani, 1993, Antimicrobial Agents and Chemotherapy.

Scedosporium prolificans Osteomyelitis in an Immunocompetent Child Treated with Voriconazole and Caspofungin, as Well as Locally Applied Polyhexamethylene Biguanide

J. Perfect, W. Schell, W. Steinbach, 2003, Journal of Clinical Microbiology.

Management of phaeohyphomycosis

J. Perfect, A. Mourad, 2019, Antifungal Therapy.

Orbitofascial conidiobolomycosis in a child.

J. Perfect, S. Al-Hajjar, S. Kayes, 1996, The Pediatric infectious disease journal.

Genetic Requirements for Virulence in Cryptococcus neoformans

J. Perfect, 2004 .

Fungal virulence genes as targets for antifungal chemotherapy

J. Perfect, 1996, Antimicrobial agents and chemotherapy.

Pharmacokinetics and Pharmacodynamics of Fluconazole for Cryptococcal Meningoencephalitis: Implications for Antifungal Therapy and In Vitro Susceptibility Breakpoints

J. Perfect, T. Harrison, P. Warn, 2013, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and Pharmacodynamics of Fluconazole For

J. Perfect, T. Harrison, P. Warn, 2013 .

Treatment of experimental disseminated candidiasis with cilofungin

J. Perfect, D. Durack, K. Wright, 1989, Antimicrobial Agents and Chemotherapy.

Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence

Christina A. Cuomo, A. Casadevall, J. Perfect, 2020, mBio.

Noninvasive Testing and Surrogate Markers in Invasive Fungal Diseases

J. Perfect, D. Boulware, E. Mylonakis, 2022, Open forum infectious diseases.

Efficacy of an Abbreviated Induction Regimen of Amphotericin B Deoxycholate for Cryptococcal Meningoencephalitis: 3 Days of Therapy Is Equivalent to 14 Days

J. Perfect, Werner Müller, T. Harrison, 2014, mBio.

Candida glabrata endophthalmitis following penetrating keratoplasty.

J. Perfect, A. Proia, M. Caldwell, 2009, Journal of cataract and refractive surgery.

A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.

C. Hamilton, J. Perfect, Melissa D. Johnson, 2003, The Journal of antimicrobial chemotherapy.

Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement

J. Perfect, R. Drew, 2022, Journal of fungi.

Prophylactic intravenous amphotericin B in neutropenic autologous bone marrow transplant recipients.

G. Rosner, J. Perfect, C. Gilbert, 1992, The Journal of infectious diseases.

Amphotericin B lipid complex in the treatment of experimental cryptococcal meningitis and disseminated candidosis.

J. Perfect, K. Wright, 1994, The Journal of antimicrobial chemotherapy.

Cryptococcus gattii Virulence Composite: Candidate Genes Revealed by Microarray Analysis of High and Less Virulent Vancouver Island Outbreak Strains

J. Perfect, T. Sorrell, W. Meyer, 2011, PloS one.

Comparison of In Vitro Activities of Camptothecin and Nitidine Derivatives against Fungal and Cancer Cells

J. Heitman, M. Del Poeta, J. Perfect, 1999, Antimicrobial Agents and Chemotherapy.

Mucormycosis Rhinosinusitis at Diagnosis of Acute Lymphoblastic Leukemia: Diagnostics and Management Challenges in a Low–Middle-income Country

J. Perfect, M. Caniza, Kyle M Johnson, 2015, Journal of pediatric hematology/oncology.

Candida meningitis in two children with severe combined immunodeficiency.

J. Perfect, H. Sampson, C. Wilfert, 1984, The Journal of pediatrics.

Fungal infections of the bones and joints

J. Perfect, Melissa D. Johnson, 2001, Current infectious disease reports.

Curvularia alcornii Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature

J. Perfect, B. Alexander, W. Schell, 2021, Open forum infectious diseases.

Evaluation of in vitro antifungal activity of LY121019

J. Perfect, D. Durack, M. Hobbs, 1988, European Journal of Clinical Microbiology and Infectious Diseases.

Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients.

J. Perfect, M. Neely, T. Harrison, 2013, The Journal of infectious diseases.

Novel Treatment of Cryptococcal Meningitis via Neurapheresis Therapy

Lefko T. Charalambous, J. Perfect, S. Lad, 2018, The Journal of infectious diseases.

A Novel Therapeutic Approach for Cryptococcal Meningitis

J. Perfect, S. Lad, C. Giamberardino, 2016 .

AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial

J. Perfect, J. Changalucha, J. Jarvis, 2015, Trials.

Emerging Issues in Antifungal Resistance.

J. Perfect, M. Ghannoum, 2020, Infectious disease clinics of North America.

Comparison and Temporal Trends of Three Groups with Cryptococcosis: HIV-Infected, Solid Organ Transplant, and HIV-Negative/Non-Transplant

J. Perfect, T. Stürmer, J. Juliano, 2012, PloS one.

Cryptococcosis

J. Perfect, E. Maziarz, 2014, Infectious disease clinics of North America.

In Vitro and In Vivo Efficacies of the New Triazole Albaconazole against Cryptococcus neoformans

J. Perfect, J. Miller, W. Schell, 2004, Antimicrobial Agents and Chemotherapy.

In vitro and in vivo efficacies of the azole SCH56592 against Cryptococcus neoformans

J. Perfect, R. Dodge, W. Schell, 1996, Antimicrobial agents and chemotherapy.

Posaconazole’s impact on prophylaxis and treatment of invasive fungal infections: an update

J. Perfect, R. Drew, Winter J. Smith, 2009, Expert review of anti-infective therapy.

Phenotypic and genotypic evaluation of fluconazole resistance in vaginal Candida strains isolated from HIV-infected women from Brazil.

J. Perfect, G. Cox, C. R. Paula, 2005, Medical mycology.

Newer antifungal therapy for emerging fungal pathogens.

J. Perfect, W. Steinbach, 2003, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Pulmonary blastomycosis presenting as primary lung cancer

J. Perfect, W. Schell, N. Thielman, 2018, BMC Infectious Diseases.

Phase 1b Study of New Posaconazole Tablet for Prevention of Invasive Fungal Infections in High-Risk Patients with Neutropenia

J. Perfect, H. Waskin, A. Langston, 2014, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics of Posaconazole Administered Orally or by Nasogastric Tube in Healthy Volunteers

Jay B. Varkey, J. Perfect, G. Krishna, 2009, Antimicrobial Agents and Chemotherapy.

Posaconazole as Salvage Therapy in Patients With Invasive Fungal Infections After Solid Organ Transplant

J. S. Daly, J. Perfect, B. Alexander, 2008, Transplantation.

Isavuconazole for treatment of invasive fungal diseases caused by more than one fungal species

J. Perfect, G. Rahav, F. Marty, 2018, Mycoses.

Real-Time Treatment Guidelines: Considerations during the Exserohilum rostratum Outbreak in the United States

J. Perfect, D. Kontoyiannis, T. Chiller, 2013, Antimicrobial Agents and Chemotherapy.

Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches.

J. Perfect, B. Alexander, 1997, Drugs.

In Vitro and In Vivo Efficacy of the Triazole TAK-187 against Cryptococcus neoformans

J. Perfect, R. Dodge, W. Schell, 1998, Antimicrobial Agents and Chemotherapy.

CHAPTER 2 – Recent advances in understanding human opportunistic fungal pathogenesis mechanisms

J. Perfect, R. Cramer, 2009 .

264 – Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii)

J. Perfect, 2015 .

Brain abscess caused by a variety of cladosporium trichoides.

J. Perfect, J. Hamilton, K. Kwon-Chung, 1983, American journal of clinical pathology.

Uncommon invasive fungal pathogens in the acquired immunodeficiency syndrome.

J. Perfect, W. Schell, M. Rinaldi, 1993, Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology.

Cryptococcal ventricular-peritoneal shunt infection: clinical and epidemiological evaluation of two closely associated cases.

R. Allen, J. Perfect, H. Haywood, 1993 .

Cryptococcal Ventricular-Peritoneal Shunt Infection: Clinical and Epidemiological Evaluation of Two Closely Associated Cases

R. Allen, J. Perfect, H. Haywood, 1993, Infection Control & Hospital Epidemiology.

Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection

J. Perfect, J. Kronstad, G. Hu, 2008, Molecular microbiology.

Calcineurin is required for virulence of Cryptococcus neoformans

J. Heitman, J. Perfect, D. Toffaletti, 1997, The EMBO journal.

Protection against Cryptococcosis by Using a Murine Gamma Interferon-Producing Cryptococcus neoformans Strain

J. Perfect, G. Cox, C. Steele, 2007, Infection and Immunity.

IRIS and Fungal Infections: What Have We Learned?

J. Perfect, E. Maziarz, J. R. Perfect, 2012, Current Fungal Infection Reports.

Immune reconstitution syndrome associated with opportunistic mycoses.

J. Perfect, N. Singh, 2007, The Lancet. Infectious diseases.

Azoles: back to the future

J. Perfect, John R. Perfect, 2011 .

New antifungal agents.

J. Perfect, 2002, Transplant infectious disease : an official journal of the Transplantation Society.

Retrospective review of amphotericin B use in a tertiary-care medical center.

J. Perfect, W. Pickard, M. H. Gross, 1987, American journal of hospital pharmacy.

Management of injuries caused by Cryptococcus neoformans--contaminated needles.

A. Casadevall, J. Perfect, J. Mukherjee, 1994, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Design of aerosolized amphotericin b formulations for prophylaxis trials among lung transplant recipients.

J. Perfect, R. Drew, E. D. Dodds Ashley, 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients

J. Perfect, D. Benjamin, S. Palmer, 2004, Transplantation.

SAFETY OF AEROSOLIZED AMPHOTERICIN B LIPID COMPLEX IN LUNG TRANSPLANT RECIPIENTS12

J. Perfect, V. Tapson, S. Palmer, 2001, Transplantation.

Candidal anastomotic infection in lung transplant recipients: successful treatment with a combination of systemic and inhaled antifungal agents.

J. Perfect, D. Howell, V. Tapson, 1998, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Candidemia in women with breast carcinoma treated with high‐dose chemotherapy and autologous bone marrow transplantation

J. Perfect, W. Schell, J. Vredenburgh, 2003, Cancer.

Pharmacokinetics of N-formimidoyl thienamycin and influence of a renal dipeptidase inhibitor in experimental meningitis.

J. Perfect, D. Durack, D. Washburn, 1983, The Journal of antimicrobial chemotherapy.

Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi.

Thomas J. Walsh, J. Perfect, D. Kontoyiannis, 2017, The Journal of infectious diseases.

824An Open-Label Phase 3 Study of Isavuconazole (VITAL): Focus on Mucormycosis

J. Perfect, G. Rahav, F. Marty, 2014, Open Forum Infectious Diseases.

Recent advances in the treatment of life-threatening, invasive fungal infections

Steven W. Johnson, J. Perfect, R. Drew, 2013, Expert opinion on pharmacotherapy.

Fungal scleritis after cataract surgery. Successful outcome using itraconazole.

J. Perfect, G. Foulks, A. Carlson, 1992, Cornea.

The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries

J. Perfect, D. Seidel, J. Meis, 2022, The Lancet Microbe.

Soft‐Tissue Fungal Infections: Surgical Management of 12 Immunocompromised Patients

J. Perfect, W. Schell, D. Serafin, 1996, Plastic and reconstructive surgery.

Aspergillus fumigatus Empyema, Arthritis, and Calcaneal Osteomyelitis in a Lung Transplant Patient Successfully Treated with Posaconazole

J. Perfect, M. Steele, E. Ashley, 2004, Journal of Clinical Microbiology.

Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans.

John R Perfect, Y. Hannun, M. Del Poeta, 2003, The Journal of clinical investigation.

Effects of cyclosporine in experimental cryptococcal meningitis

J. Perfect, D. Durack, 1985, Infection and immunity.

The (1,3)β-d-Glucan Test as an Aid to Early Diagnosis of Invasive Fungal Infections following Lung Transplantation

J. Perfect, B. Alexander, P. Smith, 2010, Journal of Clinical Microbiology.

Fungal Meningitis

J. Perfect, M. Gottfredsson, Magnús Gottfredsson1,2, 2000, Seminars in neurology.

Small intestinal histoplasmosis: successful treatment with itraconazole in an immunocompetent host.

M. Washington, J. Perfect, K. Bodily, 1996, Gastrointestinal endoscopy.

A global call for talaromycosis to be recognised as a neglected tropical disease.

J. Chan, K. Yuen, J. Perfect, 2021, The Lancet. Global health.

Outcomes of cryptococcosis in renal transplant recipients in a less‐resourced health care system

J. Perfect, J. Medina-Pestana, A. Colombo, 2018, Transplant infectious disease : an official journal of the Transplantation Society.

Liposomal amphotericin B: clinical experience and perspectives

John R Perfect, J. Perfect, R. Drew, 2005, Expert review of anti-infective therapy.

Role of Classic Dimorphic Pathogens in Contemporary Mycoses

J. Perfect, 1994 .

Inkjet Printing of Amphotericin B onto Biodegradable Microneedles Using Piezoelectric Inkjet Printing

Philip R. Miller, Roger J. Narayan, Ryan D. Boehm, 2013 .

Pulmonary cryptococcosis in patients without HIV infection: factors associated with disseminated disease

A. Zaas, J. Perfect, D. Haas, 2008, European Journal of Clinical Microbiology & Infectious Diseases.

Cryptococcal meningitis with normal cerebrospinal fluid.

J. Perfect, W. Schell, S. Shaunak, 1989, The Journal of infectious diseases.

Calcineurin is essential for survival during membrane stress in Candida albicans

Joseph Heitman, John R Perfect, J. Heitman, 2002, The EMBO journal.

Penile cryptococcosis with review of mycotic infections of penis.

J. Perfect, B. Seaworth, 1985, Urology.

Amphotericin B-induced malignant hypertensive episodes.

J. Perfect, C. Dukes, 1990, The Journal of infectious diseases.

Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam

P. Ashton, S. Baker, J. Perfect, 2020, Medical mycology.

Immunosuppressive and Nonimmunosuppressive Cyclosporine Analogs Are Toxic to the Opportunistic Fungal Pathogen Cryptococcus neoformans via Cyclophilin-Dependent Inhibition of Calcineurin

J. Heitman, M. Cárdenas, M. Del Poeta, 2000, Antimicrobial Agents and Chemotherapy.

Immunology of infection caused by Cryptococcus neoformans.

J. Perfect, F. Wormley, 2005, Methods in molecular medicine.

Morphologic criteria for the preliminary identification of Fusarium, Paecilomyces, and Acremonium species by histopathology.

J. Perfect, W. Schell, D. Howell, 1998, American journal of clinical pathology.

Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM.

J. Perfect, L. Pagano, D. Seidel, 2021, The Lancet. Infectious diseases.

Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis

J. Heitman, F. Ausubel, J. Perfect, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Comparison of Cryptococcus gattii/neoformans Species Complex to Related Genera (Papiliotrema and Naganishia) Reveal Variances in Virulence Associated Factors and Antifungal Susceptibility

J. Perfect, G. M. Chaves, A. C. Padovan, 2021, Frontiers in Cellular and Infection Microbiology.

Cryptococcus neoformans α Strains Preferentially Disseminate to the Central Nervous System during Coinfection

T. G. Mitchell, J. Heitman, A. Casadevall, 2005, Infection and Immunity.

Use of Antifungal Combination Therapy: Agents, Order, and Timing

J. Perfect, Melissa D. Johnson, John R. Perfect, 2010, Current fungal infection reports.

Outcome of lung transplantation in patients with mycetomas.

J. Perfect, V. Tapson, S. Palmer, 2002, Chest.

A Glucan Synthase FKS1 Homolog inCryptococcus neoformans Is Single Copy and Encodes an Essential Function

J. Perfect, Weili Li, John R. Thompson, 1999, Journal of bacteriology.

Black mold takes hold and story told

J. Perfect, W. Schell, J. Messina, 2020, Medical mycology case reports.

Candida Endophthalmitis: Who Is Looking?

J. Perfect, 2007 .

Cost of Invasive Fungal Infections in the Era of New Diagnostics and Expanded Treatment Options

M. Prasad, J. Perfect, Melissa D. Johnson, 2012, Pharmacotherapy.

Novel Use of a Swimming Pool Biocide in the Treatment of a Rare Fungal Mastoiditis

J. Perfect, W. Schell, G. Hulka, 2005, The Laryngoscope.

Intervertebral diskitis due to Candida tropicalis.

J. Perfect, W. Herzog, L. Roberts, 1989, Southern medical journal.

Genomic characterization of recurrent mold infections in thoracic transplant recipients

Christina A. Cuomo, J. Perfect, B. Alexander, 2018, Transplant infectious disease : an official journal of the Transplantation Society.

Cryptococcus neoformans Gene Expression during Experimental Cryptococcal Meningitis

M. Marra, Steven J. M. Jones, J. Perfect, 2003, Eukaryotic Cell.

CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.

M. Jaeger, M. Netea, J. Perfect, 2013, The Journal of clinical investigation.

Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections

J. Heitman, J. Perfect, W. Steinbach, 2007, Nature Reviews Microbiology.

Physical Defenses and Nonspecific Immunity

A. Casadevall, J. Perfect, 1998 .

Association of plasma levels of human immunodeficiency virus type 1 RNA and oropharyngeal Candida colonization.

J. Perfect, G. Cox, A. Heald, 1999, The Journal of infectious diseases.

Combination Therapy for Invasive Fungal Infections

J. Perfect, R. Drew, Spencer J. Livengood, 2020, Current Fungal Infection Reports.

Management of an Outbreak of Exophiala dermatitidis Bloodstream Infections at an Outpatient Oncology Clinic.

J. Perfect, S. Lockhart, A. Litvintseva, 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The economic costs to United States hospitals of invasive fungal infections in transplant patients.

Joseph Menzin, John R Perfect, J. Perfect, 2011, American journal of infection control.

Anastomotic infections in lung transplant recipients.

J. Perfect, D. Howell, V. Tapson, 2000, Annals of transplantation.

Posaconazole Exhibits In Vitro and In Vivo Synergistic Antifungal Activity with Caspofungin or FK506 against Candida albicans

J. Heitman, J. Perfect, A. Averette, 2013, PloS one.

Clinical effectiveness of posaconazole versus fluconazole as antifungal prophylaxis in hematology–oncology patients: a retrospective cohort study

J. Perfect, Melissa D. Johnson, P. Saha-Chaudhuri, 2014, Cancer medicine.

Calcineurin Controls Growth, Morphology, and Pathogenicity in Aspergillus fumigatus

William R. Kirkpatrick, Joseph Heitman, Daniel K. Benjamin, 2006, Eukaryotic Cell.

Calcineurin Is Essential for Candida albicans Survival in Serum and Virulence

Joseph Heitman, Scott G. Filler, Wiley A. Schell, 2003, Eukaryotic Cell.

Risk factors for mortality in patients with mucormycosis.

J. Perfect, B. Spellberg, D. Kontoyiannis, 2012, Medical mycology.

Update on epidemiology of and preventive strategies for invasive fungal infections in cancer patients.

J. Perfect, J. Wingard, R. Hachem, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Next generation multilocus sequence typing (NGMLST) and the analytical software program MLSTEZ enable efficient, cost-effective, high-throughput, multilocus sequencing typing.

T. G. Mitchell, J. Perfect, Yuan Chen, 2015, Fungal genetics and biology : FG & B.

Early treatment of candidemia in adults: a review.

J. Perfect, B. Kullberg, E. Bow, 2011, Medical mycology.

Real-world implications of QT prolongation in patients receiving voriconazole and amiodarone

J. Perfect, Melissa D. Johnson, A. Mourad, 2018, The Journal of antimicrobial chemotherapy.

INVASIVE FUNGAL infections

J. Perfect, 2007 .

Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib

J. Perfect, D. Kontoyiannis, J. Messina, 2017, Open forum infectious diseases.

Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis

A. Zaas, D. Schwartz, J. Perfect, 2008, PLoS genetics.

Complete Genome Sequences for Two Talaromyces marneffei Clinical Isolates from Northern and Southern Vietnam

P. Ashton, J. Perfect, Terrance P. Shea, 2020, Microbiology Resource Announcements.

Efficacy of immune therapy in early experimental Naegleria fowleri meningitis

J. Perfect, D. Durack, S. Reiner, 1987, Infection and immunity.

Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development

J. Perfect, R. Brennan, S. Puttikamonkul, 2017, Microbiology and Molecular Biology Reviews.

Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana

T. G. Mitchell, J. Perfect, Liuyang Wang, 2015, Molecular ecology.

Cryptococcus neoformans Differential Gene Expression Detected In Vitro and In Vivo with Green Fluorescent Protein

J. Heitman, M. Del Poeta, J. Perfect, 1999, Infection and Immunity.

Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusion.

J. Perfect, D. Toffaletti, 1997, Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology.

Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans.

J. Lodge, J. Perfect, J. Gordon, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Reply to Argüelles

J. Perfect, 2017, Virulence.

Trehalose pathway as an antifungal target

John R Perfect, J. Perfect, R. Brennan, 2017, Virulence.

Antisense repression in Cryptococcus neoformans as a laboratory tool and potential antifungal strategy.

J. Perfect, G. Cox, H. C. McDade, 2002, Microbiology.

Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct.

J. Heitman, J. Perfect, P. Wang, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Pharmacology and Cancer Biology, 2 Microbiology And

J. Heitman, M. Cárdenas, J. Perfect, 2022 .

The Hsp90 Co-Chaperone Sgt1 Governs Candida albicans Morphogenesis and Drug Resistance

A. Zaas, J. Perfect, L. Cowen, 2012, PloS one.

Mating-Type-Specific and Nonspecific PAK Kinases Play Shared and Divergent Roles in Cryptococcus neoformans

J. Heitman, M. Cárdenas, J. Perfect, 2002, Eukaryotic Cell.

RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans

J. Heitman, J. Perfect, J. Alspaugh, 2000, Molecular microbiology.

The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans.

J. Heitman, J. Perfect, P. Wang, 1999, Genetics.

Survival in Serum and Virulence Albicans Candida Calcineurin Is Essential For

J. Heitman, J. Perfect, W. Schell, 2022 .

Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation

Jacqueline E. Schein, Ian A. Wood, Tristan Rossignol, 2014, PLoS genetics.

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

Christina A. Cuomo, A. Casadevall, J. Perfect, 2017, bioRxiv.

Identification of Cryptococcus neoformans Temperature-Regulated Genes with a Genomic-DNA Microarray

P. R. Kraus, J. Heitman, F. Dietrich, 2004, Eukaryotic Cell.

Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System

Christina A. Cuomo, J. Perfect, C. Cuomo, 2021, mBio.

The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries

J. Perfect, M. Hoenigl, O. Cornely, 2021 .

Copy number variation contributes to cryptic genetic variation in outbreak lineages of Cryptococcus gattii from the North American Pacific Northwest

Jacob L. Steenwyk, J. Perfect, J. Steenwyk, 2016, BMC Genomics.

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

A. Bartesaghi, M. Borgnia, B. Haynes, 2021, Cell.

Deferoxamine treatment as a risk factor for zygomycete infection.

J. Perfect, S. Manzi, A. Herzberg, 1989, The Journal of infectious diseases.

Adenylyl Cyclase Functions Downstream of the Gα Protein Gpa1 and Controls Mating and Pathogenicity of Cryptococcus neoformans

J. Heitman, J. Perfect, J. Kronstad, 2002, Eukaryotic Cell.

Toshiaki neoformans Cryptococcus and Pathogenicity of Protein Gpa 1 and Controls Mating α the G Adenylyl Cyclase Functions Downstream

J. Heitman, J. Perfect, J. Kronstad, 2002 .

Sequential prophylactic oral and empiric once-daily parenteral antibiotics for neutropenia and fever after high-dose chemotherapy and autologous bone marrow support.

J. Perfect, J. Vredenburgh, M. Ross, 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Pharmacokinetics of cefoperazone, moxalactam, cefotaxime, trimethoprim and sulphamethoxazole in experimental meningitis.

J. Perfect, D. Durack, 1981, The Journal of antimicrobial chemotherapy.

CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival

M. Jaeger, M. Netea, J. Perfect, 2016, Science Translational Medicine.

Peroxisome Function Regulates Growth on Glucose in the Basidiomycete Fungus Cryptococcus neoformans

J. Heitman, J. Perfect, A. Idnurm, 2006, Eukaryotic Cell.

Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans

J. Heitman, J. Perfect, D. Fox, 2000, The EMBO journal.

Autophagy is redundant for the host defense against systemic Candida albicans infections

R. Xavier, S. Smeekens, M. Oosting, 2014, European Journal of Clinical Microbiology & Infectious Diseases.

First Reported Case of Cryptococcus gattii in the Southeastern USA: Implications for Travel-Associated Acquisition of an Emerging Pathogen

J. Heitman, J. Perfect, D. Carter, 2009, PloS one.

Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis

J. Perfect, M. Schumacher, R. Brennan, 2016, Proceedings of the National Academy of Sciences.

Characterization and Regulation of the Trehalose Synthesis Pathway and Its Importance in the Pathogenicity of Cryptococcus neoformans

J. Perfect, U. Himmelreich, E. Mylonakis, 2006, Infection and Immunity.

Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.

J. Heitman, J. Perfect, J. Alspaugh, 1997, Genes & development.

Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR

J. Heitman, M. Cárdenas, M. Del Poeta, 2001, Antimicrobial Agents and Chemotherapy.

Clinical mycology today: A synopsis of the mycoses study group education and research consortium (MSGERC) second biennial meeting, September 27-30, 2018, Big Sky, Montana, a proposed global research agenda.

L. Pirofski, B. Jackson, R. Wynn, 2020, Medical mycology.

Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level

Christina A. Cuomo, J. Heitman, D. Lawson, 2017, Genetics.

Population genomics of Cryptococcus neoformans var. grubii reveals new biogeographic relationships and finely maps hybridization

Christina A. Cuomo, J. Heitman, D. Lawson, 2017, bioRxiv.

Cryptococcus neoformans Requires a Functional Glycolytic Pathway for Disease but Not Persistence in the Host

J. Perfect, J. Kronstad, G. Hu, 2011, mBio.

Pericarditis mediated by respiratory syncytial virus in a hematopoietic stem cell transplant patient

J. Perfect, M. Rubach, E.N. Pavlisko, 2013, Transplant infectious disease : an official journal of the Transplantation Society.

Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment.

F. Dietrich, M. Del Poeta, J. Perfect, 2003, Microbiology.

An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility

M. Jaeger, M. Oosting, L. Joosten, 2017, PloS one.

Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype

A. Casadevall, J. Perfect, F. Dromer, 2019, bioRxiv.

Comparing outcomes of early, late, and non-surgical management of intraspinal abscess

J. Perfect, S. Lad, Jichun Xie, 2017, Journal of Clinical Neuroscience.

Schistosoma haematobium in urine: Morphology with ThinPrep® method

J. Perfect, R. Dash, M. Waugh, 2007, Diagnostic cytopathology.

, against Fungal and Cancer Cells Camptothecin and Nitidine Derivatives Comparison of In Vitro Activities of

J. Heitman, M. Del Poeta, J. Perfect, 1999 .

The G-Protein β Subunit GPB1 Is Required for Mating and Haploid Fruiting in Cryptococcus neoformans

J. Heitman, J. Perfect, Ping-ping Wang, 2000, Molecular and Cellular Biology.

Antifungal resistance: the clinical front.

J. Perfect, 2004, Oncology.

In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus

J. Heitman, J. Perfect, W. Schell, 2004, Antimicrobial Agents and Chemotherapy.

Cases of disseminated cryptococcosis in intravenous drug abusers without HIV infection: A new risk factor?

J. Perfect, M. Shorman, Derek T P Evans, 2016, Medical mycology case reports.

Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans

J. Heitman, M. Cárdenas, J. Perfect, 2001, EMBO reports.

Hsp90 Orchestrates Temperature-Dependent Candida albicans Morphogenesis via Ras1-PKA Signaling

Aimee K. Zaas, Joseph Heitman, J. Heitman, 2009, Current Biology.

Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs.

J. Heitman, J. Perfect, W. Steinbach, 2003, Current opinion in investigational drugs.

In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus

J. Heitman, J. Perfect, W. Schell, 2004, Antimicrobial Agents and Chemotherapy.

Simple Strategy for Taming Membrane-Disrupting Antibiotics

J. Perfect, W. Schell, S. Regen, 2016, Bioconjugate chemistry.

Molecular Umbrella–Amphotericin B Conjugates

J. Perfect, W. Schell, C. Bienvenu, 2014, Bioconjugate chemistry.

Genome‐wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans

D. Thiele, H. Madhani, J. Perfect, 2018, Molecular Microbiology.

Rice grassy stunt (GSV) and rice ragged stunt (RSV) carriers.

J. Perfect, H. Hibino, Z. Flores, 1986 .

Performance of the T2Bacteria Panel for Diagnosing Bloodstream Infections

J. Perfect, M. Weinstein, E. Mylonakis, 2019, Annals of Internal Medicine.

A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans.

S. Smeekens, M. Jaeger, M. Oosting, 2019, The Journal of infectious diseases.

Phenotypic Variability Correlates with Clinical Outcome in Cryptococcus Isolates Obtained from Botswanan HIV/AIDS Patients

Christina A. Cuomo, J. Perfect, C. Cuomo, 2018, mBio.

Identification of environmental and genetic factors important for Cryptococcus neoformans titan cell formation using new in vitro inducing conditions

Christina A. Cuomo, A. Casadevall, J. Perfect, 2017 .

Deletion of Cryptococcus neoformans AIF Ortholog Promotes Chromosome Aneuploidy and Fluconazole-Resistance in a Metacaspase-Independent Manner

J. Heitman, C. P. Semighini, J. Perfect, 2011, PLoS pathogens.

Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia

R. Xavier, S. Smeekens, L. Joosten, 2014, Nature Communications.

Human genetic susceptibility to Candida infections.

L. Joosten, M. Netea, W. Scott, 2012, Medical mycology.

Cyclic AMP-Dependent Protein Kinase Controls Virulence of the Fungal Pathogen Cryptococcus neoformans

J. Heitman, J. Perfect, C. D'souza, 2001, Molecular and Cellular Biology.

Flame‐resistant Finishing of Cellulosic Fabrics with Phosphorus‐containing Resins

J. Perfect, 2008 .

Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia.

M. Oosting, L. Joosten, M. Netea, 2011, The Journal of infectious diseases.

Mycobacterium avium-intracellulare complex infections in the acquired immunodeficiency syndrome.

J. Perfect, 1988, Journal of electron microscopy technique.

A Novel Antifungal Strategy

M. Klepser, J. Perfect, G. Parameswaran, 2010 .

Paediatric bacterial meningitis in the USA: outcomes and healthcare resource utilization of nosocomial versus community-acquired infection.

Syed M. Adil, Lefko T. Charalambous, Beth A. Parente, 2020, Journal of medical microbiology.

Toll-like receptor 1 polymorphisms increase susceptibility to candidemia.

M. Oosting, L. Joosten, M. Netea, 2012, The Journal of infectious diseases.

Summer Resting Metabolic Rate of the Gray Squirrel

J. Perfect, Nathan J. Bolls, 1972, Physiological Zoology.

The significance of microbial cultures of the hematopoietic support for patients receiving high-dose chemotherapy.

J. Perfect, J. Vredenburgh, C. Gilbert, 1996, Journal of hematotherapy.

Disruption of a Nonribosomal Peptide Synthetase in Aspergillus fumigatus Eliminates Gliotoxin Production

William R. Kirkpatrick, Thomas F. Patterson, Laura K. Najvar, 2006, Eukaryotic Cell.

Cryptococcus neoformans Controls Virulence of the Fungal Pathogen Cyclic AMP-Dependent Protein Kinase

J. Heitman, J. Perfect, C. D'souza, 2001 .

A link between urease and polyamine metabolism in Cryptococcus neoformans.

J. Perfect, A. Botha, M. Stander, 2021, Microbial pathogenesis.

Approaches to Antifungal Therapies and Their Effectiveness among Patients with Cryptococcosis

J. Perfect, T. Stürmer, J. Juliano, 2013, Antimicrobial Agents and Chemotherapy.

Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination.

Michael J. Davis, J. Perfect, D. Meister, 2012, The American journal of pathology.

Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates.

J. Heitman, J. Perfect, G. Cox, 2003, Infection and immunity.

Rational Use of Antifungals for Invasive Fungal Infections in the Institutional Setting

J. Perfect, Melissa D. Johnson, R. Drew, 2004 .

Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus.

F. Dietrich, J. Perfect, J. Stajich, 2006, Gene.

Genomics of Cryptococcus neoformans

G. Dougan, S. Baker, J. Beardsley, 2018, bioRxiv.

Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans

G. Dougan, S. Baker, J. Beardsley, 2019, Nature Communications.

In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus Isolates from Transplant and Nontransplant Patients

Joseph Heitman, Daniel K. Benjamin, Nina Singh, 2004, Antimicrobial Agents and Chemotherapy.

Evidence-based scaling-up of evergreen agriculture for increasing crop productivity, fodder supply and resilience of the maize-mixed and agro-pastoral farming systems in Tanzania and Malawi

J. Perfect, M. Mpanda, S. G. Weldesemayat, 2012 .

Identification of a Cryptococcus neoformans gene that directs expression of the cryptic Saccharomyces cerevisiae mannitol dehydrogenase gene

J. Perfect, B. Wong, T. Rude, 1996, Journal of bacteriology.

On-demand release of Candida albicans biofilms from urinary catheters by mechanical surface deformation

J. Perfect, V. Fowler, S. Zauscher, 2016, Biofouling.

Inositol Metabolism Regulates Capsule Structure and Virulence in the Human Pathogen Cryptococcus neoformans

A. Casadevall, J. Perfect, C. Giamberardino, 2021, mBio.

Genetic Susceptibility to Fungal Infections: What is in the Genes?

J. Perfect, Melissa D. Johnson, S. Maskarinec, 2016, Current Clinical Microbiology Reports.

Correction: Comparison and Temporal Trends of Three Groups with Cryptococcosis: HIV-Infected, Solid Organ Transplant, and HIV-Negative/Non-Transplant

J. Perfect, T. Stürmer, J. Juliano, 2012, PLoS ONE.

Vitamin D deficiency in HIV-infected South Africans: Common, and not associated with susceptibility, immune response, or outcome in HIV-associated cryptococcal meningitis

J. Perfect, J. Jarvis, G. Meintjes, 2014 .

C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection

J. Perfect, M. McClain, J. Köhl, 2023, Cell.

Cost-effectiveness of posaconazole versus fluconazole for prevention of invasive fungal infections in U.S. patients with graft-versus-host disease.

M. Weinstein, J. Perfect, D. Thompson, 2012, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

Cryptococcus neoformans phospholipase B1 activates host cell Rac1 for traversal across the blood–brain barrier

J. Perfect, Yi Zheng, K. Kim, 2012, Cellular microbiology.

Human fungal pathogens : a subject collection from Cold Spring Harbor perspectives in medicine

J. Heitman, A. Casadevall, J. Perfect, 2015 .

Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

T. Kepler, A. Bartesaghi, M. Borgnia, 2020, bioRxiv.

Pleiotropic Effects of Deubiquitinating Enzyme Ubp5 on Growth and Pathogenesis of Cryptococcus neoformans

J. Perfect, W. Liao, M. Price, 2012, PloS one.

The Cryptococcus neoformans genome sequencing project

Arturo Casadevall, Joseph Heitman, J. Heitman, 1999, Mycopathologia.

Nitrogen Source-Dependent Capsule Induction in Human-Pathogenic Cryptococcus Species

J. Perfect, M. Price, D. Toffaletti, 2013, Eukaryotic Cell.

Cryptococcus Species Induction in Human-Pathogenic Nitrogen Source-Dependent Capsule

J. Perfect, M. Price, D. Toffaletti, 2014 .

Comparative Pharmacokinetics of Voriconazole Administered Orally as either Crushed or Whole Tablets

A. Zaas, J. Perfect, B. Damle, 2006, Antimicrobial Agents and Chemotherapy.

CASE STUDIES IN SERIOUS FUNGAL INFECTIONS

J. Perfect, 2022 .

The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections

M. Huynen, R. Xavier, S. Smeekens, 2015, European Journal of Clinical Microbiology & Infectious Diseases.

Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence

J. Heitman, F. Dietrich, J. Perfect, 2004, Current Genetics.

Specific Immunity and Cytokines

A. Casadevall, J. Perfect, 1998 .

Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity.

J. Perfect, D. Durack, D. Granger, 1986, Journal of immunology.

American Thoracic Society Documents an Official American Thoracic Society Statement: Treatment of Fungal Infections in Adult Pulmonary and Critical Care Patients Contents Introduction Methods Antifungal Agents: General Considerations Polyenes Triazoles Echinocandins Treatment of Fungal Infections Hi

N. Ampel, G. Sarosi, J. Perfect, 2022 .

Antifungal Therapy

J. Perfect, M. Ghannoum, 2019, Mader's Reptile and Amphibian Medicine and Surgery.

The Current State of Clinical Mycology in Eastern and South-Eastern Europe.

J. Perfect, J. Meis, V. Arsenijevic, 2022, Medical Mycology.

Diguanidino and “Reversed” Diamidino 2,5‐Diarylfurans as Antimicrobial Agents.

J. Perfect, W. Wilson, D. Boykin, 2001 .

Treatment of methicillin-resistant staphylococcus aureus infections with quinupristin-dalfopristin in patients intolerant of or failing prior therapy. For the Synercid Emergency-Use Study Group.

J. Perfect, G. Talbot, R. Drew, 2000, The Journal of antimicrobial chemotherapy.

Hormonal steroids bind the Neisseria gonorrhoeae multidrug resistance regulator, MtrR, to induce a multidrug binding efflux pump and stress-response sigma factor

G. A. Beggs, J. Perfect, W. Shafer, 2023, bioRxiv.

Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans

G. Dougan, J. Beardsley, J. Perfect, 2019, Nature Communications.

Tracing genetic exchange and biogeography of Cryptococcus neoformans var. 1 grubii at the global population level 2

J. Heitman, Matthew Fisher, D. Lawson, 2017 .

The longitudinal health economic impact of viral encephalitis in the United States.

Syed M. Adil, Lefko T. Charalambous, J. Perfect, 2020, Journal of medical microbiology.

Posaconazole vs Standard Azole (FLU/ITRA) Therapy for Prophylaxis of Invasive Fungal Infections (IFIs) among High-Risk Neutropenic Patients: Results of a Randomized, Multicenter Trial.

J. Perfect, T. Walsh, J. Maertens, 2005 .

Survival Defects of Cryptococcus neoformans Mutants Exposed to Human Cerebrospinal Fluid Result in Attenuated Virulence in an Experimental Model of Meningitis

J. Perfect, J. Thompson, E. Soderblom, 2010, Infection and Immunity.

J. Perfect, J. Wingard, T. Calandra, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.

M. Jaeger, M. Netea, J. Perfect, 2013, The Journal of clinical investigation.

Fungi that Infect Humans.

A. Casadevall, J. Perfect, J. Köhler, 2017, Microbiology spectrum.

Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans

J. Perfect, P. Williamson, K. Kwon-Chung, 1996, The Journal of experimental medicine.

Azole antifungals: 35 years of invasive fungal infection management

J. Perfect, R. Drew, D. Allen, 2015, Expert review of anti-infective therapy.

Cryptococcus gattii genotype VGI infection in New England.

J. Heitman, J. Perfect, E. Byrnes, 2011, The Pediatric infectious disease journal.

Invasive mould infections: a multi-disciplinary update.

J. Perfect, Nina Singh, T. Calandra, 2009, Medical mycology.

Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans.

Y. Hannun, M. Del Poeta, J. Perfect, 2003, The Journal of clinical investigation.

Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis

J. Perfect, W. Schell, C. Giamberardino, 2023, Antimicrobial agents and chemotherapy.

Cost of Invasive Fungal Infections in the Era of New Diagnostics and Expanded Treatment Options

M. Prasad, J. Perfect, Melissa D. Johnson, 2012, Pharmacotherapy.

Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria.

J. Perfect, S. Holland, J. Sobel, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Calcineurin Target CrzA Regulates Conidial Germination, Hyphal Growth, and Pathogenesis of Aspergillus fumigatus

J. Heitman, J. Perfect, Nadthanan Pinchai, 2008, Eukaryotic Cell.

Editorial: Antifungal Pipeline: Build It Strong; Build It Better!

M. Del Poeta, J. Perfect, L. Cowen, 2022, Frontiers in Cellular and Infection Microbiology.

Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in Cryptococcus neoformans

J. Perfect, Yee-Seul So, J. Fraser, 2019, mSphere.

Immune reconstitution syndrome associated with opportunistic mycoses.

J. Perfect, Nina Singh, 2007, The Lancet. Infectious diseases.

Immune reconstitution syndrome in a patient with disseminated histoplasmosis and steroid taper: maintaining the perfect balance

J. Perfect, S. Naggie, A. Jazwinski, 2011, Mycoses.

Phase I Evaluation of the Safety and Pharmacokinetics of Murine-Derived Anticryptococcal Antibody 18B7 in Subjects with Treated Cryptococcal Meningitis

A. Casadevall, J. Perfect, J. Aberg, 2005, Antimicrobial Agents and Chemotherapy.

The Triple Threat of Cryptococcosis: It’s the Body Site, the Strain, and/or the Host

J. Perfect, 2012, mBio.

A randomized, double-blind, placebo-controlled clinical trial of fluconazole as early empiric treatment of coccidioidomycosis pneumonia (Valley Fever) in adults presenting with community-acquired pneumonia in endemic areas (FLEET-Valley Fever)

N. Ampel, J. Perfect, E. Walter, 2021, Contemporary clinical trials communications.

NIAID Mycoses Study Group Multicenter Trial of Oral Itraconazole Therapy for Invasive Aspergillosis.

J. Perfect, D. Denning, J. Galgiani, 1994, The American journal of medicine.

Another case of cryptococcal meningitis in a person without HIV who injects drugs: A possible risk factor in need of further investigation

J. Perfect, Becky L. White, L. M. McCrary, 2022, Medical mycology case reports.

Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt.

J. S. Daly, A. Casadevall, I. Sia, 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Efficacy of Oral APX001 in a Murine Model of Cryptococcal Meningitis

J. Perfect, W. Schell, C. Giamberardino, 2017, Open Forum Infectious Diseases.

Survival Defects of Cryptococcus neoformans Mutants Exposed to Human Cerebrospinal Fluid Result in Attenuated Virulence in an Experimental Model of Meningitis

J. Perfect, J. Thompson, E. Soderblom, 2010, Infection and Immunity.

Next generation multilocus sequence typing (NGMLST) and the analytical software program MLSTEZ enable efficient, cost-effective, high-throughput, multilocus sequencing typing.

T. G. Mitchell, J. Perfect, Yuan Chen, 2015, Fungal genetics and biology : FG & B.

Efficient, Cost-Effective, High-Throughput, Multilocus Sequencing Typing (MLST) Method, NGMLST, and the Analytical Software Program MLSTEZ.

Yuan Chen, John R Perfect, J. Perfect, 2017, Methods in molecular biology.

Tissue Responses and Special Topics in Immunity

A. Casadevall, J. Perfect, 1998 .

Nitrogen Source-Dependent Capsule Induction in Human-Pathogenic Cryptococcus Species

J. Perfect, M. Price, D. Toffaletti, 2013, Eukaryotic Cell.