R. Cencic

发表

Structural conservation of druggable hot spots in protein–protein interfaces

Laurie E. Grove, S. Vajda, D. Kozakov, 2011, Proceedings of the National Academy of Sciences.

Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication

S. Vajda, R. Dingledine, D. Kozakov, 2011, Journal of Virology.

Foot-and-Mouth Disease Virus Leader Proteinase

R. Cencic, T. Skern, W. Glaser, 2001, The Journal of Biological Chemistry.

Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation

Thomas Eggermann, Jerry Pelletier, R. Cencic, 2016, Clinical Epigenetics.

Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations

R. Cencic, J. Pelletier, A. Pichlmair, 2017, Proceedings of the National Academy of Sciences.

Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response

A. Iavarone, R. Cencic, J. Pelletier, 2017, Endocrinology.

Enantioselective synthesis of the complex rocaglate (-)-silvestrol.

R. Cencic, J. Pelletier, J. Porco, 2007, Angewandte Chemie.

A CRISPR/Cas9 Functional Screen Identifies Rare Tumor Suppressors

R. Cencic, J. Pelletier, C. Scuoppo, 2016, Scientific Reports.

A cellular response linking eIF4AI activity to eIF4AII transcription.

R. Cencic, J. Pelletier, F. Robert, 2012, RNA.

A conserved homo-dimerization interface in human IFIT1 provides insights into IFIT interactome assembly

R. Cencic, J. Pelletier, B. Nagar, 2017, bioRxiv.

Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A.

R. Cencic, J. Pelletier, P. Teesdale-Spittle, 2021, Cell chemical biology.

Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival.

R. Cencic, J. Pelletier, M. Tremblay, 2012, Cancer research.

RNA-tethering assay and eIF4G:eIF4A obligate dimer design uncovers multiple eIF4F functional complexes

R. Cencic, J. Pelletier, T. Schmeing, 2020, Nucleic acids research.

Assessing eukaryotic initiation factor 4F subunit essentiality by CRISPR-induced gene ablation in the mouse

N. Sonenberg, R. Cencic, J. Pelletier, 2021, Cellular and Molecular Life Sciences.

Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions

N. Sonenberg, R. Cencic, J. Pelletier, 2020, Nucleic acids research.

A CRISPR-based Screen Links an Inhibitor of Nonsense-mediated Decay to eIF4A3 Target Engagement.

R. Cencic, J. Pelletier, S. Naineni, 2020, ACS chemical biology.

Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells.

M. Minden, R. Cencic, J. Pelletier, 2010, Leukemia research.

A cautionary note on the use of cap analogue affinity resins.

R. Cencic, J. Pelletier, 2018, Analytical biochemistry.

The binding of foot‐and‐mouth disease virus leader proteinase to eIF4GI involves conserved ionic interactions

R. Cencic, T. Skern, Nicole Foeger, 2005, The FEBS journal.

Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors.

S. Vajda, R. Cencic, D. Beglov, 2019, Cell chemical biology.

An Antiviral Peptide Inhibitor That Is Active against Picornavirus 2A Proteinases but Not Cellular Caspases

R. Cencic, L. Deszcz, E. Kuechler, 2006, Journal of Virology.

Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies.

R. Cencic, J. Pelletier, J. Porco, 2012, Journal of medicinal chemistry.

Biomimetic photocycloaddition of 3-hydroxyflavones: synthesis and evaluation of rocaglate derivatives as inhibitors of eukaryotic translation.

R. Cencic, J. Pelletier, J. Porco, 2010, Angewandte Chemie.

Residue L143 of the Foot-and-Mouth Disease Virus Leader Proteinase Is a Determinant of Cleavage Specificity

R. Cencic, D. Neubauer, Christina Mayer, 2008, Journal of Virology.

Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim

Jerry Pelletier, R. Cencic, J. Pelletier, 2015, BMC Cancer.

Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition.

R. Cencic, J. Pelletier, J. Porco, 2016, Chemistry.

A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter

Scott W. Simpkins, C. Myers, C. Bewley, 2017, Antimicrobial Agents and Chemotherapy.

Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.

Vamsee K Voora, Vamsee K. Voora, D. Mobley, 2017, Nature chemistry.

Targeting Translation Dependence in Cancer

R. Cencic, J. Pelletier, A. Malina, 2011, Oncotarget.

Effect of 2′-5′/3′-5′ phosphodiester linkage heterogeneity on RNA interference

R. Cencic, J. Pelletier, J. Rossi, 2020, Nucleic acids research.

Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation

R. Cencic, J. Pelletier, J. Chu, 2019, Scientific Reports.

Throwing a monkey wrench in the motor: targeting DExH/D box proteins with small molecule inhibitors.

R. Cencic, J. Pelletier, 2013, Biochimica et biophysica acta.

Rocaglates as dual-targeting agents for experimental cerebral malaria

R. Cencic, J. Pelletier, I. Crandall, 2018, Proceedings of the National Academy of Sciences.

CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A

R. Cencic, J. Pelletier, J. Chu, 2016, Cell reports.

Translation Inhibition by Rocaglates Is Independent of eIF4E Phosphorylation Status

R. Cencic, J. Pelletier, J. Chu, 2015, Molecular Cancer Therapeutics.

5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells.

A. Pertsemlidis, R. Kiss, R. Cencic, 2016, European journal of medicinal chemistry.

A comparative study of small molecules targeting eIF4A

R. Cencic, J. Pelletier, Abimael D Rodríguez, 2020, RNA.

CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary

W. Foulkes, B. Clarke, B. Vanderhyden, 2019, Nature Communications.

Establishment of a Primary Screening Assay for the DHX9 Helicase.

R. Cencic, J. Pelletier, P. Sénéchal, 2015, Combinatorial chemistry & high throughput screening.

c-Myc and eIF4F are components of a feedforward loop that links transcription and translation.

R. Cencic, J. Pelletier, J. Mills, 2008, Cancer research.

Tracing MYC Expression for Small Molecule Discovery.

R. Cencic, J. Pelletier, David E. Williams, 2019, Cell chemical biology.

Repurposing CRISPR/Cas9 for in situ functional assays

Josée Dostie, Yifei Yan, Jerry Pelletier, 2013, Genes & development.

Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage

Josée Dostie, T. Martin Schmeing, Jerry Pelletier, 2014, PloS one.

Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A

R. Cencic, J. Pelletier, F. Robert, 2013, Blood Cancer Journal.

Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation

R. Cencic, J. Pelletier, T. Eggermann, 2016, Clinical Epigenetics.

Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.

Ming Yan, R. Cencic, J. Pelletier, 2016, Cell reports.

Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A

R. Cencic, J. Pelletier, 2016, Translation.

Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F

S. Vajda, R. Dingledine, D. Kozakov, 2010, Proceedings of the National Academy of Sciences.

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

R. Cencic, J. Pelletier, M. Tremblay, 2009, PloS one.

Identifying small molecule inhibitors of eukaryotic translation initiation.

R. Cencic, J. Pelletier, F. Robert, 2007, Methods in enzymology.

Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma

R. Cencic, J. Pelletier, J. Haybaeck, 2021, Cells.

Internal translation initiation from HIV-1 transcripts is conferred by a common RNA structure

R. Cencic, J. Pelletier, J. Kieft, 2014, Translation.

Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance

R. Cencic, J. Pelletier, P. Gros, 2016, Cell Death and Differentiation.

Helicases implicated in general translation initiation — eIF 4 AI ( DDX 2 A ) , eIF

R. Cencic, J. Pelletier, G. Galicia-Vázquez, 2012 .

Inhibitors of translation targeting eukaryotic translation initiation factor 4A.

R. Cencic, J. Pelletier, G. Galicia-Vázquez, 2012, Methods in enzymology.

Blocking UV‐Induced eIF2α Phosphorylation with Small Molecule Inhibitors of GCN2

S. Burley, R. Cencic, J. Pelletier, 2009, Chemical biology & drug design.

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

Patrick B. F. O'Connor, R. Cencic, J. Pelletier, 2020, Cell reports.

Investigating the substrate specificity and oligomerisation of the leader protease of foot and mouth disease virus using NMR.

R. Cencic, R. Konrat, L. Juliano, 2007, Journal of molecular biology.

eIF4A Inhibitors Suppress Cell-Cycle Feedback Response and Acquired Resistance to CDK4/6 Inhibition in Cancer

W. Foulkes, R. Cencic, J. Pelletier, 2019, Molecular Cancer Therapeutics.

Foot-and-mouth disease virus leader proteinase: Structural insights into the mechanism of intermolecular cleavage

R. Cencic, L. Juliano, M. Juliano, 2014, Virology.

Synthesis of the antiproliferative agent hippuristanol and its analogues from hydrocortisone via Hg(II)-catalyzed spiroketalization: structure-activity relationship.

R. Cencic, J. Pelletier, P. Deslongchamps, 2014, Journal of medicinal chemistry.

A forward genetic screen identifies modifiers of rocaglate responsiveness

R. Cencic, J. Pelletier, Sidong Huang, 2021, Scientific Reports.

Selective Pharmacological Targeting of a DEAD Box RNA Helicase

R. Cencic, J. Pelletier, G. Wagner, 2008, PloS one.

CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary

W. Foulkes, B. Clarke, B. Vanderhyden, 2019, Nature Communications.

RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation.

R. Cencic, J. Pelletier, G. Wagner, 2006, Chemistry & biology.

Adapting CRISPR/Cas9 for functional genomics screens.

R. Cencic, J. Pelletier, F. Robert, 2014, Methods in enzymology.

Targeted genome editing in human cells using CRISPR/Cas nucleases and truncated guide RNAs.

Ken W. Y. Cho, J Keith Joung, Margaret B. Fish, 2014, Methods in enzymology.

Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication

S. Vajda, R. Dingledine, D. Kozakov, 2011, Journal of Virology.

Supplemental Information CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase , eIF 4 A

R. Cencic, J. Pelletier, J. Chu, 2022 .

C8ORF88: A Novel eIF4E-Binding Protein

R. Cencic, S. Naineni, Mehdi Amiri, 2023, Genes.

A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer

R. Cencic, A. Koromilas, T. Schmeing, 2024, Proceedings of the National Academy of Sciences of the United States of America.

Homogenous time resolved fluorescence assay to identify modulators of cap-dependent translation initiation.

R. Cencic, J. Pelletier, Yifei Yan, 2007, Combinatorial chemistry & high throughput screening.