M. Foley

发表

Systematic discovery of multicomponent therapeutics

J. Lehár, P. Schultz, B. Stockwell, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

Tudor I. Oprea, Jennifer E. Golden, Joshua A. Bittker, 2015, Cell.

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

T. Golub, P. Tamayo, K. Ross, 2016, Nature Biotechnology.

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.

Nathan T. Ross, Carol A. Mulrooney, Jeremy R. Duvall, 2010, Journal of the American Chemical Society.

A one-bead, one-stock solution approach to chemical genetics: part 2.

P. Clemons, D. Spring, M. Foley, 2001, Chemistry & biology.

A one-bead, one-stock solution approach to chemical genetics: part 1.

John A. Tallarico, M. Foley, J. Tallarico, 2001, Chemistry & biology.

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Richard Svensson, Giovanni Muncipinto, Fabrizio Giordanetto, 2014, Journal of medicinal chemistry.

An alkylsilyl-tethered, high-capacity solid support amenable to diversity-oriented synthesis for one-bead, one-stock solution chemical genetics.

John A. Tallarico, S. Schreiber, M. Foley, 2001, Journal of combinatorial chemistry.

Loss of immunoreactivity for human calmodulin-like protein is an early event in breast cancer development.

M. Foley, J. Ingle, P. Roche, 1999, Neoplasia.

Matrix metalloproteinase inhibitors containing a (carboxyalkyl)amino zinc ligand: modification of the P1 and P2' residues.

M. Foley, D. Drewry, F. Brown, 1994 .

Diversity-Oriented Synthesis-Facilitated Medicinal Chemistry: Toward the Development of Novel Antimalarial Agents

Carol A. Mulrooney, Jeremy R. Duvall, S. Schreiber, 2014, Journal of medicinal chemistry.

Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).

M. Foley, M. Fushimi, N. Liverton, 2021, ACS medicinal chemistry letters.

Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

M. Foley, T. Walz, J. Takagi, 2019, bioRxiv.

Rapid synthesis of novel dipeptide inhibitors of human collagenase and gelatinase using solid phase chemistry

M. Lambert, M. Foley, D. Drewry, 1996 .

Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.

Joshua A. Bittker, Jeremy R. Duvall, M. Foley, 2017, ACS infectious diseases.

Synthesis of stereochemically and skeletally diverse fused ring systems from functionalized C-glycosides.

Jeremy R. Duvall, M. Foley, L. A. Marcaurelle, 2013, The Journal of organic chemistry.

Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.

James R. Porter, J. Sydor, M. Foley, 2008, Journal of medicinal chemistry.

Anti-Tumor Activity of IPI-504, a Novel Hsp90 Inhibitor in Multiple Myeloma.

J. Sydor, M. Foley, C. Mitsiades, 2004 .

Development of a Multi Kilogram-Scale, Tandem Cyclopropanation Ring-Expansion Reaction en Route to Hedgehog Antagonist IPI-926

M. Foley, S. Peluso, J. Adams, 2016 .

Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.

Jeremy R. Duvall, S. Schreiber, Ana Rodriguez, 2014, ACS medicinal chemistry letters.

Matrix metalloproteinase inhibitors containing a (carboxyalkyl)amino zinc ligand: modification of the P1 and P2' residues.

M. Foley, D. Drewry, F. Brown, 1994, Journal of medicinal chemistry.

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies

S. Schreiber, M. Foley, M. Palmer, 2012, ACS medicinal chemistry letters.

Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.

Giovanni Muncipinto, Lakshmi B. Akella, Byung-Chul Suh, 2012, The Journal of organic chemistry.

A highly stereocontrolled, four-step synthesis of (.+-.)-lasubine II

M. Foley, D. Comins, Jack D. Brown, 1988 .

The addition of alkylzinc iodides to 1-(phenoxycarbonyl)-2,3-dihydropyridinium salts. A synthesis of 2-alkyl-Δ3-piperidines.

M. Foley, D. Comins, 1988 .

Metalation of 1,4-dihydropyridine esters

M. Foley, G. Poindexter, J. Licause, 1989 .

Isosteric replacement in a series of β-substituted monophosphonate calcium antagonists

J. G. Sarmiento, M. Foley, J. Buyniski, 1993 .

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

Benito Munoz, Stuart L. Schreiber, Takashi Yoshinaga, 2016, Nature.

Stereoselective Synthesis of over Two Million Compounds Having Structural Features Both Reminiscent of Natural Products and Compatible with Miniaturized Cell-Based Assays

Stuart L. Schreiber, Derek S. Tan, S. Schreiber, 1998 .

Synthesis and Preliminary Evaluation of a Library of Polycyclic Small Molecules for Use in Chemical Genetic Assays

Stuart L. Schreiber, Brent R. Stockwell, Derek S. Tan, 1999 .

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

M. Foley, P. Rosenthal, P. Bhanot, 2018, Proceedings of the National Academy of Sciences.

Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

T. Kapoor, M. Foley, A. Carter, 2017, eLife.

A chemical strategy toward novel brain-penetrant EZH2 inhibitors

M. Foley, A. Stamford, N. Liverton, 2021, bioRxiv.

Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells.

Jeremy R. Duvall, Julien C. Vantourout, M. Foley, 2018, MedChemComm.

Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors.

P. Clemons, S. Schreiber, M. Foley, 2002, Chemistry & biology.

Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Aβ-Fibrinogen Interaction and Aβ-Induced Contact System Activation.

M. Foley, S. Strickland, P. Singh, 2018, Biochemistry.

Diversity-Oriented Synthesis Probe Targets Plasmodium falciparum Cytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors

Carol A. Mulrooney, Jeremy R. Duvall, S. Schreiber, 2014, The Journal of infectious diseases.

Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen.

Carol A. Mulrooney, Jeremy R. Duvall, M. Foley, 2016, Antiviral research.

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

Menghang Xia, Christopher P. Austin, Michel Weïwer, 2011, ACS medicinal chemistry letters.

The evolving role of molecular diversity in drug discovery.

M. Foley, L. Marcaurelle, 2010, Current opinion in chemical biology.

Structural and conformational determinants of macrocycle cell permeability.

Ulf Norinder, Christian Tyrchan, Giovanni Muncipinto, 2016, Nature chemical biology.

Modulators of Hepatic Lipoprotein Metabolism Identified in a Search for Small-Molecule Inducers of Tribbles Pseudokinase 1 Expression

Jeremy R. Duvall, A. Subramanian, M. Foley, 2015, PloS one.

Selective Phenylimidazole-based Inhibitors of the Mycobacterium tuberculosis Proteasome.

M. Foley, Huilin Li, M. Michino, 2019, Journal of medicinal chemistry.

Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia

M. Foley, A. Stamford, M. Carroll, 2022, Cancer discovery.

An efficient synthesis of indane-derived bis(oxazoline) and its application to hetero Diels-Alder reactions on polymer support

James R. Porter, M. Foley, M. Kurosu, 2004 .

Regio- and stereoselective addition of nucleophiles to 1-phenoxycarbonyl-2,3-dihydropyridinium salts

M. Foley, D. Comins, Geewon Chung, 1994 .

Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.

M. Foley, Huilin Li, J. Vendôme, 2021, Journal of medicinal chemistry.

Author response: Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

T. Kapoor, M. Foley, A. Carter, 2017 .