J. G. Kenna

发表

H. Westerhoff, J. Snoep, S. Geenen, 2012, Archives of Toxicology.

Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes.

Alison J. Foster, J. G. Kenna, H. Garside, 2014, Toxicology in vitro : an international journal published in association with BIBRA.

Human biology-based drug safety evaluation: scientific rationale, current status and future challenges

J. G. Kenna, 2017, Expert opinion on drug metabolism & toxicology.

A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism.

H. Nijhout, M. Reed, H. Westerhoff, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.

Matthew H Bridgland-Taylor, Alison J Foster, Alison J. Foster, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Cell based approaches for evaluation of drug-induced liver injury.

J. G. Kenna, J. Barber, M. L. Greer, 2010, Toxicology.

Glutathione metabolism modeling: a mechanism for liver drug-robustness and a new biomarker strategy.

Alison J. Foster, H. Westerhoff, J. Snoep, 2013, Biochimica et biophysica acta.

Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats.

Hans V Westerhoff, James W T Yates, Ian D Wilson, 2013, Integrative biology : quantitative biosciences from nano to macro.

A new twist to an old tale: novel insights into the differential toxicities of acetaminophen and its regioisomer N-acetyl-meta-aminophenol (AMAP)

J. G. Kenna, 2012, Archives of Toxicology.

In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.

Yan Li, Hugues Dolgos, R. A. Thompson, 2012, Chemical research in toxicology.

Strategies for Minimisation of the Cholestatic Liver Injury Liability Posed by Drug- Induced Bile Salt Export Pump (BSEP) Inhibition

Tobias Noeske, J. G. Kenna, S. Stahl, 2013 .

Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

A. D. Rodrigues, J. G. Kenna, P. Watkins, 2018, Clinical pharmacology and therapeutics.

In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid

I. Wilson, J. G. Kenna, S. Stahl, 2013, Archives of Toxicology.

Better science for safer medicines: the human imperative

J. G. Kenna, Kathy Archibald, P. Pound, 2018, Journal of the Royal Society of Medicine.

Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid.

Alison J. Foster, I. Wilson, J. G. Kenna, 2017, Toxicology research.

Hepatic effects of repeated oral administration of diclofenac to hepatic cytochrome P450 reductase null (HRN™) and wild-type mice

Alison J. Foster, I. Wilson, J. G. Kenna, 2015, Archives of Toxicology.

Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.

Dominic P. Williams, J. G. Kenna, B. K. Park, 2009, Toxicology and applied pharmacology.

Microsoft Word-58424088-file00.docx

Alison J. Foster, J. G. Kenna, C. Elmore, 2014 .

Hepatic effects of repeated oral administration of diclofenac to hepatic cytochrome P450 reductase null (HRN™) and wild-type mice

Alison J. Foster, I. Wilson, J. G. Kenna, 2016, Archives of Toxicology.

HPLC-MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium.

K. Kolaja, H. Westerhoff, S. Geenen, 2011, Journal of pharmaceutical and biomedical analysis.

Immunochemical identification of mouse hepatic protein adducts derived from the nonsteroidal anti-inflammatory drugs diclofenac, sulindac, and ibuprofen.

J. G. Kenna, J. Caldwell, L. T. Wade, 1997, Chemical research in toxicology.

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans

Philip Hewitt, Richard J Weaver, Yvonne Will, 2016, BioMed research international.

Characterization of THLE-Cytochrome P450 (P450) Cell Lines: Gene Expression Background and Relationship to P450-Enzyme Activity

Marie M. Ahlström, Alison J. Foster, J. G. Kenna, 2012, Drug Metabolism and Disposition.

In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid

I. Wilson, J. G. Kenna, S. Stahl, 2013, Archives of Toxicology.

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients

Dominic P. Williams, J. G. Kenna, G. Aithal, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients

Dominic P. Williams, J. G. Kenna, G. Aithal, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Managing the challenge of chemically reactive metabolites in drug development

Ian D. Wilson, Alan Boobis, Chris E. P. Goldring, 2011, Nature Reviews Drug Discovery.

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers

I. Wilson, J. G. Kenna, Y. Morikawa, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium.

K. Kolaja, H. Westerhoff, S. Geenen, 2011, Journal of pharmaceutical and biomedical analysis.

Assessment of gadoxetate DCE-MRI as a biomarker of hepatobiliary transporter inhibition

Neil Woodhouse, Paul D Hockings, James Yates, 2013, NMR in biomedicine.

Current Concepts in Drug‐Induced Bile Salt Export Pump (BSEP) Interference

J. G. Kenna, 2014, Current protocols in toxicology.

Multiple Compound-Related Adverse Properties Contribute to Liver Injury Caused by Endothelin Receptor Antagonists

R. A. Thompson, Alison J. Foster, J. G. Kenna, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Noninvasive Preclinical and Clinical Imaging of Liver Transporter Function Relevant to Drug-Induced Liver Injury

J. G. Kenna, S. Sourbron, P. Hockings, 2018 .

Cellular models for ADMET predictions and evaluation of drug-drug interactions.

J. G. Kenna, R. Riley, 2004, Current opinion in drug discovery & development.

The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human

Tommy B Andersson, J. G. Kenna, T. Andersson, 2012, Expert opinion on drug metabolism & toxicology.

The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613.

J. G. Kenna, J. Hayes, John M. Hourihan, 2013, Antioxidants & redox signaling.

Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?

J. G. Kenna, J. Uetrecht, 2018, Drug Metabolism and Disposition.

Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite.

Alison J. Foster, J. G. Kenna, D. Temesi, 2013, Chemical research in toxicology.

Safety Assessment of Pharmaceuticals

J. G. Kenna, R. Ram, 2019, The History of Alternative Test Methods in Toxicology.

INTEGRATED REACTIVE METABOLITE STRATEGIES

R. A. Thompson, J. G. Kenna, 2016 .

Advancing nonclinical innovation and safety in pharmaceutical testing.

E. Berg, J. G. Kenna, P. Watkins, 2019, Drug discovery today.

Interpretation, Integration, and Implementation of In Vitro Assay Data: The Predictive Toxicity Challenge

J. G. Kenna, M. Aleo, D. S. Light, 2018 .

Editorial: Advances in alternative methods in preclinical pharmacology and toxicology

J. G. Kenna, T. V. Van Vleet, A. H. Betti, 2023, Frontiers in pharmacology.

Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development.

Yan Li, Hugues Dolgos, R. A. Thompson, 2011, Chemico-biological interactions.

A new twist to an old tale: novel insights into the differential toxicities of acetaminophen and its regioisomer N-acetyl-meta-aminophenol (AMAP)

J. G. Kenna, 2012, Archives of Toxicology.

Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug–Drug Interactions in Rats

J. G. Kenna, S. Sourbron, P. Hockings, 2023, Pharmaceutics.

UvA-DARE ( Digital Academic Repository ) Systems biology tools for toxicology

H. Westerhoff, J. Snoep, S. Geenen, 2017 .

Mitigating the Inhibition of Human Bile Salt Export Pump by Drugs: Opportunities Provided by Physicochemical Property Modulation, In Silico Modeling, and Structural Modification

Louis-David Cantin, Daniel J. Warner, Tobias Noeske, 2012, Drug Metabolism and Disposition.

Cell based approaches for evaluation of drug-induced liver injury.

J. G. Kenna, J. Barber, J. Eakins, 2010, Toxicology.

Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment.

L. Harries, J. G. Kenna, V. Lauschke, 2023, ALTEX.

A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.

Alison J. Foster, J. G. Kenna, Frida S. Gustafsson, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism.

Jeremy K Nicholson, Muireann Coen, Ian D Wilson, 2015, Drug discovery today. Technologies.