G. López-Castejón

发表

Efficient discovery of anti-inflammatory small molecule combinations using evolutionary computing

Joshua D. Knowles, D. Kell, P. Mendes, 2011, Nature chemical biology.

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease.

G. López-Castejón, Elisabetta Marini, M. Bertinaria, 2017, Journal of medicinal chemistry.

Nanoparticles can cause DNA damage across a cellular barrier.

Stephen Mann, Roger Newson, Eileen Ingham, 2009, Nature nanotechnology.

Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness.

E Ingham, P J Gokhale, H Lin, 2011, Nature nanotechnology.

Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues

G. López-Castejón, D. Brough, K. Kovács, 2011, Journal of Neuroinflammation.

Understanding the mechanism of IL-1β secretion

G. López-Castejón, D. Brough, 2011, Cytokine & growth factor reviews.

Caspase-1: is IL-1 just the tip of the ICEberg?

G. López-Castejón, D. Brough, Á. Dénes, 2012, Cell Death and Disease.

NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury

G. López-Castejón, D. Brough, Á. Dénes, 2012, Front. Immun..

Acidosis Drives Damage-associated Molecular Pattern (DAMP)-induced Interleukin-1 Secretion via a Caspase-1-independent Pathway*

G. López-Castejón, D. Brough, S. Allan, 2013, The Journal of Biological Chemistry.

Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome*

G. López-Castejón, D. Brough, I. Kimber, 2014, The Journal of Biological Chemistry.

Zinc depletion regulates the processing and secretion of IL-1β

P. Mendes, J. Pahle, G. López-Castejón, 2014, Cell Death and Disease.

The colony-stimulating factor-1 receptor is a specific marker of macrophages from the bony fish gilthead seabream.

G. López-Castejón, J. Meseguer, V. Mulero, 2006, Molecular immunology.

Two Zinc Uptake Systems Contribute to the Full Virulence of Listeria monocytogenes during Growth In Vitro and In Vivo

G. López-Castejón, D. Brough, P. Andrew, 2011, Infection and Immunity.

Turbot TNFalpha gene: molecular characterization and biological activity of the recombinant protein.

G. López-Castejón, J. Meseguer, A. Figueras, 2007, Molecular immunology.

The inflammasomes, immune guardians at defence barriers

G. López-Castejón, Pablo Palazón-Riquelme, 2018, Immunology.

The NLRP3–inflammasome as a sensor of organelle dysfunction

G. López-Castejón, D. Brough, M. Lowe, 2020, The Journal of cell biology.

NLRP3 activation in response to disrupted endocytic traffic

G. López-Castejón, D. Brough, Hayley Bennett, 2021, bioRxiv.

Pathophysiology of NSAID-Associated Intestinal Lesions in the Rat: Luminal Bacteria and Mucosal Inflammation as Targets for Prevention

G. López-Castejón, C. Scarpignato, E. Ghelardi, 2018, Front. Pharmacol..

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

G. López-Castejón, D. Brough, C. Lawrence, 2018, Proceedings of the National Academy of Sciences.

Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation

G. López-Castejón, C. Pellegrini, M. Fornai, 2017, Front. Immunol..

NLRP3 during Macrophage Swelling Not Activate Caspase-1 in the Absence of Containing a CARD Forms Specks but Does Apoptosis-Associated Speck-like Protein

G. López-Castejón, D. Brough, P. Pelegrín, 2014 .

Caspase-1-independent Pathway Interleukin-1 Secretion via a Molecular Pattern ( DAMP )-induced Acidosis Drives Damage-associated Immunology :

G. López-Castejón, D. Brough, S. Allan, 2013 .

Cell volume regulation modulates NLRP3 inflammasome activation.

G. López-Castejón, Diego Angosto, P. Pelegrín, 2012, Immunity.

Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β

G. López-Castejón, J. Meseguer, Diego Angosto, 2012, Innate immunity.

The activation of gilthead seabream professional phagocytes by different PAMPs underlines the behavioural diversity of the main innate immune cells of bony fish.

G. López-Castejón, J. Meseguer, V. Mulero, 2007, Molecular immunology.

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification

G. López-Castejón, D. Brough, Shi Yu, 2020, The FEBS journal.

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes

G. López-Castejón, D. Brough, P. Kaldis, 2019, The Journal of Biological Chemistry.

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

G. López-Castejón, D. Brough, C. Pellegrini, 2018, EMBO reports.

Inhibition of Calpain Blocks the Phagosomal Escape of Listeria monocytogenes

G. López-Castejón, D. Brough, M. Goldrick, 2012, PloS one.

Prodromal Intestinal Events in Alzheimer’s Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition

G. López-Castejón, M. Trincavelli, C. Martini, 2020, International journal of molecular sciences.

Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro

G. López-Castejón, D. Brough, D. Davis, 2020, Frontiers in Immunology.

Priming is dispensable for NLRP3 inflammasome activation in human monocytes

G. López-Castejón, D. Brough, D. Davis, 2020, bioRxiv.

Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?

G. López-Castejón, Mariola J. Edelmann, 2016, Mediators of inflammation.

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

Aidan R. O’Brien, W. R. Thompson, Kathryn E. Hentges, 2019, Genome Biology.

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

W. R. Thompson, Kathryn E. Hentges, A. Loudon, 2018, bioRxiv.

Response to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”

Aidan R. O’Brien, W. R. Thompson, A. Loudon, 2021, Genome biology.

Control of the inflammasome by the ubiquitin system

G. López-Castejón, 2019, The FEBS journal.

NLRP3 at the crossroads between immune/inflammatory responses and enteric neuroplastic remodelling in a mouse model of diet‐induced obesity

G. López-Castejón, M. Nannipieri, C. Pellegrini, 2021, British journal of pharmacology.

Microglia and Macrophages Differentially Modulate Cell Death After Brain Injury Caused by Oxygen-Glucose Deprivation in Organotypic Brain Slices

Sylvie Girard, David Brough, G. López-Castejón, 2013, Glia.

Mechanisms of NLRP3 priming in inflammaging and age related diseases

G. López-Castejón, D. Brough, Anna Gritsenko, 2020, Cytokine & growth factor reviews.

P2X7 receptor-dependent tuning of gut epithelial responses to infection

G. López-Castejón, D. Brough, Werner Müller, 2016, Immunology and cell biology.

Current status of inflammasome blockers as anti-inflammatory drugs

G. López-Castejón, P. Pelegrín, 2012, Expert opinion on investigational drugs.

Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome

G. López-Castejón, D. Brough, Hayley Bennett, 2023, Science Signaling.

Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages

G. López-Castejón, D. Davis, G. Tannahill, 2021, Frontiers in Immunology.

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome*

G. López-Castejón, D. Brough, S. High, 2012, The Journal of Biological Chemistry.

The type II interleukin-1 receptor (IL-1RII) of the bony fish gilthead seabream Sparus aurata is strongly induced after infection and tightly regulated at transcriptional and post-transcriptional levels.

G. López-Castejón, J. Meseguer, V. Mulero, 2007, Molecular Immunology.

Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1 beta.

G. López-Castejón, J. Meseguer, A. Surprenant, 2007, Molecular immunology.

Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish.

G. López-Castejón, J. Meseguer, P. Pelegrín, 2008, Molecular immunology.

Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

G. López-Castejón, D. Brough, A. Verkhratsky, 2015, The Journal of Immunology.

Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules

G. López-Castejón, P. Pelegrín, A. Baroja-Mazo, 2011, Cellular and Molecular Life Sciences.

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

G. López-Castejón, D. Brough, N. Luheshi, 2011, European journal of immunology.

P2X7 Receptor-Mediated Release of Cathepsins from Macrophages Is a Cytokine-Independent Mechanism Potentially Involved in Joint Diseases

M. Braddock, G. López-Castejón, A. Surprenant, 2010, The Journal of Immunology.

Potentially Involved in Joint Diseases Cytokine-Independent Mechanism Cathepsins from Macrophages Is a Receptor-Mediated Release of 7 P 2 X

M. Braddock, G. López-Castejón, A. Surprenant, 2010 .

Editorial: Neurological, Metabolic and Inflammatory Disorders: A Common Root in Inflammasome

G. López-Castejón, M. Bertinaria, C. Pellegrini, 2021, Frontiers in Pharmacology.

Regulation of NLRP3 activation by the ubiquitin system

G. López-Castejón, 2014 .

NLRP3 inflammasome triggers interleukin‐37 release from human monocytes

G. López-Castejón, Anna Gritsenko, Rodrigo Díaz-Pino, 2022, European journal of immunology.

NLRP 3 during Macrophage Swelling Not Activate Caspase-1 in the Absence of Containing a CARD Forms Specks but Does Apoptosis-Associated Speck-like Protein Verkhratsky

G. López-Castejón, D. Brough, A. I. Gómez, 2015 .

Proximity labelling and evolutionary evidence reveal insights into IL-1α nuclear networks and function

G. López-Castejón, D. Brough, Hayley Bennett, 2023, bioRxiv.

Journal of Neuroinflammation

G. López-Castejón, D. Brough, R. Mrak, 2017 .

Nanoparticles can cause DNA damage across a cellular barrier.

G. López-Castejón, R. Newson, E. Ingham, 2009, Nature nanotechnology.