D. Brough

D. Brough, Á. Dénes, N. Lénárt, 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Two Zinc Uptake Systems Contribute to the Full Virulence of Listeria monocytogenes during Growth In Vitro and In Vivo

G. López-Castejón, D. Brough, P. Andrew, 2011, Infection and Immunity.

Co-design of a Smartphone App for People Living With Dementia by Applying Agile, Iterative Co-design Principles: Development and Usability Study

D. Brough, A. Parry-Jones, I. Leroi, 2022, JMIR mHealth and uHealth.

Laparoscopic hepatic resection

N. O'Rourke, D. Brough, 2020, Laparoscopic Surgery.

Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung

A. Loukas, D. Brough, P. Giacomin, 2019, The Journal of Immunology.

Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging.

D. Brough, D. Spiller, M. White, 2016, Methods in molecular biology.

Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide

D. Brough, C. Lawrence, E. Knight, 2012, Disease Models & Mechanisms.

Laparoscopic resection of a pediatric intestinal leiomyosarcoma

D. Brough, Dr Greg Miller, Dr Ian Ross, 2022, Journal of Pediatric Surgery Case Reports.

Anti-inflammatories in Alzheimer’s disease—potential therapy or spurious correlate?

D. Brough, C. Lawrence, A. Mather, 2020, Brain communications.

A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

D. Brough, G. Tresadern, P. Brennan, 2021, Scientific Reports.

A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat

N. Rothwell, D. Brough, R. Gibson, 2007, Neuropharmacology.

Interleukin‐18 induces expression and release of cytokines from murine glial cells: interactions with interleukin‐1β

N. Rothwell, D. Brough, K. Takeda, 2003, Journal of neurochemistry.

Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1β for Caspase-1 Cleavage*

D. Brough, S. Allan, M. Edye, 2015, The Journal of Biological Chemistry.

Evidence That a TRPA1-Mediated Murine Model of Temporomandibular Joint Pain Involves NLRP3 Inflammasome Activation

D. Brough, J. Gamble, F. Lundy, 2021, Pharmaceuticals.

Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death*

N. Rothwell, D. Brough, H. England, 2014, The Journal of Biological Chemistry.

The NLRP3–inflammasome as a sensor of organelle dysfunction

G. López-Castejón, D. Brough, M. Lowe, 2020, The Journal of cell biology.

Discovery of an AIM2 inflammasome inhibitor for the treatment of DNA-driven inflammatory disease

Andrew G. Leach, D. Brough, A. Leach, 2022, bioRxiv.

Inspiratory Pressures in Adult Cystic Fibrosis

D. Brough, C. Beeson, L. Griffiths, 1994 .

NLRP3 activation in response to disrupted endocytic traffic

G. López-Castejón, D. Brough, Hayley Bennett, 2021, bioRxiv.

LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activation

D. Brough, N. Humphreys, R. Bryce, 2020, bioRxiv.

Haematopoietic stem cell gene therapy with IL‐1Ra rescues cognitive loss in mucopolysaccharidosis IIIA

D. Brough, H. Boutin, C. O’Leary, 2020, EMBO molecular medicine.

Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome

D. Brough, S. Allan, Judith E. Allen, 2019, Stroke.

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

G. López-Castejón, D. Brough, C. Lawrence, 2018, Proceedings of the National Academy of Sciences.

Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways

D. Brough, J. Rivers-Auty, 2015, European journal of immunology.

NLRP3 during Macrophage Swelling Not Activate Caspase-1 in the Absence of Containing a CARD Forms Specks but Does Apoptosis-Associated Speck-like Protein

G. López-Castejón, D. Brough, P. Pelegrín, 2014 .

Caspase-1-independent Pathway Interleukin-1 Secretion via a Molecular Pattern ( DAMP )-induced Acidosis Drives Damage-associated Immunology :

G. López-Castejón, D. Brough, S. Allan, 2013 .

Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome

D. Brough, S. Freeman, A. Baldwin, 2018, Chemmedchem.

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification

G. López-Castejón, D. Brough, Shi Yu, 2020, The FEBS journal.

Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl− channel modulation†

D. Brough, Stephane De Cesco, C. Lawrence, 2020, Chemical science.

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes

G. López-Castejón, D. Brough, P. Kaldis, 2019, The Journal of Biological Chemistry.

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

G. López-Castejón, D. Brough, C. Pellegrini, 2018, EMBO reports.

Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria

A. Craig, D. Brough, D. Golenbock, 2018, Proceedings of the National Academy of Sciences.

Boron Shines A Light On The Dark Side Of Inflammation

D. Brough, M. J. Daniels, 2017 .

The structural integrity of the endoplasmic reticulum, and its possible regulation by inositol 1,3,4,5-tetrakisphosphate.

D. Brough, P. Thorn, R. Irvine, 2005, Cell calcium.

Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa

D. Brough, R. Gray, D. Davidson, 2019, PLoS pathogens.

Inhibition of Calpain Blocks the Phagosomal Escape of Listeria monocytogenes

G. López-Castejón, D. Brough, M. Goldrick, 2012, PloS one.

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease.

D. Brough, A. Tirella, M. Harte, 2019, Journal of visualized experiments : JoVE.

Neuronal injury induces the release of pro-interleukin-1β from activated microglia in vitro

N. Rothwell, D. Brough, E. Pinteaux, 2008, Brain Research.

Interleukin‐1α and brain inflammation

D. Brough, Á. Dénes, 2015, IUBMB life.

Nuclear retention of IL-1 alpha by necrotic cells: A mechanism to dampen sterile inflammation

B. McColl, D. Brough, N. Luheshi, 2018 .

Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro

G. López-Castejón, D. Brough, D. Davis, 2020, Frontiers in Immunology.

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors

D. Brough, C. Lawrence, John B Davis, 2020, Immunology.

Priming is dispensable for NLRP3 inflammasome activation in human monocytes

G. López-Castejón, D. Brough, D. Davis, 2020, bioRxiv.

Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome

Justin J. W. Powell, E. Kavanagh, D. Brough, 2022, Neuropharmacology.

Mobility of proteins associated with the plasma membrane by interaction with inositol lipids

D. Brough, R. Irvine, Farzana Bhatti, 2005, Journal of Cell Science.

Ca Stores and Ca Entry Differentially Contribute to the Release of IL-1 and IL-1 from Murine Macrophages

N. Rothwell, D. Brough, A. Verkhratsky, 2003 .

Murine Macrophages α and IL-1 β Contribute to the Release of IL-1 Entry Differentially 2 + Stores and Ca 2 + Ca

N. Rothwell, D. Brough, A. Verkhratsky, 2003 .

Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid

D. Brough, J. Bevan, R. Ledder, 2017, Medicinal Chemistry Research.

Ca2+ Stores and Ca2+ Entry Differentially Contribute to the Release of IL-1β and IL-1α from Murine Macrophages1

N. Rothwell, D. Brough, A. Verkhratsky, 2003, The Journal of Immunology.

Boron-Based Inhibitors of the NLRP3 Inflammasome

N. Rothwell, D. Brough, S. Allan, 2017, Cell chemical biology.

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

D. Brough, D. Spiller, M. White, 2016, Cell Death and Differentiation.

Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy

D. Brough, N. Luheshi, N. Luheshi, 2009, British journal of pharmacology.

Purinergic (P2X7) Receptor Activation of Microglia Induces Cell Death via an Interleukin-1-Independent Mechanism

N. Rothwell, D. Brough, Y. Iwakura, 2002, Molecular and Cellular Neuroscience.

Pannexin-1-dependent caspase-1 activation and secretion of IL-1β is regulated by zinc

N. Rothwell, D. Brough, P. Pelegrín, 2009, European journal of immunology.

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

Aidan R. O’Brien, W. R. Thompson, Kathryn E. Hentges, 2019, Genome Biology.

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

W. R. Thompson, Kathryn E. Hentges, A. Loudon, 2018, bioRxiv.

Response to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”

Aidan R. O’Brien, W. R. Thompson, A. Loudon, 2021, Genome biology.

Beyond Antoni: A Surgeon's Guide to the Vestibular Schwannoma Microenvironment

D. Brough, S. Allan, S. Rutherford, 2020, Journal of Neurological Surgery Part B: Skull Base.

Microglia and Macrophages Differentially Modulate Cell Death After Brain Injury Caused by Oxygen-Glucose Deprivation in Organotypic Brain Slices

Sylvie Girard, David Brough, G. López-Castejón, 2013, Glia.

Inhibiting the NLRP3 Inflammasome

D. Brough, S. Freeman, Lina Y. El-Sharkawy, 2020, Molecules.

Mechanisms of NLRP3 priming in inflammaging and age related diseases

G. López-Castejón, D. Brough, Anna Gritsenko, 2020, Cytokine & growth factor reviews.

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

D. Brough, P. Paszek, J. Bagnall, 2016, Nature Communications.

Inhibiting the Inflammasome: A Chemical Perspective.

Sally Freeman, David Brough, D. Brough, 2016, Journal of medicinal chemistry.

Consensus guidelines for the detection of immunogenic cell death

P. Vandenabeele, S. Loi, L. Zitvogel, 2014, Oncoimmunology.

Gene Ontology Curation of Neuroinflammation Biology Improves the Interpretation of Alzheimer’s Disease Gene Expression Data

Rachael P. Huntley, Helen Parkinson, Rina Bandopadhyay, 2020, Journal of Alzheimer's disease : JAD.

Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer’s Disease Data

Helen Parkinson, Rina Bandopadhyay, Sandra Orchard, 2018, Genes.

Inflammasomes as therapeutic targets for Alzheimer's disease

D. Brough, C. Lawrence, Claire S. White, 2017, Brain pathology.

P2X7 receptor-dependent tuning of gut epithelial responses to infection

G. López-Castejón, D. Brough, Werner Müller, 2016, Immunology and cell biology.

Caspase-1-dependent processing of pro-interleukin-1β is cytosolic and precedes cell death

N. Rothwell, D. Brough, 2007, Journal of Cell Science.

Novel perspectives on non-canonical inflammasome activation

D. Brough, A. Mortellaro, H. J. Khameneh, 2015, ImmunoTargets and therapy.

Extracellular ATP and P2X7 receptors in neurodegeneration.

N. Rothwell, D. Brough, R. L. Le Feuvre, 2002, European journal of pharmacology.

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

D. Brough, N. Humphreys, R. Bryce, 2020, eLife.

Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology

N. Rothwell, D. Brough, S. Allan, 2012, Disease Models & Mechanisms.

Increased Circulating Chemokines and Macrophage Recruitment in Growing Vestibular Schwannomas

D. Brough, C. Heal, S. Rutherford, 2022, Neurosurgery.

Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome

G. López-Castejón, D. Brough, Hayley Bennett, 2023, Science Signaling.

An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β

D. Brough, W. Nickel, P. Pelegrín, 2017, Journal of Cell Science.

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production

D. Brough, E. Vizi, A. Houlden, 2016, Brain, Behavior, and Immunity.

The inflammatory microenvironment in vestibular schwannoma

D. Brough, D. G. Evans, F. Roncaroli, 2020, Neuro-oncology advances.

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome*

G. López-Castejón, D. Brough, S. High, 2012, The Journal of Biological Chemistry.

Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture

D. Brough, S. Allan, T. Tzeng, 2020, Immunology.

Microglial Priming as Trained Immunity in the Brain

D. Brough, S. Allan, J. Quintin, 2017, Neuroscience.

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

D. Brough, C. Lawrence, S. Freeman, 2018, SLAS discovery : advancing life sciences R & D.

Unconventional Pathways of Secretion Contribute to Inflammation

David Brough, D. Brough, M. J. Daniels, 2017, International journal of molecular sciences.

The role of inflammation and interleukin-1 in acute cerebrovascular disease

D. Brough, J. Galea, 2013, Journal of inflammation research.

Mechanisms of regulation for interleukin-1β in neurodegenerative disease

D. Brough, E. Pinteaux, A. Simi, 2007, Neuropharmacology.

Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis

D. Brough, A. Mortellaro, Maurizio Vacca, 2017, Scientific Reports.

Loss of hepatocyte cell division leads to liver inflammation and fibrosis

Hyungwon Choi, D. Brough, Heike Wollmann, 2020, PLoS genetics.

Redefining the ancestral origins of the interleukin-1 superfamily

D. Robertson, D. Brough, M. J. Daniels, 2018, Nature Communications.

Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages

D. Brough, S. Allan, E. Lemarchand, 2022, Immunology.

Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation

D. Brough, J. Beattie, C. Lawrence, 2020, The Journal of Neuroscience.

Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome

Justin J. W. Powell, E. Kavanagh, D. Brough, 2022, Neuropharmacology.

Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming.

N. Rothwell, D. Brough, S. Allan, 2018, ACS nano.

Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

G. López-Castejón, D. Brough, A. Verkhratsky, 2015, The Journal of Immunology.

Renal haemofiltration prevents metabolic acidosis and reduces inflammation during normothermic machine perfusion of the vascularised composite allograft - a preclinical study.

D. Brough, J. Fildes, K. Amin, 2021, Artificial organs.

CRISPR/Cas9 mediated mutation of mouse IL-1α nuclear localisation sequence abolishes expression

D. Brough, N. Humphreys, A. Adamson, 2017, Scientific Reports.

Agonist-induced regulation of mitochondrial and endoplasmic reticulum motility.

D. Brough, M. Schell, R. Irvine, 2005, The Biochemical journal.

Unconventional Protein Secretion: Fibroblast Growth Factor 2 and Interleukin-1β as Examples

D. Brough, W. Nickel, H. Müller, 2016 .

Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast‐Enhanced MRI

G. Parker, D. Brough, R. Hinz, 2018, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

The NLRP3 inflammasome as a target for sensorineural hearing loss.

D. Brough, K. Munro, K. Couper, 2023, Clinical immunology.

Anakinra in COVID-19: important considerations for clinical trials

D. Brough, H. Patel, S. Allan, 2020, The Lancet Rheumatology.

Stroke induces early recurrent vascular events by inflammasome-dependent atherosclerotic plaque rupture

M. Endres, M. Dichgans, D. Brough, 2023, bioRxiv.

Priming of Macrophages with Lipopolysaccharide Potentiates P2X7-mediated Cell Death via a Caspase-1-dependent Mechanism, Independently of Cytokine Production*

N. Rothwell, D. Brough, K. Takeda, 2002, The Journal of Biological Chemistry.

The two pore potassium channel THIK‐1 regulates NLRP3 inflammasome activation

D. Brough, C. Lawrence, L. Dawson, 2022, Glia.

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

G. López-Castejón, D. Brough, N. Luheshi, 2011, European journal of immunology.

Role of P2X7 Receptors in Ischemic and Excitotoxic Brain Injury In Vivo

N. Rothwell, D. Brough, O. Touzani, 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Boron-Based Inhibitors of the NLRP 3 Inflammasome Graphical Abstract Highlights

N. Rothwell, D. Brough, S. Allan, 2022 .

Plasmodium falciparum-infected erythrocyte co-culture with the monocyte cell line THP-1 does not trigger production of soluble factors reducing brain microvascular barrier function

A. Craig, D. Brough, G. Camarda, 2023, PloS one.

Regulation of interleukin-1 in acute brain injury.

D. Brough, S. Allan, P. Tyrrell, 2011, TIPS - Trends in Pharmacological Sciences.

Itaconate and fumarate derivatives exert a dual inhibitory effect on canonical NLRP3 activation in macrophages and microglia

D. Brough, S. Allan, E. Lemarchand, 2021, bioRxiv.

Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung

A. Loukas, D. Brough, P. Giacomin, 2019, The Journal of Immunology.

Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages.

N. Rothwell, D. Brough, A. Verkhratsky, 2003, Journal of immunology.