J. Saunders

发表

Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.

L. Cantley, C. Kung, J. Hixon, 2012, Chemistry & biology.

Cellular and biochemical characterization of VX-710 as a chemosensitizer: reversal of P-glycoprotein-mediated multidrug resistance in vitro.

J. Saunders, V. Galullo, U. Germann, 1997, Anti-cancer drugs.

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.

Hua Yang, Fang Wang, Zenon Konteatis, 2017, Cancer discovery.

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

S. Gross, Giovanni Cianchetta, Cheng Fang, 2018, ACS medicinal chemistry letters.

Pharmacologic Inhibition of Ghrelin Receptor Signaling Is Insulin Sparing and Promotes Insulin Sensitivity

P. Distefano, M. Navia, J. Hixon, 2011, Journal of Pharmacology and Experimental Therapeutics.

Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps

P. Distefano, J. Hixon, J. Saunders, 2011, BMC Physiology.

Chapter 18. Inosine monophosphate dehydrogenase: Consideration of structure, kinetics, and therapeutic potential

J. Saunders, S. Raybuck, 2000 .

Vinylsilane-mediated spiroannulation. Synthesis of spiro[4.5]decadienones

J. Saunders, S. M. Strickland, S. D. Burke, 1981 .

A novel and efficient entry to (.+-.)-quadrone

J. Saunders, S. D. Burke, C. Murtiashaw, 1982 .

Vinylsilane-mediated polyene cyclization. Synthesis of the octahydronaphthalenol portion of dihydrocompactin.

J. Saunders, J. Oplinger, S. D. Burke, 1985 .

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

P. Distefano, M. Navia, J. Hixon, 2005, Journal of medicinal chemistry.

A novel two-step pyrone to 4-chromanone transformation

J. Saunders, S. D. Burke, C. Murtiashaw, 1981 .

Total synthesis of (±)-quadrone

J. Saunders, J. Oplinger, S. D. Burke, 1984 .

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

Fang Wang, Erica Hansen, Francesco G. Salituro, 2013, Science.

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo.

S. Gross, Shunqi Yan, J. Saunders, 2012, ACS medicinal chemistry letters.

Design, synthesis and structure of non-macrocyclic inhibitors of FKBP12, the major binding protein for the immunosuppressant FK506.

M. Murcko, M. Navia, J. Saunders, 1995, Acta crystallographica. Section D, Biological crystallography.