Shengfang Jin

发表

Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.

L. Cantley, C. Kung, J. Hixon, 2012, Chemistry & biology.

Valosin-containing protein phosphorylation at Ser784 in response to DNA damage.

H. Greulich, Shengfang Jin, K. Clauser, 2005, Cancer research.

Response to DNA Damage in 784 Valosin-Containing Protein Phosphorylation at Ser Updated

H. Greulich, Shengfang Jin, K. Clauser, 2005 .

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

L. Liau, M. V. Heiden, L. Cantley, 2009, Nature.

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

Tak W. Mak, Lenny Dang, Masato Sasaki, 2010, The Journal of experimental medicine.

Double‐strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions

Shengfang Jin, D. Weaver, 1997, The EMBO journal.

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.

Hua Yang, Fang Wang, Zenon Konteatis, 2017, Cancer discovery.

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

S. Gross, Giovanni Cianchetta, Cheng Fang, 2018, ACS medicinal chemistry letters.

A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model

A. Kernytsky, Yaguang Si, S. Gross, 2016, Journal of Inherited Metabolic Disease.

ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis

T. Mak, C. Kung, J. Hixon, 2015, Proceedings of the National Academy of Sciences.

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

L. Liau, M. V. Heiden, L. Cantley, 2010, Nature.

A mouse model of a human congenital disorder of glycosylation caused by loss of PMM2

Yan Liu, S. Su, Shengfang Jin, 2016, Human molecular genetics.

Ku 70-deficient embryonic stem cells have increased ionizing radiosensitivity , defective DNA end-binding activity , and inability to support V ( D ) J recombination

Shengfang Jin, D. Weaver, Yijie Gao, 1997 .

Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency.

A. Schambach, C. Kung, Shengfang Jin, 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH.

Yaguang Si, S. Choe, Giovanni Cianchetta, 2016, Cell reports.

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo.

S. Gross, Shunqi Yan, J. Saunders, 2012, ACS medicinal chemistry letters.

IDH mutations in glioma and acute myeloid leukemia.

S. Su, Shengfang Jin, L. Dang, 2010, Trends in molecular medicine.

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells

F. Prósper, C. Kung, Shengfang Jin, 2015, Stem cell reports.

Inactivation of DNA-Dependent Protein Kinase by Protein Kinase Cδ: Implications for Apoptosis

Shengfang Jin, Zhi-Min Yuan, D. Weaver, 1998, Molecular and Cellular Biology.

The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

P. Gaulard, S. Inoue, T. Mak, 2016, Proceedings of the National Academy of Sciences.

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Christian M. Metallo, William J. Israelsen, Abhishek K. Jha, 2012, Nature chemical biology.

Functional interaction between DNA-PK and c-Abl in response to DNA damage

S. Inoue, R. Weichselbaum, Shengfang Jin, 1997, Nature.

Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators.

Shengfang Jin, P. Iversen, M. Rolfe, 2005, Cancer research.

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

S. Choe, K. Marks, S. Gross, 2019, Nature Communications.

Abstract 3504: A chemical biology screen identifies a unique vulnerability of neuroendocrine cancer cells to SQLE inhibition

S. Choe, S. Gross, Giovanni Cianchetta, 2018, Molecular and Cellular Biology / Genetics.

Binding of Ku and c-Abl at the Kinase Homology Region of DNA-dependent Protein Kinase Catalytic Subunit*

Shengfang Jin, B. Mayer, D. Kufe, 1997, The Journal of Biological Chemistry.

Regulation of DNA-dependent Protein Kinase by the Lyn Tyrosine Kinase*

Shengfang Jin, D. Weaver, D. Kufe, 1998, The Journal of Biological Chemistry.

Metabolic analysis reveals evidence for branched chain amino acid catabolism crosstalk and the potential for improved treatment of organic acidurias.

Shengfang Jin, J. Vockley, David A. Pirman, 2019, Molecular genetics and metabolism.

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (Nature Chemical Biology (2012) 8 (839-847))

Abhishek K. Jha, G. Stephanopoulos, Noel Southall, 2012 .

IDH mutations in glioma and acute myeloid leukemia.

S. Su, Shengfang Jin, L. Dang, 2010, Trends in molecular medicine.

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

L. Liau, M. V. Heiden, K. Marks, 2009, Nature.