H. Keizer

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Perspectives in Cancer Research Synchronization in Tumour Chemotherapy

L. Putten, H. Keizer, J. Mulder, 1976 .

Synchronization in tumour chemotherapy.

H. Keizer, J. Mulder, L. V. van Putten, 1976, European journal of cancer.

THE EFFICIENCY OF THE ASSAY FOR HAEMOPIETIC COLONY FORMING CELLS

L. Putten, H. Keizer, S. Lahiri, 1970 .

In vivo characterization and modulation of the glutathione/glutathione S-transferase system in cancer patients.

H. Keizer, G. Mulder, D. Breimer, 1995, Drug metabolism reviews.

IN VlVO CHARACTERIZATION AND MODULATION OF THE GLUTATHIONE/ SYSTEM IN CANCER PATIENTS* GLUTATHIONE S-TRANSFERASE

H. Keizer, G. Mulder, D. Breimer, 1995 .

Gemcitabine in advanced adult soft-tissue sarcomas. A phase II study of the EORTC Soft Tissue and Bone Sarcoma Group.

O. S. Nielsen, J. Blay, M. van Glabbeke, 2002, European journal of cancer.

Feasibility study on daily administration of cis-diamminedichloroplatinum(II) in combination with radiotherapy.

A. Karim, G. Snow, H. Keizer, 1984, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Trimetrexate as biochemical modulator of 5-fluorouracil/leucovorin in advanced colorectal cancer: final results of a randomised European study.

H. Keizer, C. Punt, H. Lochs, 2002, Annals of oncology : official journal of the European Society for Medical Oncology.

Diabetes insipidus in metastatic cancer: two case reports with review of the literature.

H. Keizer, T. Huizinga, F. Roelfsema, 2000, Annals of oncology : official journal of the European Society for Medical Oncology.

Testicular Cancer

H. Keizer, Daan Bokkel Huinink, D. Bokkel Huinink, 1998 .

Residual mass histology in testicular cancer: development and validation of a clinical prediction rule.

J. Habbema, E. Steyerberg, H. Keizer, 2001, Statistics in medicine.

Predictors of residual mass histology following chemotherapy for metastatic non-seminomatous testicular cancer: a quantitative overview of 996 resections.

J. Habbema, E. Steyerberg, H. Keizer, 1994, European journal of cancer.

Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2′-deoxyuridine

E. De Clercq, H. Keizer, E. Clercq, 2005, Journal of Cancer Research and Clinical Oncology.

Surveillance versus adjuvant chemotherapy in stage I non-seminomatous testicular cancer: a decision analysis.

J. de Haes, A. Stiggelbout, J. Kievit, 1996, European journal of cancer.

A phase II study of M-azido-pyrimethamine ethane sulphonate (MZPES) in advanced, recurrent soft tissue sarcoma. An EORTC Soft Tissue and Bone Sarcoma Group Study.

H. Keizer, J. Verweij, R. Sylvester, 1989, European journal of cancer & clinical oncology.

N7-Methylguanine and O(6)-methylguanine levels in DNA of white blood cells from cancer patients treated with dacarbazine.

H. Keizer, R. Baan, J. V. van Delft, 1996, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Gas chromatographic determination of 2- and 3-dechloroethylifosfamide in plasma and urine.

H. Keizer, J. Beijnen, A. Bult, 1992, Journal of chromatography.

Lack of glutathione conjugation of melphalan in the isolated in situ liver perfusion in humans.

H. Keizer, C. V. D. van de Velde, J. Beijnen, 1996, Cancer research.

Evaluation of the autoinduction of ifosfamide metabolism by a population pharmacokinetic approach using NONMEM.

H. Keizer, J. Schellens, J. Beijnen, 2000, British journal of clinical pharmacology.

A phase I study of a fixed dose of cisplatin with increasing doses of raltitrexed (Tomudex) in the treatment of patients with locally advanced or metastatic squamous cell carcinoma of the head and neck.

H. Keizer, R. J. Baatenburg de Jong, D. ten Bokkel Huinink, 2001, Annals of oncology : official journal of the European Society for Medical Oncology.

Residual masses after chemotherapy for metastatic testicular cancer: the clinical implications of the association between retroperitoneal and pulmonary histology. Re-analysis of Histology in Testicular Cancer (ReHiT) Study Group.

E. Steyerberg, S. Fosså, H. Keizer, 1997, The Journal of urology.

The efficiency of the assay for haemopoietic colony forming cells.

H. Keizer, L. V. van Putten, S. Lahiri, 1970, Cell and tissue kinetics.

Treatment of mesenteric desmoid tumours with the anti-oestrogenic agent toremifene: case histories and an overview of the literature.

W. Bemelman, H. Keizer, H. Verspaget, 1999, European journal of gastroenterology & hepatology.

Thromboembolic events during chemotherapy for germ cell cancer: a cohort study and review of the literature.

A. Zwinderman, H. Keizer, F. Rosendaal, 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Ifosfamide treatment as a 10-day continuous intravenous infusion

H. Keizer, K. Welvaart, F. J. Cleton, 2005, Journal of Cancer Research and Clinical Oncology.

Randomized placebo-controlled trial of granulocyte-macrophage colony-stimulating factor in patients with chemotherapy-related febrile neutropenia.

H. Keizer, E. Vellenga, E. de Vries, 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

/Iphase Istndy of a fixed dose of cispla.in with increasing doses of ra.titrexed (Jomudex^) in the treatment of patients with locally advanced or metastatic squamous cell carcinoma of the head and neck.

H. Keizer, M. Tesselaar, H. P. Verschuur, 2001 .

A multi-center prospective phase II study of high-dose chemotherapy in germ-cell cancer patients relapsing from complete remission.

S. Rodenhuis, H. Keizer, E. de Vries, 1999, Annals of oncology : official journal of the European Society for Medical Oncology.

The antiemetic efficacy and safety of granisetron compared with metoclopramide plus dexamethasone in patients receiving fractionated chemotherapy over 5 days

V. Diehl, D. Dearnaley, H. Keizer, 1993, Journal of Cancer Research and Clinical Oncology.

Combined effects of bromovinyldeoxyuridine and fractionated or continuous administration of 5-fluorouracil in P388 leukemia-bearing mice.

E. De Clercq, R. Pauwels, H. Keizer, 1988, Cancer letters.

Randomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus ifosfamide plus recombinant human granulocyte-macrophage colony-stimulating factor in advanced soft tissue sarcomas: A trial of the European Organization for Research and Treatment of

J. Blay, S. Rodenhuis, M. van Glabbeke, 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The radioprotective action on bone marrow CFU during immobilization of mice.

H. Keizer, L. V. van Putten, 1976, Radiation research.

Use of granisetron in patients refractory to previous treatment with antiemetics.

H. Keizer, J. Carmichael, A. Schindler, 1998, Anti-cancer drugs.

Validity of predictions of residual retroperitoneal mass histology in nonseminomatous testicular cancer.

J. Habbema, E. Steyerberg, S. Fosså, 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Cancer chemotherapy: alternative routes of drug administration. A review.

H. Keizer, H. Pinedo, 1985, Cancer Drug Delivery.

Chemotherapy for operable gastric cancer: results of the Dutch randomised FAMTX trial. The Dutch Gastric Cancer Group (DGCG).

H. Keizer, C. V. D. van de Velde, J. Hermans, 1999, European journal of cancer.

Isolated liver perfusion with mitomycin C in the treatment of colorectal cancer metastases confined to the liver.

H. Keizer, J. H. van Bockel, C. V. D. van de Velde, 1996, Japanese journal of clinical oncology.

Pathogenesis of malignant ascites: Starling's law of capillary hemodynamics revisited.

H. Keizer, A. Meinders, J. Tamsma, 2001, Annals of oncology : official journal of the European Society for Medical Oncology.

High-performance liquid chromatographic determination of stabilized 4-hydroxyifosfamide in human plasma and erythrocytes.

H. Keizer, J. Beijnen, A. Huitema, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Psychologic aspects of the treatment of emesis in cancer nursing.

H. Keizer, J. Ouwerkerk, 1990, Seminars in oncology nursing.

Effect of high-dose ifosfamide in advanced soft tissue sarcomas. A multicentre phase II study of the EORTC Soft Tissue and Bone Sarcoma Group.

O. S. Nielsen, J. Blay, M. van Glabbeke, 2000, European journal of cancer.

Compassionate use programme of irinotecan in colorectal cancer patients in The Netherlands.

H. Keizer, E. Voest, J. D. de Witte, 2003, The Netherlands journal of medicine.

Clinical Pharmacokinetics and Pharmacodynamics of Ifosfamide and its Metabolites

H. Groen, H. Keizer, J. Schellens, 2001, Clinical Pharmacokinetics.

Functional outcome in patients with thoracolumbar burst fractures treated with dorsal instrumentation and transpedicular cancellous bone grafting

C. K. van der Sluis, H. Keizer, H. T. ten Duis, 2003, European Spine Journal.

Functional outcome 5 years after non-operative treatment of type A spinal fractures

C. K. van der Sluis, H. Keizer, C. K. van der Sluis, 2006, European Spine Journal.

Increased local cytostatic drug exposure by isolated hepatic perfusion: a phase I clinical and pharmacologic evaluation of treatment with high dose melphalan in patients with colorectal cancer confined to the liver

R. Tollenaar, H. Keizer, J. H. van Bockel, 2000, British Journal of Cancer.

Population pharmacokinetics and exploratory pharmacodynamics of ifosfamide and metabolites after a 72-h continuous infusion in patients with soft tissue sarcoma

S. Rodenhuis, H. Keizer, J. Schellens, 2001, European Journal of Clinical Pharmacology.

Influence of dose and infusion duration on pharmacokinetics of ifosfamide and metabolites.

H. Keizer, J. Schellens, J. Beijnen, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Stenting of roses, starch depletion and accumulation during the early development.

H. Keizer, M. Joosten, P. V. D. Pol, 1986 .

Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine.

H. Keizer, R. Baan, J. V. van Delft, 1992, Carcinogenesis.

EORTC Group Phase II Study of Oral Etoposide for Pretreated Soft Tissue Sarcoma

O. S. Nielsen, H. Keizer, D. Crowther, 1997, Sarcoma.

Bioanalysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine.

H. Keizer, J. van der Greef, U. Tjaden, 1988, Journal of chromatography.

Bioanalysis of fluorouracil applying liquid chromatography and valve switching

H. Keizer, J. Greef, U. Tjaden, 1988 .

Chromatographic analysis of the enantiomers of ifosfamide and some of its metabolites in plasma and urine.

H. Keizer, J. Beijnen, A. Bult, 1997, Journal of Chromatography B: Biomedical Sciences and Applications.

Pharmacokinetics of ifosfamide, 2- and 3-dechloroethylifosfamide in plasma and urine of cancer patients treated with a 10-day continuous infusion of ifosfamide.

H. Keizer, J. Beijnen, A. Bult, 1996, Anticancer research.

The EORTC Phase II study of iproplatin in advanced osteogenic sarcoma.

M. van Glabbeke, H. Keizer, D. Crowther, 1999, European Journal of Cancer.

A randomized trial of two doses of granisetron in the treatment of chemotherapy-induced emesis. Dutch results within a multinational study.

H. Keizer, J. Nortier, G. Blijham, 1992, The Netherlands journal of medicine.

Preferential inhibition of DNA synthesis in mouse hemopoietic cells by halothane.

H. Keizer, L. V. van Putten, R. F. Evenwel, 1976, Cancer research.

Cisplatin‐DNA adducts and protein‐bound platinum in blood of testicular cancer patients

S. Fosså, J. Kaldor, E. Weiderpass, 1998, Anti-cancer drugs.

Determination of chloroacetaldehyde, a metabolite of oxazaphosphorine cytostatic drugs, in plasma.

H. Keizer, J. Beijnen, A. Bult, 1993, Journal of chromatography.

Acute reversible neurotoxicity after intrathecal low-dose methotrexate.

H. Keizer, P. Edelbroek, F. A. de Wolff, 1991, European journal of cancer.

N7-Methylguanine and O(6)-methylguanine levels in DNA of white blood cells from cancer patients treated with dacarbazine.

H. Keizer, R. Baan, J. V. van Delft, 1996, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.