M. Loza

M. Loza, M. Cadavid, F. Fernandez‐Llimos, 2000, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models

J. Hartman, X. García‐Mera, J. Azuaje, 2022, Journal for ImmunoTherapy of Cancer.

Development of a novel in vitro assay to screen for neuroprotective drugs against iatrogenic neurite shortening

M. Loza, J. Brea, J. Burgueño, 2021, PloS one.

A New Model of Sensorial Neuron-Like Cells for HTS of Novel Analgesics for Neuropathic Pain

M. Loza, J. Brea, J. Burgueño, 2018, SLAS discovery : advancing life sciences R & D.

Exploring the influence of the substituent at position 4 in a series of 3,4-dihydropyrimidin-2(1H)-one A2B adenosine receptor antagonists

J. Azuaje, M. Loza, E. Sotelo, 2017, Chemistry of Heterocyclic Compounds.

Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists.

X. García‐Mera, M. Loza, J. Brea, 2010, Bioorganic & medicinal chemistry.

Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands.

M. Loza, M. Cadavid, J. Díaz, 2010, Bioorganic & medicinal chemistry.

Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines.

F. Sanz, M. Loza, J. Brea, 2008, Bioorganic & medicinal chemistry.

1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor.

F. Sanz, M. Loza, J. Brea, 2008, Bioorganic & medicinal chemistry.

A new chemical tool (C0036E08) supports the role of adenosine A(2B) receptors in mediating human mast cell activation.

M. Loza, J. Brea, M. Cadavid, 2008, Biochemical pharmacology.

Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.

F. Sanz, M. Loza, E. Sotelo, 2006, Journal of medicinal chemistry.

8-Substituted-9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B.

M. Loza, E. Sotelo, M. Cadavid, 2004, European journal of medicinal chemistry.

Design , Synthesis , and Structure-Activity Relationships of 1-, 3-, 8-, and 9-Substituted-9-deazaxanthines at the Human A 2 B Adenosine Receptor

F. Sanz, M. Loza, E. Sotelo, 2022 .

Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Citation

Alessandro, Serge, Tyler B. Hughes, 2016 .

A Novel Multilevel Statistical Method for the Study of the Relationships between Multireceptorial Binding Affinity Profiles and In Vivo Endpoints

A. Bauer-Mehren, F. Sanz, M. Loza, 2010, Molecular Pharmacology.

Disentangling environmental and spatial processes of community assembly in tropical forests from local to regional scales

M. Loza, A. Fuentes, P. M. Jørgensen, 2016 .

Docking Screens for Dual Inhibitors of Disparate Drug Targets for Parkinson’s Disease

P. Svenningsson, M. Loza, J. Brea, 2018, Journal of medicinal chemistry.

3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition.

J. Åqvist, X. García‐Mera, J. Azuaje, 2020, Journal of medicinal chemistry.

Modeling ANXA2-overexpressing circulating tumor cells homing and high throughput screening for metastasis impairment in endometrial carcinomas.

C. Moiola, M. Loza, J. Brea, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

3-Oxopyridazin-5-yl-Chalcone Hybrids : Potent Antiplatelet Agents That Prevent Glycoprotein IIb/IIIa Activation

M. Loza, E. Sotelo, Alberto Coelho, 2017 .

Different pharmacological properties of two equipotent antagonists (clozapine and rauwolscine) for 5-HT2B receptors in rat stomach fundus.

M. Loza, J. Brea, M. Cadavid, 2003, Biochemical pharmacology.

A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation.

M. Loza, Ángel García, Paula Vélez, 2012, Blood.

5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines

M. Loza, J. Brea, B. Cassels, 2019, PloS one.

Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles.

F. Sanz, M. Loza, J. Brea, 2014, European journal of medicinal chemistry.

Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin

M. Loza, J. Brea, R. Moratalla, 2018, Scientific Reports.

New pyrrolopyrimidin-6-yl benzenesulfonamides: potent A2B adenosine receptor antagonists.

M. Loza, M. Cadavid, J. Díaz, 2006, Bioorganic & medicinal chemistry letters.

Insights on biodiversity drivers to predict species richness in tropical forests at the local scale

M. Loza, V. Cala, A. Fuentes, 2022, Ecological Modelling.

Beyond Glutamate Antagonists for Treatment of Ischemic Stroke: Blood Glutamate Grabbing

Santiago de Compostela, M. Loza, T. Sobrino, 2016 .

Effect of urethane on hydralazine-induced tachycardia in rats.

M. Loza, J. Calleja, F. Orallo, 1992, General pharmacology.

Effects of Platelet Activating Factor on Contractions and Ca Influx Induced by Noradrenaline and Potassium in Rat Rubbed and Intact Aorta. Comparison with Its Hypotensive Effect in Anaesthetized Normotensive Rats

M. Loza, F. Orallo, I. Verde, 1992, The Journal of pharmacy and pharmacology.

signaling regulation novel clues on the CLEC-2 signalosome: implications for CLEC-2 A detailed proteomic analysis of rhodocytin-activated platelets reveals

M. Loza, Ángel García, Paula Vélez, 2014 .

Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I2 Receptor Ligand B06

M. Loza, J. Brea, M. Pallàs, 2022, International journal of molecular sciences.

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

B. Hudson, M. Loza, J. Brea, 2010, The Biochemical journal.

New Serotoninergic Ligands Containing Indolic and Methyl Indolic Nuclei: Synthesis and in Vitro Pharmacological Evaluation.

M. Loza, J. Brea, G. Caliendo, 2019, Medicinal chemistry (Shariqah (United Arab Emirates)).

Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M.

F. J. Luque, M. Loza, J. Brea, 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics.

M. Loza, J. Brea, Yolanda Caro, 2004, Bioorganic & medicinal chemistry letters.

A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity.

J. Ballesteros, M. Loza, J. Brea, 2017, Journal of medicinal chemistry.

From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia

M. Loza, J. Brea, M. Morlando, 2022, Pharmaceutics.

Butyrophenone analogues in the carbazole series as potential atypical antipsychotics: synthesis and determination of affinities at D(2), 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

M. Loza, J. Brea, C. Masaguer, 2000, European journal of medicinal chemistry.

Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors.

M. Loza, C. Masaguer, H. Tristán, 1998, Bioorganic & medicinal chemistry letters.

Butyrophenone analogues: Synthesis of 2-methyl-3-ethyl-5-aminoethyl-4,5,6,7-tetrahydroindol-4-ones, and their affinities for d1, d2 and 5-ht2a receptors

M. Loza, M. Cadavid, C. Masaguer, 1995 .

Study of the mechanism of the relaxant action of (+)‐glaucine in rat vas deferens

M. Loza, M. Cadavid, N. Vivas, 1993, British journal of pharmacology.

cis-Platinum Complex Encapsulated in Self-Assembling Cyclic Peptide Dimers.

M. Loza, J. Brea, J. Granja, 2017, Organic letters.

Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist.

M. Loza, M. Cadavid, N. Prats, 2011, ACS medicinal chemistry letters.

Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists.

X. García‐Mera, M. Loza, J. Brea, 2009, Bioorganic & medicinal chemistry.

Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors

M. Loza, J. Brea, F. Feixas, 2022, Journal of medicinal chemistry.

Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for “Diabesity”

J. Ballesteros, M. Loza, J. Brea, 2022, Journal of medicinal chemistry.

Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening

M. Loza, J. Brea, M. Cadavid, 2016, Journal of biomolecular screening.

Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice.

M. Loza, J. Brea, M. Cadavid, 2012, ACS chemical neuroscience.

Katacine Is a New Ligand of CLEC-2 that Acts as a Platelet Agonist

M. Loza, S. Watson, Ángel García, 2022, Thrombosis and haemostasis.

FunAndes – A functional trait database of Andean plants

H. Ramírez-Angulo, E. Vilanova, M. Silman, 2022, Scientific data.

Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke

J. Azuaje, M. Loza, J. Brea, 2018, Annals of neurology.

Emerging opportunities and concerns for drug discovery at serotonin 5-HT2B receptors.

M. Loza, J. Brea, A. Párraga, 2010, Current topics in medicinal chemistry.

2-(Fluoromethoxy)-4′-(S-methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson’s Disease

J. Ballesteros, M. Loza, J. Brea, 2022, Journal of medicinal chemistry.

Corrigendum to “1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor” [Bioorg. Med. Chem. 16 (2008) 2852–2869]

F. Sanz, M. Loza, E. Sotelo, 2008 .

Identification of ABA Receptor Agonists Using a Multiplexed High-Throughput Chemical Screening.

M. Loza, J. Brea, P. L. Rodriguez, 2021, Methods in molecular biology.

Exploring Non-orthosteric Interactions with a Series of Potent and Selective A3 Antagonists

X. García‐Mera, J. Azuaje, M. Loza, 2022, ACS medicinal chemistry letters.

2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenosine receptor antagonists: Synthesis and structure-activity relationships.

M. Loza, J. Brea, M. F. Proença, 2019, Bioorganic & medicinal chemistry.

From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.

V. Andrisano, M. Bartolini, M. Bolognesi, 2021, European journal of medicinal chemistry.

Cardiovascular effects of ketanserin on normotensive rats in vivo and in vitro.

M. Loza, M. Cadavid, F. Orallo, 2000, General pharmacology.

The Chembiobank project: building annotated molecular libraries for drug discovery

Fernando Albericio, Ferran Sanz, Jordi Mestres, 2009 .

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Manuel Llinás, George Papadatos, Sundari Suresh, 2016, PLoS pathogens.

Pyridazine derivatives XII. Synthesis and antipsychotic-antidepressant activity of some butyrophenone derivatives of 6-phenylpyridazine

M. Loza, M. Cadavid, M. L. Ceballos, 1994 .

Dibenzofuranylethylamines as 5-HT2A/2C Receptor Agonists

Douglas J. Matthies, M. Loza, J. Brea, 2020, ACS omega.

Novel Phthalazin-1(2H)-One Derivatives Displaying a Dithiocarbamate Moiety as Potential Anticancer Agents

M. Loza, J. Brea, P. Besada, 2022, Molecules.

Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity

M. Loza, J. Brea, P. Besada, 2022, ACS medicinal chemistry letters.

Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists.

X. García‐Mera, J. Azuaje, M. Loza, 2013, ACS medicinal chemistry letters.

Cyproheptadine analogues: synthesis, antiserotoninergic activity, and structure-activity relationships.

F. Sanz, M. Loza, M. Cadavid, 1993, Journal of pharmaceutical sciences.

Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked 1,4-dihydropyridines as potent positive inotropes

J. Mestres, M. Loza, J. Brea, 2017, Molecular Diversity.

Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease.

F. J. Luque, M. Loza, J. Brea, 2017, Future medicinal chemistry.

Study of the in vivo and in vitro cardiovascular effects of four new analogues of ketanserin: implication of 5-HT2A and alpha1 adrenergic antagonism in their hypotensive effect.

M. Loza, J. Calleja, F. Orallo, 2000, Biological & pharmaceutical bulletin.

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model.

M. A. Moro, Cristina Val, M. Loza, 2012, European journal of medicinal chemistry.

Synthesis of novel chromene scaffolds for adenosine receptors.

M. Loza, J. Brea, Marta Costa, 2011, Organic & biomolecular chemistry.

Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R).

M. Loza, J. Brea, N. Colabufo, 2020, European journal of medicinal chemistry.

Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics.

M. Loza, J. Brea, E. Domínguez, 2007, Bioorganic & medicinal chemistry letters.

Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidences of Stereospecific Recognition.

X. García‐Mera, J. Azuaje, M. Loza, 2019, Journal of medicinal chemistry.

Synthesis by microwave-assisted 1,3-dipolar cycloaddition of 1,2,3-triazole 1'-homo-3'-isoazanucleosides and evaluation of their anticancer activity.

X. García‐Mera, M. Loza, J. Brea, 2015, European journal of medicinal chemistry.

New chromene scaffolds for adenosine A(2A) receptors: synthesis, pharmacology and structure-activity relationships.

J. Mestres, Elisabet Gregori-Puigjané, M. Loza, 2012, European journal of medicinal chemistry.

Synthesis, 3D‐QSAR, and Structural Modeling of Benzolactam Derivatives with Binding Affinity for the D2 and D3 Receptors

F. Sanz, M. Loza, J. Brea, 2010, ChemMedChem.

High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides.

M. Loza, J. Brea, M. Vázquez, 2016, Chemical communications.

Syntheses and cytotoxicity of (R)- and (S)-7-methoxycryptopleurine.

M. Loza, J. Brea, J. Gonzalez-Gomez, 2015, The Journal of organic chemistry.

Concise asymmetric syntheses of novel phenanthroquinolizidines.

M. Loza, J. Brea, J. Gonzalez-Gomez, 2016, Organic & biomolecular chemistry.

Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities.

M. Loza, J. Brea, M. Cadavid, 2013, European journal of medicinal chemistry.

In vivo and in vitro pharmacological studies of a new hypotensive compound (QF0301B) in rat: comparison with prazosin, a known α1-adrenoceptor antagonist

M. Loza, F. Orallo, C. Masaguer, 2003 .

The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen‐Activated Protein Kinase Inhibitors

M. Loza, J. Brea, S. Laufer, 2015, Chemical biology & drug design.

Natural tetraponerines: a general synthesis and antiproliferative activity.

M. Loza, J. Brea, J. Gonzalez-Gomez, 2014, The Journal of organic chemistry.

Bicyclic -iminophosphonates as highly affinity imidazoline I2 receptor ligands for Alzheimer's Disease.

F. J. Luque, P. Pérez-Lozano, L. Naesens, 2020, Journal of medicinal chemistry.

Synthesis, Pharmacological and Biological Evaluation of MIF-1 Picolinoyl Peptidomimetics as Positive Allosteric Modulators of D2R.

X. García‐Mera, M. Loza, J. Brea, 2019, ACS Chemical Neuroscience.

Inhibition of P-glycoprotein pumps by PEO-PPO amphiphiles: branched versus linear derivatives.

M. Loza, J. Brea, A. Concheiro, 2010, Nanomedicine.

Doxorubicin-loaded micelles of reverse poly(butylene oxide)-poly(ethylene oxide)-poly(butylene oxide) block copolymers as efficient "active" chemotherapeutic agents.

M. Loza, J. Brea, A. Concheiro, 2013, International journal of pharmaceutics.

2-Oxaadamant-1-yl ureas as soluble epoxide hydrolase inhibitors: in vivo evaluation in a murine model of acute pancreatitis.

M. Loza, J. Brea, J. Oyarzábal, 2020, Journal of medicinal chemistry.

In silico directed chemical probing of the adenosine receptor family.

Jordi Mestres, Hugo Gutiérrez-de-Terán, Elisabet Gregori-Puigjané, 2010, Bioorganic & medicinal chemistry.

A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice

M. Loza, J. Brea, M. Pallàs, 2020, Pharmaceutics.

Chitosan-hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma.

M. Loza, J. Brea, M. Alonso, 2009, International journal of pharmaceutics.

Psychosocial and behavioural determinants of the implementation of Pharmaceutical Care in Spain

M. Loza, María Olivo del Valle, W. Markham, 2009, Pharmacy World & Science.

Cognitive Deficit in Schizophrenia: From Etiology to Novel Treatments

M. Loza, J. Brea, M. T. de Los Frailes, 2021, International journal of molecular sciences.

Design, Synthesis and 5-HT1A Binding Affinity of N-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)tricyclo[3.3.1.13,7]decan-1-amine and N-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)-3,5-dimethyl-tricylo[3.3.1.13,7]decan-1-amine

M. Loza, Grigoris Zoidis, M. Catto, 2022, Molbank.

Synthesis of new mannosyl, galactosyl and glucosyl theophylline nucleosides with potential activity as antagonists of adenosine receptors. DEMA-induced cyclization of glycosylideneiminouracils.

M. Loza, J. Brea, M. Pérez-González, 2008, Carbohydrate research.

Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

M. Loza, E. Domínguez, F. Triana-Martínez, 2020, Cells.

Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism.

M. Loza, J. Brea, F. Albericio, 2017, Cell chemical biology.

New Approaches Applied to Drug Screening

José Antonio Fraiz Brea, María Isabel Loza, M. Loza, 2012 .

Membrane-disrupting iridium(iii) oligocationic organometallopeptides.

M. Loza, J. Brea, J. Montenegro, 2016, Chemical communications.

Identification and characterization of Cardiac Glycosides as senolytic compounds

M. Loza, M. Serrano, J. Arribas, 2019, Nature Communications.

The PI3Kδ Inhibitor Idelalisib Diminishes Platelet Function and Shows Antithrombotic Potential

M. Loza, Ángel García, E. Domínguez, 2021, International journal of molecular sciences.

Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization

M. Loza, J. Brea, M. Cadavid, 2017, European journal of pharmacology.

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

M. Loza, M. Lotz, P. Robbins, 2019, EBioMedicine.

Structure‐Based Virtual Screening for Dopamine D2 Receptor Ligands as Potential Antipsychotics

Peter Kolb, Antti Poso, Agnieszka A Kaczor, 2016, ChemMedChem.

The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling

M. Loza, J. Brea, M. Cadavid, 2013, Pharmacology research & perspectives.

Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: A comparative study

M. Loza, J. Brea, M. Cadavid, 2015, Neuroscience.

Structure‐Guided Design of G‐Protein‐Coupled Receptor Polypharmacology

P. Svenningsson, P. Matricon, M. Loza, 2021, Angewandte Chemie.

A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade

M. Loza, Ángel García, M. Carrascal, 2019, Thrombosis and Haemostasis.

Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase.

M. Loza, J. Brea, E. Sotelo, 2022, Journal of medicinal chemistry.

Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease

M. Loza, J. Brea, M. Pallàs, 2020, Neurotherapeutics.

Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease

M. Loza, J. Brea, M. Pallàs, 2019, Neurotherapeutics.

Continuing education and community pharmacists in Galicia: a study of opinions

M. Loza, M. Cadavid, Carlos Díaz, 2004, Pharmacy World and Science.

N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R).

M. Loza, E. Sotelo, J. Brea, 2023, European journal of medicinal chemistry.

Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists

X. García‐Mera, Cristina Val, M. Loza, 2022, Journal of medicinal chemistry.

Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.

F. J. Luque, F. Ciruela, I. Ferrer, 2020, Journal of medicinal chemistry.

Antiserotoninergic activity of 2-aminoethylbenzocyclanones in rat aorta: structure-activity relationships.

F. Sanz, M. Loza, I. Verde, 1993, Journal of pharmaceutical sciences.

Extensive linkage disequilibrium mapping at HTR2A and DRD3 for schizophrenia susceptibility genes in the Galician population

M. Loza, Á. Carracedo, J. Costas, 2007, Schizophrenia Research.

Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists

F. Ciruela, X. García‐Mera, M. Loza, 2022, Journal of medicinal chemistry.

Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists.

X. García‐Mera, M. Loza, J. Brea, 2010, European journal of medicinal chemistry.

Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.

Dhilon S. Patel, M. Loza, J. Brea, 2022, European journal of medicinal chemistry.

From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis

M. Loza, J. Brea, F. Feixas, 2021, Journal of medicinal chemistry.

Evidence for Distinct Antagonist-Revealed Functional States of 5-Hydroxytryptamine2A Receptor Homodimers

M. Loza, J. Brea, M. Cadavid, 2009, Molecular Pharmacology.

Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.

M. Loza, J. Brea, S. Laufer, 2019, European journal of medicinal chemistry.

Influence of pH on the binding of diphenylmethylenepiperidines by 5-HT2B receptors in rat stomach fundus.

F. Sanz, M. Loza, M. Cadavid, 2002, Chemical & pharmaceutical bulletin.

Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs.

M. Loza, A. Kaczor, Oliwia Koszła, 2019, European journal of medicinal chemistry.

A novel mechanism of neuroprotection: Blood glutamate grabber

M. Loza, J. Brea, T. Sobrino, 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects

M. Loza, J. Brea, M. Cadavid, 2017, Molecules.

The Application of the Open Pharmacological Concepts Triple Store (Open PHACTS) to Support Drug Discovery Research

Barbara Zdrazil, Ronald Siebes, Maria Isabel Loza, 2014, PloS one.

Protocols for minor ailments of the TESEMED project : cold and flu

M. Loza, M. Cadavid, F. Giorgio, 2001 .

Protocols for minor ailments of the TESEMED project : cough

M. Loza, M. Cadavid, L. Cordero, 2001 .

Telematics will be useful in providing information

M. Loza, P. Baetens, F. Sanz, 1996, BMJ.

Cytocompatibility and P-glycoprotein inhibition of block copolymers: structure-activity relationship.

M. Loza, J. Brea, A. Concheiro, 2013, Molecular pharmaceutics.

Poly(styrene oxide)-poly(ethylene oxide) block copolymers: From "classical" chemotherapeutic nanocarriers to active cell-response inducers.

M. Loza, J. Brea, A. Concheiro, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Elevational Gradients in β-Diversity Reflect Variation in the Strength of Local Community Assembly Mechanisms across Spatial Scales

M. Loza, A. Fuentes, P. M. Jørgensen, 2015, PloS one.

Fluorescence based HTS-compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells

M. Loza, E. Sotelo, J. Brea, 2023, Frontiers in Molecular Biosciences.

In vivo and in vitro pharmacological studies of a new hypotensive compound (QF0301B) in rat: comparison with prazosin, a known alpha1-adrenoceptor antagonist.

M. Loza, F. Orallo, M. J. Enguix, 2003, Vascular pharmacology.

Functional characterization of serotonin receptors in rat isolated aorta.

M. Loza, M. Cadavid, F. Orallo, 2002, Biological & pharmaceutical bulletin.

Collaboration and knowledge integration for successful brain therapeutics – lessons learned from the pandemic

M. Loza, Sohini Chowdhury, C. Bountra, 2022, Disease models & mechanisms.

A GABA, reelin, and the neurodevelopmental hypothesis of schizophrenia.

M. Loza, I. G. Dopeso-Reyes, H. Caruncho, 2004, Critical reviews in neurobiology.

Structure-based discovery of selective serotonin 5-HT(1B) receptor ligands.

David Rodríguez, María Isabel Loza, Jens Carlsson, 2014, Structure.

Synthesis and Biological Evaluation of Dantrolene‐Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases

M. Loza, M. Catto, C. Altomare, 2021, ChemMedChem.

The role of niche overlap, environmental heterogeneity, landscape roughness and productivity in shaping species abundance distributions along the Amazon–Andes gradient

M. Loza, V. Cala, M. Umaña, 2016, Global Ecology and Biogeography.

A Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists.

X. García‐Mera, M. Loza, J. Brea, 2020, Journal of medicinal chemistry.

Modelling of the 5-HT2A Receptor and Its Ligand Complexes

F. Sanz, M. Loza, E. Lozoya, 2000 .

Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.

M. Loza, M. Cadavid, M. Calbet, 2007, Journal of medicinal chemistry.

Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics.

Karen Villalba, F. Sanz, M. Loza, 2008, Journal of medicinal chemistry.

Commonness and rarity determinants of woody plants in different types of tropical forests

M. Loza, M. Macía, G. Arellano, 2015, Biodiversity and Conservation.

Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

Ó. Pozo, M. Loza, J. Viña, 2023, Nature communications.

Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors

X. García‐Mera, M. Loza, J. Brea, 2017, Scientific Reports.

Phylogenetic patterns of rarity in a regional species pool of tropical woody plants

R. Ricklefs, M. Loza, P. M. Jørgensen, 2016 .

Phylogenetic patterns of rarity in a regional species pool of tropical trees

M. Loza, 2014 .

Detection of New Biased Agonists for the Serotonin 5-HT2A Receptor: Modeling and Experimental Validation

Ferran Sanz, José Brea, Jana Selent, 2015, Molecular Pharmacology.

Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents - Design, synthesis, structural studies and pharmacological profiling.

M. Loza, J. Handzlik, T. Karcz, 2023, European journal of medicinal chemistry.

Conformationally constrained butyrophenones as new pharmacological tools to study 5-HT 2A and 5-HT 2C receptor behaviours.

F. Sanz, M. Loza, J. Brea, 2003, European journal of medicinal chemistry.

A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry

F. Sanz, M. Loza, J. Brea, 2023, Archives of Toxicology.

A systematic assessment of threats affecting the rare plants of the United States

M. Loza, Adam B. Smith, Justin T. Kos, 2016 .

Synthesis, affinity at 5-HT2A, 5-HT2B and 5-HT2C serotonin receptors and structure-activity relationships of a series of cyproheptadine analogues.

F. Sanz, M. Loza, M. Cadavid, 1997, Chemical and pharmaceutical bulletin.

Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates.

X. García‐Mera, M. Loza, E. Sotelo, 2017, Journal of medicinal chemistry.

Normalization of DNA encoded library affinity selection results driven by high throughput sequencing and HPLC purification.

M. Loza, J. Amigo, E. Domínguez, 2021, Bioorganic & medicinal chemistry.

1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships.

M. Loza, J. Brea, F. Leonetti, 2008, Bioorganic & medicinal chemistry.

Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif.

M. Loza, J. Brea, E. Domínguez, 2009, Bioorganic & medicinal chemistry letters.

Sensitization to MDMA locomotor effects and changes in the functionality of 5-HT2A and D2 receptors in mice

P. Robledo, M. Loza, J. Brea, 2011, Behavioural pharmacology.

Identification of Sodium Transients Through NaV1.5 Channels as Regulators of Differentiation in Immortalized Dorsal Root Ganglia Neurons

M. Loza, J. Brea, R. Cruz, 2022, Frontiers in Cellular Neuroscience.

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease

M. Bartolini, M. Loza, J. Brea, 2022, Journal of medicinal chemistry.

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors.

M. Loza, J. Brea, M. Cadavid, 2014, Journal of medicinal chemistry.

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds.

Cristina Val, M. Loza, J. Brea, 2012, Journal of medicinal chemistry.

Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder.

M. Loza, E. Lacivita, M. Leopoldo, 2021, ACS chemical neuroscience.

Divergent solution-phase synthesis of diarylpyrimidine libraries as selective A3 adenosine receptor antagonists.

X. García‐Mera, M. Loza, E. Sotelo, 2009, Journal of combinatorial chemistry.

Docking finds GPCR ligands in dark chemical matter.

J. Irwin, M. Loza, J. Brea, 2019, Journal of medicinal chemistry.

Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells

M. Loza, E. Sotelo, J. Brea, 2006, Neuropharmacology.

Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety

M. Loza, A. Kaczor, Katarzyna M Targowska-Duda, 2022, ChemMedChem.

New Diarylureas as Activators of the Heme-Regulated EIF2α Kinase for the Treatment of Type 2 Diabetes Mellitus

M. Loza, J. Brea, J. Pizarro, 2019, Proceedings.

Essential role of the C148 - C227 disulphide bridge in the human 5-HT2A homodimeric receptor.

M. Loza, J. Brea, M. Cadavid, 2020, Biochemical pharmacology.

Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs.

X. García‐Mera, M. Loza, E. Sotelo, 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics.

M. Loza, Alberto Coelho, J. Brea, 2005, Bioorganic & medicinal chemistry letters.

8-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studies.

E. Uriarte, Cristina Val, M. Loza, 2023, European journal of medicinal chemistry.

Relative effects of edaphic conditions and climate on palm communities in the Central Andes

M. Loza, A. Fuentes, Leslie Cayola, 2021, bioRxiv.

Author Correction: Identification and characterization of Cardiac Glycosides as senolytic compounds

M. Loza, M. Serrano, J. Arribas, 2020, Nature Communications.

Multistructure 3D-QSAR studies on a series of conformationally constrained butyrophenones docked into a new homology model of the 5-HT2A receptor.

Ferran Sanz, María Isabel Loza, Cristina Dezi, 2007, Journal of medicinal chemistry.

Polyethylene Oxide-Polystyrene Oxide Triblock Copolymers as Biological-Responsive Nanocarriers.

M. Loza, J. Brea, A. Concheiro, 2012 .

Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists.

Hugo Gutiérrez-de-Terán, José Brea, Willem Jespers, 2017, Journal of medicinal chemistry.

A new chemical tool (C0036E08) supports the role of adenosine A(2B) receptors in mediating human mast cell activation.

M. Loza, J. Brea, M. Cadavid, 2008, Biochemical pharmacology.

Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism.

M. Loza, J. Brea, M. Palacín, 2017, Cell chemical biology.

Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics.

Karen Villalba, F. Sanz, M. Loza, 2008, Journal of medicinal chemistry.

Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold.

David Rodríguez, Hugo Gutiérrez-de-Terán, María Isabel Loza, 2013, European journal of medicinal chemistry.

Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: A comparative study

M. Loza, J. Brea, M. Cadavid, 2015, Neuroscience.

Synthesis by microwave-assisted 1,3-dipolar cycloaddition of 1,2,3-triazole 1'-homo-3'-isoazanucleosides and evaluation of their anticancer activity.

X. García‐Mera, M. Loza, J. Brea, 2015, European journal of medicinal chemistry.

Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands.

F. Sanz, M. Loza, J. Brea, 2009, Bioorganic & medicinal chemistry letters.

A potential nanomedicine consisting of heparin-loaded polysaccharide nanocarriers for the treatment of asthma.

M. Loza, J. Brea, M. Alonso, 2012, Macromolecular bioscience.

Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands

Ádám A. Kelemen, Krzysztof Rataj, Ádám Andor Kelemen, 2018, Molecules.

Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer's disease.

M. Loza, J. Brea, K. Nikolić, 2021, European journal of medicinal chemistry.