E. Hu

发表

Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors.

E. Hu, R. Kunz, Shannon Rumfelt, 2012, Bioorganic & medicinal chemistry letters.

AMG 580: A Novel Small Molecule Phosphodiesterase 10A (PDE10A) Positron Emission Tomography Tracer

N. Chen, E. Hu, R. Kunz, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor.

E. Hu, N. Cosford, A. Pinkerton, 2004, Bioorganic & medicinal chemistry letters.

Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity.

Jun Liang, E. Hu, P. Prasit, 2009, Bioorganic & medicinal chemistry letters.

Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit.

E. Hu, R. Kunz, N. Chen, 2008, Journal of medicinal chemistry.

Unprecedented Catalytic Three Component One-Pot Condensation Reaction: An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones

E. Hu, D. Sidler, U. Dolling, 1998 .

Efficient synthesis of the optically active dihydropyrimidinone of a potent α1A- selective adrenoceptor antagonist

M. Chartrain, E. Hu, D. Sidler, 2002 .

An aldol-based approach to the asymmetric synthesis of L-callipeltose, the deoxyamino sugar of L-callipeltoside A.

E. Hu, J. Tedrow, D. Evans, 2001, Organic letters.

Enantioselective total synthesis of callipeltoside A: two approaches to the macrolactone fragment.

E. Hu, Davidr . Evans, J. Burch, 2008, Tetrahedron.

Enantioselective total synthesis of callipeltoside A.

E. Hu, Davidr . Evans, J. Burch, 2002, Journal of the American Chemical Society.

Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A).

E. Hu, S. Chmait, J. Treanor, 2014, ACS medicinal chemistry letters.

Design and Asymmetric Synthesis of beta-Strand Peptidomimetics.

John C. Roberts, E. Hu, J. Rebek, 1996, The Journal of organic chemistry.

Use of structure based design to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A (PDE10A) inhibitors against phosphodiesterase 3 (PDE3).

E. Hu, R. Kunz, Shannon Rumfelt, 2012, Bioorganic & medicinal chemistry letters.

Design, optimization, and biological evaluation of novel keto-benzimidazoles as potent and selective inhibitors of phosphodiesterase 10A (PDE10A).

E. Hu, R. Kunz, Shannon Rumfelt, 2013, Journal of medicinal chemistry.

Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A).

E. Hu, R. Kunz, N. Chen, 2014, Journal of medicinal chemistry.

Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer.

D. Hwang, E. Hu, R. Kunz, 2012, Journal of Medicinal Chemistry.

Discovery of amido-benzisoxazoles as potent c-Kit inhibitors.

E. Hu, R. Kunz, Shannon Rumfelt, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.

E. Hu, R. Kunz, N. Chen, 2014, Bioorganic & medicinal chemistry.

Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux.

E. Hu, Shannon Rumfelt, N. Chen, 2012, Bioorganic & medicinal chemistry letters.

Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer.

D. Hwang, E. Hu, R. Kunz, 2012, Journal of medicinal chemistry.

AMG 580: A Novel Small Molecule Phosphodiesterase 10A (PDE10A) Positron Emission Tomography Tracer

N. Chen, E. Hu, R. Kunz, 2015, The Journal of Pharmacology and Experimental Therapeutics.

E. Hu, R. Kunz, N. Chen, 2014, Journal of medicinal chemistry.

Initial characterization of a PDE10A selective positron emission tomography tracer [11C]AMG 7980 in non-human primates.

D. Hwang, E. Hu, Shannon Rumfelt, 2014, Nuclear medicine and biology.

Discovery of Phosphodiesterase 10A (PDE10A) PET Tracer AMG 580 to Support Clinical Studies.

D. Hwang, E. Hu, R. Kunz, 2016, ACS medicinal chemistry letters.

Radiosynthesis and initial characterization of a PDE10A specific PET tracer [18F]AMG 580 in non-human primates.

D. Hwang, E. Hu, J. Treanor, 2015, Nuclear medicine and biology.