N. Chen

发表

Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors.

E. Hu, R. Kunz, Shannon Rumfelt, 2012, Bioorganic & medicinal chemistry letters.

Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate.

N. Chen, J. Treanor, C. Dominguez, 2007, Journal of medicinal chemistry.

Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.

N. Chen, J. Treanor, V. Viswanadhan, 2007, Journal of medicinal chemistry.

Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.

Shannon Rumfelt, N. Chen, S. Hitchcock, 2013, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of a series of pyrrolo[3,2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists.

N. Chen, Z. Chen, V. Santora, 2000, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of trisubstituted phenyl urea derivatives as neuropeptide Y5 receptor antagonists.

N. Chen, C. Fotsch, M. Norman, 2001, Journal of medicinal chemistry.

Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides.

N. Chen, C. Fotsch, A. Bannon, 2005, Bioorganic & medicinal chemistry letters.

First-in-class pan caspase inhibitor developed for the treatment of liver disease.

N. Chen, J. Díaz, K. Valentino, 2005, Journal of medicinal chemistry.

Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit.

E. Hu, R. Kunz, N. Chen, 2008, Journal of medicinal chemistry.

Schedule-dependent effects of kappa-selenocarrageenan in combination with epirubicin on hepatocellular carcinoma.

N. Chen, Yubin Ji, Wen-lan Li, 2014, Asian Pacific journal of cancer prevention : APJCP.

Electrochemically Enabled Intramolecular and Intermolecular Annulations of Alkynes

N. Chen, Kai Sun, Bing Liu, 2020 .

Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors.

N. Chen, J. McCarter, K. Rex, 2019, Journal of medicinal chemistry.

Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads.

N. Chen, J. Díaz, A. Schmitz, 2005, Bioorganic & medicinal chemistry letters.

The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement.

N. Chen, D. Whittington, M. Bartberger, 2020, Bioorganic & medicinal chemistry letters.

New ingenane diterpenoids from Euphorbia kansui reverse multi-drug resistance

N. Chen, Z. Zhan, Diheng Luo, 2021 .

Autophagy-associated targeting pathways of natural products during cancer treatment.

N. Chen, Xiaoqin Yang, Xiaoli Wang, 2015, Asian Pacific journal of cancer prevention : APJCP.

Design, optimization, and biological evaluation of novel keto-benzimidazoles as potent and selective inhibitors of phosphodiesterase 10A (PDE10A).

E. Hu, R. Kunz, Shannon Rumfelt, 2013, Journal of medicinal chemistry.

Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A).

E. Hu, R. Kunz, N. Chen, 2014, Journal of medicinal chemistry.

Narciclasine - A Potential Anticancer Drug

N. Chen, Yubin Ji, D. Song, 2013 .

Discovery of amido-benzisoxazoles as potent c-Kit inhibitors.

E. Hu, R. Kunz, Shannon Rumfelt, 2008, Bioorganic & medicinal chemistry letters.

Effect of Tumstatin T-7 Peptide on HepG-2 Cells and Human Umbilical Vein Endothelial Cells

N. Chen, Jia Liu, X. Zhang, 2013 .

Tumstatin 7 Peptide Affect Biological Activity of B16 Melanoma Cell

N. Chen, Jia Liu, X. Zhang, 2013 .

The Effect of T-7 Peptide on Human Non-Small-Cell Carcinoma A549 Cells

N. Chen, Jia Liu, X. Zhang, 2013 .

Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides.

N. Chen, J. Treanor, P. Chakrabarti, 2005, Journal of medicinal chemistry.

Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.

N. Chen, J. Díaz, A. Schmitz, 2002, Bioorganic & medicinal chemistry letters.

Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.

E. Hu, R. Kunz, N. Chen, 2014, Bioorganic & medicinal chemistry.

Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux.

E. Hu, Shannon Rumfelt, N. Chen, 2012, Bioorganic & medicinal chemistry letters.

Alkaloids from beach spider lily (Hymenocallis littoralis) induce apoptosis of HepG-2 cells by the fas-signaling pathway.

N. Chen, Shiyong Gao, Yubin Ji, 2014, Asian Pacific Journal of Cancer Prevention.

E. Hu, R. Kunz, N. Chen, 2014, Journal of medicinal chemistry.

Discovery of Phosphodiesterase 10A (PDE10A) PET Tracer AMG 580 to Support Clinical Studies.

D. Hwang, E. Hu, R. Kunz, 2016, ACS medicinal chemistry letters.