P. White

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Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy

A. T. Nguyen, Joanne Baltos, Trayder Thomas, 2016, Molecular Pharmacology.

Oligonucleotide uptake in cultured keratinocytes: influence of confluence, cationic liposomes, and keratinocyte cell type.

P. White, R. Fogarty, S. McKean, 1999, The Journal of investigative dermatology.

Interaction of viruses with host cell molecular motors.

P. White, C. Pouton, Ming Je Hsieh, 2010, Current opinion in biotechnology.

Comparison of opioid receptor distributions in the rat central nervous system.

P. White, A. C. Gray, I. Coupar, 2006, Life sciences.

The capacity of G protein-coupled receptors to modulate mammalian target of rapamycin (mTOR) activity is a newly emerging paradigm with the potential to link cell surface receptors with cell survival. Cardiomyocyte viability is linked to signaling pathways

Joanne Baltos, P. White, L. May, 2017 .

Edaravone containing isoindoline nitroxides for the potential treatment of cardiovascular ischaemia

P. White, S. Bottle, P. Scammells, 2011 .

Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation.

P. White, C. Pouton, B. Boyd, 2012, Molecular pharmaceutics.

A Novel Highly Selective Adenosine A1 Receptor Agonist VCP28 Reduces Ischemia Injury in a Cardiac Cell Line and Ischemia–Reperfusion Injury in Isolated Rat Hearts at Concentrations That Do Not Affect Heart Rate

Shane M. Devine, P. White, C. Pouton, 2010, Journal of cardiovascular pharmacology.

Effect of the 5-HT4 receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract

P. White, H. Irving, I. Coupar, 2018, BMC Research Notes.

Tissue dependent differences in G-protein coupled receptor kinases associated with 5-HT4 receptor desensitization in the rat gastro-intestinal tract.

P. White, H. Irving, I. Coupar, 2011, Biochemical pharmacology.

Antisense oligonucleotides in cutaneous therapy.

P. White, C. Wraight, P. White, 2001, Pharmacology & therapeutics.

Capadenoson, a clinically trialed partial adenosine A1 receptor agonist, can stimulate adenosine A2B receptor biased agonism

Joanne Baltos, P. White, A. Christopoulos, 2017, Biochemical pharmacology.

The Role of the Second Extracellular Loop of the Adenosine a 1 Receptor on Allosteric Modulator Binding, Signaling and Cooperativity

A. T. Nguyen, Trayder Thomas, Toan D. Nguyen, 2022 .

Cooperative Cardioprotection Through Adenosine A1 and A2A Receptor Agonism in Ischemia-Reperfused Isolated Mouse Heart

P. White, C. Ledent, C. Pouton, 2010, Journal of cardiovascular pharmacology.

Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents

W. R. Jackson, P. White, C. Wright, 2015 .

VCP746, a novel A1 adenosine receptor biased agonist, reduces hypertrophy in a rat neonatal cardiac myocyte model

Shane M. Devine, H. Krum, P. White, 2016, Clinical and experimental pharmacology & physiology.

Full title : VCP 746 , a Novel A 1 Adenosine Receptor Biased Agonist , Reduces Hypertrophy in a Rat Neonatal Cardiac Myocyte Model Short title : VCP 746 and Cardiac Myocyte Hypertrophy

Shane M. Devine, H. Krum, P. White, 2016 .

The hybrid molecule, VCP746, is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling.

Joanne Baltos, P. White, A. Christopoulos, 2016, Biochemical pharmacology.

Functional characterization of adenosine receptors in the nucleus tractus solitarius mediating hypotensive responses in the rat

P. White, W. Hope, R. Rose'meyer, 1996, British journal of pharmacology.

Dual acting antioxidant A1 adenosine receptor agonists.

Shane M. Devine, P. White, S. Bottle, 2007, Bioorganic & medicinal chemistry letters.

Use of Kv1.3 blockers for inflammatory skin conditions.

D. Manallack, P. White, H. Wulff, 2010, Current medicinal chemistry.

Changes in adenosine receptors mediating hypotension in morphine-dependent rats.

P. White, W. Hope, R. Rose'meyer, 1995, European journal of pharmacology.

CHARACTERIZATION OF THE ACUTE CARDIOVASCULAR EFFECTS OF INTRAVENOUSLY ADMINISTERED INSULIN‐LIKE GROWTH FACTOR‐I IN CONSCIOUS SPRAGUE‐DAWLEY RATS

P. White, Shannen Lau, Nga Cao, 2006, Clinical and experimental pharmacology & physiology.

Colloidal characteristics and formulation of pure protein particulate vaccines

P. White, C. Pouton, B. Boyd, 2012, The Journal of pharmacy and pharmacology.

Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides

P. White, R. Fogarty, S. McKean, 2000, Nature Biotechnology.

Cardioprotection Induced by Adenosine A1 Receptor Agonists in a Cardiac Cell Ischemia Model Involves Cooperative Activation of Adenosine A2A and A2B Receptors by Endogenous Adenosine

P. White, C. Pouton, I. Coupar, 2009, Journal of cardiovascular pharmacology.

Sequence dependence of C5-propynyl-dU,dC-phosphorothioate oligonucleotide inhibition of the human IGF-I receptor: mRNA, protein, and cell growth.

P. White, R. Fogarty, S. McKean, 2002, Antisense & nucleic acid drug development.

An Allosteric Modulator of the Adenosine A1 Receptor Improves Cardiac Function Following Ischaemia in Murine Isolated Hearts

Shane M. Devine, P. White, A. Butcher, 2013, Pharmaceuticals.

Antisense oligonucleotide treatments for psoriasis

P. White, C. Wraight, L. Atley, 2004, Expert opinion on biological therapy.

Self-Crosslinking Lipopeptide/DNA/PEGylated Particles: A New Platform for DNA Vaccination Designed for Assembly in Aqueous Solution

P. White, C. Pouton, J. Ho, 2018, Molecular therapy. Nucleic acids.

Buccal mucosal delivery of a potent peptide leads to therapeutically-relevant plasma concentrations for the treatment of autoimmune diseases.

P. White, R. Norton, B. Boyd, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants.

P. White, A. Lew, B. Boyd, 2008, Vaccine.

Commercially Supplied Amine-Modified siRNAs May Require Ultrafiltration prior to Conjugation with Amine-Reactive Compounds

P. White, C. Pouton, B. Boyd, 2011, Journal of Nucleic Acids.

Intravenous Insulin-like Growth Factor-I Receptor Antisense Treatment Reduces Angiotensin Receptor Expression and Function in Spontaneously Hypertensive Rats

P. White, J. Short, Nga Cao, 2006, Journal of Pharmacology and Experimental Therapeutics.

Comparison of opioid receptor distributions in the rat ileum.

P. White, A. C. Gray, I. Coupar, 2006, Life sciences.

Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum

P. White, A. C. Gray, I. Coupar, 2005, British journal of pharmacology.

Synthesis and Biological Evaluation of Adenosines with Heterobicyclic and Polycyclic N6‐Substituents as Adenosine A1 Receptor Agonists

P. White, M. Kassiou, C. Pouton, 2012, ChemMedChem.

The adenosine A2B G protein-coupled receptor: Recent advances and therapeutic implications.

P. White, L. May, E. A. Vecchio, 2019, Pharmacology & therapeutics.

Novel Irreversible Agonists Acting at the A1 Adenosine Receptor.

A. T. Nguyen, P. White, P. Sexton, 2016, Journal of medicinal chemistry.

Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.

Shane M. Devine, P. White, S. Bottle, 2010, Bioorganic & medicinal chemistry.

BARRIERS TO SUCCESSFUL DELIVERY OF SHORT INTERFERING RNA AFTER SYSTEMIC ADMINISTRATION

P. White, P. White, 2008, Clinical and experimental pharmacology & physiology.

Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides

P. White, C. Pouton, B. Boyd, 2009, Expert Reviews in Molecular Medicine.

Targeting Adenosine Receptors for the Treatment of Cardiac Fibrosis

P. White, L. May, E. A. Vecchio, 2017, Front. Pharmacol..

Antisense inhibition of IGF receptor expression in HaCaT keratinocytes: a model for antisense strategies in keratinocytes.

P. White, R. Fogarty, G. Werther, 2000, Antisense & nucleic acid drug development.

Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

A. T. Nguyen, P. White, P. Sexton, 2021, Nature.

Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists.

Shane M. Devine, P. White, S. Bottle, 2012, Journal of medicinal chemistry.

Biased agonism at adenosine receptors.

Joanne Baltos, P. White, L. May, 2021, Cellular signalling.

Intranuclear localization of insulin-like growth factor binding protein-3 (IGFBP-3) during cell division in human keratinocytes.

P. White, G. Werther, C. Wraight, 1998, The Journal of investigative dermatology.

HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models

D. Pinault, C. Reid, P. White, 2014, Epilepsia.

&agr;1A‐Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes

Joanne Baltos, P. White, L. May, 2018, Biochemical pharmacology.

The role of adenosine in the hypotensive actions of morphine.

P. White, W. Hope, R. Rose'meyer, 1995, European journal of pharmacology.

Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure

C. Langmead, P. White, P. Sexton, 2020, bioRxiv.

New paradigms in adenosine receptor pharmacology: allostery, oligomerization and biased agonism

A. T. Nguyen, Joanne Baltos, P. White, 2018, British journal of pharmacology.

Chronic Caffeine Treatment Causes Changes in Cardiac Adenosine Receptor Function in Rats

P. White, T. Nguyen, T.T. Nguyen, 2002, Pharmacology.

Tissue-specific Calibration of Real-time PCR Facilitates Absolute Quantification of Plasmid DNA in Biodistribution Studies

P. White, C. Pouton, J. Ho, 2016, Molecular therapy. Nucleic acids.

Live confocal microscopy of oligonucleotide uptake by keratinocytes in human skin grafts on nude mice.

P. White, P. Delaney, R. Fogarty, 1999, The Journal of investigative dermatology.

A suicidal strain of Listeria monocytogenes is effective as a DNA vaccine delivery system for oral administration.

P. White, Cheng-Yi Kuo, C. Pouton, 2017, Vaccine.

Intravenous IGF‐I receptor antisense reduces IGF‐IR expression and diminishes pressor responses to angiotensin II in conscious normotensive rats

P. White, T. Nguyen, P. White, 2005, British journal of pharmacology.

Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist

Joanne Baltos, P. White, P. Sexton, 2014, Proceedings of the National Academy of Sciences.

Quantification of adenosine A(1) receptor biased agonism: Implications for drug discovery.

Joanne Baltos, K. Gregory, P. White, 2016, Biochemical pharmacology.

Ligand-Independent Adenosine A2B Receptor Constitutive Activity as a Promoter of Prostate Cancer Cell Proliferation

K. Gregory, P. White, A. Christopoulos, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Delineating the Mode of Action of Adenosine A1 Receptor Allosteric Modulators

P. White, P. Sexton, A. Christopoulos, 2010, Molecular Pharmacology.

C-5 propyne-modified oligonucleotides penetrate the epidermis in psoriatic and not normal human skin after topical application.

P. White, R. Fogarty, G. Werther, 2002, The Journal of investigative dermatology.

Microsoft Word-85980797-file00

P. White, P. Sexton, A. Christopoulos, 2010 .

A suicidal strain of Listeria monocytogenes is effective as a DNA vaccine delivery system for oral administration.

P. White, Cheng-Yi Kuo, C. Pouton, 2017, Vaccine.