P. Sexton

Ruben Abagyan, Laurence J Miller, Patrick M Sexton, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Characterization of Amylin and Calcitonin Receptor Binding in the Mouse α-Thyroid-Stimulating Hormone Thyrotroph Cell Line.

P. Sexton, D. Myers, G. Christopoulos, 1997, Endocrinology.

Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure

C. Langmead, P. White, P. Sexton, 2020, bioRxiv.

Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor

P. Sexton, A. Christopoulos, M. Glass, 2015, Molecular Pharmacology.

Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor.

P. Sexton, A. Christopoulos, M. Canals, 2016, Biochemical pharmacology.

Biased Agonism of Endogenous Opioid Peptides at the μ-Opioid Receptor

P. Sexton, A. Christopoulos, M. Canals, 2015, Molecular Pharmacology.

Pharmacology of 5HT(2C) receptor-mediated ERK1/2 phosphorylation: agonist-specific activation pathways and the impact of RNA editing.

P. Sexton, A. Christopoulos, M. Crouch, 2008, Biochemical pharmacology.

Evolving cryo-EM structural approaches for GPCR drug discovery.

P. Sexton, R. Danev, A. Kotecha, 2021, Structure.

Allostery and Biased Agonism at Class B G Protein-Coupled Receptors.

P. Sexton, A. Christopoulos, L. Miller, 2017, Chemical reviews.

Stimulus Bias Provides Evidence for Conformational Constraints in the Structure of a G Protein-coupled Receptor*

K. Gregory, P. Sexton, A. Christopoulos, 2012, The Journal of Biological Chemistry.

Mechanisms of ERK1/2 regulation by seven-transmembrane-domain receptors.

P. Sexton, A. Christopoulos, Tim D. Werry, 2006, Current pharmaceutical design.

Pharmacological Discrimination of Calcitonin Receptor: Receptor Activity-Modifying Protein Complexes

P. Sexton, A. Christopoulos, D. Hay, 2005, Molecular Pharmacology.

Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination.

Arthur Christopoulos, Denise Wootten, Patrick M. Sexton, 2018, ACS pharmacology & translational science.

O-GlcNAc engineering of GPCR peptide-agonists improves their stability and in vivo activity.

Paul M. Levine, P. Sexton, V. Katritch, 2019, Journal of the American Chemical Society.

Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

P. Sexton, A. Christopoulos, L. Miller, 2010, Molecular Pharmacology.

Differential engagement of polar networks in the glucagon‐like peptide 1 receptor by endogenous variants of the glucagon‐like peptide 1

P. Sexton, A. Christopoulos, D. Wootten, 2018, Biochemical pharmacology.

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

P. Sexton, A. Christopoulos, L. Miller, 2021, bioRxiv.

Allostery in GPCRs: 'MWC' revisited.

P. Sexton, A. Christopoulos, M. Canals, 2011, Trends in biochemical sciences.

Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes.

P. Sexton, R. Danev, D. Wootten, 2021, Cell reports.

Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.

C. Langmead, P. Sexton, A. Christopoulos, 2020, Molecular cell.

Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.

P. Sexton, H. Xu, Ming-Wei Wang, 2020, Molecular cell.

Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism

P. Sexton, A. Christopoulos, Ming-Wei Wang, 2018, The Journal of Biological Chemistry.

A structural basis for amylin receptor phenotype

P. Sexton, A. Christopoulos, R. Danev, 2022, Science.

RAMPs regulate signalling bias and internalisation of the GIPR

G. Ladds, P. Sexton, S. Hill, 2021, bioRxiv.

Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.

P. Sexton, A. Christopoulos, H. Xu, 2020, Molecular cell.

In vitro autoradiographic localization of amylin binding sites in rat brain

G. Paxinos, P. Sexton, K. Beaumont, 1994, Neuroscience.

Probe Dependence in the Allosteric Modulation of a G Protein-Coupled Receptor: Implications for Detection and Validation of Allosteric Ligand Effects

P. Sexton, A. Christopoulos, C. Felder, 2012, Molecular Pharmacology.

Muscarinic M5 receptors modulate ethanol seeking in rats

David M. Shackleford, Alice E. Berizzi, C. Langmead, 2018, Neuropsychopharmacology.

Regulation of M2 Muscarinic Acetylcholine Receptor Expression and Signaling by Prolonged Exposure to Allosteric Modulators

P. Sexton, A. Christopoulos, L. May, 2005, Journal of Pharmacology and Experimental Therapeutics.

The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors.

P. Sexton, A. Christopoulos, C. Valant, 2012, Annual review of pharmacology and toxicology.

Identification of Orthosteric and Allosteric Site Mutations in M2 Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias*

Arthur Christopoulos, Nathan E Hall, Patrick M Sexton, 2010, The Journal of Biological Chemistry.

Homology modeling of GPCRs.

Ruben Abagyan, Arthur Christopoulos, John Simms, 2009, Methods in molecular biology.

Bridging the gap: bitopic ligands of G-protein-coupled receptors.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2013, Trends in pharmacological sciences.

High throughput, quantitative analysis of human osteoclast differentiation and activity.

C. Langmead, P. Sexton, A. Christopoulos, 2017, Analytical biochemistry.

Structure-Activity Relationships of Pan-Gαq/11 Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators.

Alice E. Berizzi, C. Langmead, P. Sexton, 2018, ACS chemical neuroscience.

Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators

Alice E. Berizzi, C. Langmead, P. Sexton, 2016, Molecular Pharmacology.

Molecular Mechanisms of Action and In Vivo Validation of an M4 Muscarinic Acetylcholine Receptor Allosteric Modulator with Potential Antipsychotic Properties

P. Sexton, A. Christopoulos, D. McKinzie, 2010, Neuropsychopharmacology.

Mechanisms of signalling and biased agonism in G protein-coupled receptors

M. Babu, P. Sexton, A. Christopoulos, 2018, Nature Reviews Molecular Cell Biology.

Molecular insights into peptide agonist engagement with the PTH receptor.

Elliot J. Gerrard, P. Sexton, D. Wootten, 2023, Structure.

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

Arthur Christopoulos, Laurence J Miller, Patrick M Sexton, 2013, Proceedings of the National Academy of Sciences.

Cryo-EM structure of the dual incretin receptor agonist, peptide-19, in complex with the glucagon-like peptide-1 receptor.

C. Langmead, P. Sexton, R. Danev, 2021, Biochemical and biophysical research communications.

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

K. Gregory, P. Sexton, A. Christopoulos, 2021, bioRxiv.

Structural and Functional Diversity among Agonist-Bound States of the GLP-1 Receptor

P. Sexton, S. Gellman, R. Danev, 2021, bioRxiv.

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

K. Gregory, P. Sexton, A. Christopoulos, 2022, Nature Communications.

Molecular Basis for Benzodiazepine Agonist Action at the Type 1 Cholecystokinin Receptor*

R. Abagyan, P. Sexton, A. Christopoulos, 2013, The Journal of Biological Chemistry.

Molecular Basis for Binding and Subtype Selectivity of 1,4-Benzodiazepine Antagonist Ligands of the Cholecystokinin Receptor*

R. Abagyan, P. Sexton, P. Lam, 2012, The Journal of Biological Chemistry.

Benzodiazepine ligands can act as allosteric modulators of the Type 1 cholecystokinin receptor.

P. Sexton, A. Christopoulos, L. Miller, 2008, Bioorganic & medicinal chemistry letters.

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

W. Baumeister, P. Sexton, A. Christopoulos, 2018, Nature.

Characterization of signal bias at the GLP‐1 receptor induced by backbone modification of GLP‐1

P. Sexton, S. Gellman, D. Wootten, 2017, Biochemical pharmacology.

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy

P. Sexton, A. Christopoulos, A. Inoue, 2016, Cell.

Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor.

P. Sexton, A. Christopoulos, C. Reynolds, 2019, ACS pharmacology & translational science.

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

P. Sexton, A. Christopoulos, C. Reynolds, 2018, Biochemical pharmacology.

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

P. Sexton, C. Reynolds, T. Sakmar, 2017, The Journal of Biological Chemistry.

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

P. Sexton, A. Christopoulos, C. Reynolds, 2016, Biochemical pharmacology.

Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor Involved in Peptide Activity and Small-Molecule Allostery

P. Sexton, A. Christopoulos, L. Miller, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Molecular Mechanisms of Bitopic Ligand Engagement with the M1 Muscarinic Acetylcholine Receptor*

Shane M. Devine, P. Sexton, A. Christopoulos, 2014, The Journal of Biological Chemistry.

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.

P. Sexton, A. Christopoulos, L. Miller, 2013, Biochemical Society transactions.

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands*

Arthur Christopoulos, Patrick M Sexton, Michael W Parker, 2007, Journal of Biological Chemistry.

Structure-Function Studies of Allosteric Agonism at M2 Muscarinic Acetylcholine Receptors

C. Langmead, P. Sexton, A. Christopoulos, 2007, Molecular Pharmacology.

Characterization of serotonin 5‐HT2C receptor signaling to extracellular signal‐regulated kinases 1 and 2

K. Gregory, P. Sexton, A. Christopoulos, 2005, Journal of neurochemistry.

Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms

C. Langmead, M. Febbraio, P. Sexton, 2021, BMJ Open Diabetes Research & Care.

A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity

Arthur Christopoulos, Nathan E Hall, Patrick M Sexton, 2008, Journal of Biological Chemistry.

Quantification of Allosteric Interactions at G Protein–Coupled Receptors Using Radioligand Binding Assays

P. Sexton, A. Christopoulos, K. Leach, 2000, Current protocols in pharmacology.

Molecular Determinants of Allosteric Modulation at the M1 Muscarinic Acetylcholine Receptor*

Arthur Christopoulos, Patrick M Sexton, Laura López, 2014, The Journal of Biological Chemistry.

The Role of Transmembrane Domain 3 in the Actions of Orthosteric, Allosteric, and Atypical Agonists of the M4 Muscarinic Acetylcholine Receptor

P. Sexton, A. Christopoulos, C. Felder, 2011, Molecular Pharmacology.

Pattern of Intra-Family Hetero-Oligomerization Involving the G-Protein-Coupled Secretin Receptor

P. Sexton, L. Miller, M. Morfis, 2008, Journal of Molecular Neuroscience.

Light-activated chimeric GPCRs: limitations and opportunities.

Elliot J. Gerrard, P. Sexton, H. Janovjak, 2019, Current opinion in structural biology.

Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors

P. Sexton, C. Reynolds, D. Wootten, 2021, Frontiers in Molecular Biosciences.

Amylin receptor phenotypes derived from human calcitonin receptor/RAMP coexpression exhibit pharmacological differences dependent on receptor isoform and host cell environment.

P. Sexton, S. Foord, G. Christopoulos, 2000, The Journal of pharmacology and experimental therapeutics.

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

W. Baumeister, A. T. Nguyen, Joanne Baltos, 2018, Nature.

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

R. Dror, A. Venkatakrishnan, P. Sexton, 2019, Nature Communications.

Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor.

P. Sexton, A. Christopoulos, C. Valant, 2013, Journal of medicinal chemistry.

Structural Determinants of Allosteric Agonism and Modulation at the M4 Muscarinic Acetylcholine Receptor

P. Sexton, A. Christopoulos, C. Felder, 2010, The Journal of Biological Chemistry.

Structure and dynamics of the CGRP receptor in apo and peptide-bound forms

K. Gregory, P. Sexton, A. Christopoulos, 2021, Science.

Spatial Approximation between Secretin Residue Five and the Third Extracellular Loop of Its Receptor Provides New Insight into the Molecular Basis of Natural Agonist Binding

R. Abagyan, P. Sexton, P. Lam, 2008, Molecular Pharmacology.

Fluorescence Resonance Energy Transfer Analysis of Secretin Docking to Its Receptor

R. Abagyan, P. Sexton, P. Lam, 2007, Journal of Biological Chemistry.

Rational development of a high-affinity secretin receptor antagonist.

P. Sexton, A. Christopoulos, C. Reynolds, 2020, Biochemical pharmacology.

Localization of binding sites for calcitonin gene-related peptide in rat brain by in vitro autoradiography

J. McKenzie, P. Sexton, T. Martin, 1986, Neuroscience.

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

Arthur Christopoulos, Patrick M Sexton, Ben Capuano, 2016, Journal of Medicinal Chemistry.

Structural basis of efficacy-driven ligand selectivity at GPCRs

S. Paul, P. Sexton, A. Christopoulos, 2023, Nature Chemical Biology.

Constitutive Formation of Oligomeric Complexes between Family B G Protein-Coupled Vasoactive Intestinal Polypeptide and Secretin Receptors

Laurence J Miller, Patrick M Sexton, P. Sexton, 2006, Molecular Pharmacology.

Substance dependence.

John F. G. Atack, C. McDougle, D. Posey, 1998, Harvard women's health watch.

Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors.

P. Sexton, Sung‐Hyun Yang, M. Brimble, 2020, ACS pharmacology & translational science.

Receptor activity modifying proteins and their potential as drug targets.

P. Sexton, A. Christopoulos, D. Hay, 2010, Progress in molecular biology and translational science.

Determinants of 1-Piperidinecarboxamide, N-[2-[[5-Amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) Affinity for Calcitonin Gene-Related Peptide and Amylin Receptors—The Role of Rec

P. Sexton, A. Christopoulos, D. Hay, 2006, Molecular Pharmacology.

A simple method to generate stable cell lines for the analysis of transient protein-protein interactions.

P. Sexton, A. Christopoulos, D. Wootten, 2013, BioTechniques.

Crystal structure of the M5 muscarinic acetylcholine receptor

Alice E. Berizzi, C. Langmead, P. Sexton, 2019, Proceedings of the National Academy of Sciences.

Activation of M1 muscarinic receptors reduce pathology and slow progression of neurodegenerative disease

Shailesh N Mistry, P. Sexton, A. Christopoulos, 2021, bioRxiv.

Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist

Joanne Baltos, P. White, P. Sexton, 2014, Proceedings of the National Academy of Sciences.

Quantification of adenosine A(1) receptor biased agonism: Implications for drug discovery.

Joanne Baltos, K. Gregory, P. White, 2016, Biochemical pharmacology.

Functional Importance of a Structurally Distinct Homodimeric Complex of the Family B G Protein-Coupled Secretin Receptor

Ruben Abagyan, Arthur Christopoulos, Laurence J Miller, 2009, Molecular Pharmacology.

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling

Arthur Christopoulos, John Simms, Denise Wootten, 2017, PLoS Comput. Biol..

Allosteric Modulation of a Chemogenetically Modified G Protein-Coupled Receptor

P. Sexton, A. Christopoulos, M. Canals, 2013, Molecular Pharmacology.

The Emergence of Allosteric Modulators for G Protein‐Coupled Receptors

K. Gregory, P. Sexton, A. Christopoulos, 2010 .

Crystal structure of the M5muscarinic acetylcholine receptor.

Alice E. Berizzi, C. Langmead, P. Sexton, 2019 .

Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold.

Alice E. Berizzi, C. Langmead, P. Sexton, 2018, ACS chemical neuroscience.

Subtype

Husseini K. Manji, John F. G. Atack, D. Posey, 2020, Definitions.

Delineating the Mode of Action of Adenosine A1 Receptor Allosteric Modulators

P. White, P. Sexton, A. Christopoulos, 2010, Molecular Pharmacology.

Determination of Adenosine A1 Receptor Agonist and Antagonist Pharmacology Using Saccharomyces cerevisiae: Implications for Ligand Screening and Functional Selectivity

P. Sexton, A. Christopoulos, S. Dowell, 2009, Journal of Pharmacology and Experimental Therapeutics.

A Monod-Wyman-Changeux Mechanism Can Explain G Protein-coupled Receptor (GPCR) Allosteric Modulation*

P. Sexton, A. Christopoulos, P. Scammells, 2011, The Journal of Biological Chemistry.

Responses of GPCR135 to Human Gene 3 (H3) Relaxin in CHO‐K1 Cells Determined by Microphysiometry

P. Sexton, R. Summers, R. Bathgate, 2005, Annals of the New York Academy of Sciences.

Electrophoretic mobility and glycosylation characteristics of heterogeneously expressed calcitonin receptors.

P. Sexton, M. Dowton, K. J. Perry, 1997, Endocrinology.

Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor*

Arthur Christopoulos, Laura López, Patrick M. Sexton, 2014, The Journal of Biological Chemistry.

Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor*

R. Abagyan, P. Sexton, A. Christopoulos, 2016, The Journal of Biological Chemistry.

Small Molecule Allosteric Modulation of the Glucagon-Like Peptide-1 Receptor Enhances the Insulinotropic Effect of Oxyntomodulin

P. Sexton, A. Christopoulos, F. Willard, 2012, Molecular Pharmacology.

Secretin Occupies a Single Protomer of the Homodimeric Secretin Receptor Complex

R. Abagyan, P. Sexton, P. Lam, 2010, The Journal of Biological Chemistry.

Molecular Approximations between Residues 21 and 23 of Secretin and Its Receptor: Development of a Model for Peptide Docking with the Amino Terminus of the Secretin Receptor

R. Abagyan, P. Sexton, P. Lam, 2007, Molecular Pharmacology.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

Gebhard F. X. Schertler, Christofer S. Tautermann, Philip C. Biggin, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX

J. Jeppesen, P. Sexton, L. Edvinsson, 2018, European journal of pharmacology.

To Bind or Not to Bind: Unravelling GPCR Polypharmacology

Arthur Christopoulos, Patrick M. Sexton, P. Sexton, 2018, Cell.

Photoaffinity scanning in the mapping of the peptide receptor interface of class II G protein—coupled receptors

Patrick M Sexton, P. Sexton, V I Pham, 2004, Journal of peptide science : an official publication of the European Peptide Society.

The Impact of Orthosteric Radioligand Depletion on the Quantification of Allosteric Modulator Interactions

P. Sexton, A. Christopoulos, David J. McLoughlin, 2008, Journal of Pharmacology and Experimental Therapeutics.

Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor

P. Sexton, A. Christopoulos, A. Tobin, 2018, Biochemical pharmacology.

Structure-function studies of muscarinic acetylcholine receptors.

Arthur Christopoulos, Patrick M Sexton, John Simms, 2012, Handbook of experimental pharmacology.

Structure-Function Studies of Allosteric Agonism at M 2 Muscarinic Acetylcholine Receptors

C. Langmead, P. Sexton, A. Christopoulos, 2007 .

Overview of receptor allosterism.

K. Gregory, P. Sexton, A. Christopoulos, 2000, Current protocols in pharmacology.

The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors

P. Sexton, A. Christopoulos, G. Christopoulos, 2008, Regulatory Peptides.

Protein-Coupling Efficiency of Amylin Receptors Receptor Activity-Modifying Proteins Differentially Modulate the G

P. Sexton, G. Christopoulos, M. Morfis, 2008 .

1 RECEPTOR ACTIVITY MODIFYING PROTEINS DIFFERENTIALLY MODULATE THE G PROTEIN-COUPLING EFFICIENCY OF AMYLIN RECEPTORS Abbreviated title : RAMPs modulate G protein selectivity

P. Sexton, A. Christopoulos, M. Morfis, 2007 .

Structural insight into selectivity of amylin and calcitonin receptor agonists.

Elliot J. Gerrard, P. Sexton, R. Danev, 2023, Nature Chemical Biology.

Prediction of Loops in G Protein-Coupled Receptor Homology Models: Effect of Imprecise Surroundings and Constraints

Arthur Christopoulos, Santosh B. Noronha, Bhumika Arora, 2016, J. Chem. Inf. Model..

Patient-controlled analgesia.

B. J. Harrison, Stephanie A. Carmack, John F. G. Atack, 1986, Nursing.

Drug transporters in drug efficacy and toxicity.

P. Sexton, R. Kim, R. Lefkowitz, 2012, Annual review of pharmacology and toxicology.

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

P. Sexton, A. Christopoulos, C. Reynolds, 2016, Cell.

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

P. Sexton, P. Wookey, D. Hutchinson, 2019, BMC Cancer.

Coding GPCR-G protein specificity

P. Sexton, S. G. Furness, 2017, Cell Research.

Relaxin family peptide receptor 4

P. Sexton, R. Summers, E. T. Westhuizen, 2008 .

Function of the rat calcitonin receptors, C1a and C1b, expressed in Xenopus oocytes.

P. Sexton, Y. Uezono, K. Sumikawa, 1998, Biochemical and biophysical research communications.

Heterogeneity in ligand recognition of calcitonin receptors

P. Sexton, S. Houssami, D. Findlay, 1994 .

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

P. Sexton, A. Christopoulos, R. Danev, 2023, Nature communications.

Structure of the M5 muscarinic acetylcholine receptor (M5-T4L) bound to tiotropium

Alice E. Berizzi, C. Langmead, P. Sexton, 2019 .

Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs

R Abagyan, R. Abagyan, P. Sexton, 2007, Proceedings of the National Academy of Sciences.

Allosteric modulation of G protein-coupled receptors.

P. Sexton, A. Christopoulos, L. May, 2004, Current pharmaceutical design.

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity.

P. Sexton, A. Christopoulos, A. Tobin, 2018, ACS chemical neuroscience.

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.

Shailesh N Mistry, P. Sexton, A. Christopoulos, 2017 .

Acetylcholine Receptor Muscarinic 1 Modulation at the M Molecular Determinants of Allosteric Signal Transduction

Shailesh N Mistry, P. Sexton, A. Christopoulos, 2016 .

Muscarinic Acetylcholine Receptor 1 Structure-Function Relationships at the M Mechanistic Insights into Allosteric

P. Sexton, A. Christopoulos, P. Scammells, 2014 .

Microsoft Word-85980797-file00

P. White, P. Sexton, A. Christopoulos, 2010 .

Application of a Kinetic Model to the Apparently Complex Behavior of Negative and Positive Allosteric Modulators of Muscarinic Acetylcholine Receptors

P. Sexton, A. Christopoulos, L. May, 2004, Journal of Pharmacology and Experimental Therapeutics.

Allosteric Modulation of a Chemogenetically Modified G Protein-Coupled Receptor

P. Sexton, A. Christopoulos, M. Canals, 2013, Molecular Pharmacology.

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.

P. Sexton, A. Christopoulos, L. Miller, 2013, Biochemical Society transactions.

Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A(1) adenosine receptor modulation.

P. Sexton, A. Christopoulos, J. White, 2010, Journal of Medicinal Chemistry.

Endogenous Allosteric Modulators of G Protein–Coupled Receptors

P. Sexton, A. Christopoulos, C. Valant, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

Stephanie A. Carmack, C. McDougle, D. Posey, 2002, Nature.

H2 Relaxin Is a Biased Ligand Relative to H3 Relaxin at the Relaxin Family Peptide Receptor 3 (RXFP3)

P. Sexton, A. Christopoulos, J. Wade, 2010, Molecular Pharmacology.

Chromatin Immunoprecipitation

Stephanie A. Carmack, S. K. Zaidi, C. McDougle, 2020, Definitions.

Small Molecule Allosteric Modulation of the Glucagon-Like Peptide-1 Receptor Enhances the Insulinotropic Effect of Oxyntomodulin

P. Sexton, A. Christopoulos, F. Willard, 2012, Molecular Pharmacology.

Procalcitonin has bioactivity at calcitonin receptor family complexes: Potential mediator implications in sepsis*

P. Sexton, A. Christopoulos, K. Becker, 2008, Critical care medicine.

Posttranslational Protein Modification

Stephanie A. Carmack, John F. G. Atack, C. McDougle, 2021, Encyclopedia of Molecular Pharmacology.

To Bind or Not to Bind: Unravelling GPCR Polypharmacology

P. Sexton, A. Christopoulos, 2018, Cell.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

T. Ceska, P. Biggin, M. Bodkin, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor.

Alice E. Berizzi, C. Langmead, P. Sexton, 2021, ACS chemical neuroscience.

Multiparameter prediction of myeloid neoplasia risk

Sara M. Willems, C. Gieger, U. Thorsteinsdóttir, 2023, Nature Genetics.

Serotonin Transporter

John F. G. Atack, C. McDougle, D. Posey, 2021, Encyclopedia of Evolutionary Psychological Science.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society)

P. Biggin, P. Sexton, C. Tautermann, 2018 .

Pharmacological Discrimination of Calcitonin Receptor: Receptor Activity-Modifying Protein Complexes

P. Sexton, A. Christopoulos, D. Hay, 2005, Molecular Pharmacology.

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

P. Sexton, A. Christopoulos, C. Lindsley, 2022, bioRxiv.

Impact of species variability and ‘probe‐dependence’ on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor

P. Sexton, A. Christopoulos, K. Leach, 2011, British journal of pharmacology.

Biased agonism of endogenous opioid peptides at the mu-opioid receptor and Canals

P. Sexton, Thomas Coudrat, Georgina L. Thompson, 2015 .

P. Sexton, A. Christopoulos, L. Miller, 2016, Biochemical pharmacology.

Label-Free Kinetics: Exploiting Functional Hemi-Equilibrium to Derive Rate Constants for Muscarinic Receptor Antagonists

C. Langmead, P. Sexton, A. Christopoulos, 2015, Molecular Pharmacology.

Constitutive Formation of Oligomeric Complexes between Family B G Protein-Coupled Vasoactive Intestinal Polypeptide and Secretin Receptors

P. Sexton, L. Miller, M. Morfis, 2006, Molecular Pharmacology.

International Union of Basic and Clinical Pharmacology. XC. Multisite Pharmacology: Recommendations for the Nomenclature of Receptor Allosterism and Allosteric Ligands

J. Changeux, R. Neubig, C. Langmead, 2014, Pharmacological Reviews.

The class B G-protein-coupled GLP-1 receptor: an important target for the treatment of type-2 diabetes mellitus.

P. Sexton, L. Miller, M. Dong, 2014, International journal of obesity supplements.

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Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors

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Isoform-Specific Biased Agonism of Histamine H3 Receptor Agonists

C. Langmead, P. Sexton, A. Christopoulos, 2017, Molecular Pharmacology.

Molecular Pharmacology

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GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Sara M. Willems, C. Gieger, U. Thorsteinsdóttir, 2023, Nature Genetics.

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Faculty of 1000 evaluation for Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche.

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Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits

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Utility of an “Allosteric Site-Impaired” M2 Muscarinic Acetylcholine Receptor as a Novel Construct for Validating Mechanisms of Action of Synthetic and Putative Endogenous Allosteric Modulators

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Molecular Determinants of Allosteric Modulation at the M1 Muscarinic Acetylcholine Receptor*

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