Sarah L. Huszar

发表

Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.

John D. Schreier, I. Raheem, J. Fuerst, 2016, Bioorganic & medicinal chemistry letters.

T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats

Jason M. Uslaner, John J. Renger, Victor N. Uebele, 2012, Neuropharmacology.

MK-801 produces a deficit in sucrose preference that is reversed by clozapine, d-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: Relevance to negative symptoms associated with schizophrenia?

Sarah L. Huszar, J. Uslaner, P. Hutson, 2010, Pharmacology Biochemistry and Behavior.

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target

Sarah L. Huszar, J. Uslaner, T. Tucker, 2014, Neuropharmacology.

Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma.

Christopher M. Tan, D. Slipetz, Sarah L. Huszar, 2011, American journal of respiratory cell and molecular biology.

Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.

Sarah L. Huszar, J. Uslaner, M. Jacobson, 2016, Bioorganic & medicinal chemistry letters.

Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.

John D. Schreier, I. Raheem, J. Fuerst, 2012, Bioorganic & medicinal chemistry letters.

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.

Leo A. Joyce, Sarah L. Huszar, J. Uslaner, 2016, ACS medicinal chemistry letters.

3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts.

Sarah L. Huszar, J. Uslaner, C. Culberson, 2010, Bioorganic & medicinal chemistry letters.

Combined administration of an mGlu2/3 receptor agonist and a 5-HT2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants

Sarah L. Huszar, J. Uslaner, Sean M. Smith, 2009, Psychopharmacology.

Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor.

Sarah L. Huszar, J. Uslaner, M. Jacobson, 2010, ACS medicinal chemistry letters.

The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey

Dawn M. Toolan, John D. Schreier, I. Raheem, 2013, Neuropharmacology.

The Behavioral and Neurochemical Effects of a Novel d-Amino Acid Oxidase Inhibitor Compound 8 [4H-Thieno [3,2-b]pyrrole-5-carboxylic Acid] and d-Serine

Sarah L. Huszar, Monika Kandebo, J. Uslaner, 2008, Journal of Pharmacology and Experimental Therapeutics.

Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia

I. Raheem, J. Fuerst, Sarah L. Huszar, 2023, Journal of medicinal chemistry.

Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.

John D. Schreier, I. Raheem, J. Fuerst, 2012, Bioorganic & medicinal chemistry letters.

Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma.

Christopher M. Tan, D. Slipetz, Sarah L. Huszar, 2011, American journal of respiratory cell and molecular biology.