S. Meegalla

发表

Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors.

S. Meegalla, Hui-Sheng Huang, C. Illig, 2016, Bioorganic & medicinal chemistry letters.

IPT: A novel iodinated ligand for the CNS dopamine transporter

I. Lucki, H. Kung, S. Meegalla, 1995, Synapse.

Imaging of dopamine transporters in humans with technetium-99m TRODAT 1

H. Kung, S. Meegalla, M. Kung, 1996, European Journal of Nuclear Medicine.

Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.

S. Meegalla, C. Illig, D. Parks, 2011, Journal of medicinal chemistry.

Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α-Fluorination.

S. Meegalla, Hui-Sheng Huang, Brian Rady, 2018, ACS medicinal chemistry letters.

Kinetic modeling of [99mTc]TRODAT-1: a dopamine transporter imaging agent.

S. Kushner, H. Kung, S. Meegalla, 1999, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2010, Bioorganic & medicinal chemistry letters.

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

B. Tomczuk, S. Meegalla, C. Illig, 2009, Molecular Cancer Therapeutics.

An improved kit formulation of a dopamine transporter imaging agent: [Tc-99m]TRODAT-1.

H. Kung, S. Meegalla, M. Kung, 1999, Nuclear medicine and biology.

Bioassay of quinoline, 5-fluoroquinoline, carbazole, 9-methylcarbazole and 9-ethylcarbazole in newborn mice.

S. Meegalla, E. LaVoie, C. Mcqueen, 1993, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

An unusual doubly substituted product from the phase-transfer-catalyzed Heck reactions of o-bromobenzaldehydes with methyl acrylate

S. Meegalla, N. Taylor, R. Rodrigo, 1992 .

Alkyl Isobenzofurans from Phthalides; Inter and Intramolecular Diels-Alder Reactions

S. Meegalla, R. Rodrigo, 1989 .

Synthesis and insecticidal activity of fluorinated 2-(2,6-dichloro-4-trifluoromethylphenyl)-2,4,5,6-tetrahydrocyclopentapyrazoles.

S. Meegalla, D. Doller, R. Soll, 2006, Bioorganic & medicinal chemistry letters.

A general synthetic route to isobenzofurans bearing a functionalized C-1 substituent

S. Meegalla, R. Rodrigo, 1991 .

Synthesis and GABA receptor potency of 3-thiomethyl-4-(hetero)aryl-5-amino-1-phenylpyrazoles.

S. Meegalla, D. Doller, R. Soll, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin.

S. Meegalla, C. Yu, L. Liu, 1994, Journal of medicinal chemistry.

Tc-99m-labeled tropanes as dopamine transporter imaging agents.

H. Kung, S. Meegalla, M. Kung, 1996, Bioconjugate chemistry.

First Example of a 99mTc Complex as a Dopamine Transporter Imaging Agent

H. Kung, S. Meegalla, M. Kung, 1995 .

Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2008, Bioorganic & medicinal chemistry letters.

Discovery of novel FMS kinase inhibitors as anti-inflammatory agents.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2008, Bioorganic & medicinal chemistry letters.

[99mTc]TRODAT-1: A novel technetium-99m complex as a dopamine transporter imaging agent

Hank F. Kung, I. Lucki, H. Kung, 1997, European Journal of Nuclear Medicine.

Synthesis and characterization of technetium-99m-labeled tropanes as dopamine transporter-imaging agents.

S. Kushner, H. Kung, S. Meegalla, 1997, Journal of medicinal chemistry.

Exploratory synthetic investigations related to 12a-deoxypillaromycinone

S. Meegalla, N. Taylor, R. Rodrigo, 2002 .

Discovery of novel benzo[b]thiophene tetrazoles as non-carboxylate GPR40 agonists.

S. Meegalla, Hui-Sheng Huang, Brian Rady, 2017, Bioorganic & medicinal chemistry letters.

5-amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-3-[3H3]-methylsulfanyl-1H-pyrazole-4-carbonitrile (CTOM): synthesis and characterization of a novel and selective insect GABA receptor radioligand.

S. Meegalla, D. Doller, R. Soll, 2003, Bioorganic & medicinal chemistry letters.

Simultaneous SPECT studies of pre- and postsynaptic dopamine binding sites in baboons.

H. Kung, S. Meegalla, M. Kung, 1999, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).

B. Tomczuk, R. DesJarlais, S. Meegalla, 2011, Journal of medicinal chemistry.

Structure-based optimization of a potent class of arylamide FMS inhibitors.

Jinsheng Chen, Mark R Player, B. Tomczuk, 2008, Bioorganic & medicinal chemistry letters.

Dosimetry of an iodine-123-labeled tropane to image dopamine transporters.

H. Kung, S. Meegalla, M. Kung, 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Pharmacological effects of dopaminergic drugs on in vivo binding of [99mTc]TRODAT-1 to the central dopamine transporters in rats

H. Kung, S. Meegalla, M. Kung, 1997, European Journal of Nuclear Medicine.

Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia.

S. Meegalla, D. Parks, M. Player, 2012, Bioorganic & medicinal chemistry letters.

Specificity of diastereomers of [99mTc]TRODAT-1 as dopamine transporter imaging agents.

S. Kushner, H. Kung, S. Meegalla, 1998, Journal of medicinal chemistry.

Discovery of novel FMS kinase inhibitors as anti-inflammatory agents.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2008, Bioorganic & medicinal chemistry letters.