S. Dowell

发表

Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.

G. Ladds, A. Knight, J. Hemmings, 2016, Journal of medicinal chemistry.

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids*

S. Dowell, F. Marshall, M. Wigglesworth, 2003, The Journal of Biological Chemistry.

Mapping of a yeast G protein betagamma signaling interaction.

A. Brown, S. Dowell, M. Whiteway, 1998, Genetics.

Stepwise assembly of initiation complexes at budding yeast replication origins during the cell cycle

J. Diffley, S. Dowell, J. Harwood, 1995, Journal of Cell Science.

Characterization of 16 human G protein-coupled receptors expressed in baculovirus-infected insect cells.

S. Dowell, M. Koglin, N. Folschweiller, 2005, Protein expression and purification.

RAMP 2 engenders signal bias at the glucagon receptor 1 Modulation of Glucagon Receptor Pharmacology by RAMP 2

G. Ladds, S. Dowell, C. Reynolds, 2015 .

Pharmacology of GPR 55 in Yeast and Identification of GSK 494581 A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR 55 Agonist

S. Dowell, D. Daniels, Andrew J. Brown, 2011 .

Mutagenesis of human Mel1a melatonin receptor expressed in yeast reveals domains important for receptor function.

S. Dowell, T. Kokkola, J. Laitinen, 1998, Biochemical and biophysical research communications.

Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation

S. Dowell, M. Szczepek, P. Scheerer, 2022, International journal of molecular sciences.

G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody

S. Dowell, D. Grillot, Ashley A. Barnes, 2020, Scientific Reports.

Self-compatible B mutants in coprinus with altered pheromone-receptor specificities.

A. Brown, S. Dowell, L. Casselton, 2000, Genetics.

The utility of pharmacokinetic–pharmacodynamic modeling in the discovery and optimization of selective S1P1 agonists

S. Dowell, E. Demont, J. Witherington, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

Yeast assays for G-protein-coupled receptors.

A. Brown, S. Dowell, 2002, Receptors & channels.

Structure-Activity Relationship of the GPR55 Antagonist, CID16020046

S. Dowell, Andrew J. Brown, Carl P. Haslam, 2018, Pharmacology.

Mapping of a Yeast G Protein (cid:98)(cid:103) Signaling Interaction

A. Brown, S. Dowell, M. Whiteway, 1998 .

Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.

S. Dowell, E. Demont, J. Witherington, 2016, Journal of medicinal chemistry.

Functional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein α‐subunit chimeras

M. Marzioch, S. Dowell, M. Whiteway, 2000, Yeast.

Pharmacological properties of acid N-thiazolylamide FFA2 agonists

S. Dowell, Andrew J. Brown, A. Gangar, 2015, Pharmacology research & perspectives.

Molecular Identification of High and Low Affinity Receptors for Nicotinic Acid*

S. Dowell, F. Marshall, P. Murdock, 2003, The Journal of Biological Chemistry.

Discovery of a brain-penetrant S1P₃-sparing direct agonist of the S1P₁ and S1P₅ receptors efficacious at low oral dose.

S. Dowell, K. Philpott, T. Heightman, 2011, Journal of medicinal chemistry.

The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects

S. Dowell, N. Aiyar, W. Bao, 2007, British journal of pharmacology.

N‐Palmitoylglycine and other N‐acylamides activate the lipid receptor G2A/GPR132

A. Irving, S. Dowell, Andrew J. Brown, 2019, Pharmacology research & perspectives.

The centromere and promoter factor 1, CPFI, of Saccharomyces cerevisiae modulates gene activity through a family of factors including SPT21, RPD1 (SIN3), RPD3 and CCR4

S. Dowell, L. Bird, J. Mellor, 1993, Molecular and General Genetics MGG.

Recent developments in the initiation of chromosomal DNA replication: a complex picture emerges.

J. Diffley, S. Dowell, A. Rowley, 1994, Biochimica et biophysica acta.

Investigating G protein signalling bias at the glucagon-like peptide-1 receptor in yeast

G. Ladds, S. Dowell, D. Poyner, 2014, British journal of pharmacology.

Development of a yeast trihybrid screen using stable yeast strains and regulated protein expression.

S. Dowell, J. White, M. Morse, 1998, BioTechniques.

Arginine 199 and Leucine 208 Have Key Roles in the Control of Adenosine A2A Receptor Signalling Function

S. Dowell, B. Byrne, A. Strege, 2014, PloS one.

Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo.

J. Diffley, S. Dowell, J F Diffley, 1994, Science.

Complex chimeras to map ligand binding sites of GPCRs.

S. Dowell, K. Patel, J. Barnett, 2003, Protein engineering.

Two steps in the assembly of complexes at yeast replication origins in vivo

J. Diffley, S. Dowell, A. Rowley, 1994, Cell.

The centromere and promoter factor 1 of yeast contains a dimerisation domain located carboxy-terminal to the bHLH domain.

S. Dowell, J. Tsang, J. Mellor, 1992, Nucleic acids research.

DNA binding of CPF1 is required for optimal centromere function but not for maintaining methionine prototrophy in yeast.

S. Dowell, J. Mellor, W. Jiang, 1991, Nucleic acids research.

Pharmacology of GPR55 in Yeast and Identification of GSK494581A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR55 Agonist

S. Dowell, D. Daniels, Andrew J. Brown, 2011, Journal of Pharmacology and Experimental Therapeutics.

Heterologous expression of G-protein-coupled receptors in yeast.

S. Dowell, B. Byrne, Shweta Singh, 2015, Methods in enzymology.

A constitutively active G‐protein‐coupled receptor causes mating self‐compatibility in the mushroom Coprinus

S. Dowell, L. Casselton, Andrew J. Brown, 1999, The EMBO journal.

Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate.

S. Dowell, E. Demont, J. Witherington, 2011, ACS medicinal chemistry letters.

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2)*

G. Ladds, S. Dowell, C. Reynolds, 2015, The Journal of Biological Chemistry.

Yeast assays for G protein-coupled receptors.

S. Dowell, Andrew J. Brown, 2009, Methods in molecular biology.

A high-throughput assay for connexin 43 (Cx43, GJA1) gap junctions using codon-optimized aequorin.

S. Dowell, N. Tigue, A. Powell, 2013, Assay and drug development technologies.

Author Correction: G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody

S. Dowell, D. Grillot, Ashley A. Barnes, 2020, Scientific Reports.

Unlocking the secrets of the gatekeeper: methods for stabilizing and crystallizing GPCRs.

Shweta Singh, Michael M Hann, Bernadette Byrne, 2013, Biochimica et biophysica acta.

Loss of constitutive activity is correlated with increased thermostability of the human adenosine A2A receptor

S. Dowell, B. Byrne, Shweta Singh, 2013, British journal of pharmacology.

Determination of Adenosine A1 Receptor Agonist and Antagonist Pharmacology Using Saccharomyces cerevisiae: Implications for Ligand Screening and Functional Selectivity

P. Sexton, A. Christopoulos, S. Dowell, 2009, Journal of Pharmacology and Experimental Therapeutics.

Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors.

G. Ladds, I. Winfield, S. Dowell, 2016, The Journal of Biological Chemistry.

G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody

S. Dowell, D. Grillot, Ashley A. Barnes, 2020, Scientific Reports.

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors*

G. Ladds, I. Winfield, S. Dowell, 2016, The Journal of Biological Chemistry.

Understanding GPCRs - from orphan receptors to novel drugs.

S. Dowell, 2001, Drug discovery today.