D. Guo

发表

Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength.

A. IJzerman, E. Segala, D. Guo, 2016, Journal of medicinal chemistry.

Drug‐Target Residence Time—A Case for G Protein‐Coupled Receptors

Adriaan P IJzerman, Dong Guo, A. IJzerman, 2014, Medicinal research reviews.

Functional efficacy of adenosine A2A receptor agonists is positively correlated to their receptor residence time

A. IJzerman, T. Mulder-Krieger, D. Guo, 2012, British journal of pharmacology.

The Added Value of Assessing Ligand-Receptor Binding Kinetics in Drug Discovery.

A. IJzerman, D. Guo, L. Heitman, 2016, ACS medicinal chemistry letters.

GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor

G. V. van Westen, A. IJzerman, C. Müller, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Molecular Basis of Ligand Dissociation from the Adenosine A2A Receptor

Albert C. Pan, R. Dror, D. Shaw, 2016, Molecular Pharmacology.

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time.

Leigh A. Stoddart, R. Wade, R. Leurs, 2017, Drug discovery today.

A two‐state model for the kinetics of competitive radioligand binding

L. Peletier, A. IJzerman, H. de Vries, 2018, British journal of pharmacology.

Molecular mechanism of allosteric modulation at GPCRs: insight from a binding kinetics study at the human A1 adenosine receptor

A. IJzerman, D. Guo, L. Heitman, 2014, British journal of pharmacology.

Biased and Constitutive Signaling in the CC-chemokine Receptor CCR5 by Manipulating the Interface between Transmembrane Helices 6 and 7*

D. Guo, T. Frimurer, M. Rosenkilde, 2013, The Journal of Biological Chemistry.

Drug-Target Association Kinetics in Drug Discovery.

A. IJzerman, D. Guo, 2019, Trends in biochemical sciences.

Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists.

A. IJzerman, T. Mulder-Krieger, D. Guo, 2015, European journal of medicinal chemistry.

Dual-Point Competition Association Assay

A. IJzerman, T. Mulder-Krieger, D. Guo, 2013, Journal of biomolecular screening.

Long residence time adenosine A1 receptor agonists produce sustained wash-resistant antilipolytic effect in rat adipocytes.

A. IJzerman, D. Guo, L. Heitman, 2019, Biochemical pharmacology.

Revisit ligand-receptor interaction at the human vasopressin V2 receptor: A kinetic perspective.

L. Peletier, D. Guo, Xudong Cao, 2020, European journal of pharmacology.

Mass spectrometry-based ligand binding assays on adenosine A1 and A2A receptors

T. Hankemeier, A. IJzerman, D. Guo, 2015, Purinergic Signalling.

Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines.

A. IJzerman, H. de Vries, D. Guo, 2014, Journal of medicinal chemistry.

Importance of Drug–Target Residence Time at G Protein‐Coupled Receptors – a Case for the Adenosine Receptors

A. IJzerman, D. Guo, L. Heitman, 2015 .

Gating function of isoleucine‐116 in TM‐3 (position III:16/3.40) for the activity state of the CC‐chemokine receptor 5 (CCR5)

D. Guo, T. Frimurer, M. Rosenkilde, 2014, British journal of pharmacology.

Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics

A. IJzerman, D. Guo, M. Waring, 2017, Molecular Pharmacology.

Structure-Activity Relationships of the Sustained Effects of Adenosine A 2 A Receptor Agonists Driven by Slow Dissociation Kinetics s

A. IJzerman, D. Guo, M. Waring, 2016 .

Kinetic Aspects of the Interaction between Ligand and G Protein-Coupled Receptor: The Case of the Adenosine Receptors.

A. IJzerman, D. Guo, L. Heitman, 2017, Chemical reviews.

Equilibrium and kinetic selectivity profiling on the human adenosine receptors.

A. IJzerman, D. Guo, L. Heitman, 2016, Biochemical pharmacology.

Binding Kinetics of ZM241385 Derivatives at the Human Adenosine A2A Receptor

A. IJzerman, D. Guo, L. Heitman, 2014, ChemMedChem.

Mass spectrometry-based ligand binding assays on adenosine A1 and A2A receptors

T. Hankemeier, A. IJzerman, D. Guo, 2015, Purinergic Signalling.

5'-Substituted Amiloride Derivatives as Allosteric Modulators Binding in the Sodium Ion Pocket of the Adenosine A2A Receptor.

Berend J. H. Huisman, A. IJzerman, D. Guo, 2016, Journal of medicinal chemistry.

An allosteric modulator of the adenosine A1 receptor potentiates the antilipolytic effect in rat adipose tissue.

D. Guo, Kequan Fu, Huimin Zhao, 2023, European journal of pharmacology.

Disturbance of Mammary UDP-Glucuronosyltransferase Represses Estrogen Metabolism and Exacerbates Experimental Breast Cancer.

D. Guo, Junnian Zheng, Juan Wang, 2017, Journal of pharmaceutical sciences.

The Role of Target Binding Kinetics in Drug Discovery

A. IJzerman, D. Guo, L. Heitman, 2015, ChemMedChem.

Exploring Chemical Substructures Essential for hERG K+ Channel Blockade by Synthesis and Biological Evaluation of Dofetilide Analogues

Johannes Brussee, Shagufta, Dong Guo, 2009, ChemMedChem.

Molecular Basis of Ligand Dissociation from G Protein-Coupled Receptors and Predicting Residence Time.

A. IJzerman, D. Guo, 2018, Methods in molecular biology.