T. Hitaka

发表

Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket.

M. Yoshikawa, T. Hitaka, Tomoaki Hasui, 2016, Bioorganic & medicinal chemistry.

Synthesis of queuine, the base of naturally occurring hypermodified nucleoside (queuosine), and its analogues

T. Hitaka, S. Nishimura, H. Akimoto, 1988 .

Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys

T. Hitaka, S. Asahi, A. Tasaka, 2012, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.

T. Hitaka, Masaharu Nakayama, J. Yano, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part I.

T. Hitaka, Katsuji Aikawa, Y. Imai, 2015, Bioorganic & medicinal chemistry.

Synthesis and antitumor activity of pyrrolo[2,3-d]pyrimidine antifolates with a bridge chain containing a nitrogen atom.

T. Hitaka, H. Akimoto, K. Aso, 1995, Chemical & pharmaceutical bulletin.

Novel pyrrolo[2,3-d]pyrimidine antifolates: synthesis and antitumor activities.

T. Hitaka, H. Akimoto, H. Nomura, 1991, Journal of medicinal chemistry.

Novel Pyrrolo(2,3‐d)pyrimidine Antifolates: Synthesis and Antitumor Activities.

T. Hitaka, H. Akimoto, H. Nomura, 1991 .

Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor.

T. Hitaka, S. Sasaki, T. Imada, 2011, Journal of medicinal chemistry.

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.

T. Hitaka, Toshimasa Tanaka, A. Ojida, 2011, Bioorganic & medicinal chemistry.

Semisynthetic beta-lactam antibiotics. 6. 1 Sulfocephalosporins and their antipseudomonal activities.

T. Hitaka, H. Nomura, S. Morimoto, 1974, Journal of medicinal chemistry.

Semisynthetic beta-lactam antibiotics. 8 Structure-activity relationships of alpha-sulfocephalosporins.

T. Hitaka, H. Nomura, T. Fugono, 1976, The Journal of antibiotics.

Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys

T. Hitaka, A. Tasaka, M. Yamaoka, 2013, The Journal of Steroid Biochemistry and Molecular Biology.

Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists.

T. Hitaka, A. Tasaka, M. Yamada, 2012, Bioorganic & medicinal chemistry.